{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:44:17Z","timestamp":1784324657830,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Depression is a major psychiatric disorder in Brazil and worldwide. Vaccinium ashei (V. ashei) leaves are cultivation by-products with high bioactive compound levels. Here, a hydroalcoholic extract of V. ashei leaves (HEV) was associated with Eudragit\u00ae RS100-based nanoparticles (NPHEV) to evaluate the in vitro antioxidant and in vivo antidepressant-like effects. Interfacial deposition of the preformed polymer method was used for NPHEV production. The formulations were evaluated regarding physicochemical characteristics, antioxidant activity (DPPH radical scavenging and oxygen radical absorbance capacity), and antidepressant-like action (1\u201325 mg\/kg, single intragastric administration) assessed in forced swimming and tail suspension tests in male Balb-C mice. The NPHEV presented sizes in the nanometric range (144\u2013206 nm), positive zeta potential values (8\u201315 mV), polydispersity index below 0.2, and pH in the acid range. The phenolic compound content was near the theoretical values, although the rutin presented higher encapsulation efficiency (~95%) than the chlorogenic acid (~60%). The nanoencapsulation improved the HEV antioxidant effect and antidepressant-like action by reducing the immobility time in both behavioral tests. Hence, Eudragit\u00ae RS100 nanoparticles containing HEV were successfully obtained and are a promising alternative to manage depression.<\/jats:p>","DOI":"10.3390\/ph16010084","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T07:05:09Z","timestamp":1673247909000},"page":"84","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nanoencapsulation of Vaccinium ashei Leaf Extract in Eudragit\u00ae RS100-Based Nanoparticles Increases Its In Vitro Antioxidant and In Vivo Antidepressant-like Actions"],"prefix":"10.3390","volume":"16","author":[{"given":"Verciane Schneider","family":"Cezarotto","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia Industrial, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade, Curso de Farm\u00e1cia, Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es, Frederico Westphalen 98400-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda Piovesan","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade, Curso de Farm\u00e1cia, Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es, Frederico Westphalen 98400-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Stein","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade, Curso de Farm\u00e1cia, Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es, Frederico Westphalen 98400-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Emanuelli","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia dos Alimentos, Departamento de Tecnologia e Ci\u00eancia dos Alimentos, Centro de Ci\u00eancias Rurais, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Haselein","family":"Maurer","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia dos Alimentos, Departamento de Tecnologia e Ci\u00eancia dos Alimentos, Centro de Ci\u00eancias Rurais, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-9306","authenticated-orcid":false,"given":"Marcel Henrique Marcondes","family":"Sari","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia Industrial, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-587X","authenticated-orcid":false,"given":"Luana Mota","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia, Universidade Federal do Paran\u00e1, Curitiba 80210-170, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6230-4577","authenticated-orcid":false,"given":"Let\u00edcia","family":"Cruz","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia Industrial, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-022-06623-z","article-title":"Digital Psychosocial Intervention for Depression among Older Adults in Socioeconomically Deprived Areas in Brazil (PRODIGITAL-D): Protocol for an Individually Randomised Controlled Trial","volume":"23","author":"Nakamura","year":"2022","journal-title":"Trials"},{"key":"ref_2","unstructured":"(2022, December 28). 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