{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:55:42Z","timestamp":1790873742920,"version":"4.1.0"},"reference-count":185,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81970814"],"award-info":[{"award-number":["81970814"]}]},{"name":"National Natural Science Foundation of China","award":["81670863"],"award-info":[{"award-number":["81670863"]}]},{"name":"National Natural Science Foundation of China","award":["2021JSTS28"],"award-info":[{"award-number":["2021JSTS28"]}]},{"name":"Clinical AFFMU Foundation","award":["81970814"],"award-info":[{"award-number":["81970814"]}]},{"name":"Clinical AFFMU Foundation","award":["81670863"],"award-info":[{"award-number":["81670863"]}]},{"name":"Clinical AFFMU Foundation","award":["2021JSTS28"],"award-info":[{"award-number":["2021JSTS28"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Oxidative stress is an imbalance between the increased production of reactive species and reduced antioxidant activity, which can cause a variety of disturbances including ocular diseases. Lycium barbarum polysaccharides (LBPs) are complex polysaccharides isolated from the fruit of L. barbarum, showing distinct roles in antioxidants. Moreover, it is relatively safe and non-toxic. In recent years, the antioxidant activities of LBPs have attracted remarkable attention. In order to illustrate its significance and underlying therapeutic value for vision, we comprehensively review the recent progress on the antioxidant mechanisms of LBP and its potential applications in ocular diseases, including diabetic retinopathy, hypertensive neuroretinopathy, age-related macular degeneration, retinitis pigmentosa, retinal ischemia\/reperfusion injury, glaucoma, dry eye syndrome, and diabetic cataract.<\/jats:p>","DOI":"10.3390\/ph16020215","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T02:27:56Z","timestamp":1675132076000},"page":"215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Distinct Role of Lycium barbarum L. Polysaccharides in Oxidative Stress-Related Ocular Diseases"],"prefix":"10.3390","volume":"16","author":[{"given":"Yali","family":"Niu","sequence":"first","affiliation":[{"name":"College of Life Sciences, Northwestern University, Xi\u2019an 710069, China"},{"name":"Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-1835","authenticated-orcid":false,"given":"Guorui","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1111\/aos.13526","article-title":"Dry eye disease and oxidative stress","volume":"96","author":"Seen","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2011.03.010","article-title":"Unraveling the biological roles of reactive oxygen species","volume":"13","author":"Murphy","year":"2011","journal-title":"Cell Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1042\/BST20140060","article-title":"ROS signalling, NADPH oxidases and cancer","volume":"42","author":"Landry","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1100\/2011\/741046","article-title":"Biochemistry of the phagosome: The challenge to study a transient organelle","volume":"11","year":"2011","journal-title":"Sci. World J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2174\/0929867043365323","article-title":"Oxidative stress and cell signalling","volume":"11","author":"Poli","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1042\/CS20171246","article-title":"Oxidative stress and reactive oxygen species: A review of their role in ocular disease","volume":"131","author":"Ung","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.2174\/1381612825666190115121531","article-title":"Oxidative Stress, Ocular Disease and Diabetes Retinopathy","volume":"24","author":"Tangvarasittichai","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kabra, A., Sharma, R., Hano, C., Kabra, R., Martins, N., and Baghel, U.S. (2019). Phytochemical Composition, Antioxidant, and Antimicrobial Attributes of Different Solvent Extracts from Myrica esculenta Buch.-Ham.ex. D. Don Leaves. Biomolecules, 9.","DOI":"10.3390\/biom9080357"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11746-998-0032-9","article-title":"Free radicals, oxidative stress, and antioxidants in human health and disease","volume":"75","author":"Aruoma","year":"1998","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mrrev.2013.01.001","article-title":"Environmental light and endogenous antioxidants as the main determinants of non-cancer ocular diseases","volume":"752","author":"Roszkowska","year":"2013","journal-title":"Mutat. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3164734","DOI":"10.1155\/2016\/3164734","article-title":"The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults","volume":"2016","author":"Nita","year":"2016","journal-title":"Oxid Med. Cell Longev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jams.2012.09.002","article-title":"In Vitro antioxidant activities of methanol and aqueous extract of Annona squamosa (L.) fruit pulp","volume":"6","author":"Nandhakumar","year":"2013","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-8741(99)00171-3","article-title":"In vitro antioxidant activity of Anthriscus cerefolium L.(Hoffm.) extracts","volume":"69","author":"Fejes","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.2174\/1389450118666170123145357","article-title":"The Antioxidant Activities of Natural Polysaccharides","volume":"18","author":"Huang","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1389557516666151120114605","article-title":"The Role Oxidative Stress in the Pathogenesis of Eye Diseases: Current Status and a Dual Role of Physical Activity","volume":"16","author":"Kruk","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/10408398.2021.1944974","article-title":"Dietary polysaccharides exert biological functions via epigenetic regulations: Advance and prospectives","volume":"63","author":"Guo","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1142\/S0192415X16500269","article-title":"The Anti-Oxidant and Antitumor Properties of Plant Polysaccharides","volume":"44","author":"Jiao","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tian, X., Liang, T., Liu, Y., Ding, G., Zhang, F., and Ma, Z. (2019). Extraction, Structural Characterization, and Biological Functions of Lycium Barbarum Polysaccharides: A Review. Biomolecules, 9.","DOI":"10.3390\/biom9090389"},{"key":"ref_19","first-page":"e13927","article-title":"Polysaccharides from traditional Asian food source and their antitumor activity","volume":"46","author":"Yang","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.foodchem.2017.08.026","article-title":"Lycium ruthenicum studies: Molecular biology, Phytochemistry and pharmacology","volume":"240","author":"Wang","year":"2018","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"778","DOI":"10.14336\/AD.2017.0725","article-title":"Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent","volume":"8","author":"Gao","year":"2017","journal-title":"Aging Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0029-1186218","article-title":"Goji (Lycium barbarum and L.chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity","volume":"76","author":"Potterat","year":"2010","journal-title":"Planta Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ijbiomac.2006.11.002","article-title":"Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats","volume":"40","author":"Li","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.foodchem.2018.01.176","article-title":"Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review","volume":"254","author":"Masci","year":"2018","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chen, Y., Yao, F., Ming, K., Wang, D., Hu, Y., and Liu, J. (2016). Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity. Molecules, 21.","DOI":"10.3390\/molecules21121705"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yang, C., Zhao, Q., Li, S., Pu, L., Yu, L., Liu, Y., and Lai, X. (2022). Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review. Molecules, 27.","DOI":"10.3390\/molecules27175628"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.carbpol.2008.04.025","article-title":"Optimization of extraction technology of the Lycium barbarum polysaccharides by Box\u2013Behnken statistical design","volume":"74","author":"Yin","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2000614","DOI":"10.1002\/cbdv.202000614","article-title":"Polysaccharide from Lycium arabicum: Structural Features, in Vitro Antioxidant Activities and Protective Effect against Oxidative Damage in Human Erythrocytes","volume":"17","author":"Fakhfakh","year":"2020","journal-title":"Chem. Biodivers."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"916271","DOI":"10.3389\/fnut.2022.916271","article-title":"Hypoglycemic Effects of Lycium barbarum Polysaccharide in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota","volume":"9","author":"Ma","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/bs.pmbts.2019.03.003","article-title":"The structures and biological functions of polysaccharides from traditional Chinese herbs","volume":"163","author":"Zeng","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.foodchem.2016.07.105","article-title":"Polyphenols from wolfberry and their bioactivities","volume":"214","author":"Zhou","year":"2017","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chanioti, S., Katsouli, M., and Tzia, C. (2021). Novel Processes for the Extraction of Phenolic Compounds from Olive Pomace and Their Protection by Encapsulation. Molecules, 26.","DOI":"10.3390\/molecules26061781"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Luo, Q., Zhang, J.R., Li, H.B., Wu, D.T., Geng, F., Corke, H., Wei, X.L., and Gan, R.Y. (2020). Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis). Antioxidants, 9.","DOI":"10.3390\/antiox9090785"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pollini, L., Rocchi, R., Cossignani, L., Ma\u00f1es, J., Compagnone, D., and Blasi, F. (2019). Phenol Profiling and Nutraceutical Potential of Lycium spp. Leaf Extracts Obtained with Ultrasound and Microwave Assisted Techniques. Antioxidants, 8.","DOI":"10.3390\/antiox8080260"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.foodchem.2016.09.093","article-title":"Extraction optimization and identification of anthocyanins from Nitraria tangutorun Bobr.seed meal and establishment of a green analytical method of anthocyanins","volume":"218","author":"Sang","year":"2017","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e12522","DOI":"10.1111\/jfpe.12522","article-title":"Optimization of ultrasound assisted extraction of of goji berry (Lycium barbarum) fruits and evaluation of extracts\u2019 bioactivity","volume":"40","author":"Skenderidis","year":"2017","journal-title":"J. Food Process Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"119618","DOI":"10.1016\/j.carbpol.2022.119618","article-title":"Isolation, structure and biological activity of polysaccharides from the fruits of Lycium ruthenicum Murr: A review","volume":"291","author":"Yun","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100282","DOI":"10.1016\/j.fochx.2022.100282","article-title":"Physicochemical and antioxidant properties of Lycium barbarum seed dreg polysaccharides prepared by continuous extraction","volume":"14","author":"Zhang","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ijbiomac.2022.04.184","article-title":"The anti-aging activity of Lycium barbarum polysaccharide extracted by yeast fermentation: In vivo and in vitro studies","volume":"209","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3892\/mmr.2014.1964","article-title":"Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway","volume":"9","author":"Xia","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chang, R.C., and So, K.F. (2015). Lycium Barbarum and Human Health, Springer.","DOI":"10.1007\/978-94-017-9658-3"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.intimp.2014.01.010","article-title":"Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4\/MD2-MAPK signaling pathway activator and inducer","volume":"19","author":"Zhang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.carbpol.2018.10.057","article-title":"Mechanism of Lycium barbarum polysaccharides liposomes on activating murine dendritic cells","volume":"205","author":"Bo","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.vetimm.2013.05.006","article-title":"Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells","volume":"158","author":"Su","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cellimm.2010.04.001","article-title":"Sulfated modification can enhance the immune-enhancing activity of lycium barbarum polysaccharides","volume":"263","author":"Wang","year":"2010","journal-title":"Cell Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fncel.2017.00288","article-title":"Neuroprotective Mechanisms of Lycium barbarum Polysaccharides Against Ischemic Insults by Regulating NR2B and NR2A Containing NMDA Receptor Signaling Pathways","volume":"11","author":"Shi","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"ref_47","first-page":"55","article-title":"The protective effects of lycium barbarum polysaccharides on retinal neurons in diabetic rats and its mechanism","volume":"35","author":"Pan","year":"2019","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.bbrc.2017.11.165","article-title":"Lycium barbarum polysaccharide protects against oxygen glucose deprivation\/reoxygenation-induced apoptosis and autophagic cell death via the PI3K\/Akt\/mTOR signaling pathway in primary cultured hippocampal neurons","volume":"495","author":"Yu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijbiomac.2012.11.023","article-title":"Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.","volume":"54","author":"Jin","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ijbiomac.2020.01.251","article-title":"Arabinogalactan derived from Lycium barbarum fruit inhibits cancer cell growth via cell cycle arrest and apoptosis","volume":"149","author":"Gong","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1399770","DOI":"10.1080\/16546628.2017.1399770","article-title":"Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: An in vitro and in vivo study","volume":"61","author":"Deng","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10787-011-0107-3","article-title":"A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit","volume":"20","author":"Tang","year":"2012","journal-title":"Inflammopharmacology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.lfs.2004.11.009","article-title":"Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: Inhibition of proliferation and induction of apoptosis","volume":"76","author":"Zhang","year":"2005","journal-title":"Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1177\/1534735417753544","article-title":"Fraction From Lycium barbarum Polysaccharides Reduces Immunotoxicity and Enhances Antitumor Activity of Doxorubicin in Mice","volume":"17","author":"Deng","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_55","first-page":"7","article-title":"Protective effect of Lycium barbarum polysaccharides against high-fat diet-induced renal injury and lipid deposition in rat kidneys","volume":"33","author":"Liao","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1038\/srep05587","article-title":"Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model","volume":"4","author":"Xiao","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3140290","DOI":"10.1155\/2016\/3140290","article-title":"Lycium barbarum Polysaccharide Mediated the Antidiabetic and Antinephritic Effects in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats via Regulation of NF-\u03baB","volume":"2016","author":"Du","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s11658-018-0084-2","article-title":"Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2","volume":"23","author":"Liang","year":"2018","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/10715762.2017.1294755","article-title":"Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage","volume":"51","author":"Li","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15593258211057768","DOI":"10.1177\/15593258211057768","article-title":"Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation","volume":"19","author":"Guo","year":"2021","journal-title":"Dose Response"},{"key":"ref_61","first-page":"12","article-title":"Influence of LBP on Blood Glucose and Blood Lipid in Type 2 Diabetic Rats","volume":"36","author":"Yuan","year":"2015","journal-title":"J. Liaoning Med. Univ."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.carbpol.2013.04.057","article-title":"Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L.","volume":"98","author":"Zhu","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.foodres.2018.12.043","article-title":"An untargeted metabolomics approach reveals further insights of Lycium barbarum polysaccharides in high fat diet and streptozotocin-induced diabetic rats","volume":"116","author":"Xia","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_64","first-page":"196198","article-title":"Crude extracts from Lycium barbarum suppress SREBP-1c expression and prevent diet-induced fatty liver through AMPK activation","volume":"2014","author":"Li","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1038\/emm.2017.24","article-title":"The interplay between host immune cells and gut microbiota in chronic inflammatory diseases","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/intimm\/dxac020","article-title":"The role of immune cells in the liver tumor microenvironment: An involvement of gut microbiota-derived factors","volume":"34","author":"Kamiya","year":"2022","journal-title":"Int. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"109591","DOI":"10.1016\/j.biopha.2019.109591","article-title":"Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide","volume":"121","author":"Zhu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"112087","DOI":"10.1016\/j.biopha.2021.112087","article-title":"Lycium barbarum polysaccharide attenuates emotional injury of offspring elicited by prenatal chronic stress in rats via regulation of gut microbiota","volume":"143","author":"Zhao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"119626","DOI":"10.1016\/j.carbpol.2022.119626","article-title":"The polysaccharides from the fruits of Lycium barbarum L. confer anti-diabetic effect by regulating gut microbiota and intestinal barrier","volume":"291","author":"Zhou","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1039\/D1FO01200B","article-title":"An arabinogalactan from Lycium barbarum attenuates DSS-induced chronic colitis in C57BL\/6J. mice associated with the modulation of intestinal barrier function and gut microbiota","volume":"12","author":"Cao","year":"2021","journal-title":"Food Funct."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijbiomac.2018.04.056","article-title":"The antiviral activity of polysaccharides and their derivatives","volume":"115","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijbiomac.2009.11.011","article-title":"Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast","volume":"46","author":"Wang","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijbiomac.2015.12.089","article-title":"The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo","volume":"85","author":"Bo","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"113764","DOI":"10.1016\/j.biopha.2022.113764","article-title":"Therapeutic strategies for liver diseases based on redox control systems","volume":"156","author":"Lee","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"F145","DOI":"10.1530\/REP-22-0152","article-title":"Oxidative Stress and Reproductive Function: Oxidative stress in polycystic ovary syndrome","volume":"164","author":"Rudnicka","year":"2022","journal-title":"Reproduction"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"G\u0119gotek, A., and Skrzydlewska, E. (2022). Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid. Antioxidants, 11.","DOI":"10.3390\/antiox11101993"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pnpbp.2013.02.015","article-title":"Free radicals, antioxidant defense systems, and schizophrenia","volume":"46","author":"Wu","year":"2013","journal-title":"Progr. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.freeradbiomed.2022.11.017","article-title":"Targeting NRF2-KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases","volume":"193","author":"Davinelli","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"106346","DOI":"10.1016\/j.biocel.2022.106346","article-title":"Free radicals: Relationship to Human Diseases and Potential Therapeutic applications","volume":"154","author":"Zaric","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s13205-022-03409-7","article-title":"Ellagic acid: Insight into its protective effects in age-associated disorders","volume":"12","author":"Deepika","year":"2022","journal-title":"3 Biotech."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5692852","DOI":"10.1155\/2016\/5692852","article-title":"Reviews on Mechanisms of In Vitro Antioxidant Activity of Polysaccharides","volume":"2016","author":"Wang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijbiomac.2013.06.042","article-title":"Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity","volume":"61","author":"Liu","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.toxrep.2018.02.001","article-title":"Assessment of the antioxidant and antimutagenic activity of extracts from goji berry of Greek cultivation","volume":"5","author":"Skenderidis","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_84","first-page":"741","article-title":"Process optimization of lycium ruthenicum murr. powder preparation by airflow ultrafine pulverization at low temperature and characterization of its antioxidant activity","volume":"41","author":"Kai","year":"2019","journal-title":"J. Chem. Soc. Pak."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"He, Q., Du, B., and Xu, B. (2018). Extraction Optimization of Phenolics and Antioxidants from Black Goji Berry by Accelerated Solvent Extractor Using Response Surface Methodology. Appl. Sci., 8.","DOI":"10.3390\/app8101905"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jff.2017.01.015","article-title":"Isolation, antioxidant property and protective effect on PC12 cell of the main anthocyanin in fruit of Lycium ruthenicum Murray","volume":"30","author":"Tang","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/fsn3.1393","article-title":"Fatty acid and mineral contents of Lycium ruthenicum Murr.and antioxidant activity against isoproterenol-induced acute myocardial ischemia in mice","volume":"8","author":"Xia","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"112620","DOI":"10.1016\/j.biopha.2022.112620","article-title":"Effect of Lycium barbarum polysaccharides on cell signal transduction pathways","volume":"147","author":"Qi","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/cbdd.13798","article-title":"Antioxidant activities and mechanisms of polysaccharides","volume":"97","author":"Mu","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ijbiomac.2019.07.129","article-title":"Antioxidant activity of Momordica charantia polysaccharide and its derivatives","volume":"138","author":"Chen","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3945\/an.112.003103","article-title":"Emerging role of Nrf2 in adipocytes and adipose biology","volume":"4","author":"Schneider","year":"2013","journal-title":"Adv Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"145641","DOI":"10.1155\/2014\/145641","article-title":"Dietary Lycium barbarum polysaccharide induces Nrf2\/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K\/AKT signaling","volume":"2014","author":"Yang","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/jog.13416","article-title":"Lycium barbarum polysaccharide attenuates chemotherapy-induced ovarian injury by reducing oxidative stress","volume":"43","author":"Yang","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e108690","DOI":"10.15252\/embj.2021108690","article-title":"BCL-2-family protein tBID can act as a BAX-like effector of apoptosis","volume":"41","author":"Hohorst","year":"2022","journal-title":"EMBO J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"a036319","DOI":"10.1101\/cshperspect.a036319","article-title":"BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins","volume":"12","author":"Moldoveanu","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_96","first-page":"11","article-title":"Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Ophthalmol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1002\/fsn3.1942","article-title":"Hepatoprotective effect of crude polysaccharide isolated from Lycium barbarum L.against alcohol-induced oxidative damage involves Nrf2 signaling","volume":"8","author":"Wang","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3892\/mmr.2021.12418","article-title":"Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia\/reperfusion injury via Nrf2 activation through autophagy inhibition","volume":"24","author":"Pan","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1631\/jzus.B2100748","article-title":"A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells","volume":"23","author":"Du","year":"2022","journal-title":"J. Zhejiang Univ Sci. B"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/13510002.2022.2036507","article-title":"Lycium Barbarum polysaccharide protects HaCaT cells from PM2.5-induced apoptosis via inhibiting oxidative stress, ER stress and autophagy","volume":"27","author":"Zhu","year":"2022","journal-title":"Redox Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/0963689719835181","article-title":"Lycium barbarum (Wolfberry) Increases Retinal Ganglion Cell Survival and Affects both Microglia\/Macrophage Polarization and Autophagy after Rat Partial Optic Nerve Transection","volume":"28","author":"Li","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jchemneu.2017.12.011","article-title":"Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR\/p70S6K inhibition in Streptozotocin-induced diabetic rats","volume":"89","author":"Liu","year":"2018","journal-title":"J. Chem. Neuroanat."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s12272-019-01175-4","article-title":"Attenuation of hyperoxic acute lung injury by Lycium barbarum polysaccharide via inhibiting NLRP3 inflammasome","volume":"42","author":"Hong","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Yang, M., So, K.F., Lo, A.C.Y., and Lam, W.C. (2020). The Effect of Lycium barbarum Polysaccharides on Pyroptosis-Associated Amyloid \u03b2(1-40) Oligomers-Induced Adult Retinal Pigment Epithelium 19 Cell Damage. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134658"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cels.2017.12.006","article-title":"Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease","volume":"6","author":"Kurt","year":"2018","journal-title":"Cell Syst."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12031-012-9837-y","article-title":"Inhibition of phosphorylation of JNK suppresses A\u03b2-induced ER stress and upregulates prosurvival mitochondrial proteins in rat hippocampus","volume":"49","author":"Yenki","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s11064-014-1315-1","article-title":"Curcumin prevents cerebral ischemia reperfusion injury via increase of mitochondrial biogenesis","volume":"39","author":"Liu","year":"2014","journal-title":"Neurochem. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s11655-021-3309-6","article-title":"Lycium barbarum Polysaccharides Promotes Mitochondrial Biogenesis and Energy Balance in a NAFLD Cell Model","volume":"28","author":"Zhang","year":"2022","journal-title":"Chin. J. Integr. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"110252","DOI":"10.1016\/j.cellsig.2022.110252","article-title":"Lycium barbarum polysaccharide antagonizes cardiomyocyte apoptosis by inhibiting the upregulation of GRK2 induced by I\/R injury, and salvage mitochondrial fission\/fusion imbalance and AKT\/eNOS signaling","volume":"92","author":"Li","year":"2022","journal-title":"Cell Signal."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1159\/000486165","article-title":"Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress","volume":"44","author":"Cui","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12935-019-0805-2","article-title":"Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague-Dawley rats","volume":"19","author":"Karna","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejcb.2016.02.002","article-title":"The role of the endoplasmic reticulum stress in stemness, pluripotency and development","volume":"95","author":"Stejskal","year":"2016","journal-title":"Eur. J. Cell Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12944-020-01210-0","article-title":"Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease","volume":"19","author":"Wang","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fphar.2020.00742","article-title":"Effects of Lycium barbarum Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.4103\/1673-5374.189197","article-title":"Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury","volume":"11","author":"Zhao","year":"2016","journal-title":"Neural Regen. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41536-022-00233-8","article-title":"Clinically relevant small-molecule promotes nerve repair and visual function recovery","volume":"7","author":"Au","year":"2022","journal-title":"npj Regen. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1258\/ebm.2011.010400","article-title":"Dietary wolfberry ameliorates retinal structure abnormalities in db\/db mice at the early stage of diabetes","volume":"236","author":"Tang","year":"2011","journal-title":"Exp. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1463-5224.2012.01018.x","article-title":"The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats","volume":"15","author":"Hu","year":"2012","journal-title":"Vet. Ophthalmol."},{"key":"ref_120","first-page":"1404","article-title":"Effect of Lycium barbarum polysaccharides on the retinal ultrastructure of streptozocin-induced diabetic rats","volume":"33","author":"Guo","year":"2013","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7943212","DOI":"10.1155\/2018\/7943212","article-title":"Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats","volume":"2018","author":"Yao","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/mnfr.201200642","article-title":"Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db\/db diabetic mice","volume":"57","author":"Yu","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12177-009-9023-9","article-title":"Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model","volume":"2","author":"Chiu","year":"2009","journal-title":"J. Ocul. Biol. Dis. Inform."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.4103\/1673-5374.284998","article-title":"Lycium barbarum polysaccharides related RAGE and A\u03b2 levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier","volume":"15","author":"Mi","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/OPX.0b013e318205a18f","article-title":"Goji berry effects on macular characteristics and plasma antioxidant levels","volume":"88","author":"Bucheli","year":"2011","journal-title":"Optom. Vis. Sci."},{"key":"ref_126","first-page":"970","article-title":"Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration","volume":"11","author":"Li","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Li, X., Holt, R.R., Keen, C.L., Morse, L.S., Yiu, G., and Hackman, R.M. (2021). Goji Berry Intake Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Pilot Trial. Nutrients, 13.","DOI":"10.21203\/rs.3.rs-785757\/v1"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4077\/CJP.2016.BAE404","article-title":"Effect of a complex lutein formula in an animal model for light-induced retinal degeneration","volume":"59","author":"Cheng","year":"2016","journal-title":"Chin. J. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.biopha.2018.04.104","article-title":"Antioxidant effects of Lycium barbarum polysaccharides on photoreceptor degeneration in the light-exposed mouse retina","volume":"103","author":"Tang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"4814928","DOI":"10.1155\/2018\/4814928","article-title":"Protective Effects of Lycium barbarum Extracts on UVB-Induced Damage in Human Retinal Pigment Epithelial Cells Accompanied by Attenuating ROS and DNA Damage","volume":"2018","author":"Hsieh","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3892\/mmr.2021.12409","article-title":"Lycium barbarum polysaccharide protects ARPE-19 cells against H(2)O(2)-induced oxidative stress via the Nrf2\/HO-1 pathway","volume":"24","author":"Liang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jep.2019.03.023","article-title":"Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement","volume":"236","author":"Chan","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1038\/srep07601","article-title":"Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration","volume":"4","author":"Wang","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1167\/iovs.17-22881","article-title":"Lycium Barbarum Polysaccharides Protect Retina in rd1 Mice During Photoreceptor Degeneration","volume":"59","author":"Liu","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Li, S.Y., Yang, D., Yeung, C.M., Yu, W.Y., Chang, R.C., So, K.F., Wong, D., and Lo, A.C. (2011). Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia\/reperfusion injury. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016380"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"He, M., Pan, H., Chang, R.C., So, K.F., Brecha, N.C., and Pu, M. (2014). Activation of the Nrf2\/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084800"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/ceo.12950","article-title":"Lycium barbarum polysaccharide extracts preserve retinal function and attenuate inner retinal neuronal damage in a mouse model of transient retinal ischaemia","volume":"45","author":"Yang","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_138","first-page":"645","article-title":"Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma","volume":"7","author":"Mi","year":"2012","journal-title":"Neural Regen. Res."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Mi, X.S., Feng, Q., Lo, A.C., Chang, R.C., Lin, B., Chung, S.K., and So, K.F. (2012). Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045469"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Chu, P.H., Li, H.Y., Chin, M.P., So, K.F., and Chan, H.H. (2013). Effect of lycium barbarum (wolfberry) polysaccharides on preserving retinal function after partial optic nerve transection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081339"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Li, H., Liang, Y., Chiu, K., Yuan, Q., Lin, B., Chang, R.C., and So, K.F. (2013). Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068881"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.expneurol.2006.05.031","article-title":"Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma","volume":"203","author":"Chan","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1167\/iovs.19-27886","article-title":"Posttreatment Intervention With Lycium Barbarum Polysaccharides is Neuroprotective in a Rat Model of Chronic Ocular Hypertension","volume":"60","author":"Lakshmanan","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_144","first-page":"809","article-title":"Effects of Lycium barbarum (goji berry) on dry eye disease in rats","volume":"17","author":"Chien","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"113165","DOI":"10.1016\/j.jep.2020.113165","article-title":"Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract","volume":"261","author":"Yao","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global prevalence and major risk factors of diabetic retinopathy","volume":"35","author":"Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.08.001","article-title":"The progress in understanding and treatment of diabetic retinopathy","volume":"51","author":"Stitt","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2213-8587(19)30411-5","article-title":"Screening for diabetic retinopathy: New perspectives and challenges","volume":"8","author":"Vujosevic","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41574-020-00451-4","article-title":"Current understanding of the molecular and cellular pathology of diabetic retinopathy","volume":"17","author":"Antonetti","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1196\/annals.1395.019","article-title":"Antioxidant enzymes and diabetic retinopathy","volume":"1100","author":"Yildirim","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.bbadis.2015.08.001","article-title":"Oxidative stress, mitochondrial damage and diabetic retinopathy","volume":"1852","author":"Kowluru","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.2337\/db11-0816","article-title":"Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage","volume":"60","author":"Kowluru","year":"2011","journal-title":"Diabetes"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41598-018-36474-1","article-title":"Retinal Microvascular Change in Hypertension as measured by Optical Coherence Tomography Angiography","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s10571-021-01049-8","article-title":"The GFAP Monoclonal Antibody GA-5 Identifies Astrocyte Remodeling and Glio-Vascular Uncoupling During the Evolution of EAE","volume":"42","author":"Halder","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0140-6736(12)60282-7","article-title":"Age-related macular degeneration","volume":"379","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"100858","DOI":"10.1016\/j.preteyeres.2020.100858","article-title":"Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration","volume":"79","author":"Kaarniranta","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","article-title":"Immune regulation in the aging retina","volume":"69","author":"Chen","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Newton, F., and Megaw, R. (2020). Mechanisms of Photoreceptor Death in Retinitis Pigmentosa. Genes, 11.","DOI":"10.3390\/genes11101120"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/15569527.2019.1685535","article-title":"(Z)-7, 4\u2019-Dimethoxy-6-hydroxy-aurone-4-O-\u03b2-glucopyranoside mitigates retinal degeneration in Rd10 mouse model through inhibiting oxidative stress and inflammatory responses","volume":"39","author":"Chen","year":"2020","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.preteyeres.2008.04.001","article-title":"Functions of aquaporins in the eye","volume":"27","author":"Verkman","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"100953","DOI":"10.1016\/j.preteyeres.2021.100953","article-title":"Adaptive responses to neurodegenerative stress in glaucoma","volume":"84","author":"Calkins","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.preteyeres.2006.07.003","article-title":"Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences","volume":"25","author":"Tezel","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.optom.2017.06.002","article-title":"Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy","volume":"11","author":"McMonnies","year":"2018","journal-title":"J. Optom."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3109\/02713683.2011.556299","article-title":"Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patients","volume":"39","author":"Goyal","year":"2014","journal-title":"Curr. Eye Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1196\/annals.1354.003","article-title":"Free radical theory of aging: An update: Increasing the functional life span","volume":"1067","author":"Harman","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2016.12.005","article-title":"Neuroprotection for glaucoma: Requirements for clinical translation","volume":"157","author":"Levin","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_169","first-page":"1157","article-title":"Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum","volume":"17","author":"Yu","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1292\/jvms.17-0623","article-title":"The Neuroprotective and antioxidative effects of submicron and blended Lycium barbarum in experimental retinal degeneration in rats","volume":"80","author":"Chang","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jcb.22539","article-title":"Up-regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model","volume":"110","author":"Chiu","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3727\/096368915X686896","article-title":"Effect of Lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection","volume":"24","author":"Li","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_173","first-page":"475","article-title":"Spontaneous regression of retinopathy of prematurity: Incidence and predictive factors","volume":"6","author":"Ju","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"100842","DOI":"10.1016\/j.preteyeres.2020.100842","article-title":"Advances in the diagnosis and treatment of dry eye","volume":"78","author":"Kojima","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/jama.2022.5978","article-title":"What Is Dry Eye Disease?","volume":"328","author":"Walter","year":"2022","journal-title":"JAMA"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1128\/CMR.13.4.662","article-title":"Fungal and parasitic infections of the eye","volume":"13","author":"Klotz","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e20887","DOI":"10.1097\/MD.0000000000020887","article-title":"The clinical efficiency of lycium-rehmannia pills in treating dry eye symptom: A meta-analysis","volume":"99","author":"Lou","year":"2020","journal-title":"Medicine"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1001\/jama.290.15.2057","article-title":"Important causes of visual impairment in the world today","volume":"290","author":"Congdon","year":"2003","journal-title":"JAMA"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0968-0004(02)02113-8","article-title":"Cell cycle and death control: Long live Forkheads","volume":"27","author":"Burgering","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exer.2013.07.017","article-title":"The role of SIRT1 in ocular aging","volume":"116","author":"Mimura","year":"2013","journal-title":"Exp. Eye Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2013.03.015","article-title":"Redox regulation of SIRT1 in inflammation and cellular senescence","volume":"61","author":"Hwang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"8669","DOI":"10.1038\/s41598-018-26837-z","article-title":"Lycium barbarum polysaccharide encapsulated Poly lactic-co-glycolic acid Nanofibers: Cost effective herbal medicine for potential application in peripheral nerve tissue engineering","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ijbiomac.2021.03.018","article-title":"Synthesis, stability and anti-fatigue activity of selenium nanoparticles stabilized by Lycium barbarum polysaccharides","volume":"179","author":"Liu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijbiomac.2022.05.087","article-title":"A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide","volume":"211","author":"Gong","year":"2022","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/16\/2\/215\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:20:40Z","timestamp":1760120440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/16\/2\/215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":185,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ph16020215"],"URL":"https:\/\/doi.org\/10.3390\/ph16020215","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}