{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:30:16Z","timestamp":1778502616959,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010609","name":"Medical University of Gdansk, Poland","doi-asserted-by":"publisher","award":["01-0517\/08\/510"],"award-info":[{"award-number":["01-0517\/08\/510"]}],"id":[{"id":"10.13039\/501100010609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010609","name":"Medical University of Gdansk, Poland","doi-asserted-by":"publisher","award":["UMO-2018\/30\/E\/ST4\/00481"],"award-info":[{"award-number":["UMO-2018\/30\/E\/ST4\/00481"]}],"id":[{"id":"10.13039\/501100010609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004442","name":"National Science Centre, Poland","doi-asserted-by":"publisher","award":["01-0517\/08\/510"],"award-info":[{"award-number":["01-0517\/08\/510"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004442","name":"National Science Centre, Poland","doi-asserted-by":"publisher","award":["UMO-2018\/30\/E\/ST4\/00481"],"award-info":[{"award-number":["UMO-2018\/30\/E\/ST4\/00481"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS (multiple-unit pellet system) containing rosuvastatin calcium as a model drug substance was successfully developed. The formulation was prepared by drug layering technique using novel calcium phosphate-based starting pellets (PharSQ\u00ae Spheres CM) of three different particle sizes. The study showed that the developed multiparticulates were characterized by uniform distribution of coating layers thickness, as well as fast dissolution rate (more than 85% of rosuvastatin calcium dissolved within 30 min, as required by the relevant USP\/NF monograph). Rosuvastatin calcium, like other statins, has a bitter, unpleasant taste. Investigations conducted with an electronic tongue suggested that the developed formulation achieved the desired taste-masking efficiency. The effect was found to be particle size-dependent, improving as the size of the multiparticulates increased.<\/jats:p>","DOI":"10.3390\/ph16020242","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:34:30Z","timestamp":1675654470000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-5626","authenticated-orcid":false,"given":"Krzysztof","family":"Cal","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, al. Gen. J. Hallera 107, 80-416 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-7705","authenticated-orcid":false,"given":"Barbara","family":"Mikolaszek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, al. Gen. J. Hallera 107, 80-416 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-9010","authenticated-orcid":false,"given":"Tobias","family":"Hess","sequence":"additional","affiliation":[{"name":"Chemische Fabrik Budenheim KG, Rheinstrasse 27, 55257 Budenheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markos","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Chemische Fabrik Budenheim KG, Rheinstrasse 27, 55257 Budenheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Lenik","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sk\u0142odowska University, M. Curie-Sk\u0142odowska Sq. 3, 20-031 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Ciosek-Skibi\u0144ska","sequence":"additional","affiliation":[{"name":"Chair of Medical Biotechnology, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Wall","sequence":"additional","affiliation":[{"name":"Harke Pharma GmbH, Xantener Stra\u00dfe 1, 45479 M\u00fclheim an der Ruhr, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-8128","authenticated-orcid":false,"given":"Jadwiga","family":"Paszkowska","sequence":"additional","affiliation":[{"name":"Physiolution Polska sp. z o.o., Skarbowcow 81\/7, 53-025 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svitlana","family":"Romanova","sequence":"additional","affiliation":[{"name":"Physiolution Polska sp. z o.o., Skarbowcow 81\/7, 53-025 Wroclaw, Poland"},{"name":"Department of Pharmacognosy, National University of Pharmacy, Pushkinska 53, 61002 Kharkiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Garbacz","sequence":"additional","affiliation":[{"name":"Physiolution Polska sp. z o.o., Skarbowcow 81\/7, 53-025 Wroclaw, Poland"},{"name":"Physiolution GmbH, Walther-Rathenau-Strasse 49a, 17489 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-4263","authenticated-orcid":false,"given":"Daniel","family":"Zakowiecki","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, al. Gen. J. Hallera 107, 80-416 Gdansk, Poland"},{"name":"Chemische Fabrik Budenheim KG, Rheinstrasse 27, 55257 Budenheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.eujim.2018.07.002","article-title":"Oropharyngeal dysphagia and its related health problems in Iranian elderly people: A scope of work for the future","volume":"21","author":"Farpour","year":"2018","journal-title":"Eur. J. Integr. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/0194599814549156","article-title":"The prevalence of dysphagia among adults in the United States","volume":"151","author":"Bhattacharyya","year":"2014","journal-title":"Otolaryngol. 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