{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:30:31Z","timestamp":1774621831104,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"program for strategic academic leadership, Priority-2030, Strategic Project","award":["#4\/1"],"award-info":[{"award-number":["#4\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The enzyme 11\u03b2-hydroxysteroid dehydrogenase type 1 (11\u03b2-HSD-1) is an NADPH-dependent reductase, responsible for the activation of cortisol by reducing cortisone. Resveratrol (RES), a type of natural polyphenol, is reported to be able to slow the progression of cancer and cardiovascular disease and improve the health of mice on a high-calorie diet. In this article, we applied molecular docking and molecular dynamics simulations to investigate the possibility of binding RES to 11\u03b2-HSD-1. The 11\u03b2-HSD-1:RES complex is stable on the \u03bcs time scale, and backbone RMSD-based clustering identified three conformations. Special attention was paid to the interaction pattern between the ligand and the target molecule, revealing hydrogen bonds between the hydroxyl group of RES and Thr124, as well as hydrophobic interactions responsible for the binding. In vivo studies demonstrated the ability of resveratrol at a dose of 40 mg\/kg to reduce 11\u03b2-HSD-1 activity in the liver of rats under conditions of experimental post-traumatic stress disorder (PTSD), as well as in non-stressed animals. In both cases, the resveratrol-induced reduction in 11\u03b2-HSD-1 activity was accompanied by an increase in plasma corticosterone levels and a decrease in anxiety levels in the plus maze test.<\/jats:p>","DOI":"10.3390\/ph16020251","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T02:29:08Z","timestamp":1675823348000},"page":"251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Can Resveratrol Influence the Activity of 11\u03b2-Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-6677","authenticated-orcid":false,"given":"Jurica","family":"Novak","sequence":"first","affiliation":[{"name":"Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia"},{"name":"Center for Artificial Intelligence and Cyber Security, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim E.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga B.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana S.","family":"Lazuko","sequence":"additional","affiliation":[{"name":"Department of Physiology, Vitebsk State Medical University, Frunze Av. 27, 210023 Vitebsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmila E.","family":"Belyeva","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Vitebsk State Medical University, Frunze Av. 27, 210023 Vitebsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran P.O. Box 14665-354, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-9299","authenticated-orcid":false,"given":"Julia","family":"Fedotova","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology RAS, 6 Emb. Makarova, 199034 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e14264","DOI":"10.1111\/jfbc.14264","article-title":"Health Benefits of Polyphenols: A Concise Review","volume":"46","author":"Rana","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kubczak, M., Szustka, A., and Rogali\u0144ska, M. (2021). Molecular Targets of Natural Compounds with Anti-Cancer Properties. Int. J. Mol. 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