{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:45:24Z","timestamp":1783381524236,"version":"3.54.6"},"reference-count":58,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tuniso-Morocain project","award":["20PRD16"],"award-info":[{"award-number":["20PRD16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>This study aimed to evaluate the potentiality of a mineral and antioxidant-rich methanolic extract of the red marine alga Falkenbergia rufolanosa (FRE) against methyl-thiophanate (MT)-induced toxicity in adult rats. The animals were allocated into four groups: controls, MT (300 mg\/kg), MT + FRE, and FRE-treated group for 7 days. Our results demonstrated severe mineral perturbations due to MT treatment, especially in calcium and phosphorus levels in plasma, urine, and bone. Similarly, the hematological analysis revealed increased red blood cells, platelets, and white blood cells associated with striking genotoxicity. Interestingly, a significant rise in lipid peroxidation and advanced oxidation protein products level in erythrocytes and bone were noted. Meanwhile, a depletion of the antioxidant status in both tissues occurred. These biochemical alterations were in harmony with DNA degradation and histological variation in bone and blood. In the other trend, data showed that treatment with alga improved MT-induced hematotoxicity, genotoxicity, and oxidative stress in the blood and bone. Osteo-mineral metabolism and bone histo-architecture were also noted. In conclusion, these findings demonstrated that the red alga Falkenbergia rufolanosa is a potent source of antioxidant and antibacterial agents, as revealed by the in vitro analysis.<\/jats:p>","DOI":"10.3390\/ph16040529","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T02:32:27Z","timestamp":1680489147000},"page":"529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bioactivity of Falkenbergia rufolanosa Methanolic Extract: Assessment of Its Effect on Methyl-Thiophanate Induced Bone and Blood Disorders"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-5969","authenticated-orcid":false,"given":"Amal","family":"Feki","sequence":"first","affiliation":[{"name":"Laboratory of Medicinal and Environment Chemistry, University of Sfax, Higher Institute of Biotechnology, Sfax 3000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Intissar","family":"Kammoun","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal and Environment Chemistry, University of Sfax, Higher Institute of Biotechnology, Sfax 3000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Eleroui","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal and Environment Chemistry, University of Sfax, Higher Institute of Biotechnology, Sfax 3000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Kallel","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomopathology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Megdiche","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwa","family":"Hariz","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Faculty of Medicine of Sfax, Department of Orthopedic and Traumatological Surgery, CHU Habib Bourguiba, Sfax 3029, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahia","family":"Boudawara","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomopathology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choumous","family":"Kallel","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Kallel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana"},{"name":"Tropical Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, University of Guyane, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"Pujo","sequence":"additional","affiliation":[{"name":"Tropical Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, University of Guyane, Cayenne 97300, French Guiana"},{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtissem","family":"Ben Amara","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal and Environment Chemistry, University of Sfax, Higher Institute of Biotechnology, Sfax 3000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2004.01.021","article-title":"Pesticide Exposure\u2014Indian Scene","volume":"198","author":"Gupta","year":"2004","journal-title":"Toxicology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2008.12.026","article-title":"Chlorpyrifos Induces Oxidative Stress in Oligodendrocyte Progenitor Cells","volume":"259","author":"Saulsbury","year":"2009","journal-title":"Toxicology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/(SICI)1099-1263(199807\/08)18:4<241::AID-JAT500>3.0.CO;2-Q","article-title":"In Vivo Studies on Possible Adverse Effects on Reproduction of the Fungicide Methyl Thiophanate","volume":"18","author":"Traina","year":"1998","journal-title":"J. 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