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Many studies have demonstrated the association between gut microbiota and diabetes development and probiotic supplementation in improving glycemic properties in T2DM. The study aimed to evaluate the influence of Bifidobacterium breve supplementation on glycemic control, lipid profile, and microbiome of T2DM subjects. Forty participants were randomly divided into two groups, and they received probiotics (50 \u00d7 109 CFU\/day) or placebo interventions (corn starch; 10 mg\/day) for 12 weeks. The changes in the blood-urea nitrogen (BUN), aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), fasting blood sugar (FBS), glycated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine levels, and other factors such as body-mass index, visceral fat, body fat, and body weight were assessed at baseline and after 12 weeks. B. breve supplementation significantly reduced BUN, creatinine, LDL, TG, and HbA1c levels compared to the placebo group. Significant changes were observed in the microbiome of the probiotic-treated group compared to the placebo group. Firmicutes and proteobacteria were predominant in the placebo and probiotic-treated groups. Genera Streptococcus, Butyricicoccus, and species Eubacterium hallii were significantly reduced in the probiotic-treated group compared to the placebo. Overall results suggested that B. breve supplementation could prevent worsening of representative clinical parameters in T2DM subjects. The current study has limitations, including fewer subjects, a single probiotic strain, and fewer metagenomic samples for microbiome analysis. Therefore, the results of the current study require further validation using more experimental subjects.<\/jats:p>","DOI":"10.3390\/ph16050695","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:56:51Z","timestamp":1683255411000},"page":"695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Influence of Bifidobacterium breve on the Glycaemic Control, Lipid Profile and Microbiome of Type 2 Diabetic Subjects: A Preliminary Randomized Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-2419","authenticated-orcid":false,"given":"Chaiyavat","family":"Chaiyasut","sequence":"first","affiliation":[{"name":"Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, 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(2010). Gut microbiota in human adults with type 2 diabetes differs from nondiabetic adults. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009085"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1080\/10408398.2018.1536646","article-title":"Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota","volume":"59","author":"Nie","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/ncpendmet1066","article-title":"Dyslipidemia in type 2 diabetes mellitus","volume":"5","author":"Mooradian","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jdi.12673","article-title":"Understanding the role of the gut ecosystem in diabetes mellitus","volume":"9","author":"Aw","year":"2018","journal-title":"J. Diabetes Investig."},{"key":"ref_8","first-page":"206","article-title":"Implication of gut microbiota in diabetes mellitus and obesity","volume":"12","author":"Grigorescu","year":"2016","journal-title":"Acta Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sivamaruthi, B.S., Kesika, P., and Chaiyasut, C. (2020). The Influence of Supplementation of Anthocyanins on Obesity-Associated Comorbidities: A Concise Review. Foods, 9.","DOI":"10.3390\/foods9060687"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/MED.0000000000000483","article-title":"The Gut Microbiota in Type 1 Diabetes: Friend or Foe?","volume":"26","author":"Gavin","year":"2019","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fendo.2020.00125","article-title":"Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11892-018-1057-6","article-title":"Altered gut microbiota in type 2 diabetes: Just a coincidence?","volume":"18","author":"Sircana","year":"2018","journal-title":"Curr. Diabetes Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut microbial metabolites in obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/2221-1691.228000","article-title":"A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases","volume":"8","author":"Sivamaruthi","year":"2018","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.22159\/ijap.2018v10i5.28249","article-title":"A review on anti-aging properties of probiotics","volume":"10","author":"Sivamaruthi","year":"2018","journal-title":"Int. J. Appl. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tenorio-Jim\u00e9nez, C., Mart\u00ednez-Ram\u00edrez, M.J., Gil, \u00c1., and G\u00f3mez-Llorente, C. (2020). Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials. Nutrients, 12.","DOI":"10.3390\/nu12010124"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1032494","DOI":"10.3389\/fnagi.2022.1032494","article-title":"Effects of probiotic supplements on cognition, anxiety, and physical activity in subjects with mild and moderate Alzheimer\u2019s disease: A randomized, double-blind, and placebo-controlled study","volume":"14","author":"Akhgarjand","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Thangaleela, S., Sivamaruthi, B.S., Kesika, P., Bharathi, M., and Chaiyasut, C. (2022). Role of the Gut-Brain Axis, Gut Microbial Composition, Diet, and Probiotic Intervention in Parkinson\u2019s Disease. Microorganisms, 10.","DOI":"10.3390\/microorganisms10081544"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1531567","DOI":"10.1155\/2019\/1531567","article-title":"Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials","volume":"2019","author":"Kesika","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Toejing, P., Khampithum, N., Sirilun, S., Chaiyasut, C., and Lailerd, N. (2021). Influence of Lactobacillus paracasei HII01 Supplementation on Glycemia and Inflammatory Biomarkers in Type 2 Diabetes: A Randomized Clinical Trial. Foods, 10.","DOI":"10.3390\/foods10071455"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103843","DOI":"10.1016\/j.jff.2020.103843","article-title":"Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model","volume":"67","author":"Zhang","year":"2020","journal-title":"J. Funct. Foods."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-0-12-800147-9.00002-9","article-title":"The ubiquitin system in immune regulation","volume":"124","author":"Park","year":"2014","journal-title":"Adv. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Qian, X., Si, Q., Lin, G., Zhu, M., Lu, J., Zhang, H., Wang, G., and Chen, W. (2022). Bifidobacterium adolescentis Is Effective in Relieving Type 2 Diabetes and May Be Related to Its Dominant Core Genome and Gut Microbiota Modulation Capacity. Nutrients, 14.","DOI":"10.3390\/nu14122479"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5110276","DOI":"10.1155\/2021\/5110276","article-title":"Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications","volume":"2021","author":"Zhang","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/cmi.12308","article-title":"Defining Dysbiosis and Its Influence on Host Immunity and Disease","volume":"16","author":"Petersen","year":"2014","journal-title":"Cell Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Harsch, I., and Konturek, P. (2018). The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into \u201cOld\u201d Diseases. Med. Sci., 6.","DOI":"10.3390\/medsci6020032"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e242818","DOI":"10.1590\/1519-6984.242818","article-title":"Gut dysbiosis, inflammation and type 2 diabetes in mice using synthetic gut microbiota from diabetic humans","volume":"83","author":"Liaqat","year":"2021","journal-title":"Braz. J. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11240","DOI":"10.12998\/wjcc.v10.i31.11240","article-title":"Intestinal microbiota in the treatment of metabolically associated fatty liver disease","volume":"10","author":"Wang","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/jnsbm.JNSBM_31_18","article-title":"Impact of probiotics on health-related quality of life in type II diabetes mellitus: A randomized, single-blind, placebo-controlled study","volume":"10","author":"Venkataraman","year":"2019","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00592-018-1175-2","article-title":"The effects of probiotics and synbiotic supplementation on glucose and insulin metabolism in adults with prediabetes: A double-blind randomized clinical trial","volume":"55","author":"Kassaian","year":"2018","journal-title":"Acta Diabetol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13690-015-0088-6","article-title":"Correlation of fasting and postprandial plasma glucose with HbA1c in assessing glycemic control; systematic review and meta-analysis","volume":"73","author":"Ketema","year":"2015","journal-title":"Arch. Public Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/193229680900300306","article-title":"A review of the challenge in measuring hemoglobin A1c","volume":"3","author":"Weykamp","year":"2009","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_35","first-page":"53","article-title":"Glycated haemoglobin (HbA1c) as a stable indicator of type 2 diabetes","volume":"1","author":"Pasupathi","year":"2010","journal-title":"Int. J. Pharm. Biomed. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"754401","DOI":"10.3389\/fendo.2022.754401","article-title":"Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic levels and inflammatory cytokines in patients with Type 1 Diabetes Mellitus","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000349922","article-title":"Effect of Multispecies Probiotic Supplements on Metabolic Profiles, Hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes","volume":"63","author":"Asemi","year":"2013","journal-title":"Ann. Nutr. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.3168\/jds.2010-4128","article-title":"Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus","volume":"94","author":"Ejtahed","year":"2011","journal-title":"J. Dairy Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13098-022-00822-z","article-title":"Effects of probiotic supplementation on major cardiovascular-related parameters in patients with type-2 diabetes mellitus: A secondary-data analysis of a randomized double-blind controlled trial","volume":"14","author":"Ahmadian","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e23650","DOI":"10.1002\/jcla.23650","article-title":"Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study","volume":"35","author":"Jiang","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/DMSO.S400119","article-title":"The Beneficial Effects of a Multispecies Probiotic Supplement on Glycaemic Control and Metabolic Profile in Adults with Type 1 Diabetes: A Randomised, Double-Blinded, Placebo-Controlled Pilot-Study","volume":"16","author":"Zhang","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1016\/j.clnu.2021.06.002","article-title":"Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial","volume":"40","author":"Solito","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Madempudi, R.S., Ahire, J.J., Neelamraju, J., Tripathi, A., and Nanal, S. (2019). Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo-controlled study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225168"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"16791","DOI":"10.1038\/s41598-018-35014-1","article-title":"The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: A randomized, double-blinded, placebo-controlled trial","volume":"8","author":"Hsieh","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/cmi.2010.67","article-title":"The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: Contribution of germ-free and gnotobiotic animal models of human diseases","volume":"8","author":"Hudcovic","year":"2011","journal-title":"Cell Mol. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.revmed.2015.12.012","article-title":"Gut microbiota: Description, role and pathophysiologic implications","volume":"37","author":"Landman","year":"2016","journal-title":"Rev. Med. Interne"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41598-019-56561-1","article-title":"FBA ecological guild: Trio of firmicutes-bacteroidetes alliance against actinobacteria in human oral microbiome","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00284-010-9582-9","article-title":"Molecular characterisation of the faecal microbiota in patients with type II diabetes","volume":"61","author":"Wu","year":"2010","journal-title":"Curr. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12020-019-02103-8","article-title":"Comprehensive relationships between gut microbiome and faecal metabolome in individuals with type 2 diabetes and its complications","volume":"66","author":"Zhao","year":"2019","journal-title":"Endocrine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7150\/ijms.51164","article-title":"The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus","volume":"18","author":"Hung","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Murri, M., Leiva, I., Gomez-Zumaquero, J.M., Tinahones, F.J., Cardona, F., Soriguer, F., and Queipo-Ortu\u00f1o, M.I. (2013). Gut microbiota in children with type 1 diabetes differs from that in healthy children: A case-control study. BMC Med., 11.","DOI":"10.1186\/1741-7015-11-46"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EC-15-0094","article-title":"Gut microbiota and diet in patients with different glucose tolerance","volume":"5","author":"Egshatyan","year":"2016","journal-title":"Endocr. Connect."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s10620-016-4179-1","article-title":"Impact of hypocaloric hyper proteic diet on gut microbiota in overweight or obese patients with nonalcoholic fatty liver disease: A pilot study","volume":"61","author":"Pataky","year":"2016","journal-title":"Digest Dis. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1875796","article-title":"Blautia\u2014A new functional genus with potential probiotic properties?","volume":"13","author":"Liu","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1128\/AEM.02821-13","article-title":"Oral bacterial communities in individuals with type 2 diabetes who live in southern Thailand","volume":"80","author":"Kampoo","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jnutbio.2016.05.015","article-title":"Colonic inflammation accompanies an increase of \u03b2-catenin signaling and Lachnospiraceae\/Streptococcaceae bacteria in the hind gut of high-fat diet-fed mice","volume":"35","author":"Zeng","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ajcn\/nqab150","article-title":"Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study","volume":"114","author":"Muralidharan","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature12198","article-title":"Gut metagenome in European women with normal, impaired and diabetic glucose control","volume":"498","author":"Karlsson","year":"2013","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chaiyasut, C., Sirilun, S., Juntarachot, N., Tongpong, P., Ouparee, W., Sivamaruthi, B.S., Peerajan, S., Waditee-Sirisattha, R., Prombutara, P., and Klankeo, P. (2022). Effect of Dextranase and Dextranase-and-Nisin-Containing Mouthwashes on Oral Microbial Community of Healthy Adults\u2014A Pilot Study. Appl. Sci., 12.","DOI":"10.3390\/app12031650"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3389\/fmicb.2019.01743","article-title":"Gut Microbiome Biomarkers and Functional Diversity Within an Amazonian Semi-Nomadic Hunter-Gatherer Group","volume":"30","author":"Conteville","year":"2019","journal-title":"Front. Microbiol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/16\/5\/695\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:29:08Z","timestamp":1760124548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/16\/5\/695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":62,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["ph16050695"],"URL":"https:\/\/doi.org\/10.3390\/ph16050695","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]}}}