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Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting inflammation and other forms of cellular stress during intense energy demand and maintaining tissue biomass and glucose disposal. This article documents the known biological functions of ASA and explores its potential application for the treatment of neuromuscular and other chronic diseases.<\/jats:p>","DOI":"10.3390\/ph16060822","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T03:06:00Z","timestamp":1685588760000},"page":"822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adenylosuccinic Acid: An Orphan Drug with Untapped Potential"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-0036","authenticated-orcid":false,"given":"Emma","family":"Rybalka","sequence":"first","affiliation":[{"name":"Institute for Health and Sport (IHeS), Victoria University, Melbourne, VIC 8001, Australia"},{"name":"Inherited and Acquired Myopathy Program, Australian Institute for Musculoskeletal Science (AIMSS), St Albans, VIC 3021, Australia"},{"name":"Department of Medicine\u2014Western Health, Melbourne Medical School, The University of Melbourne, St Albans, VIC 3021, Australia"},{"name":"Division of Neuropaediatrics and Developmental Medicine, University Children\u2019s Hospital of Basel (UKBB), 4056 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-9989","authenticated-orcid":false,"given":"Stephanie","family":"Kourakis","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (IHeS), Victoria University, Melbourne, VIC 8001, Australia"},{"name":"Inherited and Acquired Myopathy Program, Australian Institute for Musculoskeletal Science (AIMSS), St Albans, VIC 3021, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Bonsett","sequence":"additional","affiliation":[{"name":"Dystrophy Concepts Incorporated, Indianapolis, IN 46226, USA"},{"name":"School of Medicine, Indiana University, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-0106","authenticated-orcid":false,"given":"Behzad","family":"Moghadaszadeh","sequence":"additional","affiliation":[{"name":"The Manton Center for Orphan Disease Research, Division of Genetics and Genomics, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-0568","authenticated-orcid":false,"given":"Alan H.","family":"Beggs","sequence":"additional","affiliation":[{"name":"The Manton Center for Orphan Disease Research, Division of Genetics and Genomics, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4567-4319","authenticated-orcid":false,"given":"Cara A.","family":"Timpani","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (IHeS), Victoria University, Melbourne, VIC 8001, Australia"},{"name":"Inherited and Acquired Myopathy Program, Australian Institute for Musculoskeletal Science (AIMSS), St Albans, VIC 3021, Australia"},{"name":"Department of Medicine\u2014Western Health, Melbourne Medical School, The University of Melbourne, St Albans, VIC 3021, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0306-9877(92)90087-S","article-title":"The dystrophin connection\u2014ATP?","volume":"38","author":"Bonsett","year":"1992","journal-title":"Med. 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