{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:17:57Z","timestamp":1789600677477,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8M0911"],"award-info":[{"award-number":["CMRPG8M0911"]}]},{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8M0912"],"award-info":[{"award-number":["CMRPG8M0912"]}]},{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8M0101"],"award-info":[{"award-number":["CMRPG8M0101"]}]},{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["MOST 110-2314-B-182A-153"],"award-info":[{"award-number":["MOST 110-2314-B-182A-153"]}]},{"name":"National Science and Technology Council, Taiwan, to Mei-Hsin Hsu","award":["CMRPG8M0911"],"award-info":[{"award-number":["CMRPG8M0911"]}]},{"name":"National Science and Technology Council, Taiwan, to Mei-Hsin Hsu","award":["CMRPG8M0912"],"award-info":[{"award-number":["CMRPG8M0912"]}]},{"name":"National Science and Technology Council, Taiwan, to Mei-Hsin Hsu","award":["CMRPG8M0101"],"award-info":[{"award-number":["CMRPG8M0101"]}]},{"name":"National Science and Technology Council, Taiwan, to Mei-Hsin Hsu","award":["MOST 110-2314-B-182A-153"],"award-info":[{"award-number":["MOST 110-2314-B-182A-153"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Endothelial dysfunction is characterized by disturbances in nitric oxide (NO) bioavailability and increased circulating asymmetric dimethylarginine (ADMA) due to the enormous release of free radicals. Increased circulating ADMA may cause endothelial dysfunction and a variety of clinical disorders, such as liver and kidney disease. Young male Sprague-Dawley rats at postnatal day 17 \u00b1 1 received continuous ADMA infusion via an intraperitoneal pump to induce endothelial dysfunction. Four groups of rats (n = 10 per group) were allocated: control, control and resveratrol, ADMA infusion, and ADMA infusion and resveratrol groups. Spatial memory, NLR family pyrin-domain-containing 3 (NLRP3) inflammasome, cytokine expression, tight junction proteins in the ileum and dorsal hippocampus, and microbiota composition were examined. We found cognitive deficits; increased NLRP3 inflammasome in the plasma, ileum, and dorsal hippocampus; decreased ileum and dorsal hippocampal cytokine activation and tight junction proteins; and microbiota composition alterations in the ADMA-infusion young male rats. Resveratrol had beneficial effects in this context. In conclusion, we observed NLRP3 inflammasome activation in peripheral and central dysbiosis in young male rats with increased circulating ADMA, and found that resveratrol had beneficial effects. Our work adds to the mounting evidence that inhibiting systemic inflammation is a promising therapeutic avenue for cognition impairment, probably via the gut-brain axis.<\/jats:p>","DOI":"10.3390\/ph16060825","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T03:06:00Z","timestamp":1685588760000},"page":"825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Increased Circulating ADMA in Young Male Rats Caused Cognitive Deficits and Increased Intestinal and Hippocampal NLRP3 Inflammasome Expression and Microbiota Composition Alterations: Effects of Resveratrol"],"prefix":"10.3390","volume":"16","author":[{"given":"Mei-Hsin","family":"Hsu","sequence":"first","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Ming","family":"Sheen","sequence":"additional","affiliation":[{"name":"Chiayi Chang Gung Memorial Hospital, Puzi City 613, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-288X","authenticated-orcid":false,"given":"Li-Tung","family":"Huang","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fncel.2016.00167","article-title":"Combined Intraperitoneal and Intrathecal Etanercept Reduce Increased Brain Tumor Necrosis Factor-Alpha and Asymmetric Dimethylarginine Levels and Rescues Spatial Deficits in Young Rats after Bile Duct Ligation","volume":"10","author":"Sheen","year":"2016","journal-title":"Front. 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