{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:41:39Z","timestamp":1791636099925,"version":"4.3.4"},"reference-count":136,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Iron deficiency (ID) and iron deficiency anemia (IDA) are highly prevalent worldwide. Oral iron salts, especially ferrous sulfate, are commonly used for the treatment of iron deficiency (ID). However, its use is associated with gastrointestinal side effects, thus compromising treatment compliance. Intravenous iron administration is a more costly and logistically complex alternative and is not risk-free, as infusion and hypersensitivity reactions may occur. Sucrosomial\u00ae iron is an oral formulation consisting of ferric pyrophosphate conveyed by a phospholipid and sucrester matrix (sucrosome\u00ae). Intestinal Sucrosomial\u00ae iron absorption is mediated by enterocytes and M cells, through the paracellular and transcellular routes, and occurs mostly as intact particles. These pharmacokinetic properties of Sucrosomial\u00ae iron result in higher iron intestinal absorption and excellent gastrointestinal tolerance compared to oral iron salts. The evidence derived from clinical studies supports the use of Sucrosomial\u00ae iron as a valid first option for the treatment of ID and IDA, especially for subjects who are intolerant or refractory to conventional iron salts. Newer evidence also demonstrates the effectiveness of Sucrosomial\u00ae iron, with a lower cost and fewer side effects, in certain conditions usually treated with IV iron in current clinical practice.<\/jats:p>","DOI":"10.3390\/ph16060847","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T02:02:15Z","timestamp":1686103335000},"page":"847","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Sucrosomial\u00ae Iron: An Updated Review of Its Clinical Efficacy for the Treatment of Iron Deficiency"],"prefix":"10.3390","volume":"16","author":[{"given":"Susana","family":"G\u00f3mez-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Hospital \u201cVirgen de la Victoria\u201d, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Brilli","sequence":"additional","affiliation":[{"name":"Scientific Department, Alesco S.r.l., Via delle Lenze, 56122 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germano","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Scientific Department, Pharmanutra S.p.A., Via delle Lenze, 56122 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-1899","authenticated-orcid":false,"given":"Domenico","family":"Girelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-8959","authenticated-orcid":false,"given":"Manuel","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Perioperative Transfusion Medicine, Department of Surgical Specialties, Biochemistry and Immunology, School of Medicine, Campus de Teatinos, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"ref_1","first-page":"830","article-title":"Global, Regional, and National Prevalence of Anemia and Its Causes in 204 Countries and Territories, 1990\u20132019","volume":"4","author":"Gardner","year":"2020","journal-title":"Curr. 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