{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:22Z","timestamp":1791925702881,"version":"4.3.4"},"reference-count":220,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR) Project","award":["202209PJT-486512-CIA-CDAA-111824"],"award-info":[{"award-number":["202209PJT-486512-CIA-CDAA-111824"]}]},{"name":"Canadian Institutes of Health Research (CIHR) Project","award":["202203PJG-482520-CIA-CDAA-111824"],"award-info":[{"award-number":["202203PJG-482520-CIA-CDAA-111824"]}]},{"name":"Children Hospital Research Institute of Manitoba (CHRIM) Operating Grant","award":["202209PJT-486512-CIA-CDAA-111824"],"award-info":[{"award-number":["202209PJT-486512-CIA-CDAA-111824"]}]},{"name":"Children Hospital Research Institute of Manitoba (CHRIM) Operating Grant","award":["202203PJG-482520-CIA-CDAA-111824"],"award-info":[{"award-number":["202203PJG-482520-CIA-CDAA-111824"]}]},{"name":"University of Manitoba Research Grant Program (URGP)","award":["202209PJT-486512-CIA-CDAA-111824"],"award-info":[{"award-number":["202209PJT-486512-CIA-CDAA-111824"]}]},{"name":"University of Manitoba Research Grant Program (URGP)","award":["202203PJG-482520-CIA-CDAA-111824"],"award-info":[{"award-number":["202203PJG-482520-CIA-CDAA-111824"]}]},{"name":"University of Manitoba Collaborative Research Program (UCRP)","award":["202209PJT-486512-CIA-CDAA-111824"],"award-info":[{"award-number":["202209PJT-486512-CIA-CDAA-111824"]}]},{"name":"University of Manitoba Collaborative Research Program (UCRP)","award":["202203PJG-482520-CIA-CDAA-111824"],"award-info":[{"award-number":["202203PJG-482520-CIA-CDAA-111824"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Statins are common drugs that are clinically used to reduce elevated plasma cholesterol levels. Based on their solubility, statins are considered to be either hydrophilic or lipophilic. Amongst them, simvastatin has the highest lipophilicity to facilitate its ability to cross the blood-brain barrier. Recent studies have suggested that simvastatin could be a promising therapeutic option for different brain complications and diseases ranging from brain tumors (i.e., medulloblastoma and glioblastoma) to neurological disorders (i.e., Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease). Specific mechanisms of disease amelioration, however, are still unclear. Independent studies suggest that simvastatin may reduce the risk of developing certain neurodegenerative disorders. Meanwhile, other studies point towards inducing cell death in brain tumor cell lines. In this review, we outline the potential therapeutic effects of simvastatin on brain complications and review the clinically relevant molecular mechanisms in different cases.<\/jats:p>","DOI":"10.3390\/ph16070914","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T02:57:53Z","timestamp":1687489073000},"page":"914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action"],"prefix":"10.3390","volume":"16","author":[{"given":"Yen My","family":"Vuu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Kadar Shahib","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-6116","authenticated-orcid":false,"given":"Mojgan","family":"Rastegar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"ref_1","unstructured":"Varolius, C., and Varolio, C. (2023, May 01). In De Nervis Opticis Nonnullisque Aliis Praeter Communem Opinionem in Humano Capite Observatis: Patavij 1573. Culture et Civilisation, 1969. Available online: https:\/\/books.google.ca\/books\/about\/De_nervis_opticis_nonnullisque_aliis_pra.html?id=KIXqpwAACAAJ&redir_esc=y."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1227\/01.neu.0000317323.63859.2a","article-title":"Costanzo Varolio (Constantius Varolius 1543\u20131575) and the Pons Varolli","volume":"62","author":"Tubbs","year":"2008","journal-title":"Neurosurgery"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.mcn.2005.02.006","article-title":"Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron","volume":"29","author":"Goritz","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nn1426","article-title":"High cholesterol level is essential for myelin membrane growth","volume":"8","author":"Saher","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1073\/pnas.1620506114","article-title":"Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism","volume":"114","author":"Ferris","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1515\/BC.2009.035","article-title":"Central nervous system: Cholesterol turnover, brain development and neurodegeneration","volume":"390","author":"Dietschy","year":"2009","journal-title":"Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s002920050040","article-title":"Normal weight of the brain in adults in relation to age, sex, body height and weight","volume":"15","author":"Hartmann","year":"1994","journal-title":"Pathologe"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/brain\/awv166","article-title":"CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer\u2019s disease","volume":"138","author":"Djelti","year":"2015","journal-title":"Brain"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/mds.28396","article-title":"The Role of Cholesterol in \u03b1-Synuclein and Lewy Body Pathology in GBA1 Parkinson\u2019s Disease","volume":"36","author":"Moratalla","year":"2021","journal-title":"Mov. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"797220","DOI":"10.3389\/fnagi.2022.797220","article-title":"Altered Cholesterol Homeostasis in Huntington\u2019s Disease","volume":"14","author":"Kacher","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"159123","DOI":"10.1016\/j.bbalip.2022.159123","article-title":"Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders","volume":"1867","author":"Turri","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1570159X15666170703101816","article-title":"Statins and the Brain: More than Lipid Lowering Agents?","volume":"17","author":"Fracassi","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.081620098","article-title":"Simvastatin strongly reduces levels of Alzheimer\u2019s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo","volume":"98","author":"Fassbender","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/S0022-2275(20)32188-X","article-title":"Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation","volume":"39","author":"Bjorkhem","year":"1998","journal-title":"J. Lipid Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1194\/jlr.R300017-JLR200","article-title":"Functions of lipoprotein receptors in neurons","volume":"45","author":"Beffert","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14009","DOI":"10.1074\/jbc.M313828200","article-title":"Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures","volume":"279","author":"Hayashi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-019-0337-1","article-title":"Lack of hepatic apoE does not influence early Abeta deposition: Observations from a new APOE knock-in model","volume":"14","author":"Huynh","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer\u2019s disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0896-6273(00)80861-2","article-title":"Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation","volume":"24","author":"Hiesberger","year":"1999","journal-title":"Neuron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0959-4388(98)80082-2","article-title":"Cajal-Retzius cells, Reelin, and the formation of layers","volume":"8","author":"Frotscher","year":"1998","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1055\/s-2003-43053","article-title":"24S-hydroxycholesterol: A marker of brain cholesterol metabolism","volume":"36","author":"Lutjohann","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"22980","DOI":"10.1074\/jbc.M303415200","article-title":"Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover","volume":"278","author":"Lund","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","article-title":"Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2009.03.049","article-title":"Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol","volume":"137","author":"Kwon","year":"2009","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fnmol.2017.00211","article-title":"Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis","volume":"10","author":"Ayciriex","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12799","DOI":"10.1074\/jbc.M601019200","article-title":"24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux","volume":"281","author":"Abildayeva","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e02776","DOI":"10.1016\/j.heliyon.2019.e02776","article-title":"In Vivo evidence of cortical amyloid deposition in the adult form of Niemann Pick type C","volume":"5","author":"Esposito","year":"2019","journal-title":"Heliyon"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.274.5285.255","article-title":"Cholesterol modification of hedgehog signaling proteins in animal development","volume":"274","author":"Porter","year":"1996","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(01)00369-5","article-title":"Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1","volume":"105","author":"Lewis","year":"2001","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/375322a0","article-title":"Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants","volume":"375","author":"Marti","year":"1995","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(00)81386-0","article-title":"Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity","volume":"87","author":"Ericson","year":"1996","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"Hammerschmidt","year":"1999","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2353\/ajpath.2007.060066","article-title":"Hedgehog signaling promotes medulloblastoma survival via Bc\/II","volume":"170","author":"Bar","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/096876899294607","article-title":"Detergent-insoluble glycosphingolipid\/cholesterol-rich membrane domains, lipid rafts and caveolae","volume":"16","author":"Hooper","year":"1999","journal-title":"Mol. Membr. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1113\/JP270590","article-title":"Membrane lipid rafts and neurobiology: Age-related changes in membrane lipids and loss of neuronal function","volume":"594","author":"Egawa","year":"2016","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biochi.2018.07.019","article-title":"CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington\u2019s disease: Analysis of lipid raft content","volume":"153","author":"Boussicault","year":"2018","journal-title":"Biochimie"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Fuentealba, R.A., Liu, Q., Zhang, J., Kanekiyo, T., Hu, X., Lee, J.M., LaDu, M.J., and Bu, G. (2010). Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011884"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1523\/JNEUROSCI.5543-03.2004","article-title":"Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"24","author":"Kawarabayashi","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2119\/molmed.2011.00119","article-title":"Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson\u2019s disease and incidental Parkinson\u2019s disease","volume":"17","author":"Fabelo","year":"2011","journal-title":"Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jnr.22184","article-title":"Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington\u2019s disease","volume":"88","author":"Valencia","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5334\/gh.1154","article-title":"World Heart Federation Cholesterol Roadmap 2022","volume":"17","author":"Ray","year":"2022","journal-title":"Glob. Heart"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/ajcn\/66.2.438","article-title":"Regulation of cholesterol biosynthesis by diet in humans","volume":"66","author":"Jones","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1161\/01.ATV.17.11.2955","article-title":"Assembly and secretion of VLDL in nondifferentiated Caco-2 cells stably transfected with human recombinant ApoB48 cDNA","volume":"17","author":"Luchoomun","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0022-2275(20)34932-4","article-title":"Hepatic uptake of chylomicron remnants","volume":"38","author":"Cooper","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/CIRCULATIONAHA.122.058883","article-title":"Insulin and Bile Acids in Cholesterol Homeostasis: New Players in Diabetes-Associated Atherosclerosis","volume":"145","author":"Cortes","year":"2022","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1520-037X.2003.01691.x","article-title":"The intestinal absorption of biliary and dietary cholesterol as a drug target for lowering the plasma cholesterol level","volume":"6","author":"Turley","year":"2003","journal-title":"Prev. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1093\/eurheartj\/ehab551","article-title":"Triglyceride-rich lipoproteins and their remnants: Metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society","volume":"42","author":"Ginsberg","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.atherosclerosis.2018.06.881","article-title":"Endocytosis of lipoproteins","volume":"275","author":"Zanoni","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fcell.2015.00003","article-title":"Lysosomal acid lipase: At the crossroads of normal and atherogenic cholesterol metabolism","volume":"3","author":"Dubland","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/ATVBAHA.119.312136","article-title":"Lysosomal Acid Lipase in Lipid Metabolism and Beyond","volume":"39","author":"Li","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Williams, K.B., Horst, M., Young, M., Pascua, C., Puffenberger, E.G., Brigatti, K.W., Gonzaga-Jauregui, C., Shuldiner, A.R., Gidding, S., and Strauss, K.A. (2022). Clinical characterization of familial hypercholesterolemia due to an amish founder mutation in Apolipoprotein, B. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02539-3"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e001236","DOI":"10.1161\/JAHA.114.001236","article-title":"Mortality among patients with familial hypercholesterolemia: A registry-based study in Norway, 1992\u20132010","volume":"3","author":"Mundal","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1073\/pnas.70.10.2804","article-title":"Familial hypercholesterolemia: Identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol","volume":"70","author":"Goldstein","year":"1973","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjmed.2009.08.015","article-title":"Higher incidence of mild cognitive impairment in familial hypercholesterolemia","volume":"123","author":"Zambon","year":"2010","journal-title":"Am. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/01.STR.19.9.1097","article-title":"Risk of brain infarction in familial hypercholesterolemia","volume":"19","author":"Kaste","year":"1988","journal-title":"Stroke"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1021\/acschemneuro.9b00248","article-title":"Cholesterol Biosynthesis and Uptake in Developing Neurons","volume":"10","author":"Anderson","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Vuu, Y.M., Roberts, C.T., and Rastegar, M. (2023). MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24044218"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/mthe.2000.0028","article-title":"Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis without reducing cholesterol levels in LDL receptor-deficient mice","volume":"1","author":"Tsukamoto","year":"2000","journal-title":"Mol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nbd.2013.12.016","article-title":"Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner","volume":"64","author":"Johnson","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13195-021-00921-5","article-title":"The apolipoprotein receptor LRP3 compromises APP levels","volume":"13","author":"Lennol","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"18000","DOI":"10.1074\/jbc.M101589200","article-title":"Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1016\/S0021-9258(19)40786-2","article-title":"Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease","volume":"250","author":"Goldstein","year":"1975","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8872","DOI":"10.1128\/MCB.24.20.8872-8883.2004","article-title":"Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice","volume":"24","author":"May","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1523\/JNEUROSCI.3487-13.2013","article-title":"Neuronal clearance of amyloid-beta by endocytic receptor LRP1","volume":"33","author":"Kanekiyo","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/revneuro-2017-0063","article-title":"Amyloid toxicity in Alzheimer\u2019s disease","volume":"29","author":"Reiss","year":"2018","journal-title":"Rev. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0169-328X(03)00032-9","article-title":"Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1","volume":"112","author":"Benhayon","year":"2003","journal-title":"Mol. Brain Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1161\/01.CIR.0000041434.28573.0B","article-title":"Low-density lipoprotein upregulates low-density lipoprotein receptor-related protein expression in vascular smooth muscle cells: Possible involvement of sterol regulatory element binding protein-2-dependent mechanism","volume":"106","author":"Sanchez","year":"2002","journal-title":"Circulation"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1073\/pnas.93.18.9799","article-title":"Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation","volume":"93","author":"Lutjohann","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"734001","DOI":"10.3389\/fnins.2021.734001","article-title":"Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability","volume":"15","author":"Konings","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"24367","DOI":"10.1074\/jbc.M002184200","article-title":"Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein","volume":"275","author":"Davies","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_72","first-page":"154","article-title":"Sphingolipid Organization in the Plasma Membrane and the Mechanisms That Influence It","volume":"4","author":"Kraft","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13023-018-0785-7","article-title":"Consensus clinical management guidelines for Niemann-Pick disease type C","volume":"13","author":"Geberhiwot","year":"2018","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3233\/JAD-160214","article-title":"Role of Niemann-Pick Type C Disease Mutations in Dementia","volume":"55","author":"Cupidi","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/genetics\/142.3.965","article-title":"Evolution of the hedgehog gene family","volume":"142","author":"Kumar","year":"1996","journal-title":"Genetics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1242\/dev.128.18.3485","article-title":"Hedgehog signaling is required for primary motoneuron induction in zebrafish","volume":"128","author":"Lewis","year":"2001","journal-title":"Development"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/MCB.15.4.2294","article-title":"Proteolytic processing yields two secreted forms of sonic hedgehog","volume":"15","author":"Bumcrot","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0092-8674(00)80074-4","article-title":"Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain","volume":"86","author":"Porter","year":"1996","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1073\/pnas.0308449101","article-title":"The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins","volume":"101","author":"Peters","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1073\/pnas.97.13.7307","article-title":"Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation","volume":"97","author":"Guy","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/374363a0","article-title":"The product of hedgehog autoproteolytic cleavage active in local and long-range signalling","volume":"374","author":"Porter","year":"1995","journal-title":"Nature"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ydbio.2004.06.012","article-title":"The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth","volume":"273","author":"Boulet","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1242\/dev.127.10.2133","article-title":"Role of dHAND in the anterior-posterior polarization of the limb bud: Implications for the Sonic hedgehog pathway","volume":"127","author":"Piedra","year":"2000","journal-title":"Development"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bechtold, T.E., Kurio, N., Nah, H.D., Saunders, C., Billings, P.C., and Koyama, E. (2019). The Roles of Indian Hedgehog Signaling in TMJ Formation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246300"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Dilower, I., Niloy, A.J., Kumar, V., Kothari, A., Lee, E.B., and Rumi, M.A.K. (2023). Hedgehog Signaling in Gonadal Development and Function. Cells, 12.","DOI":"10.3390\/cells12030358"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00401-021-02358-4","article-title":"Subgroup and subtype-specific outcomes in adult medulloblastoma","volume":"142","author":"Coltin","year":"2021","journal-title":"Acta Neuropathol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/jnc.15044","article-title":"Role of sphingolipid metabolism in neurodegeneration","volume":"158","author":"Alaamery","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/1073858419882619","article-title":"Amyloid, APP, and Electrical Activity of the Brain","volume":"26","author":"Hefter","year":"2020","journal-title":"Neuroscientist"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid precursor protein processing and Alzheimer\u2019s disease","volume":"34","author":"Wong","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(94)90458-8","article-title":"Visualization of A\u03b242(43) and A\u03b240 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A\u03b242(43)","volume":"13","author":"Iwatsubo","year":"1994","journal-title":"Neuron"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"937056","DOI":"10.3389\/fnmol.2022.937056","article-title":"Cholesterol as a key player in amyloid beta-mediated toxicity in Alzheimer\u2019s disease","volume":"15","author":"Rudajev","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1503\/cmaj.070796","article-title":"Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease","volume":"178","author":"Patterson","year":"2008","journal-title":"CMAJ"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"a006270","DOI":"10.1101\/cshperspect.a006270","article-title":"Trafficking and proteolytic processing of APP","volume":"2","author":"Haass","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fnmol.2020.00137","article-title":"Targeting Amyloidogenic Processing of APP in Alzheimer\u2019s Disease","volume":"13","author":"Zhao","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Cho, Y.Y., Kwon, O.H., Park, M.K., Kim, T.W., and Chung, S. (2019). Elevated cellular cholesterol in Familial Alzheimer\u2019s presenilin 1 mutation is associated with lipid raft localization of beta-amyloid precursor protein. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210535"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"44945","DOI":"10.1074\/jbc.M407986200","article-title":"Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes","volume":"279","author":"Vetrivel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/nbdi.2001.0470","article-title":"Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains","volume":"9","author":"Wahrle","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1194\/jlr.M400333-JLR200","article-title":"Association of active gamma-secretase complex with lipid rafts","volume":"46","author":"Urano","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e2102191118","DOI":"10.1073\/pnas.2102191118","article-title":"Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","first-page":"2661","article-title":"Cholesterol facilitates interactions between alpha-synuclein oligomers and charge-neutral membranes","volume":"589 Pt B","author":"Vetri","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2005.09.028","article-title":"\u03b1-synuclein cooperates with CSP\u03b1 in preventing neurodegeneration","volume":"123","author":"Chandra","year":"2005","journal-title":"Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3389\/fphar.2020.00356","article-title":"Modeling Parkinson\u2019s Disease with the Alpha-Synuclein Protein","volume":"11","author":"Granado","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnins.2020.00018","article-title":"A Role of Cholesterol in Modulating the Binding of alpha-Synuclein to Synaptic-Like Vesicles","volume":"14","author":"Man","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e2135371","DOI":"10.1001\/jamanetworkopen.2021.35371","article-title":"Trends in Use and Expenditures for Brand-name Statins after Introduction of Generic Statins in the US, 2002\u20132018","volume":"4","author":"Lin","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Buist, M., Fuss, D., and Rastegar, M. (2021). Transcriptional Regulation of MECP2E1-E2 Isoforms and BDNF by Metformin and Simvastatin through Analyzing Nascent RNA Synthesis in a Human Brain Cell Line. Biomolecules, 11.","DOI":"10.3390\/biom11081253"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Sheikholeslami, K., Ali Sher, A., Lockman, S., Kroft, D., Ganjibakhsh, M., Nejati-Koshki, K., Shojaei, S., Ghavami, S., and Rastegar, M. (2019). Simvastatin Induces Apoptosis in Medulloblastoma Brain Tumor Cells via Mevalonate Cascade Prenylation Substrates. Cancers, 11.","DOI":"10.3390\/cancers11070994"},{"key":"ref_108","first-page":"107243","article-title":"Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome. Comput","volume":"86","author":"Li","year":"2020","journal-title":"Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.wneu.2022.03.089","article-title":"Simvastatin Inhibits Tumor Growth and Migration by Mediating Caspase-1-Dependent Pyroptosis in Glioblastoma Multiforme","volume":"165","author":"Yang","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jamaneurol.2022.3718","article-title":"Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients with Parkinson Disease: A Randomized Clinical Trial","volume":"79","author":"Stevens","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s11606-021-06651-6","article-title":"The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: An Observational Cohort Study","volume":"36","author":"Mueller","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"687585","DOI":"10.3389\/fcvm.2021.687585","article-title":"Hydrophilic or Lipophilic Statins?","volume":"8","author":"Climent","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1517\/14656566.5.12.2583","article-title":"Simvastatin: A review","volume":"5","author":"Pedersen","year":"2004","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0002-9149(91)90181-J","article-title":"Cholesterol-lowering effects of a 10 mg daily dose of lovastatin in patients with initial total cholesterol levels 200 to 240 mg\/dl (5.18 to 6.21 mmol\/liter)","volume":"68","author":"Rubinstein","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/01.ATV.14.10.1569","article-title":"Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern","volume":"14","author":"Franceschini","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/01.ATV.15.5.678","article-title":"Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor","volume":"15","author":"Nawrocki","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s41669-021-00257-8","article-title":"The Healthcare Cost Burden in Adults with High Risk for Cardiovascular Disease","volume":"5","author":"Tran","year":"2021","journal-title":"Pharmacoecon. Open."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"De Giorgi, R., De Crescenzo, F., Rizzo Pesci, N., Martens, M., Howard, W., Cowen, P.J., and Harmer, C.J. (2021). Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249409"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1073\/pnas.92.4.935","article-title":"Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver","volume":"92","author":"Sheng","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1007\/s13277-015-3551-7","article-title":"The effect of statins on cancer cells\u2014Review","volume":"36","author":"Matusewicz","year":"2015","journal-title":"Tumour. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1038\/s41598-019-47956-1","article-title":"Lipophilic statins inhibit Zika virus production in Vero cells","volume":"9","author":"Espano","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1074-5521(99)80061-1","article-title":"Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene","volume":"6","author":"Hendrickson","year":"1999","journal-title":"Chem. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.7164\/antibiotics.29.1346","article-title":"ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium","volume":"29","author":"Endo","year":"1976","journal-title":"J. Antibiot."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1073\/pnas.77.7.3957","article-title":"Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent","volume":"77","author":"Alberts","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/jm00155a040","article-title":"3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin","volume":"29","author":"Hoffman","year":"1986","journal-title":"J. Med. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(10)60310-8","article-title":"Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: A double-blind randomised trial","volume":"376","author":"Armitage","year":"2010","journal-title":"Lancet"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Heart Protection Study Collaborative, Group (2002). MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet, 360, 7\u201322.","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"ref_128","first-page":"1383","article-title":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)","volume":"344","author":"Pedersen","year":"1994","journal-title":"Lancet"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Morofuji, Y., Nakagawa, S., Ujifuku, K., Fujimoto, T., Otsuka, K., Niwa, M., and Tsutsumi, K. (2022). Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer. Pharmaceuticals, 15.","DOI":"10.3390\/ph15020151"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1059344","article-title":"Structural mechanism for statin inhibition of HMG-CoA reductase","volume":"292","author":"Istvan","year":"2001","journal-title":"Science"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s11010-022-04621-y","article-title":"Facts and ideas on statins with respect to their lipophilicity: A focus on skeletal muscle cells and bone besides known cardioprotection","volume":"478","author":"Svec","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e013225","DOI":"10.1161\/JAHA.119.013225","article-title":"Diagnosis and Treatment of Heterozygous Familial Hypercholesterolemia","volume":"8","author":"McGowan","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11745-002-0916-0","article-title":"High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production","volume":"37","author":"Roglans","year":"2002","journal-title":"Lipids"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"6508709","DOI":"10.1155\/2018\/6508709","article-title":"Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia","volume":"2018","author":"Barale","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jconrel.2022.04.017","article-title":"Formulation of simvastatin within high density lipoprotein enables potent tumour radiosensitisation","volume":"346","author":"Dehghankelishadi","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Zendehdel Baher, S., Yaqoubi, S., Asare-Addo, K., Hamishehkar, H., and Nokhodchi, A. (2022). Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial Hypertension. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14050895"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1517\/17425247.2015.963054","article-title":"Dry powder formulation of simvastatin","volume":"12","author":"Tulbah","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1100\/tsw.2003.121","article-title":"Differences between lovastatin and simvastatin hydrolysis in healthy male and female volunteers:gut hydrolysis of lovastatin is twice that of simvastatin","volume":"3","author":"Vree","year":"2003","journal-title":"Sci. World J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0163-7258(99)00045-5","article-title":"New insights into the pharmacodynamic and pharmacokinetic properties of statins","volume":"84","author":"Corsini","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"575678","DOI":"10.3389\/fgene.2020.575678","article-title":"Pharmacogenetics of Statin-Induced Myotoxicity","volume":"11","author":"Kee","year":"2020","journal-title":"Front. Genet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1124\/dmd.110.037523","article-title":"Complex drug interactions of HIV protease inhibitors 1: Inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir","volume":"39","author":"Kirby","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1208\/s12248-014-9663-y","article-title":"Reliability and extension of quantitative prediction of CYP3A4-mediated drug interactions based on clinical data","volume":"16","author":"Loue","year":"2014","journal-title":"AAPS J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/106002809102500309","article-title":"Simvastatin: A review of its pharmacology and clinical use","volume":"25","author":"Mauro","year":"1991","journal-title":"DICP"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0002-9149(91)90182-K","article-title":"Long-term safety and efficacy profile of simvastatin","volume":"68","author":"Boccuzzi","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2147\/DHPS.S333738","article-title":"A Narrative Review of Statin-Induced Rhabdomyolysis: Molecular Mechanism, Risk Factors, and Management","volume":"13","author":"Safitri","year":"2021","journal-title":"Drug Healthc. Patient Saf."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10557-005-5686-z","article-title":"Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study","volume":"19","author":"Bruckert","year":"2005","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Turner, R.M., and Pirmohamed, M. (2019). Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010022"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejps.2007.12.009","article-title":"Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro","volume":"33","author":"Skottheim","year":"2008","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/archneur.62.1.67","article-title":"Expanding indications for statins in cerebral ischemia: A quantitative study","volume":"62","author":"Ovbiagele","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8408","DOI":"10.1073\/pnas.0602852103","article-title":"Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells","volume":"103","author":"Corcoran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40478-022-01326-7","article-title":"Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs","volume":"10","author":"Lee","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41586-022-05439-w","article-title":"APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes","volume":"611","author":"Blanchard","year":"2022","journal-title":"Nature"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/mds.27609","article-title":"Brain cholesterol metabolism and Parkinson\u2019s disease","volume":"34","author":"Huang","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_154","first-page":"545","article-title":"Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson\u2019s Disease: Rationale for Clinical Trial, and Current Progress","volume":"7","author":"Carroll","year":"2017","journal-title":"J. Park. Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/nan.12286","article-title":"Evidence for altered cholesterol metabolism in Huntington\u2019s disease post mortem brain tissue","volume":"42","author":"Kreilaus","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/1078-0432.CCR-17-2923","article-title":"Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma","volume":"24","author":"Gordon","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2013.03.042","article-title":"Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington\u2019s disease like symptoms and related cognitive dysfunction in rats","volume":"709","author":"Kumar","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1474-4422(17)30113-8","article-title":"Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: Secondary analyses from the MS-STAT randomised, placebo-controlled trial","volume":"16","author":"Chan","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0140-6736(13)62242-4","article-title":"Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): A randomised, placebo-controlled, phase 2 trial","volume":"383","author":"Chataway","year":"2014","journal-title":"Lancet"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3233\/JAD-2006-10408","article-title":"Effect of statins on Alzheimer\u2019s disease biomarkers in cerebrospinal fluid","volume":"10","author":"Riekse","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/ana.24534","article-title":"Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial","volume":"78","author":"Buettner","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1161\/STROKEAHA.116.014600","article-title":"Combination of Thrombolysis and Statins in Acute Stroke Is Safe: Results of the STARS Randomized Trial (Stroke Treatment with Acute Reperfusion and Simvastatin)","volume":"47","author":"Montaner","year":"2016","journal-title":"Stroke"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1161\/STROKEAHA.107.505875","article-title":"A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage","volume":"39","author":"Chou","year":"2008","journal-title":"Stroke"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1038\/s41388-021-01701-z","article-title":"Statins repress hedgehog signaling in medulloblastoma with no bone toxicities","volume":"40","author":"Fan","year":"2021","journal-title":"Oncogene"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e12108","DOI":"10.1002\/trc2.12108","article-title":"Statin therapy and risk of Alzheimer\u2019s and age-related neurodegenerative diseases","volume":"6","author":"Branigan","year":"2020","journal-title":"Alzheimers Dement. (NY)"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13195-017-0237-y","article-title":"Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer\u2019s disease","volume":"9","author":"Geifman","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/sj.bjp.0706106","article-title":"High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: Possible involvement of endothelial nitric oxide synthase","volume":"144","author":"Wang","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neulet.2006.09.009","article-title":"Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats","volume":"408","author":"Wang","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1471-4159.2010.06912.x","article-title":"Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington\u2019s disease","volume":"115","author":"Xifro","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/mds.27591","article-title":"Statin use and delayed onset of Huntington\u2019s disease","volume":"34","author":"Schultz","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s13256-022-03531-3","article-title":"Adult medulloblastoma: A case report","volume":"16","author":"Mduma","year":"2022","journal-title":"J. Med. Case Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"165839","DOI":"10.1016\/j.bbadis.2020.165839","article-title":"Ubiquitin ligases and medulloblastoma: Genetic markers of the four consensus subgroups identified through transcriptome datasets","volume":"1866","author":"Vriend","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3389\/fncel.2014.00450","article-title":"Cellular commitment in the developing cerebellum","volume":"8","author":"Marzban","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_174","first-page":"192","article-title":"Medulloblastoma cerebelli: A common type of midcerebellar glioma of childhood","volume":"14","author":"Bailey","year":"1925","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00401-015-1389-0","article-title":"Medulloblastoma subgroups remain stable across primary and metastatic compartments","volume":"129","author":"Wang","year":"2015","journal-title":"Acta Neuropathol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1177\/0883073815600866","article-title":"Medulloblastoma","volume":"31","author":"Millard","year":"2016","journal-title":"J. Child Neurol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/cas.15691","article-title":"Recent advances in the molecular understanding of medulloblastoma","volume":"114","author":"Funakoshi","year":"2023","journal-title":"Cancer Sci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nrn1990","article-title":"Morphogen to mitogen: The multiple roles of hedgehog signalling in vertebrate neural development","volume":"7","author":"Fuccillo","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.stem.2011.02.021","article-title":"Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells","volume":"8","author":"Brownell","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.devcel.2022.07.016","article-title":"Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice","volume":"57","author":"Zhu","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"20611","DOI":"10.1073\/pnas.1315729110","article-title":"Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration","volume":"110","author":"Peng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature09851","article-title":"Hedgehog\/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder","volume":"472","author":"Shin","year":"2011","journal-title":"Nature"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1158\/0008-5472.CAN-04-1813","article-title":"The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas","volume":"64","author":"Hallahan","year":"2004","journal-title":"Cancer Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nchembio.765","article-title":"Oxysterols are allosteric activators of the oncoprotein Smoothened","volume":"8","author":"Nachtergaele","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jcp.21678","article-title":"Epigenetic control","volume":"219","author":"Delcuve","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Shevkoplyas, D., Vuu, Y.M., Davie, J.R., and Rastegar, M. (2022). The Chromatin Structure at the MECP2 Gene and In Silico Prediction of Potential Coding and Non-Coding MECP2 Splice Variants. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415643"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Pejhan, S., and Rastegar, M. (2021). Role of DNA Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome Pathobiology and Mechanism of Disease. Biomolecules, 11.","DOI":"10.3390\/biom11010075"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"151237","DOI":"10.1016\/j.ejcb.2022.151237","article-title":"MeCP2 and transcriptional control of eukaryotic gene expression","volume":"101","author":"Buist","year":"2022","journal-title":"Eur. J. Cell Biol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/nan.12619","article-title":"Differential brain region-specific expression of MeCP2 and BDNF in Rett Syndrome patients: A distinct grey-white matter variation","volume":"46","author":"Pejhan","year":"2020","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Buist, M., El Tobgy, N., Shevkoplyas, D., Genung, M., Sher, A.A., Pejhan, S., and Rastegar, M. (2022). Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to MECP2 Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain. Cells, 11.","DOI":"10.3390\/cells11091442"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3389\/fgene.2018.00635","article-title":"MECP2 Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients","volume":"9","author":"Olson","year":"2018","journal-title":"Front. Genet."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fcell.2020.00763","article-title":"The MeCP2E1\/E2-BDNF-miR132 Homeostasis Regulatory Network Is Region-Dependent in the Human Brain and Is Impaired in Rett Syndrome Patients","volume":"8","author":"Pejhan","year":"2020","journal-title":"Front. Cell Dev Biol."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Nejati-Koshki, K.R.C., Babaei, G., and Rastegar, M. (2023). The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology. Cancers, 15.","DOI":"10.3390\/cancers15102683"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/alz.12253","article-title":"The search for a convenient procedure to detect one of the earliest signs of Alzheimer\u2019s disease: A systematic review of the prediction of brain amyloid status","volume":"17","author":"Ashford","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1471-4159.2001.00063.x","article-title":"Cholesterol-dependent modulation of tau phosphorylation in cultured neurons","volume":"76","author":"Fan","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-2275(20)32052-6","article-title":"Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients","volume":"41","author":"Lutjohann","year":"2000","journal-title":"J. Lipid Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3940(02)00164-7","article-title":"Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer\u2019s disease compared to healthy controls","volume":"324","author":"Schonknecht","year":"2002","journal-title":"Neurosci. Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00439-004-1107-9","article-title":"Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer\u2019s disease","volume":"114","author":"Johansson","year":"2004","journal-title":"Hum. Genet."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13195-022-01151-z","article-title":"CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer\u2019s disease","volume":"14","author":"Lerner","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer\u2019s disease: Pathophysiology and therapeutic strategies","volume":"17","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1001\/jama.2021.4925","article-title":"APOE Allele Testing and Alzheimer Disease-Reply","volume":"325","author":"Choudhury","year":"2021","journal-title":"JAMA"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/biof.1597","article-title":"The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review","volume":"46","author":"Bagheri","year":"2020","journal-title":"Biofactors"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1227\/01.NEU.0000346272.76537.DC","article-title":"Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury","volume":"65","author":"Li","year":"2009","journal-title":"Neurosurgery"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"120196","DOI":"10.1016\/j.jns.2022.120196","article-title":"The pathophysiology of Parkinson\u2019s disease tremor","volume":"435","author":"Dirkx","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1073\/pnas.1906124116","article-title":"Parkinson\u2019s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of alpha-synuclein","volume":"116","author":"Araki","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"27646","DOI":"10.1073\/pnas.2003021117","article-title":"Cell type-specific lipid storage changes in Parkinson\u2019s disease patient brains are recapitulated by experimental glycolipid disturbance","volume":"117","author":"Brekk","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41531-022-00410-y","article-title":"Incidence of Parkinson disease in North America","volume":"8","author":"Willis","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"21020","DOI":"10.1038\/s41598-022-25180-8","article-title":"Association between serum lipid levels over time and risk of Parkinson\u2019s disease","volume":"12","author":"Hurh","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fneur.2017.00501","article-title":"Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson\u2019s Risk","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"e1976","DOI":"10.1212\/WNL.0000000000200182","article-title":"Association of Statins with Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults","volume":"98","author":"Oveisgharan","year":"2022","journal-title":"Neurology"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1176\/jnp.15.1.109","article-title":"On chorea","volume":"15","author":"Huntington","year":"2003","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"The Huntington\u2019s Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell, 72, 971\u2013983.","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/0896-6273(95)90106-X","article-title":"CAG expansion affects the expression of mutant Huntingtin in the Huntington\u2019s disease brain","volume":"15","author":"Aronin","year":"1995","journal-title":"Neuron"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/mds.29228","article-title":"Prevalence and Incidence of Huntington\u2019s Disease: An Updated Systematic Review and Meta-Analysis","volume":"37","author":"Medina","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/brain\/awl027","article-title":"Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles","volume":"129","author":"Underwood","year":"2006","journal-title":"Brain"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(92)90143-Z","article-title":"Caveolin, a protein component of caveolae membrane coats","volume":"68","author":"Rothberg","year":"1992","journal-title":"Cell"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1073\/pnas.94.8.3753","article-title":"Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers","volume":"94","author":"Fielding","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.4103\/1673-5374.194713","article-title":"Molecular mechanisms of NMDA receptor-mediated excitotoxicity: Implications for neuroprotective therapeutics for stroke","volume":"11","author":"Li","year":"2016","journal-title":"Neural Regen. Res."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/16\/7\/914\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:58:39Z","timestamp":1760126319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/16\/7\/914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,22]]},"references-count":220,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ph16070914"],"URL":"https:\/\/doi.org\/10.3390\/ph16070914","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,22]]}}}