{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:51:12Z","timestamp":1790117472626,"version":"4.0.1"},"reference-count":81,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Ministry of Economy and Competitiveness and Basque Government","doi-asserted-by":"publisher","award":["PID2019-106845RB-100 (AEI\/FEDER, UE)"],"award-info":[{"award-number":["PID2019-106845RB-100 (AEI\/FEDER, UE)"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Ministry of Economy and Competitiveness and Basque Government","doi-asserted-by":"publisher","award":["GIC-IT-1546-22"],"award-info":[{"award-number":["GIC-IT-1546-22"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Ministry of Economy and Competitiveness and Basque Government","doi-asserted-by":"publisher","award":["390715994"],"award-info":[{"award-number":["390715994"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cluster of Excellence Advanced Imaging of Matter of the Deursche Forschungsgemeinschaft","award":["PID2019-106845RB-100 (AEI\/FEDER, UE)"],"award-info":[{"award-number":["PID2019-106845RB-100 (AEI\/FEDER, UE)"]}]},{"name":"Cluster of Excellence Advanced Imaging of Matter of the Deursche Forschungsgemeinschaft","award":["GIC-IT-1546-22"],"award-info":[{"award-number":["GIC-IT-1546-22"]}]},{"name":"Cluster of Excellence Advanced Imaging of Matter of the Deursche Forschungsgemeinschaft","award":["390715994"],"award-info":[{"award-number":["390715994"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe3O4 nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe3O4 nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe3O4 nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents.<\/jats:p>","DOI":"10.3390\/ph16070949","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T01:03:02Z","timestamp":1688346182000},"page":"949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor"],"prefix":"10.3390","volume":"16","author":[{"given":"Itziar","family":"Galarreta-Rodriguez","sequence":"first","affiliation":[{"name":"Departamento Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Facultad de Ciencia y Tecnolog\u00eda, University of the Basque Country (UPV\/EHU), Sarriena s\/n, 48940 Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Etxebeste-Mitxeltorena","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain"},{"name":"The Navarra Medical Research Institute (IdiSNA), Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-4608","authenticated-orcid":false,"given":"Esther","family":"Moreno","sequence":"additional","affiliation":[{"name":"Tropical Health Institute of the University of Navarra (ISTUN), University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain"},{"name":"Fachbereich Physik, Universit\u00e4t Hamburg, 22761 Hamburg, Germany"},{"name":"Physics Department, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-0445","authenticated-orcid":false,"given":"Daniel","family":"Plano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain"},{"name":"The Navarra Medical Research Institute (IdiSNA), Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3431-7826","authenticated-orcid":false,"given":"Carmen","family":"Sanmart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain"},{"name":"The Navarra Medical Research Institute (IdiSNA), Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-5710","authenticated-orcid":false,"given":"Saad","family":"Megahed","sequence":"additional","affiliation":[{"name":"Fachbereich Physik, Universit\u00e4t Hamburg, 22761 Hamburg, Germany"},{"name":"Physics Department, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7886-1711","authenticated-orcid":false,"given":"Neus","family":"Feliu","sequence":"additional","affiliation":[{"name":"Center for Applied Nanotechnology CAN, Fraunhofer Institute for Applied Polymer Research IAP, 20146 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-6650","authenticated-orcid":false,"given":"Wolfgang J.","family":"Parak","sequence":"additional","affiliation":[{"name":"Fachbereich Physik, Universit\u00e4t Hamburg, 22761 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eneko","family":"Garaio","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias, Universidad P\u00fablica de Navarra, Campus Arrosad\u00eda, 31006 Pamplona, Spain"},{"name":"Institute for Advanced Materials and Mathematics (INAMAT2), Universidad P\u00fablica de Navarra, Campus de Arrosad\u00eda, 31006 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-7386","authenticated-orcid":false,"given":"Izaskun","family":"Gil de Muro","sequence":"additional","affiliation":[{"name":"Departamento Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Facultad de Ciencia y Tecnolog\u00eda, University of the Basque Country (UPV\/EHU), Sarriena s\/n, 48940 Leioa, Spain"},{"name":"BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, 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