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Cannabidiol (CBD) has been considered a promising treatment for these conditions. This study investigated whether chronic systemic treatment with CBD alters pain in high- (CHF) and low-freezing (CLF) Carioca rats (GAD model) and control rats (CTL) submitted to chronic neuropathic pain. The rats were evaluated in the sensory aspects (von Frey, acetone, and hot plate tests) before the chronic constriction injury of the ischiatic nerve (CCI) or not (SHAM) and on days 13 and 23 after surgery. Chronic treatment with CBD (5 mg\/kg daily) was used for ten days, starting the 14th day after surgery. The open field test on the 22nd also evaluated locomotion and anxiety-like behavior. CBD treatment had an anti-allodynic effect on the mechanical and thermal threshold in all lineages; however, these effects were lower in the CHF and CLF lineages. Considering emotional evaluation, we observed an anxiolytic effect in CTL+CCI and CHF+CCI after CBD treatment and increased mobility in CLF+SHAM rats. These results suggest that the CBD mechanical anti-allodynic and emotional effects can depend on anxiety level.<\/jats:p>","DOI":"10.3390\/ph16071003","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T08:35:47Z","timestamp":1689323747000},"page":"1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systemic Chronic Treatment with Cannabidiol in Carioca High- and Low-Conditioned Freezing Rats in the Neuropathic Pain Model: Evaluation of Pain Sensitivity"],"prefix":"10.3390","volume":"16","author":[{"given":"Carolina","family":"Mac\u00eado-Souza","sequence":"first","affiliation":[{"name":"Department of Psychology, Faculty of Philosophy, Science and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"},{"name":"National Institute for Translational Medicine (INCT-TM; CNPq), S\u00e3o Paulo 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Soares","family":"Maisonnette","sequence":"additional","affiliation":[{"name":"Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E.","family":"Hallak","sequence":"additional","affiliation":[{"name":"National Institute for Translational Medicine (INCT-TM; CNPq), S\u00e3o Paulo 14049-900, Brazil"},{"name":"Department of Neuroscience and Behavioral Sciences, Ribeir\u00e3o Preto School of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Crippa","sequence":"additional","affiliation":[{"name":"National Institute for Translational Medicine (INCT-TM; CNPq), S\u00e3o Paulo 14049-900, Brazil"},{"name":"Department of Neuroscience and Behavioral Sciences, Ribeir\u00e3o Preto School of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-6670","authenticated-orcid":false,"given":"Ant\u00f4nio W.","family":"Zuardi","sequence":"additional","affiliation":[{"name":"National Institute for Translational Medicine (INCT-TM; CNPq), S\u00e3o Paulo 14049-900, Brazil"},{"name":"Department of Neuroscience and Behavioral Sciences, Ribeir\u00e3o Preto School of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8395-8008","authenticated-orcid":false,"given":"J.","family":"Landeira-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-2730","authenticated-orcid":false,"given":"Christie Ramos Andrade","family":"Leite-Panissi","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Philosophy, Science and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"},{"name":"National Institute for Translational Medicine (INCT-TM; CNPq), S\u00e3o Paulo 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/j.pain.0000000000000454","article-title":"Pain and the global burden of disease","volume":"157","author":"Rice","year":"2016","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1097\/j.pain.0000000000001009","article-title":"Defining chronic pain in epidemiological studies","volume":"158","author":"Landmark","year":"2017","journal-title":"Pain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/S0140-6736(06)69865-6","article-title":"Generalised anxiety disorder","volume":"368","author":"Tyrer","year":"2006","journal-title":"Lancet"},{"key":"ref_4","unstructured":"World Health Organization (2023, May 10). 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