{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:01:18Z","timestamp":1764306078545,"version":"build-2065373602"},"reference-count":100,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"Deanship of Scientific Research, King Khalid University, Abha, Saudi Arabia","doi-asserted-by":"publisher","award":["RGP. 1\/219\/44"],"award-info":[{"award-number":["RGP. 1\/219\/44"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Balancing the therapeutic advantages of a medicine with its possible risks and side effects is an important part of medical practice and drug regulation. When a drug is designed to treat a particular disease or medical condition ends up causing additional risks or side effects that lead to the development of other serious health problems, it can have detrimental consequences for patients. This article explores the correlation between persistent proton pump inhibitor (PPI) use and hypertension, a common cardiovascular ailment. While PPIs are beneficial in treating various gastrointestinal problems, their availability without a prescription has resulted in self-medication and long-term use without medical monitoring. Recent findings have revealed a link between long-term PPI usage and increased cardiovascular risks, particularly hypertension. This study investigates the intricate mechanisms underlying PPI\u2019s effects, focusing on potential pathways contributing to hypertension, such as endothelial dysfunction, disruption of nitric oxide bioavailability, vitamin B deficiency, hypocalcemia, and hypomagnesemia. The discussion explains how long-term PPI use can disrupt normal endothelial function, vascular control, and mineral balance, eventually leading to hypertension. The article emphasizes the significance of using PPIs with caution and ongoing research to better understand the implications of these medications on cardiovascular health.<\/jats:p>","DOI":"10.3390\/ph16101387","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:57:06Z","timestamp":1696179426000},"page":"1387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?"],"prefix":"10.3390","volume":"16","author":[{"given":"Rohit","family":"Tayal","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Yasmin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-6534","authenticated-orcid":false,"given":"Samrat","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Saini","sequence":"additional","affiliation":[{"name":"M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala 133207, Haryana, India"},{"name":"Swami Vivekanand College of Pharmacy, Ramnagar, Banur 140601, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0763-1510","authenticated-orcid":false,"given":"Eman","family":"Shorog","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam M.","family":"Althubyani","sequence":"additional","affiliation":[{"name":"Department of Clinical Services, Pharmaceutical Care Services, King Salman Medical City, Ministry of Health MOH, Al Madinah Al Munawwarah 11176, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiaan H.","family":"Alsaadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Services, Pharmaceutical Care Services, King Salman Medical City, Ministry of Health MOH, Al Madinah Al Munawwarah 11176, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Prince Sultan Armed Forces Hospital, Al Madenah Al Monwarah 42375, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maram A.","family":"Alenazi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Services, King Salman Specialist Hospital, Ministry of Health (MOH), Hail 55471, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Abutaily","sequence":"additional","affiliation":[{"name":"Ambulatory Care Clinical, Prince Sultan Military Medical City, Riyadh 12233, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-7104","authenticated-orcid":false,"given":"Mohammad Yousuf","family":"Ansari","sequence":"additional","affiliation":[{"name":"M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala 133207, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Scarpignato, C., Gatta, L., Zullo, A., Blandizzi, C., SIF-AIGO-FIMMG Group, and Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of General Practitioners (2016). Effective and Safe Proton Pump Inhibitor Therapy in Acid-Related Diseases\u2014A Position Paper Addressing Benefits and Potential Harms of Acid Suppression. 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