{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:52:11Z","timestamp":1777326731960,"version":"3.51.4"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302469\/2022-2"],"award-info":[{"award-number":["302469\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["17\/2022"],"award-info":[{"award-number":["17\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by dexamethasone. The animals were randomly divided into groups containing eight animals and were pre-administered with dexamethasone (64 \u03bcg\/kg subcutaneously). After 165 and 180 min, they were treated with ME (25, 50 and 100 mg\/kg intraperitoneally) or imipramine (10 mg\/kg intraperitoneally) after 45 min and 30 min, respectively; they were then submitted to tests which were filmed. The videos were analyzed blindly. In the tail suspension test, ME (50 mg\/kg) increased latency and reduced immobility time. In the splash test, ME (50 mg\/kg) decreased grooming latency and increased grooming time. In the open field, there was no statistical difference for the ME groups regarding the number of crosses, and ME (50 mg\/kg) increased the number of rearing and time spent in the center. Regarding in silico studies, ME interacted with dopaminergic D1 and \u03b11 adrenergic pathway receptors and with tryptophan hydroxylase inhibitor. In the in vivo evaluation of the pathways of action, the antidepressant potential of ME (50 mg\/kg) was reversed by SCH23390 (4 mg\/kg intraperitoneally) dopaminergic D1 receptor, Prazosin (1 mg\/kg intraperitoneally) \u03b11 adrenergic receptor, and PCPA (4 mg\/kg intraperitoneally) tryptophan hydroxylase inhibitor. Our findings indicate that ME did not alter with the locomotor activity of the animals and shows antidepressant activity in female mice with the participation of the D1, \u03b11 and serotonergic systems.<\/jats:p>","DOI":"10.3390\/ph16101408","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:47:52Z","timestamp":1696405672000},"page":"1408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence"],"prefix":"10.3390","volume":"16","author":[{"given":"Mayara Cecile Nascimento","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikla Lima","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Natal\u00edcia","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Matilde","family":"Ferreira dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2718-4914","authenticated-orcid":false,"given":"Renata Priscila Barros","family":"de Menezes","sequence":"additional","affiliation":[{"name":"Laboratory of Cheminformatics, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6220-9091","authenticated-orcid":false,"given":"Chonny","family":"Herrera-Acevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Cheminformatics, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia","family":"Ferreira de Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Cheminformatics, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jailane","family":"de Souza Aquino","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Maria","family":"Barbosa-Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-7376","authenticated-orcid":false,"given":"Ricardo Dias","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo N\u00f3brega","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-4107","authenticated-orcid":false,"given":"Luciana","family":"Scotti","sequence":"additional","affiliation":[{"name":"Laboratory of Cheminformatics, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-8057","authenticated-orcid":false,"given":"Marcus Tullius","family":"Scotti","sequence":"additional","affiliation":[{"name":"Laboratory of Cheminformatics, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-7922","authenticated-orcid":false,"given":"Mirian Graciela","family":"Da Silva Stiebbe Salvadori","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopharmacology, Institute for Research in Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11033-019-05129-3","article-title":"The cellular and molecular basis of major depressive disorder: Towards a unified model for understanding clinical depression","volume":"47","author":"Pitsillou","year":"2020","journal-title":"Mol. 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