{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:29:34Z","timestamp":1770229774828,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006181","name":"PRONEX","doi-asserted-by":"publisher","award":["0002\/2014"],"award-info":[{"award-number":["0002\/2014"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"PRONEX","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["0002\/2014"],"award-info":[{"award-number":["0002\/2014"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel superior\u2014Brasil (CAPES)","award":["0002\/2014"],"award-info":[{"award-number":["0002\/2014"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel superior\u2014Brasil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it necessary to search for new anti-inflammatory drugs. Here, we investigated the anti-inflammatory activity of solidagenone. Initially, we observed that a single dose of 30, 60, or 90 mg\/kg of solidagenone did not result in mortality or elicit any discernible signs of toxicity in mice. At the same doses, solidagenone promoted a significant reduction in the migration of neutrophils in an acute peritonitis model and decreased mortality in a lipopolysaccharide-induced endotoxic shock model. Interestingly, treatment with solidagenone conferred a protective effect against leukopenia and thrombocytopenia, hematological disorders commonly observed in sepsis conditions. In addition, treatment with all the doses of solidagenone promoted a significant reduction in nitric oxide, TNF-\u03b1, and IL-1\u03b2 levels relative to the LPS-stimulated vehicle-treated cultures. Furthermore, gene expression and in silico analyses also supported the modulation of the NF-\u03baB pathway by solidagenone. Finally, in silico pharmacokinetics predictions indicated a favorable drugability profile for solidagenone. Taken together, the findings of the present investigation show that solidagenone exhibits significant anti-inflammatory properties in acute experimental models, potentially through the modulation of the NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.3390\/ph17030273","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T03:30:26Z","timestamp":1708572626000},"page":"273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-\u03baB Signaling Pathway"],"prefix":"10.3390","volume":"17","author":[{"given":"Ivanilson Pimenta","family":"Santos","sequence":"first","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00eds Peres","family":"Silva","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahara Keyse Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Padilha Zurita Claro","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temistocles Barroso","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology Institute\u2014FarManguinhos, Natural Products Department, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro 21041-250, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa Maia","family":"Kelly","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology Institute\u2014FarManguinhos, Natural Products Department, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro 21041-250, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edivaldo","family":"dos Santos Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling and Computational Structural Biology, Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Valeria Campos","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling and Computational Structural Biology, Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Fernando","family":"Oliveira-Costa","sequence":"additional","affiliation":[{"name":"Center for Infusions and Specialized Medicines of Bahia, Bahia State Health Department, Salvador 41745-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Sacramento","family":"Valverde","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology Institute\u2014FarManguinhos, Natural Products Department, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro 21041-250, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7407-158X","authenticated-orcid":false,"given":"Osvaldo Andrade","family":"Santos-Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling and Computational Structural Biology, Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-2992","authenticated-orcid":false,"given":"Milena Botelho Pereira","family":"Soares","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, Brazil"},{"name":"Institute of Innovation in Advanced Health Systems (ISI SAS), University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssio Santana","family":"Meira","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, Brazil"},{"name":"Institute of Innovation in Advanced Health Systems (ISI SAS), University Center SENAI\/CIMATEC, Salvador 41650-010, BA, 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