{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:50Z","timestamp":1787029310264,"version":"build-2736575974"},"reference-count":67,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>It has been shown that the Medication Regimen Complexity Index (MRCI) is a useful and reliable tool for calculating the complexity of the pharmacotherapeutic regimen (CPR). Furthermore, a high MRCI is associated with lower adherence. However, the MRCI of opioid-dependent patients (ODP) has not been studied. The aim of this study is to calculate the Methadone Maintenance Program (MMP) persistence and the MRCI score in a ODP cohort. Second, to analyze its relationship and association with other variables. To accomplish this research, an observational study including adults with a confirmed diagnosis of opiate-dependency according to the DSM-5 in a MMP center was carried out. To define MMP-persistence, a group was created by the researchers who defined five weighted items according to their agreed importance. Our first contribution was to create a new definition of MMP-persistence. This study also identified age, comorbidities, and received methadone maintenance doses as successful predictors for MMP-persistence. We have also shown that the MRCI does not seem to be a useful tool to determine MMP-persistence, probably because there are multiple factors that influence it in addition to the CPR. It is necessary to continue searching for more precise selection and stratification tools for ODP to improve their persistence.<\/jats:p>","DOI":"10.3390\/ph17050567","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:33:31Z","timestamp":1714559611000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistence in the Methadone Maintenance Program and Its Relationship with the Medication Regimen Complexity Index in Opioid-Dependent Patients"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-8054","authenticated-orcid":false,"given":"Elena Alba","family":"\u00c1lvaro-Alonso","sequence":"first","affiliation":[{"name":"Pharmacy Department, Infanta Leonor University Hospital, Av. Gran V\u00eda del Este, 80, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"G\u00f3mez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"General Subdirectorate of Pharmaceutical Inspection and Management, Authorization Area for Pharmaceutical Centers, Services and Establishments, Ministry of Health, C\/Aduana, 29, 28013 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Segovia-Tapiador","sequence":"additional","affiliation":[{"name":"Vallecas Comprehensive Care Center for Drug Addicts, Calle de las Cinco Villas, 5, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Del-Pino-Illaconza","sequence":"additional","affiliation":[{"name":"Vallecas Comprehensive Care Center for Drug Addicts, Calle de las Cinco Villas, 5, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-2422","authenticated-orcid":false,"given":"Jorge","family":"Valencia","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Infanta Leonor University Hospital, Av. Gran V\u00eda del Este, 80, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ryan","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Infanta Leonor University Hospital, Av. Gran V\u00eda del Este, 80, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-3856","authenticated-orcid":false,"given":"Antonio","family":"Aguilar-Ros","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Estudios de las Adicciones IEA-CEU, Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Escobar-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Infanta Leonor University Hospital, Av. Gran V\u00eda del Este, 80, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref_1","unstructured":"Resoluci\u00f3n Del Director General de Coordinaci\u00f3n de La Asistencia Sanitaria Por La Que Se Encomienda al Hospital Universitario Infanta Leonor Las Tareas de Suministro Diario de Metadona a Los Centros de Atenci\u00f3n Integral a Drogodependientes de La Subdirecci\u00f3n General de Asistencia En Adicciones Del Servicio Madrile\u00f1o de Salud. Direcci\u00f3n General de Coordinaci\u00f3n de La Asistencia Sanitaria, No 189\/2018, (27 de Febrero de 2018)."},{"key":"ref_2","first-page":"185","article-title":"Centralization of the Methadone Maintenance Plan in a Hospital Pharmacy Department in the Community of Madrid","volume":"44","year":"2020","journal-title":"Farm. 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