{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:35:31Z","timestamp":1772127331432,"version":"3.50.1"},"reference-count":77,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin\/hesperidin on neuropathy induced by vinca alkaloids. Patients were randomized into one of three groups as follows: group 1 was the control group, group 2 received 450 mg diosmin and 50 mg hesperidin combination orally twice daily, and group 3 received loratadine 10 mg orally once daily. Subjective scores (numeric pain rating scale, douleur neuropathique 4, and functional assessment of cancer therapy\/gynecologic oncology group\u2013neurotoxicity (FACT\/GOG-Ntx) scores), neuroinflammation biomarkers, adverse drug effects, quality of life, and response to chemotherapy were compared among the three groups. Both diosmin\/hesperidin and loratadine improved the results of the neurotoxicity subscale in the FACT\/GOG-Ntx score (p &lt; 0.001, p &lt; 0.01 respectively) and ameliorated the upsurge in neuroinflammation serum biomarkers. They also reduced the incidence and timing of paresthesia (p = 0.001 and p &lt; 0.001, respectively) and dysuria occurrence (p = 0.042). Both loratadine and diosmin\/hesperidin attenuated the intensity of acute neuropathy triggered by vinca alkaloids. Furthermore, they did not increase the frequency of adverse effects or interfere with the treatment response.<\/jats:p>","DOI":"10.3390\/ph17050609","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T03:21:04Z","timestamp":1715311264000},"page":"609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Effect of Loratadine versus Diosmin\/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-9017","authenticated-orcid":false,"given":"Noha","family":"Kamal","sequence":"first","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy, University of Sadat City (USC), Sadat City 32897, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-1792","authenticated-orcid":false,"given":"Mahmoud S.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy, University of Sadat City (USC), Sadat City 32897, Egypt"},{"name":"Department of PharmD, Faculty of Pharmacy, Jadara University, Irbid 21110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essam","family":"Abdel Wahed","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-4853","authenticated-orcid":false,"given":"Nagwa A.","family":"Sabri","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-3434","authenticated-orcid":false,"given":"Sarah Farid","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref_1","first-page":"1231","article-title":"Vinca alkaloids","volume":"4","author":"Moudi","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.bmcl.2018.06.044","article-title":"Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead","volume":"28","author":"Martino","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00280-012-2042-4","article-title":"Marqibo\u00ae (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine","volume":"71","author":"Silverman","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_4","first-page":"475298","article-title":"Pharmacological Treatment of Chemotherapy-Induced Neuropathic Pain: PPAR\u03b3 Agonists as a Promising Tool","volume":"13","author":"Santin","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/bcpt.12261","article-title":"Drug-Induced Peripheral Neuropathy","volume":"115","author":"Vilholm","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuro.2020.10.004","article-title":"Vincristine-induced peripheral neuropathy: A mini-review","volume":"81","author":"Li","year":"2020","journal-title":"Neurotoxicology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1200\/JCO.1989.7.10.1457","article-title":"Long-term neurotoxicity in patients treated with cisplatin, vinblastine, and bleomycin for metastatic germ cell cancer","volume":"7","author":"Hansen","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113519","DOI":"10.1016\/j.expneurol.2020.113519","article-title":"Vincristine- and bortezomib-induced neuropathies\u2014From bedside to bench and back","volume":"336","author":"Geisler","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_9","first-page":"252","article-title":"Risk factors for early-onset peripheral neuropathy caused by vincristine in patients with a first administration of R-CHOP or R-CHOP-like chemotherapy","volume":"6","author":"Okada","year":"2014","journal-title":"J. Clin. Med. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clbc.2011.03.006","article-title":"Peripheral Neuropathy with Microtubule-Targeting Agents: Occurrence and Management Approach","volume":"11","author":"Carlson","year":"2011","journal-title":"Clin. Breast Cancer"},{"key":"ref_11","first-page":"2416","article-title":"Vincristine-induced peripheral neuropathy in pediatric cancer patients","volume":"6","author":"Mora","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12098-009-0254-3","article-title":"Vincristine induced neurotoxicity in cancer patients","volume":"77","author":"Gomber","year":"2010","journal-title":"Indian J. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1007\/s10072-020-04970-w","article-title":"Effect of pyridoxine plus pyridostigmine treatment on vincristine-induced peripheral neuropathy in pediatric patients with acute lymphoblastic leukemia: A single-center experience","volume":"42","author":"Karapinar","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1200\/JCO.20.01399","article-title":"Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update","volume":"38","author":"Loprinzi","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.annonc.2020.07.003","article-title":"Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO\u2013EONS\u2013EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up","volume":"31","author":"Jordan","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2174\/1381612829666230515124044","article-title":"Mechanism-Based Pharmacological Management of Chemotherapy-Induced Neuropathic Pain from Preclinical Studies to Clinical Prospective: Platinum-based drugs, Taxanes, and Vinca Alkaloids","volume":"29","author":"Zafari","year":"2023","journal-title":"Curr. Pharm. Des."},{"key":"ref_17","first-page":"256","article-title":"The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients","volume":"12","author":"Vertommen","year":"1999","journal-title":"Diabetes Nutr. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.biopha.2017.10.077","article-title":"Central and peripheral anti-hyperalgesic effects of diosmin in a neuropathic pain model in rats","volume":"97","author":"Pellicer","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.lfs.2018.11.029","article-title":"Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice","volume":"216","author":"Adamante","year":"2019","journal-title":"Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jneuroim.2016.08.018","article-title":"Diosmin reduces cerebral A\u03b2 levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice","volume":"299","author":"Sawmiller","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bhargava, P., Verma, V.K., Malik, S., Khan, S.I., Bhatia, J., and Arya, D.S. (2019). Hesperidin regresses cardiac hypertrophy by virtue of PPAR-\u03b3 agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties. J. Biochem. Mol. Toxicol., 33.","DOI":"10.1002\/jbt.22283"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1007\/s00520-016-3119-0","article-title":"Randomized phase II study of loratadine for the prevention of bone pain caused by pegfilgrastim","volume":"24","author":"Moukharskaya","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jang, J., Hunto, S.T., Kim, J.W., Lee, H.P., Kim, H.G., and Cho, J.Y. (2022). Anti-Inflammatory Activities of an Anti-Histamine Drug, Loratadine, by Suppressing TAK1 in AP-1 Pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073986"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/bph.14696","article-title":"Histamine, histamine receptors, and neuropathic pain relief","volume":"177","author":"Obara","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1590\/S0034-70942009000400008","article-title":"Analgesic effects of H1 receptor antagonists in the rat model of formalin-induced pain","volume":"59","author":"Ashmawi","year":"2009","journal-title":"Rev. Bras. Anestesiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12264-013-1316-0","article-title":"Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy","volume":"29","author":"Yu","year":"2013","journal-title":"Neurosci. Bull."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00210-017-1426-8","article-title":"Pharmacological investigations on mast cell stabilizer and histamine receptor antagonists in vincristine-induced neuropathic pain","volume":"390","author":"Jaggi","year":"2017","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00520-017-3959-2","article-title":"NOLAN: A randomized, phase 2 study to estimate the effect of prophylactic naproxen or loratadine vs. no prophylactic treatment on bone pain in patients with early-stage breast cancer receiving chemotherapy and pegfilgrastim","volume":"26","author":"Kirshner","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1078155214527858","article-title":"Severe pegfilgrastim-induced bone pain completely alleviated with loratadine: A case report","volume":"21","author":"Romeo","year":"2015","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1007\/s00520-021-06042-x","article-title":"Chemotherapy-induced peripheral neuropathy (CIPN): Current therapies and topical treatment option with high-concentration capsaicin","volume":"29","author":"Diel","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kerckhove, N., Tougeron, D., Lepage, C., Pezet, D., Le Malicot, K., Pelkowski, M., Pereira, B., and Balayssac, D. (2022). Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09806-8"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12955-020-01493-y","article-title":"Psychometric testing of the Functional Assessment of Cancer Therapy\/Gynecologic Oncology Group\u2014Neurotoxicity (FACT\/GOG-Ntx) subscale in a longitudinal study of cancer patients treated with chemotherapy","volume":"18","author":"Cheng","year":"2020","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2239788","DOI":"10.1001\/jamanetworkopen.2022.39788","article-title":"Association of Taxane Type With Patient-Reported Chemotherapy-Induced Peripheral Neuropathy Among Patients With Breast Cancer","volume":"5","author":"Mo","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/bcpt.13454","article-title":"The protective effect of modafinil on vincristine-induced peripheral neuropathy in rats: A possible role for TRPA1 receptors","volume":"127","author":"Amirkhanloo","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"135739","DOI":"10.1016\/j.neulet.2021.135739","article-title":"Blood molecular biomarkers for chemotherapy-induced peripheral neuropathy: From preclinical models to clinical practice","volume":"749","author":"Meregalli","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1038\/s41598-020-64511-5","article-title":"Serum neurofilament light chain levels as a biomarker of neuroaxonal injury and severity of oxaliplatin-induced peripheral neuropathy","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Youk, J., Kim, Y.-S., Lim, J.-A., Shin, D.-Y., Koh, Y., Lee, S.-T., and Kim, I. (2017). Depletion of nerve growth factor in chemotherapy-induced peripheral neuropathy associated with hematologic malignancies. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183491"},{"key":"ref_38","first-page":"E589","article-title":"Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain","volume":"19","author":"Kim","year":"2016","journal-title":"Pain Physician"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/jns.12493","article-title":"Prospectively assessing serum neurofilament light chain levels as a biomarker of paclitaxel-induced peripheral neurotoxicity in breast cancer patients","volume":"27","author":"Karteri","year":"2022","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10549-020-05762-8","article-title":"Evaluation of the effect of N-acetylcysteine on the prevention and amelioration of paclitaxel-induced peripheral neuropathy in breast cancer patients: A randomized controlled study","volume":"183","author":"Khalefa","year":"2020","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jpainsymman.2017.04.021","article-title":"Neuropathic pain and nerve growth factor in chemotherapy-induced peripheral neuropathy: Prospective clinical-pathological study","volume":"54","author":"Velasco","year":"2017","journal-title":"J. Pain Symptom Manag."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1470-2045(00)00418-6","article-title":"Minimal residual disease in leukaemia patients","volume":"2","author":"Szczepariski","year":"2001","journal-title":"Lancet Oncol."},{"key":"ref_43","unstructured":"(2023, May 19). Online Lexicomp Interaction Checker. Available online: https:\/\/online.lexi.com\/lco\/action\/interact."},{"key":"ref_44","first-page":"77","article-title":"Incidence and Severity of Neuropathy with Concurrent Use of Voriconazole and Vincristine in Pediatric Patients with Cancer","volume":"13","author":"Sabus","year":"2023","journal-title":"J. Hematol. Oncol. Pharm."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1470-2045(10)70105-4","article-title":"Drug interactions in childhood cancer","volume":"12","author":"Haidar","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.37201\/req\/013.2023","article-title":"Recommendations on the use of azole antifungals in hematology-oncology patients","volume":"36","author":"Azanza","year":"2023","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00280-019-03884-5","article-title":"Aspects of vincristine-induced neuropathy in hematologic malignancies: A systematic review","volume":"84","author":"Madsen","year":"2019","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.biopha.2018.09.127","article-title":"Diosmin is neuroprotective in a rat model of scopolamine-induced cognitive impairment","volume":"108","author":"Shabani","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/ijp.IJP_837_19","article-title":"Therapeutic potential of diosmin, a citrus flavonoid against arsenic-induced neurotoxicity via suppression of NOX 4 and its subunits","volume":"53","author":"Peruru","year":"2021","journal-title":"Indian J. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12272-015-0662-z","article-title":"Hesperidin attenuates learning and memory deficits in APP\/PS1 mice through activation of Akt\/Nrf2 signaling and inhibition of RAGE\/NF-\u03baB signaling","volume":"41","author":"Hong","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cbi.2017.11.018","article-title":"Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson\u2019s disease","volume":"279","author":"Poetini","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bellavite, P. (2023). Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action. Antioxidants, 12.","DOI":"10.3390\/antiox12020280"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00726-023-03273-6","article-title":"P19-derived neuronal cells express H1, H2, and H3 histamine receptors: A biopharmaceutical approach to evaluate antihistamine agents","volume":"55","author":"Perez","year":"2023","journal-title":"Amino Acids"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ptr.6046","article-title":"Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial","volume":"32","author":"Homayouni","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_55","first-page":"411","article-title":"Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum","volume":"18","author":"Wei","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2008.07.001","article-title":"The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats","volume":"1229","author":"Cata","year":"2008","journal-title":"Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4236\/odem.2021.93011","article-title":"Neuroprotective Effects of Hesperidin and Benfotiamine against Paraquat Induced Spinal Cord Neurotoxicity in Adult Male Albino Rats","volume":"9","author":"Amin","year":"2021","journal-title":"Occup. Dis. Environ. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e2248593","DOI":"10.1001\/jamanetworkopen.2022.48593","article-title":"Types and Concentrations of Blood-Based Biomarkers in Adults With Peripheral Neuropathies: A Systematic Review and Meta-analysis","volume":"5","author":"Fundaun","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1073\/pnas.93.20.10955","article-title":"Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma","volume":"93","author":"Bonini","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jung, H.H., Kim, J.-Y., Cho, E.Y., Oh, J.M., Lee, J.E., Kim, S.W., Nam, S.J., Park, Y.H., Ahn, J.S., and Im, Y.-H. (2021). Elevated Level of Nerve Growth Factor (NGF) in Serum-Derived Exosomes Predicts Poor Survival in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy. Cancers, 13.","DOI":"10.3390\/cancers13215260"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/FOC.2009.26.2.E3","article-title":"The role of neurotrophic factors in nerve regeneration","volume":"26","author":"Gordon","year":"2009","journal-title":"Neurosurg. Focus FOC"},{"key":"ref_62","first-page":"4199","article-title":"Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat","volume":"22","author":"Cavaletti","year":"2002","journal-title":"Anticancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"pkaa048","DOI":"10.1093\/jncics\/pkaa048","article-title":"Yoga for Chemotherapy-Induced Peripheral Neuropathy and Fall Risk: A Randomized Controlled Trial","volume":"4","author":"Bao","year":"2020","journal-title":"JNCI Cancer Spectrum"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pbb.2014.05.013","article-title":"Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: An evidence of anti-inflammatory and anti-oxidative activity","volume":"124","author":"Aswar","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Carballo-Villalobos, A.I., Gonz\u00e1lez-Trujano, M.E., Pellicer, F., and L\u00f3pez-Mu\u00f1oz, F.J. (2016). Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain. BioMed Res. Int., 2016.","DOI":"10.1155\/2016\/8263463"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Basu, P., and Basu, A. (2020). In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain. Molecules, 25.","DOI":"10.3390\/molecules25051171"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1049909119864083","article-title":"Loratadine for Paclitaxel-Induced Myalgias and Arthralgias","volume":"37","author":"Smith","year":"2019","journal-title":"Am. J. Hosp. Palliat. Med."},{"key":"ref_68","first-page":"471","article-title":"Diosmin reduces cell viability of A431 skin cancer cells through apoptotic induction","volume":"13","author":"Buddhan","year":"2017","journal-title":"J. Cancer Res. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e20191031","DOI":"10.1590\/0001-3765201920191031","article-title":"Diosmin induces caspase-dependent apoptosis in human glioblastoma cells","volume":"91","author":"Soares","year":"2019","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.kint.2020.10.041","article-title":"Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity","volume":"99","author":"Hamano","year":"2021","journal-title":"Kidney Int."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Anwer, T., Alshahrani, S., Somaili, A.M.H., Khubrani, A.H., Ahmed, R.A., Jali, A.M., Alshamrani, A., Rashid, H., Nomeir, Y., and Khalid, M. (2023). Nephroprotective Effect of Diosmin against Cisplatin-Induced Kidney Damage by Modulating IL-1\u03b2, IL-6, TNF\u03b1 and Renal Oxidative Damage. Molecules, 28.","DOI":"10.3390\/molecules28031302"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.fct.2018.07.027","article-title":"Hepatoprotective effects of diosmin and\/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1\/Nrf-2 and P38-MAPK\/NF-\u03baB\/iNOS signaling pathway","volume":"120","author":"Ali","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ansar, S., Abudawood, M., Alaraj, A.S.A., and Hamed, S.S. (2018). Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. BMC Pharmacol. Toxicol., 19.","DOI":"10.1186\/s40360-018-0256-8"},{"key":"ref_74","first-page":"25","article-title":"Hesperidin and diosmin-a novel drugs","volume":"10","author":"Roy","year":"2020","journal-title":"Int. J. Pharm. Res. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s43163-020-00060-y","article-title":"Daflon use for reducing post-tonsillectomy pain and hemorrhage: A prospective study","volume":"37","author":"Saleh","year":"2021","journal-title":"Egypt. J. Otolaryngol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1200\/jco.2004.22.90140.6098","article-title":"The NCI Common Terminology Criteria for Adverse Events (CTCAE) v 3.0 is the new standard for oncology clinical trials","volume":"22","author":"Colevas","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1177\/03635465211059821","article-title":"Evaluation of Therapeutic Effects of Quercetin Against Achilles Tendinopathy in Rats via Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Metalloproteinases","volume":"50","author":"Semis","year":"2022","journal-title":"Am. J. Sports Med."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/5\/609\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:42:51Z","timestamp":1760107371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/5\/609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":77,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ph17050609"],"URL":"https:\/\/doi.org\/10.3390\/ph17050609","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]}}}