{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:07Z","timestamp":1783948807343,"version":"3.55.0"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: We recently reported that extract prepared from the aerial part of Cichorium intybus L. (CE) possesses hepatoprotective, hypolipidemic, and hypoglycemic properties. This paper focuses on the effects of CE on the male rat reproductive system and the effects of this treatment on pregnancy and offspring development. Methods: The experimental male rats received 100 mg\/kg bw\/day, 500 mg\/kg bw\/day, and 1000 mg\/kg bw\/day of CE orally for 60 consecutive days. Rats that received tap water were used as controls. After treatment, we evaluated the effects of CE on the male reproductive system, fertility, and offspring development. Results: For CE-treated male rats, there was a significant increase in the (1) diameter of seminiferous tubules, (2) spermatogenic index, (3) number of total and motile spermatozoa, and (4) testosterone levels. Additionally, there was a decrease in the pre- and post-implantation death of the embryos in the CE-treated group. All pups born from CE-treated males demonstrated normal development. Conclusions: CE treatment significantly improved male reproductive functions. No adverse effects on pregnancy and offspring development were observed when males were treated with CE. Further clinical evaluation of CE should lead to the development of a safe and effective phytodrug for treating male infertility.<\/jats:p>","DOI":"10.3390\/ph17060700","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:32:55Z","timestamp":1716903175000},"page":"700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Chicory (Cichorium intybus L.) Extract on Male Rat Reproductive System, Pregnancy and Offspring Development"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-5525","authenticated-orcid":false,"given":"Alexandra N.","family":"Babenko","sequence":"first","affiliation":[{"name":"All-Russian Institute of Medicinal and Aromatic Plants (VILAR), Moscow 113628, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubov V.","family":"Krepkova","sequence":"additional","affiliation":[{"name":"All-Russian Institute of Medicinal and Aromatic Plants (VILAR), Moscow 113628, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Borovkova","sequence":"additional","affiliation":[{"name":"All-Russian Institute of Medicinal and Aromatic Plants (VILAR), Moscow 113628, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Kuzina","sequence":"additional","affiliation":[{"name":"All-Russian Institute of Medicinal and Aromatic Plants (VILAR), Moscow 113628, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Mkhitarov","sequence":"additional","affiliation":[{"name":"FSBI \u201cResearch Institute of Human Morphology\u201d, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0255-654X","authenticated-orcid":false,"given":"Kathleen M.","family":"Job","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-1460","authenticated-orcid":false,"given":"Elena Y.","family":"Enioutina","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/MOU.0000000000000745","article-title":"Reasons for worldwide decline in male fertility","volume":"30","author":"Mann","year":"2020","journal-title":"Curr. 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