{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:32:52Z","timestamp":1794004372529,"version":"4.8.0"},"reference-count":137,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Neurodegenerative diseases (Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and others) and cancer, seemingly disparate in their etiology and manifestation, exhibit intriguing associations in certain cellular and molecular processes. Both cancer and neurodegenerative diseases involve the deregulation of cellular processes such as apoptosis, proliferation, and DNA repair and pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is a flavonoid compound abundant in various plant sources. Afzelin exhibits a diverse range of biological activities, offering promising prospects for the treatment of diseases hallmarked by oxidative stress and deregulation of cell death pathways. Its protective potential against oxidative stress is also promising for alleviating the side effects of chemotherapy. This review explores the potential therapeutic implications of afzelin, including its capacity to mitigate oxidative stress, modulate inflammation, and promote cellular regeneration in neurodegenerative and cancer diseases.<\/jats:p>","DOI":"10.3390\/ph17060701","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:32:55Z","timestamp":1716903175000},"page":"701","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-3825","authenticated-orcid":false,"given":"Mateusz","family":"Kciuk","sequence":"first","affiliation":[{"name":"Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 12\/16 Banacha St., 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitika","family":"Garg","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-359X","authenticated-orcid":false,"given":"Sanchit","family":"Dhankhar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Saini","sequence":"additional","affiliation":[{"name":"M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala 133207, Haryana, India"},{"name":"Swami Vivekanand College of Pharmacy, Ramnagar, Banur 140601, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-5475","authenticated-orcid":false,"given":"Somdutt","family":"Mujwar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-9072","authenticated-orcid":false,"given":"Sushma","family":"Devi","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-6534","authenticated-orcid":false,"given":"Samrat","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":false,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randhir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Central University of Punjab, Bathinda 151401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-6478","authenticated-orcid":false,"given":"Beata","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 12\/16 Banacha St., 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9562-3582","authenticated-orcid":false,"given":"Adrianna","family":"Gieleci\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 12\/16 Banacha St., 90-237 Lodz, Poland"},{"name":"Doctoral School of Exact and Natural Sciences, University of Lodz, 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2859-9839","authenticated-orcid":false,"given":"Renata","family":"Kontek","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 12\/16 Banacha St., 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dugger, B.N., and Dickson, D.W. (2017). Pathology of Neurodegenerative Diseases. Cold Spring Harb. Perspect. Biol., 9.","DOI":"10.1101\/cshperspect.a028035"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic Mechanisms of Neurodegeneration: A Critical Update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lamptey, R.N.L., Chaulagain, B., Trivedi, R., Gothwal, A., Layek, B., and Singh, J. (2022). A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031851"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S611","DOI":"10.3233\/JAD-179935","article-title":"Role of Amyloid-\u03b2 and Tau Proteins in Alzheimer\u2019s Disease: Confuting the Amyloid Cascade","volume":"64","author":"Gulisano","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer\u2019s Disease and the \u03b2-Amyloid Peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-017-0099-z","article-title":"Current Understanding of the Molecular Mechanisms in Parkinson\u2019s Disease: Targets for Potential Treatments","volume":"6","author":"Maiti","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/nrdp.2017.71","article-title":"Amyotrophic Lateral Sclerosis","volume":"3","author":"Hardiman","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_8","first-page":"1","article-title":"Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy","volume":"19","author":"Ghasemi","year":"2017","journal-title":"Cell J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/2045125317739818","article-title":"Frontotemporal Dementia: Latest Evidence and Clinical Implications","volume":"8","author":"Young","year":"2018","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ajmal, M.R. (2023). Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response. Diseases, 11.","DOI":"10.3390\/diseases11010030"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3945\/an.110.000117","article-title":"Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain Function","volume":"2","author":"Kennedy","year":"2011","journal-title":"Adv. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6565396","DOI":"10.1155\/2020\/6565396","article-title":"Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases","volume":"2020","author":"Sirajudeen","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, M., Lankatillake, C., Dias, D.A., Docea, A.O., Mahomoodally, M.F., Lobine, D., Chazot, P.L., Kurt, B., Tumer, T.B., and Moreira, A.C. (2020). Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041061"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-3-319-28383-8_7","article-title":"Efficacy of Natural Compounds in Neurodegenerative Disorders","volume":"12","author":"Srivastava","year":"2016","journal-title":"Adv. Neurobiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gieleci\u0144ska, A., Kciuk, M., Mujwar, S., Celik, I., Ko\u0142at, D., Ka\u0142uzi\u0144ska-Ko\u0142at, \u017b., and Kontek, R. (2023). Substances of Natural Origin in Medicine: Plants vs. Cancer. Cells, 12.","DOI":"10.3390\/cells12070986"},{"key":"ref_16","first-page":"376","article-title":"Oxidative Stress in Neurodegenerative Diseases","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2525967","DOI":"10.1155\/2017\/2525967","article-title":"Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications","volume":"2017","author":"Liu","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1007\/s12035-015-9337-5","article-title":"Oxidative Stress in Neurodegenerative Diseases","volume":"53","author":"Niedzielska","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2019). Oxidative Stress: A Key Modulator in Neurodegenerative Diseases. Molecules, 24.","DOI":"10.3390\/molecules24081583"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Arfin, S., Jha, N.K., Jha, S.K., Kesari, K.K., Ruokolainen, J., Roychoudhury, S., Rathi, B., and Kumar, D. (2021). Oxidative Stress in Cancer Cell Metabolism. Antioxidants, 10.","DOI":"10.3390\/antiox10050642"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.2174\/1381612825666190215121712","article-title":"Oxidative Stress and Cancer","volume":"24","author":"Klaunig","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","article-title":"Oxidative Stress in Cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"da Cunha Germano, B.C., de Morais, L.C.C., Idalina Neta, F., Fernandes, A.C.L., Pinheiro, F.I., do Rego, A.C.M., Ara\u00fajo Filho, I., de Azevedo, E.P., de Paiva Cavalcanti, J.R.L., and Guzen, F.P. (2023). Vitamin E and Its Molecular Effects in Experimental Models of Neurodegenerative Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311191"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Trela-Makowej, A., Le\u015bkiewicz, M., Kruk, J., \u017b\u0105d\u0142o, A., Basta-Kaim, A., and Szyma\u0144ska, R. (2022). Antioxidant and Neuroprotective Activity of Vitamin E Homologues: In Vitro Study. Metabolites, 12.","DOI":"10.3390\/metabo12070608"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109320","DOI":"10.1016\/j.mehy.2019.109320","article-title":"The Sour Side of Vitamin C Might Mediate Neuroprotective, Anticonvulsive and Antidepressant-like Effects","volume":"131","author":"Bonnet","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1089\/neu.2020.7443","article-title":"Neuroprotective Properties of Vitamin C: A Scoping Review of Pre-Clinical and Clinical Studies","volume":"38","author":"Kangisser","year":"2021","journal-title":"J. Neurotrauma"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hasan, S., Khatri, N., Rahman, Z.N., Menezes, A.A., Martini, J., Shehjar, F., Mujeeb, N., and Shah, Z.A. (2023). Neuroprotective Potential of Flavonoids in Brain Disorders. Brain Sci., 13.","DOI":"10.3390\/brainsci13091258"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.2174\/1389450119666180326125252","article-title":"Flavonoids and Its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases","volume":"19","author":"Putteeraj","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Akter, M., Parvin, M.S., Hasan, M.M., Rahman, M.A.A., and Islam, M.E. (2022). Anti-Tumor and Antioxidant Activity of Kaempferol-3-O-Alpha-L-Rhamnoside (Afzelin) Isolated from Pithecellobium dulce Leaves. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03633-x"},{"key":"ref_30","first-page":"2516","article-title":"Afzelin Suppresses Proinflammatory Responses in Particulate Matter-Exposed Human Keratinocytes","volume":"43","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/bph.13669","article-title":"Afzelin Ameliorates D-Galactosamine and Lipopolysaccharide-Induced Fulminant Hepatic Failure by Modulating Mitochondrial Quality Control and Dynamics","volume":"174","author":"Lee","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.micpath.2018.04.044","article-title":"Plant Nutraceuticals (Quercetrin and Afzelin) Capped Silver Nanoparticles Exert Potent Antibiofilm Effect against Food Borne Pathogen Salmonella enterica Serovar Typhi and Curtail Planktonic Growth in Zebrafish Infection Model","volume":"120","author":"Lotha","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/ene.13985","article-title":"Oxidative Stress, Inflammation and Risk of Neurodegeneration in a Population Sample","volume":"26","author":"Cherbuin","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Simpson, D.S.A., and Oliver, P.L. (2020). ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9080743"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s12272-015-0585-8","article-title":"Flavonoids from the Aerial Parts of Houttuynia Cordata Attenuate Lung Inflammation in Mice","volume":"38","author":"Lee","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8440","DOI":"10.1002\/slct.202001657","article-title":"Screening of \u03b1-Glucosidase Inhibitors from Houttuynia Cordata and Evaluation of the Binding Mechanisms","volume":"5","author":"Zhang","year":"2020","journal-title":"ChemistrySelect"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/np020442j","article-title":"Phenolic Compounds from Nymphaea Odorata","volume":"66","author":"Zhang","year":"2003","journal-title":"J. Nat. Prod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.3892\/ol.2015.3619","article-title":"Afzelin Exhibits Anti-Cancer Activity against Androgen-Sensitive LNCaP and Androgen-Independent PC-3 Prostate Cancer Cells through the Inhibition of LIM Domain Kinase 1","volume":"10","author":"Zhu","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Caballero, M.E., Sierra-Ram\u00edrez, J.A., Villalobos-Valencia, R., and Sese\u00f1a-M\u00e9ndez, E. (2022). Potential of Kalanchoe Pinnata as a Cancer Treatment Adjuvant and an Epigenetic Regulator. Molecules, 27.","DOI":"10.3390\/molecules27196425"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mej\u00eda-M\u00e9ndez, J.L., Bach, H., Lorenzo-Leal, A.C., Navarro-L\u00f3pez, D.E., L\u00f3pez-Mena, E.R., Hern\u00e1ndez, L.R., and S\u00e1nchez-Arreola, E. (2023). Biological Activities and Chemical Profiles of Kalanchoe Fedtschenkoi Extracts. Plants, 12.","DOI":"10.3390\/plants12101943"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Nascimento, L.B.d.S., Casanova, L.M., and Costa, S.S. (2023). Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs. Life, 13.","DOI":"10.3390\/life13030646"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-8741(03)00074-6","article-title":"Hepatoprotective Activity of Leaves of Kalanchoe Pinnata Pers","volume":"86","author":"Yadav","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1120146","DOI":"10.3389\/fphar.2023.1120146","article-title":"UHPLC-MS Profiles and Antidiarrheal Activity of Quercus coccinea M\u00fcnchh. and Quercus robur L. Employing In Vivo Technique","volume":"14","author":"Mady","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3892\/mmr.2023.13062","article-title":"Quercus spp. Extract as a Promising Preventive or Therapeutic Strategy for Cancer: A Systematic Review","volume":"28","author":"Oliveira","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jung, J., Kim, H., Lee, S., Hong, M., and Hwang, D. (2022). Antioxidant and Anti-Inflammatory Activity of Filipendula Glaberrima Nakai Ethanolic Extract and Its Chemical Composition. Molecules, 27.","DOI":"10.3390\/molecules27144628"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mar\u010deti\u0107, M., Samard\u017ei\u0107, S., Ili\u0107, T., Bo\u017ei\u0107, D.D., and Vidovi\u0107, B. (2022). Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits. Foods, 11.","DOI":"10.3390\/foods11203289"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Soares, S.S., Bekbolatova, E., Cotrim, M.D., Sakipova, Z., Ibragimova, L., Kukula-Koch, W., Giorno, T.B.S., Fernandes, P.D., Fonseca, D.A., and Boylan, F. (2019). Chemistry and Pharmacology of the Kazakh Crataegus almaatensis Pojark: An Asian Herbal Medicine. Antioxidants, 8.","DOI":"10.3390\/antiox8080300"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1021\/acs.jnatprod.0c00274","article-title":"Diuretic and Renal Protective Effect of Kaempferol 3-O-Alpha-l-Rhamnoside (Afzelin) in Normotensive and Hypertensive Rats","volume":"83","author":"Boeing","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/exd.13277","article-title":"Melanocyte-Protective Effect of Afzelin Is Mediated by the Nrf2-ARE Signalling Pathway via GSK-3\u03b2 Inactivation","volume":"26","author":"Jung","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1248\/cpb.c21-00398","article-title":"Evaluating the Sun Protection Factor of Cosmetic Formulations Containing Afzelin","volume":"69","author":"Kim","year":"2021","journal-title":"Chem. Pharm. Bull."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Juan, C.A., de la Lastra, J.M.P., Plou, F.J., and P\u00e9rez-Lebe\u00f1a, E. (2021). The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094642"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Liu, Y., Chen, P., Zhou, M., Wang, T., Fang, S., Shang, X., and Fu, X. (2018). Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from Cyclocarya paliurus (Batal) Iljinskaja Leaves. Molecules, 23.","DOI":"10.3390\/molecules23102440"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"62","DOI":"10.12691\/jfnr-3-1-11","article-title":"High Anti-Oxidative and Lipid-Lowering Activities of Flavonoid Glycosides-Rich Extract from the Leaves of Zanthoxylum bungeanum in Multi-System","volume":"3","author":"Ma","year":"2015","journal-title":"J. Food Nutr. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1080\/14786419.2018.1543673","article-title":"Evaluation of Cytoprotective Effects of Compounds Isolated from Copaifera langsdorffii Desf. against Induced Cytotoxicity by Exposure to Methylmercury and Lead","volume":"34","author":"Aldana","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0162-0134(02)00511-1","article-title":"Iron and Copper Chelation by Flavonoids: An Electrospray Mass Spectrometry Study","volume":"92","author":"Fernandez","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Merino, J.J., Parmigiani-Izquierdo, J.M., Toledano Gasca, A., and Caba\u00f1a-Mu\u00f1oz, M.E. (2019). The Long-Term Algae Extract (Chlorella and Fucus sp.) and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg++, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations. Antioxidants, 8.","DOI":"10.3390\/antiox8040101"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jff.2017.01.022","article-title":"Kaempferol\u2014A Dietary Anticancer Molecule with Multiple Mechanisms of Action: Recent Trends and Advancements","volume":"30","author":"Kashyap","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mito.2023.05.007","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease, and Parkinson\u2019s Disease, Huntington\u2019s Disease and Amyotrophic Lateral Sclerosis\u2014An Updated Review","volume":"71","author":"Alqahtani","year":"2023","journal-title":"Mitochondrion"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"617588","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/ejn.14264","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Induced Pluripotent Stem Cell Models of Parkinson\u2019s Disease","volume":"49","author":"Bose","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2012.10.011","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Parkinson\u2019s Disease and Monogenic Parkinsonism","volume":"51","author":"Hauser","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"ref_64","first-page":"136","article-title":"Mitochondrial Dysfunction in Cancer","volume":"13","year":"2014","journal-title":"Prz. Menopauzalny"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Luo, Y., Ma, J., and Lu, W. (2020). The Significance of Mitochondrial Dysfunction in Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165598"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Chen, C., Jiang, Y., Wang, S., Wu, X., and Wang, K. (2017). PPAR\u03b3 Coactivator-1\u03b1 (PGC-1\u03b1) Protects Neuroblastoma Cells against Amyloid-Beta (A\u03b2) Induced Cell Death and Neuroinflammation via NF-\u03baB Pathway. BMC Neurosci., 18.","DOI":"10.1186\/s12868-017-0387-7"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Mota, B.C., and Sastre, M. (2021). The Role of PGC1\u03b1 in Alzheimer\u2019s Disease and Therapeutic Interventions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115769"},{"key":"ref_68","first-page":"237","article-title":"Deciphering the Role of PGC-1\u03b1 in Neurological Disorders: From Mitochondrial Dysfunction to Synaptic Failure","volume":"17","author":"Panes","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_69","first-page":"198","article-title":"The Metabolic Modulator PGC-1\u03b1 in Cancer","volume":"9","author":"Bost","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/1873-3468.12989","article-title":"The Mitochondrial Transcription Factor TFAM in Neurodegeneration: Emerging Evidence and Mechanisms","volume":"592","author":"Kang","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s40478-020-01062-w","article-title":"PINK1\/PARKIN Signalling in Neurodegeneration and Neuroinflammation","volume":"8","author":"Quinn","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1111\/cas.15568","article-title":"The Emerging Multifaceted Role of PINK1 in Cancer Biology","volume":"113","author":"Wang","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12672-021-00454-1","article-title":"Mitophagy in Carcinogenesis and Cancer Treatment","volume":"12","author":"Denisenko","year":"2021","journal-title":"Discov. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Lee, D., Kim, J.-Y., Qi, Y., Park, S., Lee, H.L., Yamabe, N., Kim, H., Jang, D.S., and Kang, K.S. (2021). Phytochemicals from the Flowers of Prunus persica (L.) Batsch: Anti-Adipogenic Effect of Mandelamide on 3T3-L1 Preadipocytes. Bioorg. Med. Chem. Lett., 49.","DOI":"10.1016\/j.bmcl.2021.128326"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.1021\/acsomega.2c06916","article-title":"Antioxidant and Antineuroinflammatory Mechanisms of Kaempferol-3-O-\u03b2-d-Glucuronate on Lipopolysaccharide-Stimulated BV2 Microglial Cells through the Nrf2\/HO-1 Signaling Cascade and MAPK\/NF-\u03baB Pathway","volume":"8","author":"Lim","year":"2023","journal-title":"ACS Omega"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/ars.2008.2242","article-title":"The Nrf2\/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease","volume":"11","author":"Calkins","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1196\/annals.1427.036","article-title":"The Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration","volume":"1147","author":"Johnson","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"757161","DOI":"10.3389\/fphar.2021.757161","article-title":"Pharmacological Modulation of Nrf2\/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson\u2019s Disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Kaur, K., Narang, R.K., and Singh, S. (2023). Role of Nrf2 in Oxidative Stress, Neuroinflammation and Autophagy in Alzheimer\u2019s Disease: Regulation of Nrf2 by Different Signaling Pathways. Curr. Mol. Med., in press.","DOI":"10.2174\/1566524023666230726145447"},{"key":"ref_80","first-page":"630","article-title":"Targeting Abnormal Nrf2\/HO-1 Signaling in Amyotrophic Lateral Sclerosis: Current Insights on Drug Targets and Influences on Neurological Disorders","volume":"21","author":"Minj","year":"2021","journal-title":"Curr. Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s43440-022-00390-z","article-title":"GSK-3\u03b2-Mediated Regulation of Nrf2\/HO-1 Signaling as a New Therapeutic Approach in the Treatment of Movement Disorders","volume":"74","author":"Soni","year":"2022","journal-title":"Pharmacol. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/cam4.2101","article-title":"Nrf2 in Cancers: A Double-edged Sword","volume":"8","author":"Wu","year":"2019","journal-title":"Cancer Med."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Consoli, V., Sorrenti, V., Grosso, S., and Vanella, L. (2021). Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions. Biomolecules, 11.","DOI":"10.3390\/biom11040589"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1089\/ars.2013.5667","article-title":"Heme Oxygenase-1: A Metabolic Nike","volume":"20","author":"Wegiel","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fphar.2012.00030","article-title":"Direct Antioxidant Properties of Bilirubin and Biliverdin. Is There a Role for Biliverdin Reductase?","volume":"3","author":"Jansen","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fphar.2014.00115","article-title":"Heme on Innate Immunity and Inflammation","volume":"5","author":"Dutra","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4110\/in.2009.9.1.12","article-title":"Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases","volume":"9","author":"Pae","year":"2009","journal-title":"Immune Netw."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2174\/138161208783597407","article-title":"Heme Oxygenase-1 as a Therapeutic Target in Neurodegenerative Diseases and Brain Infections","volume":"14","author":"Cuadrado","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2174\/1381612824666180717160623","article-title":"Involvement of Heme Oxygenase-1 in Neuropsychiatric and Neurodegenerative Diseases","volume":"24","author":"Neis","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_90","first-page":"150","article-title":"Heme Oxygenase-1 in Inflammation and Cardiovascular Disease","volume":"1","author":"Wu","year":"2011","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wu, Y.-H., and Hsieh, H.-L. (2022). Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders. Antioxidants, 11.","DOI":"10.3390\/antiox11050923"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Ahmad, M.A., Kareem, O., Khushtar, M., Akbar, M., Haque, M.R., Iqubal, A., Haider, M.F., Pottoo, F.H., Abdulla, F.S., and Al-Haidar, M.B. (2022). Neuroinflammation: A Potential Risk for Dementia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020616"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: The Devil Is in the Details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1021\/acschemneuro.0c00427","article-title":"Neuroinflammation Mechanisms and Phytotherapeutic Intervention: A Systematic Review","volume":"11","author":"Kaur","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in Neurodegenerative Disorders: The Roles of Microglia and Astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Onyango, I.G., Jauregui, G.V., \u010carn\u00e1, M., Bennett, J.P., and Stokin, G.B. (2021). Neuroinflammation in Alzheimer\u2019s Disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9050524"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","article-title":"Neuroinflammation Pathways: A General Review","volume":"127","author":"Shabab","year":"2017","journal-title":"Int. J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and Cancer: Triggers, Mechanisms and Consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Rho, H.S., Ghimeray, A.K., Yoo, D.S., Ahn, S.M., Kwon, S.S., Lee, K.H., Cho, D.H., and Cho, J.Y. (2011). Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties. Molecules, 16.","DOI":"10.3390\/molecules16043338"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s12272-001-1174-9","article-title":"Anti-Oxidative and Inhibitory Activities on Nitric Oxide (NO) and Prostaglandin E2 (COX-2) Production of Flavonoids from Seeds of Prunus tomentosa Thunberg","volume":"31","author":"Kim","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Shin, S.W., Jung, E., Kim, S., Kim, J.-H., Kim, E.-G., Lee, J., and Park, D. (2013). Antagonizing Effects and Mechanisms of Afzelin against UVB-Induced Cell Damage. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061971"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Yoon, C.-S., Lee, H., Liu, Z., Lee, H.-K., and Lee, D.-S. (2022). Effects of Compounds Isolated from Lindera Erythrocarpa on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137122"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s11696-018-0664-7","article-title":"Attenuation of Hydrogen Peroxide-Induced Oxidative Stress in SH-SY5Y Cells by Three Flavonoids from Acer Okamotoanum","volume":"73","author":"Kim","year":"2019","journal-title":"Chem. Pap."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10068-018-0381-6","article-title":"Acer Okamotoanum Protects SH-SY5Y Neuronal Cells against Hydrogen Peroxide-Induced Oxidative Stress","volume":"28","author":"Kim","year":"2019","journal-title":"Food Sci. Biotechnol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Radziejewska, I., Supruniuk, K., Czarnomysy, R., Buzun, K., and Bielawska, A. (2021). Anti-Cancer Potential of Afzelin towards AGS Gastric Cancer Cells. Pharmaceuticals, 14.","DOI":"10.3390\/ph14100973"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Xia, L., Xu, X., Li, M., Zhang, X., and Cao, F. (2023). Afzelin Induces Immunogenic Cell Death against Lung Cancer by Targeting NQO2. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-04221-3"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Colucci-D\u2019Amato, L., Speranza, L., and Volpicelli, F. (2020). Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207777"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"16514","DOI":"10.1523\/JNEUROSCI.2676-10.2010","article-title":"The Interaction between Tropomyosin-Related Kinase B Receptors and Presynaptic Muscarinic Receptors Modulates Transmitter Release in Adult Rodent Motor Nerve Terminals","volume":"30","author":"Garcia","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s12035-014-8958-4","article-title":"Brain-Derived Neurotrophic Factor in Alzheimer\u2019s Disease: Risk, Mechanisms, and Therapy","volume":"52","author":"Song","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Mittal, P., Dhankhar, S., Chauhan, S., Garg, N., Bhattacharya, T., Ali, M., Chaudhary, A.A., Rudayni, H.A., Al-Zharani, M., and Ahmad, W. (2023). A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson\u2019s Disease. Pharmaceuticals, 16.","DOI":"10.3390\/ph16070908"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Azman, K.F., and Zakaria, R. (2022). Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126827"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9182","DOI":"10.1038\/s41598-021-88463-6","article-title":"Central Administration of Afzelin Extracted from Ribes Fasciculatum Improves Cognitive and Memory Function in a Mouse Model of Dementia","volume":"11","author":"Oh","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/sj.cdd.4401662","article-title":"Neuroprotection by BDNF against Glutamate-Induced Apoptotic Cell Death Is Mediated by ERK and PI3-Kinase Pathways","volume":"12","author":"Almeida","year":"2005","journal-title":"Cell Death Differ."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Huang, Y.-K., Liu, C.-C., Wang, S., Cheng, H.-C., Meadows, C., and Chang, K.-C. (2022). The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315088"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/chromsci\/bmaa127","article-title":"Determination of Afzelin and Astragalin from Lespedeza Cuneata on Aldose Reductase Inhibition","volume":"59","author":"Lee","year":"2021","journal-title":"J. Chromatogr. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.intimp.2017.06.005","article-title":"Aldose Reductase Inhibitors Attenuate \u03b2-Amyloid-Induced TNF-\u03b1 Production in Microlgia via ROS-PKC-Mediated NF-\u03baB and MAPK Pathways","volume":"50","author":"Song","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Iannitelli, A.F., Segal, A., Pare, J.-F., Mulvey, B., Liles, L.C., Sloan, S.A., McCann, K.E., Dougherty, J.D., Smith, Y., and Weinshenker, D. (2023). Tyrosinase-Induced Neuromelanin Accumulation Triggers Rapid Dysregulation and Degeneration of the Mouse Locus Coeruleus. bioRxiv.","DOI":"10.1101\/2023.03.07.530845"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Nagatsu, T., Nakashima, A., Watanabe, H., Ito, S., and Wakamatsu, K. (2022). Neuromelanin in Parkinson\u2019s Disease: Tyrosine Hydroxylase and Tyrosinase. Int. J. Mol. Sci., 23.","DOI":"10.20944\/preprints202203.0274.v1"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1016\/j.bmcl.2010.09.082","article-title":"Changes in Flavonoid Content and Tyrosinase Inhibitory Activity in Kenaf Leaf Extract after Far-Infrared Treatment","volume":"20","author":"Rho","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Sayuti, N.H., Zulkefli, N., Tan, J.K., Saad, N., Baharum, S.N., Hamezah, H.S., Bunawan, H., Ahmed, Q.U., Parveen, H., and Mukhtar, S. (2023). Ethanolic Extract of Polygonum Minus Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H2O2-Induced Oxidative Stress. Molecules, 28.","DOI":"10.3390\/molecules28186726"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/13813455.2019.1683584","article-title":"AChE mRNA Expression as a Possible Novel Biomarker for the Diagnosis of Coronary Artery Disease and Alzheimer\u2019s Disease, and Its Association with Oxidative Stress","volume":"128","author":"Beydemir","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"77","DOI":"10.7324\/JAPS.2020.101010","article-title":"Afzelin Inhibits Migration of MDA-MB-231 Cells by Suppressing FAK Expression and Rac1 Activation","volume":"10","author":"Rachmi","year":"2020","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Rachmi, E., Purnomo, B.B., Endharti, A.T., and Fitri, L.E. (2020). Identification of Afzelin Potential Targets in Inhibiting Triple-Negative Breast Cancer Cell Migration Using Reverse Docking. Porto Biomed. J., 5.","DOI":"10.1097\/j.pbj.0000000000000095"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3892\/ol.2012.596","article-title":"Kaempferol-3-O-Rhamnoside Isolated from the Leaves of Schima wallichii Korth. Inhibits MCF-7 Breast Cancer Cell Proliferation through Activation of the Caspase Cascade Pathway","volume":"3","author":"Diantini","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/00498254.2019.1700319","article-title":"Comparative Pharmacokinetics of Quercitrin, Astragalin, Afzelin and Taxifolin in Plasma after Oral Administration of Polygonum Orientale Inflorescence in Sham-Operated and Myocardial Ischemia-Reperfusion Injury Rats","volume":"50","author":"Zheng","year":"2020","journal-title":"Xenobiotica"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/jat.2777","article-title":"In Vivo Protective Effect of Copaifera langsdorffii Hydroalcoholic Extract on Micronuclei Induction by Doxorubicin","volume":"33","author":"Alves","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/15287394.2021.1898505","article-title":"Preventive Activity of Copaifera langsdorffii Desf. Leaves Extract and Its Major Compounds, Afzelin and Quercitrin, on DNA Damage in In Vitro and In Vivo Models","volume":"84","author":"Ozelin","year":"2021","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1271\/bbb.120562","article-title":"Separation of the Antioxidant Compound Quercitrin from Lindera obtusiloba blume and Its Antimelanogenic Effect on B16F10 Melanoma Cells","volume":"77","author":"Hong","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s12272-014-0487-1","article-title":"Preliminary in Vitro and Ex Vivo Evaluation of Afzelin, Kaempferitrin and Pterogynoside Action over Free Radicals and Reactive Oxygen Species","volume":"38","author":"Vellosa","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Devi, S., Kumar, V., Singh, S.K., Dubey, A.K., and Kim, J.-J. (2021). Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020099"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F.T., and Arab-Tehrany, E. (2022). Alzheimer\u2019s Disease: Treatment Strategies and Their Limitations. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213954"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and Treatment of Parkinson Disease: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"101928","DOI":"10.1016\/j.jsps.2023.101928","article-title":"Neuroprotective Potential of Afzelin: A Novel Approach for Alleviating Catalepsy and Modulating Bcl-2 Expression in Parkinson\u2019s Disease Therapy","volume":"32","author":"Alharthy","year":"2024","journal-title":"Saudi Pharm. J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00262-021-03013-3","article-title":"Chemotherapy: A Double-Edged Sword in Cancer Treatment","volume":"71","author":"Behranvand","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Najafi, M., Majidpoor, J., Toolee, H., and Mortezaee, K. (2021). The Current Knowledge Concerning Solid Cancer and Therapy. J. Biochem. Mol. Toxicol., 35.","DOI":"10.1002\/jbt.22900"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1111\/1750-3841.14282","article-title":"Simultaneous Enrichment and Separation of Four Flavonoids from Zanthoxylum bungeanum Leaves by Ultrasound-Assisted Extraction and Macroporous Resins with Evaluation of Antioxidant Activities","volume":"83","author":"Wu","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_137","first-page":"25","article-title":"A Validated Chromatographic Method for the Determination of Flavonoids in Copaifera langsdorffii by HPLC","volume":"7","author":"Brancalion","year":"2012","journal-title":"Nat. Prod. 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