{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:10:06Z","timestamp":1791544206638,"version":"4.3.4"},"reference-count":300,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-75-30001"],"award-info":[{"award-number":["23-75-30001"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with cognitive impairment and Alzheimer\u2019s disease (AD) progression. Once it enters the brain, the SARS-CoV-2 virus stimulates accumulation of amyloids in the brain that are highly toxic to neural cells. These amyloids may trigger neurological symptoms in COVID-19. The meningeal lymphatic vessels (MLVs) play an important role in removal of toxins and mediate viral drainage from the brain. MLVs are considered a promising target to prevent COVID-19-exacerbated dementia. However, there are limited methods for augmentation of MLV function. This review highlights new discoveries in the field of COVID-19-mediated amyloid accumulation in the brain associated with the neurological symptoms and the development of promising strategies to stimulate clearance of amyloids from the brain through lymphatic and other pathways. These strategies are based on innovative methods of treating brain dysfunction induced by COVID-19 infection, including the use of photobiomodulation, plasmalogens, and medicinal herbs, which offer hope for addressing the challenges posed by the SARS-CoV-2 virus.<\/jats:p>","DOI":"10.3390\/ph17060788","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T12:48:40Z","timestamp":1718628520000},"page":"788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7876-9758","authenticated-orcid":false,"given":"Nikita","family":"Navolokin","sequence":"first","affiliation":[{"name":"Department of Pathological Anatomy, Saratov Medical State University, Bolshaya Kazachaya Str. 112, 410012 Saratov, Russia"},{"name":"Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Adushkina","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Zlatogorskaya","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-6366","authenticated-orcid":false,"given":"Valeria","family":"Telnova","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina","family":"Evsiukova","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-7423","authenticated-orcid":false,"given":"Elena","family":"Vodovozova","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16\/10, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Eroshova","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Leeners LLC, Nagornyi Proezd 3a, 117105 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Dosadina","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Leeners LLC, Nagornyi Proezd 3a, 117105 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Diduk","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Leeners LLC, Nagornyi Proezd 3a, 117105 Moscow, Russia"},{"name":"Research Institute of Carcinogenesis of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Kashirskoe Shosse 24, 115522 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-7513","authenticated-orcid":false,"given":"Oxana","family":"Semyachkina-Glushkovskaya","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"ref_1","first-page":"17","article-title":"Racial and ethnic estimates of Alzheimer\u2019s disease and related dementias in the United States (2015\u20132060) in adults aged \u226565 years","volume":"15","author":"Xu","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"(2023). 2023 Alzheimer\u2019s disease facts and figures. 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