{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:50:16Z","timestamp":1784307016859,"version":"3.55.0"},"reference-count":0,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Natural Science Foundation of Hunan","award":["2022JJ30784"],"award-info":[{"award-number":["2022JJ30784"]}]},{"name":"Provincial Natural Science Foundation of Hunan","award":["81920108004"],"award-info":[{"award-number":["81920108004"]}]},{"name":"Provincial Natural Science Foundation of Hunan","award":["81770107"],"award-info":[{"award-number":["81770107"]}]},{"name":"the National Natural Science Foundation of China","award":["2022JJ30784"],"award-info":[{"award-number":["2022JJ30784"]}]},{"name":"the National Natural Science Foundation of China","award":["81920108004"],"award-info":[{"award-number":["81920108004"]}]},{"name":"the National Natural Science Foundation of China","award":["81770107"],"award-info":[{"award-number":["81770107"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Currently, multiple myeloma (MM) is a prevalent hematopoietic system malignancy, known for its insidious onset and unfavorable prognosis. Recently developed chemotherapy drugs for MM have exhibited promising therapeutic outcomes. Nevertheless, to overcome the shortcomings of traditional clinical drug treatment, such as off-target effects, multiple drug resistance, and systemic toxicity, targeted drug delivery systems are optimizing the conventional pharmaceuticals for precise delivery to designated sites at controlled rates, striving for maximal efficacy and safety, presenting a promising approach for MM treatment. This review will delve into the outstanding performance of antibody\u2013drug conjugates, peptide\u2013drug conjugates, aptamer\u2013drug conjugates, and nanocarrier drug delivery systems in preclinical studies or clinical trials for MM and monitor their adverse reactions during treatment.<\/jats:p>","DOI":"10.3390\/ph17070832","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T13:26:43Z","timestamp":1719494803000},"page":"832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeted Delivery Strategies for Multiple Myeloma and Their Adverse Drug Reactions"],"prefix":"10.3390","volume":"17","author":[{"given":"Shuting","family":"Li","sequence":"first","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha 410011, China"},{"name":"Department of Biochemistry and Molecular Biology, Center for Medical Genetics, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-3865","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha 410011, China"},{"name":"Department of Biochemistry and Molecular Biology, Center for Medical Genetics, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-8979","authenticated-orcid":false,"given":"Shuming","family":"Sun","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha 410011, China"},{"name":"Department of Biochemistry and Molecular Biology, Center for Medical Genetics, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,25]]},"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/832\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:04:00Z","timestamp":1760108640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ph17070832"],"URL":"https:\/\/doi.org\/10.3390\/ph17070832","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]}}}