{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:03Z","timestamp":1787029263123,"version":"build-2736575974"},"reference-count":113,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Plants are being researched as potential sources of novel drugs, which has led to a recent acceleration in the discovery of new bioactive compounds. Research on tissue culture technology for the synthesis and processing of plant compounds has skyrocketed, surpassing all expectations. These plants can be bought either raw or as extracts, where some of the chemicals are extracted by mashing the plant in water, alcohol, or another solvent. The use of herbal medicine may open new chances for reducing the onset of infections and treating different diseases including cancer. A perennial plant that blooms in the winter, Cyclamen, is one of the most widely used potted flowers in many nations. Alkaloids, flavonoids, phenols, tannins, saponins, sterols, and glycosides are the main active components of Cyclamen. Analgesic, cytotoxic, antioxidant, antimicrobial, and anti-inflammatory properties have all been demonstrated as potential effects of various extracts of Cyclamen tubers. However, the use of this medicinal plant in official medicine will require further research in the areas of pharmacology. Furthermore, it is necessary to create standard operating procedures for a crude herbal medication. In this regard, this review aims to highlight the key characteristics of the Cyclamen plant, such as its various parts, species, stages of development, and geographic range; pinpoint its intriguing bioactivities, its antioxidant, anti-inflammatory, and its anti-cancerous effects; and ascertain its potential medicinal uses and the main future perspectives.<\/jats:p>","DOI":"10.3390\/ph17070848","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:42:30Z","timestamp":1719546150000},"page":"848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive Review of Cyclamen: Development, Bioactive Properties, and Therapeutic Applications"],"prefix":"10.3390","volume":"17","author":[{"given":"Aya","family":"Sharara","sequence":"first","affiliation":[{"name":"Plateforme de Recherche et D\u2019Analyse en Sciences de L\u2019Environnement (EDST-PRASE), Beirut P.O. Box 6573\/14, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Badran","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Petra, Amman P.O. Box 961343, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-8531","authenticated-orcid":false,"given":"Akram","family":"Hijazi","sequence":"additional","affiliation":[{"name":"Plateforme de Recherche et D\u2019Analyse en Sciences de L\u2019Environnement (EDST-PRASE), Beirut P.O. Box 6573\/14, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-6606","authenticated-orcid":false,"given":"Ghosoon","family":"Albahri","sequence":"additional","affiliation":[{"name":"Plateforme de Recherche et D\u2019Analyse en Sciences de L\u2019Environnement (EDST-PRASE), Beirut P.O. Box 6573\/14, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2913-2846","authenticated-orcid":false,"given":"Mikhael","family":"Bechelany","sequence":"additional","affiliation":[{"name":"Institut Europ\u00e9en des Membranes, IEM, UMR-5635, University Montpellier, ENSCM, CNRS, Place Eugene Bataillon, 34095 Montpellier, France"},{"name":"Functional Materials Group, Gulf University for Science and Technology (GUST), Mubarak Al-Abdullah 32093, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7193-8079","authenticated-orcid":false,"given":"Joelle Edward","family":"Mesmar","sequence":"additional","affiliation":[{"name":"Department of Biology, American University of Beirut, Beirut P.O. Box 110236, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Baydoun","sequence":"additional","affiliation":[{"name":"Department of Biology, American University of Beirut, Beirut P.O. Box 110236, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-81-322-1774-9_3","article-title":"Application of Plant Cell and Tissue Culture for the Production of Phytochemicals in Medicinal Plants","volume":"Volume 808","author":"Adhikari","year":"2014","journal-title":"Infectious Diseases and Nanomedicine II"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Welz, A.N., Emberger-Klein, A., and Menrad, K. (2019). The Importance of Herbal Medicine Use in the German Health-Care System: Prevalence, Usage Pattern, and Influencing Factors. BMC Health Serv. Res., 19.","DOI":"10.1186\/s12913-019-4739-0"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Illamola, S.M., Amaeze, O.U., Krepkova, L.V., Birnbaum, A.K., Karanam, A., Job, K.M., Bortnikova, V.V., Sherwin, C.M.T., and Enioutina, E.Y. (2020). Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01483"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jac\/dkg087","article-title":"Herbal Medicines for Treatment of Bacterial Infections: A Review of Controlled Clinical Trials","volume":"51","author":"Martin","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"109129","DOI":"10.1016\/j.foodres.2020.109129","article-title":"Chemical Characterization, Antioxidant, Enzyme Inhibitory and Cytotoxic Properties of Two Geophytes: Crocus pallasii and Cyclamen cilicium","volume":"133","author":"Zengin","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_6","first-page":"40","article-title":"Comparison of Aglycon and Glycosidic Saponin Extracts of Cyclamen coum Tuber against Candida spp.","volume":"2","author":"Saboora","year":"2016","journal-title":"Curr. Med. Mycol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Damke, E., Tsuzuki, J.K., Cortez, D.A., Ferreira, I.C., Bertoni, T.A., Batista, M.R., Donati, L., Svidzinski, T.I., and Consolaro, M.E. (2011). In Vivo Activity of Sapindus saponaria against Azole-Susceptible and -Resistant Human Vaginal Candida Species. BMC Complement. Altern. Med., 11.","DOI":"10.1186\/1472-6882-11-35"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jep.2004.05.016","article-title":"Biological Activities and Distribution of Plant Saponins","volume":"94","author":"Sparg","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_9","first-page":"40","article-title":"Assessing the Risks and Benefits of Herbal Medicine: An Overview of Scientific Evidence","volume":"5","author":"Barrett","year":"1999","journal-title":"Altern. Ther. Health Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nabi, F., Shi, D., Wu, Q., and Baloch, D.M. (2023). Editorial: Treatment of Animal Diseases with Veterinary Phytotherapy. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1171987"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s11606-008-0632-y","article-title":"Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation: Grand Rounds at University of California, San Francisco Medical Center","volume":"23","author":"Bent","year":"2008","journal-title":"J. Gen. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fitzgerald, M., Heinrich, M., and Booker, A. (2020). Medicinal Plant Analysis: A Historical and Regional Discussion of Emergent Complex Techniques. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01480"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"28705","DOI":"10.3390\/ijms161226126","article-title":"Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects","volume":"16","author":"Hong","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.2174\/1381612829666230809094304","article-title":"Development and Validation of a Simple, Fast, and Accessible HPLC-UVMethod for Cannabinoids Determination in Cannabis sativa L. Extracts andMedicinal Oils","volume":"29","author":"Alonso","year":"2023","journal-title":"Curr. Pharm. Des."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wang, H., Yang, Y., Pei, G., Wang, Z., and Chen, N. (2023). Neurotrophic Basis to the Pathogenesis of Depression and Phytotherapy. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1182666"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Boase, M.R., Lewis, D.H., Davies, K.M., Marshall, G.B., Patel, D., Schwinn, K.E., and Deroles, S.C. (2010). Isolation and Antisense Suppression of Flavonoid 3\u2032, 5\u2032-Hydroxylase Modifies Flower Pigments and Colour in Cyclamen. BMC Plant Biol., 10.","DOI":"10.1186\/1471-2229-10-107"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0031-9422(99)00297-6","article-title":"Peonidin 3-O-Neohesperidoside and Other Flavonoids from Cyclamen Persicum Petals","volume":"52","author":"Webby","year":"1999","journal-title":"Phytochemistry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1270\/jsbbs.17117","article-title":"Breeding of Fragrant Cyclamen by Interspecific Hybridization and Ion-Beam Irradiation","volume":"68","author":"Ishizaka","year":"2018","journal-title":"Breed. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-2006-924649","article-title":"The Anatomy of the Stigma and Style from Cyclamen persicum (Mill.) Cv. \u201cPure White\u201d and Its Relation to Pollination Success","volume":"9","author":"Reinhardt","year":"2007","journal-title":"Plant Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1034\/j.1398-9995.2000.00555.x","article-title":"Occupational Allergy to Cyclamen","volume":"55","author":"Bolhaar","year":"2000","journal-title":"Allergy"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yesson, C., and Culham, A. (2006). A Phyloclimatic Study of Cyclamen. BMC Evol. Biol., 6.","DOI":"10.1186\/1471-2148-6-72"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Yan, X., Liu, T., Yuan, X., Xu, Y., Yan, H., and Hao, G. (2019). Chloroplast Genomes and Comparative Analyses among Thirteen Taxa within Myrsinaceae s.Str. Clade (Myrsinoideae, Primulaceae). Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184534"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF00935953","article-title":"Cyclamen (Primulaceae) in Tropical Africa","volume":"166","author":"Thulin","year":"1989","journal-title":"Plant Syst. Evol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41598-022-27163-1","article-title":"Insights into Chloroplast Genome Structure, Intraspecific Variation, and Phylogeny of Cyclamen Species (Myrsinoideae)","volume":"13","author":"Mao","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Cornea-Cipcigan, M., Bunea, A., Bouari, C.M., Pamfil, D., P\u00e1ll, E., Urcan, A.C., and M\u0103rg\u0103oan, R. (2022). Anthocyanins and Carotenoids Characterization in Flowers and Leaves of Cyclamen Genotypes Linked with Bioactivities Using Multivariate Analysis Techniques. Antioxidants, 11.","DOI":"10.3390\/antiox11061126"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1365-3040.2006.01630.x","article-title":"Variegation Mutants and Mechanisms of Chloroplast Biogenesis: Variegation Mutants","volume":"30","author":"Yu","year":"2007","journal-title":"Plant Cell Environ."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3109\/13880209.2013.879600","article-title":"In Vitro Cytotoxic and Anticlastogenic Activities of Saxifragifolin B and Cyclamin Isolated from Cyclamen persicum and Cyclamen libanoticum","volume":"52","author":"Birer","year":"2014","journal-title":"Pharm. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1700265","DOI":"10.1002\/pmic.201700265","article-title":"Insights from Proteomic Studies into Plant Somatic Embryogenesis","volume":"18","author":"Heringer","year":"2018","journal-title":"Proteomics"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Simpson, M.G. (2010). Diversity and Classification of Flowering Plants: Eudicots. Plant Systematics, Elsevier.","DOI":"10.1016\/B978-0-12-374380-0.50008-7"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1126\/science.266.5185.605","article-title":"Plant Embryogenesis: Zygote to Seed","volume":"266","author":"Goldberg","year":"1994","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-60327-114-1_26","article-title":"Clonal Propagation of Cyclamen persicum Via Somatic Embryogenesis","volume":"Volume 589","author":"Jain","year":"2010","journal-title":"Protocols for In Vitro Propagation of Ornamental Plants"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xia, D., He, G., Wang, K., Wang, T., Zhu, Z., Niu, Z., Shi, G., and Liu, G. (2022). Anthocyanins Profiling Analysis and RNA-Seq Revealed the Dominating Pigments and Coloring Mechanism in Cyclamen Flowers. Biology, 11.","DOI":"10.3390\/biology11121721"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-313X.2008.03447.x","article-title":"Biosynthesis of Plant Pigments: Anthocyanins, Betalains and Carotenoids","volume":"54","author":"Tanaka","year":"2008","journal-title":"Plant J."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wong, D.C.J., Perkins, J., and Peakall, R. (2022). Anthocyanin and Flavonol Glycoside Metabolic Pathways Underpin Floral Color Mimicry and Contrast in a Sexually Deceptive Orchid. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.860997"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"109092","DOI":"10.1016\/j.foodres.2020.109092","article-title":"Anthocyanins: New Techniques and Challenges in Microencapsulation","volume":"133","author":"Tarone","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/ptr.5642","article-title":"Chemistry, Pharmacology and Health Benefits of Anthocyanins: Anthocyanins and Human Health","volume":"30","author":"Smeriglio","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1146\/annurev-biochem-060614-033904","article-title":"Transport of Sugars","volume":"84","author":"Chen","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-arplant-050213-040251","article-title":"Sucrose Metabolism: Gateway to Diverse Carbon Use and Sugar Signaling","volume":"65","author":"Ruan","year":"2014","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pouris, J., Levizou, E., Karatassiou, M., Meletiou-Christou, M.-S., and Rhizopoulou, S. (2022). The Influence of the Partitioning of Sugars, Starch, and Free Proline in Various Organs of Cyclamen graecum on the Biology of the Species and Its Resistance to Abiotic Stressors. Plants, 11.","DOI":"10.3390\/plants11091254"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/plants2040699","article-title":"The Role of Temperature in the Growth and Flowering of Geophytes","volume":"2","author":"Khodorova","year":"2013","journal-title":"Plants"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00035281","article-title":"Interspecific Hybrids of Cyclamen persicum and C. Graecum","volume":"91","author":"Ishizaka","year":"1996","journal-title":"Euphytica"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Funck, D., Winter, G., Baumgarten, L., and Forlani, G. (2012). Requirement of Proline Synthesis during Arabidopsis Reproductive Development. BMC Plant Biol., 12.","DOI":"10.1186\/1471-2229-12-191"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Carfagna, S., Salbitani, G., Innangi, M., Menale, B., De Castro, O., Di Martino, C., and Crawford, T.W. (2021). Simultaneous Biochemical and Physiological Responses of the Roots and Leaves of Pancratium maritimum (Amaryllidaceae) to Mild Salt Stress. Plants, 10.","DOI":"10.3390\/plants10020345"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mostafa, S., Wang, Y., Zeng, W., and Jin, B. (2022). Floral Scents and Fruit Aromas: Functions, Compositions, Biosynthesis, and Regulation. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.860157"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1104\/pp.122.3.627","article-title":"Biochemical and Molecular Genetic Aspects of Floral Scents","volume":"122","author":"Dudareva","year":"2000","journal-title":"Plant Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/jf9801973","article-title":"Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products","volume":"46","author":"Velioglu","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting Oxidative Stress in Disease: Promise and Limitations of Antioxidant Therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Losada-Barreiro, S., Sezgin-Bayindir, Z., Paiva-Martins, F., and Bravo-D\u00edaz, C. (2022). Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123051"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"24","DOI":"10.18016\/ksujns.03907","article-title":"\u00c7e\u015fitli G\u0131da At\u0131klar\u0131n\u0131n Toplam Fenolik Madde \u0130\u00e7eri\u011finin, Antioksidan ve Antimikrobiyal Etkilerinin Ara\u015ft\u0131r\u0131lmas\u0131","volume":"17","author":"Zoral","year":"2014","journal-title":"KS\u00dc Do\u011f. Bil. Derg"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0378-4274(90)90165-I","article-title":"Comparison of Lung Injury Induced in 4 Strains of Mice by Butylated Hydroxytoluene","volume":"52","author":"Kehrer","year":"1990","journal-title":"Toxicol. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.foodchem.2015.02.025","article-title":"Production and Characterization of Functional Biscuits Obtained from Purple Wheat","volume":"180","author":"Pasqualone","year":"2015","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.talanta.2010.02.004","article-title":"Simultaneous Determination of Butylated Hydroxyanisole (BHA) and Butylated Hydroxytoluene (BHT) in Food Samples Using a Carbon Composite Electrode Modified with Cu3(PO4)2 Immobilized in Polyester Resin","volume":"81","author":"Freitas","year":"2010","journal-title":"Talanta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","article-title":"Comparison of ABTS, DPPH, FRAP, and ORAC Assays for Estimating Antioxidant Activity from Guava Fruit Extracts","volume":"19","author":"Thaipong","year":"2006","journal-title":"J. Food Compos. Anal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/jxb\/erj028","article-title":"Are the Metabolic Components of Crassulacean Acid Metabolism Up-Regulated in Response to an Increase in Oxidative Burden?","volume":"57","author":"Borland","year":"2006","journal-title":"J. Exp. Bot."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1365-313x.2001.01074.x","article-title":"Generation and Properties of Ascorbic Acid-Deficient Transgenic Tobacco Cells Expressing Antisense RNA for L-Galactono-1,4-Lactone Dehydrogenase: GalLDH in Ascorbic Acid-Deficient Transgentic Tobacco","volume":"27","author":"Tabata","year":"2001","journal-title":"Plant J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1360-1385(00)01649-6","article-title":"Transport and Action of Ascorbate at the Plant Plasma Membrane","volume":"5","author":"Horemans","year":"2000","journal-title":"Trends Plant Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-3040.2005.01476.x","article-title":"Metabolic Signalling in Defence and Stress: The Central Roles of Soluble Redox Couples","volume":"29","author":"Noctor","year":"2006","journal-title":"Plant Cell Environ."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.colsurfb.2007.05.003","article-title":"The Mutual Responses of Higher Plants to Environment: Physiological and Microbiological Aspects","volume":"59","author":"Gang","year":"2007","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.foodchem.2005.02.024","article-title":"Antioxidant Constituents in Feverfew (Tanacetum parthenium) Extract and Their Chromatographic Quantification","volume":"96","author":"Wu","year":"2006","journal-title":"Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4236\/pp.2018.94008","article-title":"Antioxidant, Antimicrobial, Cytotoxic, Larvicidal and Anthelmintic Activities and Phenolic Contents of Cyclamen alpinum","volume":"9","author":"Turan","year":"2018","journal-title":"Pharmacol. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s004420050756","article-title":"Growth Response of Altitudinal Ecotypes of Mountain Birch to Temperature and Fertilisation","volume":"119","author":"Weih","year":"1999","journal-title":"Oecologia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/s7102080","article-title":"Determination of DPPH Radical Oxidation Caused by Methanolic Extracts of Some Microalgal Species by Linear Regression Analysis of Spectrophotometric Measurements","volume":"7","author":"Marxen","year":"2007","journal-title":"Sensors"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00572-013-0477-z","article-title":"Influence of Arbuscular Mycorrhiza on the Growth and Antioxidative Activity in Cyclamen under Heat Stress","volume":"23","author":"Maya","year":"2013","journal-title":"Mycorrhiza"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12149-011-0521-z","article-title":"The Molecular Imaging Approach to Image Infections and Inflammation by Nuclear Medicine Techniques","volume":"25","author":"Signore","year":"2011","journal-title":"Ann. Nucl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jep.2005.11.019","article-title":"In Vivo Efficacy of Different Extracts of Edelweiss (Leontopodium alpinum Cass.) in Animal Models","volume":"105","author":"Speroni","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Pagnacco, M.C., Maksimovi\u0107, J.P., Nikoli\u0107, N.T., Bajuk Bogdanovi\u0107, D.V., Kragovi\u0107, M.M., Stojmenovi\u0107, M.D., Blagojevi\u0107, S.N., and Sen\u0107anski, J.V. (2022). Indigo Carmine in a Food Dye: Spectroscopic Characterization and Determining Its Micro-Concentration through the Clock Reaction. Molecules, 27.","DOI":"10.3390\/molecules27154853"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant Activity Applying an Improved ABTS Radical Cation Decolorization Assay","volume":"26","author":"Re","year":"1999","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1055\/s-1999-13954","article-title":"Selective Inhibition of Eukaryote Protein Kinases by Anti-Inflammatory Triterpenoids","volume":"65","author":"Hasmeda","year":"1999","journal-title":"Planta Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/ptr.2145","article-title":"Analgesic and Antiinflammatory Activity of Cyclamen repandum S. et S","volume":"21","author":"Speroni","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_70","first-page":"13","article-title":"Comparative characteristic of different methods of conservative treatment of exudative rhinosinusitis","volume":"5","author":"Mashkova","year":"2010","journal-title":"Vestn. Otorinolaringol."},{"key":"ref_71","first-page":"CD011341","article-title":"Cyclamen europaeum Extract for Acute Sinusitis","volume":"5","author":"Barua","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0030-6657(09)70179-9","article-title":"Trends on Rhinosinusitis Diagnosis and Treatment","volume":"63","author":"Mullol","year":"2009","journal-title":"Otolaryngol. Pol."},{"key":"ref_73","first-page":"151","article-title":"Epidemiological Characteristics of and Risk Factors for Breast Cancer in the World","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Breast Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-7075-7-7","article-title":"Cancer as a Metabolic Disease","volume":"7","author":"Seyfried","year":"2010","journal-title":"Nutr. Metab."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/427787a","article-title":"Cancer without Disease","volume":"427","author":"Folkman","year":"2004","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5306\/wjco.v7.i1.54","article-title":"Historical Review of the Causes of Cancer","volume":"7","author":"Blackadar","year":"2016","journal-title":"World J. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer Statistics for the Year 2020: An Overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_78","first-page":"42","article-title":"Cytotoxic Activity of Cyclamen persicum Ethanolic Extract on MCF-7, PC-3 and LNCaP Cancer Cell Lines","volume":"10","author":"Khalilia","year":"2020","journal-title":"J. Nat. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s11418-018-1204-z","article-title":"Anti-Invasive Effect of Cyclamen Pseudibericum Extract on A549 Non-Small Cell Lung Carcinoma Cells via Inhibition of ZEB1 Mediated by miR-200c","volume":"72","author":"Karagur","year":"2018","journal-title":"J. Nat. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-\u03b2-Induced Epithelial to Mesenchymal Transition","volume":"19","author":"Xu","year":"2009","journal-title":"Cell Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/hep.23221","article-title":"Comprehensive Analysis of the Independent Effect of Twist and Snail in Promoting Metastasis of Hepatocellular Carcinoma","volume":"50","author":"Yang","year":"2009","journal-title":"Hepatology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.7314\/APJCP.2013.14.10.5911","article-title":"Cyclamen Exerts Cytotoxicity in Solid Tumor Cell Lines: A Step Toward New Anticancer Agents?","volume":"14","author":"Yildiz","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10555-012-9368-6","article-title":"MicroRNA Control of Epithelial\u2013Mesenchymal Transition and Metastasis","volume":"31","author":"Zhang","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 Family and miR-205 Regulate Epithelial to Mesenchymal Transition by Targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1038\/sj.onc.1210508","article-title":"The Transcription Factor ZEB1 (\u03b4EF1) Promotes Tumour Cell Dedifferentiation by Repressing Master Regulators of Epithelial Polarity","volume":"26","author":"Aigner","year":"2007","journal-title":"Oncogene"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/np960658j","article-title":"Triterpene Saponins from Cyclamen mirabile and Their Biological Activities","volume":"60","author":"Kelican","year":"1997","journal-title":"J. Nat. Prod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1073\/pnas.81.14.4457","article-title":"Spontaneous and Mutagen-Induced Deletions: Mechanistic Studies in Salmonella Tester Strain TA102","volume":"81","author":"Levin","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-1218(89)90036-0","article-title":"Use of the Cytokinesis-Block Method for the Analysis of Munuclei in V79 Chinese Hamster Lung Cells: Results with Mitomycin C and Cyclophosphamide","volume":"222","author":"Krishna","year":"1989","journal-title":"Mutat. Res. Genet. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s11136-023-03390-5","article-title":"Measuring Frailty Using Patient-Reported Outcomes (PRO) Data: A Feasibility Study in Patients with Multiple Myeloma","volume":"32","author":"Murugappan","year":"2023","journal-title":"Qual. Life Res."},{"key":"ref_90","first-page":"294","article-title":"Isoprenoid-Mediated Inhibition of Mevalonate Synthesis: Potential Application to Cancer","volume":"221","author":"Elson","year":"1999","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11745-997-0019-y","article-title":"Inhibition of Pancreatic Cancer Growth by the Dietary Isoprenoids Farnesol and Geraniol","volume":"32","author":"Burke","year":"1997","journal-title":"Lipids"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/153537020422900701","article-title":"Studies of the Isoprenoid-Mediated Inhibition of Mevalonate Synthesis Applied to Cancer Chemotherapy and Chemoprevention","volume":"229","author":"Mo","year":"2004","journal-title":"Exp. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11745-008-3192-3","article-title":"Farnesol Decreases Serum Triglycerides in Rats: Identification of Mechanisms Including Up-Regulation of PPAR\u03b1 and Down-Regulation of Fatty Acid Synthase in Hepatocytes","volume":"43","author":"Duncan","year":"2008","journal-title":"Lipids"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"E1022","DOI":"10.1152\/ajpendo.00061.2011","article-title":"Farnesol, an Isoprenoid, Improves Metabolic Abnormalities in Mice via Both PPAR\u03b1-Dependent and -Independent Pathways","volume":"301","author":"Goto","year":"2011","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1593\/neo.08444","article-title":"Farnesol, a Fungal Quorum-Sensing Molecule Triggers Apoptosis in Human Oral Squamous Carcinoma Cells","volume":"10","author":"Scheper","year":"2008","journal-title":"Neoplasia"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1055\/s-0029-1240727","article-title":"Triterpene Saponins from Cyclamen trocopteranthum","volume":"76","author":"Ozbey","year":"2010","journal-title":"Planta Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"231","DOI":"10.15171\/PS.2017.34","article-title":"Preliminary Phytochemical and Biological Screening of Cyclamen coum a Member of Palestinian Flora","volume":"23","author":"Hussen","year":"2017","journal-title":"Pharm. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.phytochem.2011.09.003","article-title":"Triterpene Saponins from Cyclamen hederifolium","volume":"73","author":"Altunkeyik","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2298\/VSP190703096K","article-title":"Chemical and Pharmacological Characterization of Aqueous and Ethanolic Extracts of Cyclamen hederifolium Ait. (Primulaceae) Tuber","volume":"78","author":"Kojicic","year":"2021","journal-title":"Vojnosanit. Pregl."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.21037\/jtd-22-1435","article-title":"Worldwide Prevalence, Risk Factors and Burden of Chronic Cough in the General Population: A Narrative Review","volume":"15","author":"Yang","year":"2023","journal-title":"J. Thorac Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5604\/01.3001.0016.1076","article-title":"Clinical Characteristics of Acute Rhinosinusitisin COVID-19 a Post-Hoc Analysis of a Longitudinalstudy","volume":"77","author":"Burska","year":"2022","journal-title":"Otolaryngol. Pol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/lary.23366","article-title":"An Exploratory Trial of Cyclamen europaeum Extract for Acute Rhinosinusitis","volume":"122","author":"Ponikau","year":"2012","journal-title":"The Laryngoscope"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4193\/Rhino11.141","article-title":"Long-Term Follow-up of Posttraumatic Olfactory Disorders","volume":"50","author":"Hilgenfeld","year":"2012","journal-title":"Rhin"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2165\/00019053-200422130-00002","article-title":"Acute Rhinosinusitis: A Pharmacoeconomic Review of Antibacterial Use","volume":"22","author":"Wasserfallen","year":"2004","journal-title":"PharmacoEconomics"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1002\/lary.24167","article-title":"Pharmacoeconomics of Cyclamen europaeum in the Management of Acute Rhinosinusitis","volume":"123","author":"Mullol","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"(2019). Fern\u00e1ndez-Campos; Clares; Rodr\u00edguez-Lagunas; Jauregui; Casals; Calpena Ex-Vivo and In-Vivo Assessment of Cyclamen europaeum Extract After Nasal Administration. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11090426"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"115","DOI":"10.14639\/0392-100X-1342","article-title":"Cyclamen europaeum Improves the Effect of Oral Antibiotics on Exacerbations and Recurrences of Chronic Rhinosinusitis: A Real-Life Observational Study (CHRONOS)","volume":"38","author":"Lopatin","year":"2018","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.autneu.2007.01.008","article-title":"Parasympathetic Control of Airway Submucosal Glands: Central Reflexes and the Airway Intrinsic Nervous System","volume":"133","author":"Wine","year":"2007","journal-title":"Auton. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1016\/j.bmc.2012.03.032","article-title":"Saponins Can Perturb Biologic Membranes and Reduce the Surface Tension of Aqueous Solutions: A Correlation?","volume":"20","author":"Hofmann","year":"2012","journal-title":"Bioorganic Med. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5604\/00306657.1195609","article-title":"Lyophilized Cyclamen europaeum Tuber Extract in the Treatment of Rhinosinusitis","volume":"70","author":"Jurkiewicz","year":"2016","journal-title":"Otolaryngol. Pol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8488","DOI":"10.1038\/s41598-024-58332-z","article-title":"Anticancer, Antioxidant, and Antibacterial Activity of Chemically Fingerprinted Extract from Cyclamen persicum Mill","volume":"14","author":"Khalid","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"204","DOI":"10.5530\/pj.2020.12.31","article-title":"Pharmacognostic, Phytochemical and Ethnopharmacological Potential of Cyclamen coum Mill","volume":"12","year":"2020","journal-title":"Pharmacogn. J."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Arslan, S., and Ozgun, O. (2012). Cyclamen trochopteranthum: Cytotoxic Activity and Possible Adverse Interactions Including Drugs and Carcinogens. Chin. J. Integr. Med.","DOI":"10.1007\/s11655-012-1253-1"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/848\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:06:42Z","timestamp":1760108802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":113,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ph17070848"],"URL":"https:\/\/doi.org\/10.3390\/ph17070848","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]}}}