{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:47:18Z","timestamp":1780393638767,"version":"3.54.1"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["TR31020\/200110"],"award-info":[{"award-number":["TR31020\/200110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Here we have shown for the first time altered expression of the vascular smooth muscle (VSM) KATP channel subunits in segments of the human internal mammary artery (HIMA) in patients with type-2 diabetes mellitus (T2DM). Functional properties of vascular KATP channels in the presence of T2DM, and the interaction between its subunits and endogenous ligands known to relax this vessel, were tested using the potassium (K) channels opener, pinacidil. HIMA is the most commonly used vascular graft in cardiac surgery. Previously it was shown that pinacidil relaxes HIMA segments through interaction with KATP (SUR2B\/Kir6.1) vascular channels, but it is unknown whether pinacidil sensitivity is changed in the presence of T2DM, considering diabetes-induced vascular complications commonly seen in patients undergoing coronary artery bypass graft surgery (CABG). KATP subunits were detected in HIMA segments using Western blot and immunohistochemistry analyses. An organ bath system was used to interrogate endothelium-independent vasorelaxation caused by pinacidil. In pharmacological experiments, pinacidil was able to relax HIMA from patients with T2DM, with sensitivity comparable to our previous results. All three KATP subunits (SUR2B, Kir6.1 and Kir6.2) were observed in HIMA from patients with and without T2DM. There were no differences in the expression of the SUR2B subunit. The expression of the Kir6.1 subunit was lower in HIMA from T2DM patients. In the same group, the expression of the Kir6.2 subunit was higher. Therefore, KATP channels might not be the only method of pinacidil-induced dilatation of T2DM HIMA. T2DM may decrease the level of Kir6.1, a dominant subunit in VSM of HIMA, altering the interaction between pinacidil and those channels.<\/jats:p>","DOI":"10.3390\/ph17070857","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:04:18Z","timestamp":1719986658000},"page":"857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Type-2 Diabetes Mellitus on the Expression and Function of Smooth Muscle ATP-Sensitive Potassium Channels in Human Internal Mammary Artery Grafts"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-2219","authenticated-orcid":false,"given":"Jovana","family":"Rajkovic","sequence":"first","affiliation":[{"name":"Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Peric","sequence":"additional","affiliation":[{"name":"Dedinje Cardiovascular Institute, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Stanisic","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Gostimirovic","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Novakovic","sequence":"additional","affiliation":[{"name":"Center for Genome Sequencing and Bioinformatics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-964X","authenticated-orcid":false,"given":"Vladimir","family":"Djokic","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snezana","family":"Tepavcevic","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Rakocevic","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1471-0014","authenticated-orcid":false,"given":"Milica","family":"Labudovic-Borovic","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Gojkovic-Bukarica","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Dedinje Cardiovascular Institute, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","article-title":"The Global Burden of Cardiovascular Diseases and Risk","volume":"80","author":"Vaduganathan","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","first-page":"726158","article-title":"Coronary artery bypass graft surgery: The past, present, and future of myocardial revascularisation","volume":"2014","author":"Diodato","year":"2014","journal-title":"Surg. Res. Pract."},{"key":"ref_3","first-page":"551","article-title":"Complications of coronary artery surgery in diabetic patients","volume":"57","author":"Fietsam","year":"1991","journal-title":"Am. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S222","DOI":"10.1161\/CIRCULATIONAHA.107.757161","article-title":"The Impact of Diabetic Status on Coronary Artery Bypass Graft Patency","volume":"118","author":"Singh","year":"2008","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/icvts\/ivaa009","article-title":"Long-term outcomes after coronary artery bypass surgery in patients with diabetes","volume":"30","author":"Axelsson","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.mayocp.2022.10.003","article-title":"Left Internal Mammary Artery as an Endocrine Organ: Insights into Graft Biology and Long-term Impact Following Coronary Artery Bypass Grafting","volume":"98","author":"Shadrin","year":"2023","journal-title":"Mayo Clin. Proc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4236\/ijcm.2014.55042","article-title":"Management of Internal Mammary Artery Spasm","volume":"5","author":"Ziadinov","year":"2014","journal-title":"Int. J. Clin. Med."},{"key":"ref_8","first-page":"507","article-title":"Arterial grafts: Clinical classification and pharmacological management","volume":"2","author":"He","year":"2013","journal-title":"Ann. Cardiothorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejcts.2007.03.047","article-title":"Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting","volume":"32","author":"Novella","year":"2007","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1475-2840-13-25","article-title":"Associations of metabolic syndrome and diabetes mellitus with 16-year survival after CABG","volume":"13","author":"Lahtela","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00059-018-4708-0","article-title":"Endothelial dysfunction following coronary artery bypass grafting: Influence of patient and procedural factors","volume":"45","author":"Hadem","year":"2020","journal-title":"Herz"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11886-019-1107-y","article-title":"Epidemiology of Diabetes Mellitus and Cardiovascular Disease","volume":"21","author":"Glovaci","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_13","first-page":"397","article-title":"Preoperative cardiovascular risk factor control in elective coronary artery bypass graft patients: A failure of present management","volume":"18","author":"Baskett","year":"2002","journal-title":"Can. J. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.apha.2016.07.001","article-title":"Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth","volume":"78","author":"Jackson","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1254\/jphs.FP0050863","article-title":"The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery","volume":"101","author":"Novakovic","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/ATVBAHA.114.303032","article-title":"Perivascular adipose tissue, potassium channels, and vascular dysfunction","volume":"34","author":"Tano","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2147\/JRLCR.S36062","article-title":"K+ channels in biological processes: Vascular K+ channels in the regulation of blood pressure","volume":"7","author":"Werner","year":"2014","journal-title":"J. Recept. Ligand Channel Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e12423","DOI":"10.1111\/micc.12423","article-title":"Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders","volume":"25","author":"Syed","year":"2018","journal-title":"Microcirculation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14058","DOI":"10.1038\/s41598-017-14565-9","article-title":"Impaired BK(Ca) channel function in native vascular smooth muscle from humans with type 2 diabetes","volume":"7","author":"Syed","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1002\/jcp.25003","article-title":"Impairment of the Vascular KATP Channel Imposes Fatal Susceptibility to Experimental Diabetes due to Multi-Organ Injuries","volume":"230","author":"Li","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_21","first-page":"125","article-title":"The role of the adenosine triphosphate-sensitive potassium channels in pinacidil-induced vasodilatation of the human saphenous vein in patients with and without type 2 diabetes mellitus","volume":"71","author":"Rajkovic","year":"2020","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"104323","DOI":"10.1016\/j.yexmp.2019.104323","article-title":"Effect of gestational diabetes mellitus and pregnancy-induced hypertension on human umbilical vein smooth muscle K(ATP) channels","volume":"111","author":"Djokic","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/fcp.12461","article-title":"Potassium channels in vascular smooth muscle: A pathophysiological and pharmacological perspective","volume":"33","author":"Dogan","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.yjmcc.2004.05.022","article-title":"K ATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits","volume":"37","author":"Yoshida","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0165-6147(00)01563-7","article-title":"New windows on the mechanism of action of K(ATP) channel openers","volume":"21","author":"Ashcroft","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/0306-3623(94)90376-X","article-title":"A comparison of the relaxant effects of pinacidil in rabbit renal and mesenteric artery","volume":"25","year":"1994","journal-title":"Gen. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejphar.2010.12.026","article-title":"Effect of potassium channel opener pinacidil on the contractions elicited electrically or by noradrenaline in the human radial artery","volume":"654","author":"Savic","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1472-8206.1997.tb00860.x","article-title":"The effects of levcromakalim and pinacidil on the human internal mammary artery","volume":"11","year":"1997","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.clinbiochem.2014.12.026","article-title":"ATP-dependent potassium channels and type 2 diabetes mellitus","volume":"48","author":"Bonfanti","year":"2015","journal-title":"Clin. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nm0502-466","article-title":"Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1","volume":"8","author":"Miki","year":"2002","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1161\/01.RES.0000207498.40005.e7","article-title":"Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process","volume":"98","author":"Kakkar","year":"2006","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0003-4975(99)01341-7","article-title":"Injection of vasodilators into arterial grafts through cardiac catheter to relieve spasm","volume":"69","author":"He","year":"2000","journal-title":"Ann. Thorac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00508-016-1143-1","article-title":"Patterns of diabetes care in Slovenia, Croatia, Serbia, Bulgaria and Romania: An observational, non-interventional, cross-sectional study","volume":"129","author":"Cokolic","year":"2017","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10557-007-6047-x","article-title":"The gender differences in the relaxation to levosimendan of human internal mammary artery","volume":"21","author":"Akar","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1053\/j.jvca.2019.02.040","article-title":"Sex Difference in Coronary Artery Bypass Grafting: Preoperative Profile and Early Outcome","volume":"33","author":"Houterman","year":"2019","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0735-1097(01)01428-0","article-title":"Gender-specific difference in cardiac ATP-sensitive K+ channels","volume":"38","author":"Ranki","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1254\/jphs.FP0061434","article-title":"Potassium channel opener pinacidil induces relaxation of the isolated human radial artery","volume":"104","author":"Stojnic","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1161\/01.ATV.0000158497.09626.3b","article-title":"Redox modulation of vascular tone: Focus of potassium channel mechanisms of dilation","volume":"25","author":"Gutterman","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.biocel.2004.10.008","article-title":"KATP channel: Relation with cell metabolism and role in the cardiovascular system","volume":"37","author":"Zhuo","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1172\/JCI0215672","article-title":"Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels","volume":"110","author":"Chutkow","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.yjmcc.2004.11.021","article-title":"KATP channel interaction with adenine nucleotides","volume":"38","author":"Matsuo","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_42","first-page":"1256","article-title":"Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2\/SUR2A","volume":"57","author":"Gribble","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/FJC.0b013e3182145850","article-title":"The effects of potassium channel opener P1075 on the human saphenous vein and human internal mammary artery","volume":"57","author":"Novakovic","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"C48","DOI":"10.1152\/ajpcell.00209.2018","article-title":"Multivalent activation of GLP-1 and sulfonylurea receptors modulates \u03b2-cell second-messenger signaling and insulin secretion","volume":"316","author":"Hart","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-019-1498-3","article-title":"Identification of an ATP-sensitive potassium channel in mitochondria","volume":"572","author":"Paggio","year":"2019","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/sj.bjp.0705062","article-title":"Contribution of Na+-Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery","volume":"138","author":"Tsang","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejphar.2011.01.053","article-title":"Acidosis induces relaxation mediated by nitric oxide and potassium channels in rat thoracic aorta","volume":"656","author":"Celotto","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejphar.2005.02.041","article-title":"Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels","volume":"514","author":"Rohra","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Jankovi\u0107, J., Davidovi\u0107, M., Bjegovi\u0107-Mikanovi\u0107, V., and Jankovi\u0107, S. (2019). Status of cardiovascular health in the Republic of Serbia: Results from the National Health Survey. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214505"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/HYPERTENSIONAHA.114.03116","article-title":"The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control","volume":"64","author":"Aziz","year":"2014","journal-title":"Hypertension"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e000365","DOI":"10.1161\/JAHA.113.000365","article-title":"Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle","volume":"2","author":"Li","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1111\/jcmm.16346","article-title":"Kir6.1 improves cardiac dysfunction in diabetic cardiomyopathy via the AKT-FoxO1 signalling pathway","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00424-006-0112-3","article-title":"Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes","volume":"453","author":"Girard","year":"2006","journal-title":"Pflugers Arch."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Beltrand, J., Busiah, K., Vaivre-Douret, L., Fauret, A.L., Berdugo, M., Cav\u00e9, H., and Polak, M. (2020). Neonatal Diabetes Mellitus. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.540718"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejphar.2008.03.039","article-title":"Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels","volume":"587","author":"Gamallo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"C170","DOI":"10.1152\/ajpcell.00041.2012","article-title":"Alteration of ATP-sensitive K+ channels in rabbit aortic smooth muscle during left ventricular hypertrophy","volume":"303","author":"Park","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00424-018-2154-8","article-title":"Alterations of ATP-sensitive K+ channels in human umbilical arterial smooth muscle during gestational diabetes mellitus","volume":"470","author":"Li","year":"2018","journal-title":"Pflugers Arch."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/bem.22111","article-title":"ATP sensitive K+ channel subunits (Kir6.1, Kir6.2) are the candidate mediators regulating ameliorating effects of pulsed magnetic field on aortic contractility in diabetic rats","volume":"39","author":"Ocal","year":"2018","journal-title":"Bioelectromagnetics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(01)01412-1","article-title":"The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: Comparison with the sulfonylureas and nateglinide","volume":"431","author":"Sunaga","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/sj.bjp.0705228","article-title":"Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A","volume":"139","author":"Cui","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_61","first-page":"1","article-title":"K(ATP) channel action in vascular tone regulation: From genetics to diseases","volume":"64","author":"Shi","year":"2012","journal-title":"Sheng Li Xue Bao"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jff.2018.11.009","article-title":"The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels","volume":"52","author":"Heinle","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mce.2015.11.032","article-title":"Low intensity exercise prevents disturbances in rat cardiac insulin signaling and endothelial nitric oxide synthase induced by high fructose diet","volume":"420","year":"2016","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/857\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:08:28Z","timestamp":1760108908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ph17070857"],"URL":"https:\/\/doi.org\/10.3390\/ph17070857","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}