{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T06:29:36Z","timestamp":1781418576748,"version":"3.54.1"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inova Fiocruz\/VPCCB","award":["2018\/22214-6"],"award-info":[{"award-number":["2018\/22214-6"]}]},{"name":"Inova Fiocruz\/VPCCB","award":["310745\/2022-5"],"award-info":[{"award-number":["310745\/2022-5"]}]},{"name":"Inova Fiocruz\/VPCCB","award":["440017\/2022-0"],"award-info":[{"award-number":["440017\/2022-0"]}]},{"name":"FAPESP","award":["2018\/22214-6"],"award-info":[{"award-number":["2018\/22214-6"]}]},{"name":"FAPESP","award":["310745\/2022-5"],"award-info":[{"award-number":["310745\/2022-5"]}]},{"name":"FAPESP","award":["440017\/2022-0"],"award-info":[{"award-number":["440017\/2022-0"]}]},{"name":"CNPq","award":["2018\/22214-6"],"award-info":[{"award-number":["2018\/22214-6"]}]},{"name":"CNPq","award":["310745\/2022-5"],"award-info":[{"award-number":["310745\/2022-5"]}]},{"name":"CNPq","award":["440017\/2022-0"],"award-info":[{"award-number":["440017\/2022-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Mefloquine (MQ) is an antimalarial medication prescribed to treat or malaria prevention.. When taken by children, vomiting usually occurs, and new doses of medication frequently need to be taken. So, developing pediatric medicines using taste-masked antimalarial drug complexes is mandatory for the success of mefloquine administration. The hypothesis that binding mefloquine to an ion-exchange resin (R) could circumvent the drug\u2019s bitter taste problem was proposed, and solid-state 13C cross-polarization magic angle spinning (CPMAS) NMR was able to follow MQ\u2013R mixtures through chemical shift and relaxation measurements. The nature of MQ\u2013R complex formation could then be determined. Impedimetric electronic tongue equipment also verified the resinate taste-masking efficiency in vitro. Variations in chemical shifts and structure dynamics measured by proton relaxation properties (e.g., T1\u03c1H) were used as probes to follow the extension of mixing and specific interactions that would be present in MQ\u2013R. A significant decrease in T1\u03c1H values was observed for MQ carbons in MQ\u2013R complexes, compared to the ones in MQ (from 100\u2013200 ms in MQ to 20\u201350 ms in an MQ\u2013R complex). The results evidenced that the cationic resin interacts strongly with mefloquine molecules in the formulation of a 1:1 ratio complex. Thus, 13C CPMAS NMR allowed the confirmation of the presence of a binding between mefloquine and polacrilin in the MQ\u2013R formulation studied.<\/jats:p>","DOI":"10.3390\/ph17070870","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:04:18Z","timestamp":1719986658000},"page":"870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Solid-State NMR Characterization of Mefloquine Resinate Complexes Designed for Taste-Masking Pediatric Formulations"],"prefix":"10.3390","volume":"17","author":[{"given":"Leandro B.","family":"Borr\u00e9","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-4834","authenticated-orcid":false,"given":"Eduardo G. R.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia em F\u00e1rmacos (Farmanguinhos), Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21041-250, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane A. S.","family":"San Gil","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil"},{"name":"Instituto de Pesquisa de Produtos Naturais, Universidade Federal do Rio de Janeiro, CCS, Rio de Janeiro 21941-599, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus M.","family":"Baptista","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-486X","authenticated-orcid":false,"given":"Alexandre A.","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-4339","authenticated-orcid":false,"given":"Jo\u00e3o M. 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R.","family":"De Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ol\u00edvia","family":"Carr","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Osvaldo N.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-9893","authenticated-orcid":false,"given":"Fl\u00e1vio M.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Applied Physics, Institute of Physics (IFGW), University of Campinas (UNICAMP), \u201cGleb Wataghin\u201d, Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-6414","authenticated-orcid":false,"given":"Thiago F.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia em F\u00e1rmacos (Farmanguinhos), Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21041-250, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1039\/C9GC02478F","article-title":"Mechanochemistry for the production of a hybrid salt used in the treatment of malaria","volume":"22","author":"Prado","year":"2020","journal-title":"Green Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/1475-2875-10-292","article-title":"Use of mefloquine in children\u2014A review of dosage, pharmacokinetics and tolerability data","volume":"10","author":"Schlagenhauf","year":"2011","journal-title":"Malar. 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