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If this occurs in the coronary arteries, the blood vessels may be completely blocked, resulting in myocardial infarction; if it occurs in the blood vessels of the brain, the blood vessels may be blocked, resulting in cerebral infarction, i.e., stroke. Studies have shown that the pathogenesis of atherosclerosis involves the processes of inflammation, lipid infiltration, oxidative stress, and endothelial damage, etc. SIRT, as a key factor regulating the molecular mechanisms of oxidative stress, inflammation, and aging, has an important impact on the pathogenesis of plaque formation, progression, and vulnerability. Statistics show that AS accounts for about 50 per cent of deaths in Western countries. Currently, oral medication is the mainstay of AS treatment, but its development is limited by side effects, low bioavailability and other unfavourable factors. In recent years, with the rapid development of nano-preparations, researchers have combined statins and natural product drugs within nanopreparations to improve their bioavailability. Based on this, this paper summarises the main pathogenesis of AS and also proposes new oral nanoformulations such as liposomes, nanoparticles, nanoemulsions, and nanocapsules to improve their application in the treatment of AS.<\/jats:p>","DOI":"10.3390\/ph17070919","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oral Nanoformulations in Cardiovascular Medicine: Advances in Atherosclerosis Treatment"],"prefix":"10.3390","volume":"17","author":[{"given":"Xu","family":"Sun","sequence":"first","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xushuang","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolin","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1039\/D0BM00418A","article-title":"Biomimetic oral targeted delivery of bindarit for immunotherapy of atherosclerosis","volume":"8","author":"Yin","year":"2020","journal-title":"Biomater. 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Target."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e2102640","DOI":"10.1002\/advs.202102640","article-title":"Cancer Patient Tissueoid with Self-Homing Nano-Targeting of Metabolic Inhibitor","volume":"8","author":"Yoon","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jcis.2022.10.003","article-title":"Biomimetic nanoprodrugs from fatty acid modified camptothecin and albumin for enhanced pharmacotherapy","volume":"630","author":"Gao","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"115114","DOI":"10.1016\/j.addr.2023.115114","article-title":"Protein corona on brain targeted nanocarriers: Challenges and prospects","volume":"202","author":"Jiang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mohammad, H.-U.-R., Israt, J., Tahmina, F., and Abu Bin, I. (2023). Bio-Inspired Nanomaterials for Micro\/Nanodevices: A New Era in Biomedical Applications. Micromachines, 14.","DOI":"10.3390\/mi14091786"},{"key":"ref_17","first-page":"1523","article-title":"Enhancement in Biological Availability of Vitamins by Nano-engineering and its Applications: An Update","volume":"25","author":"Sadhna","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"137676","DOI":"10.1016\/j.foodchem.2023.137676","article-title":"Nanoparticle encapsulation using self-assembly abietic acid to improve oral bioavailability of curcumin","volume":"436","author":"Han","year":"2023","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41569-021-00647-9","article-title":"Prevention of atherosclerosis from childhood","volume":"19","author":"Raitakari","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11883-020-00862-8","article-title":"Premature Atherosclerotic Cardiovascular Disease: What Have We Learned Recently?","volume":"22","author":"Mahtta","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.114.014310","article-title":"Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study","volume":"131","author":"Penalvo","year":"2015","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Perrotta, I. (2022). Atherosclerosis: From Molecular Biology to Therapeutic Perspective 2.0. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315158"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jacc.2021.12.016","article-title":"Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review","volume":"79","author":"Stone","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00441-008-0678-5","article-title":"Vascular endothelium in atherosclerosis","volume":"335","author":"Sima","year":"2009","journal-title":"Cell Tissue Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41569-022-00739-0","article-title":"Mechanisms and consequences of endothelial cell senescence","volume":"20","author":"Bloom","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mvr.2016.02.006","article-title":"Roles of LOX-1 in microvascular dysfunction","volume":"105","author":"Lubrano","year":"2016","journal-title":"Microvasc. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wanschel, A., Guizoni, D.M., Lorza-Gil, E., Salerno, A.G., Paiva, A.A., Dorighello, G.G., Davel, A.P., Balkan, W., Hare, J.M., and Oliveira, H.C.F. (2021). The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction. Biomolecules, 11.","DOI":"10.3390\/biom11010069"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/HYPERTENSIONAHA.115.06597","article-title":"Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients with Primary Hyperaldosteronemia","volume":"67","author":"Chen","year":"2016","journal-title":"Hypertension"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115261","DOI":"10.1016\/j.jep.2022.115261","article-title":"The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against atherosclerosis by suppressing EndMT via modulating Akt1\/beta-catenin signaling pathway","volume":"293","author":"Diao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","first-page":"7533","article-title":"Research on mechanism of PCS in damaging vascular endothelial cells and promoting formation of atherosclerosis via TLR4\/TREM-1","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/fcp.12915","article-title":"Pro-inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis","volume":"37","author":"Shang","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10741-022-10224-y","article-title":"Endothelial-cell-mediated mechanism of coronary microvascular dysfunction leading to heart failure with preserved ejection fraction","volume":"28","author":"Wang","year":"2023","journal-title":"Heart Fail. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wautier, J.L., and Wautier, M.P. (2021). Endothelial Cell Participation in Inflammatory Reaction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126341"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117658","DOI":"10.1016\/j.lfs.2020.117658","article-title":"Curcumin inhibits the formation of atherosclerosis in ApoE\u2212\/\u2212 mice by suppressing cytomegalovirus activity in endothelial cells","volume":"257","author":"Lv","year":"2020","journal-title":"Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/fsn3.2096","article-title":"Hypolipidemic, anti-inflammatory, and anti-atherosclerotic effects of tea before and after microbial fermentation","volume":"9","author":"Deng","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41419-020-2343-1","article-title":"Laminar flow inhibits the Hippo\/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carpath.2012.06.006","article-title":"Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis","volume":"22","author":"Gimbrone","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bu, L.L., Yuan, H.H., Xie, L.L., Guo, M.H., Liao, D.F., and Zheng, X.L. (2023). New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015160"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5830\/CVJA-2011-068","article-title":"Endothelial dysfunction: The early predictor of atherosclerosis","volume":"23","author":"Mudau","year":"2012","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/cvr\/cvad102","article-title":"Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stres","volume":"119","author":"Yang","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pengnet, S., Prommaouan, S., Sumarithum, P., and Malakul, W. (2019). Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/3708497"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2017815","DOI":"10.1155\/2022\/2017815","article-title":"Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis","volume":"2022","author":"Yuan","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"155002","DOI":"10.1016\/j.phymed.2023.155002","article-title":"Salvianolic acid B inhibits atherosclerosis and TNF-alpha-induced inflammation by regulating NF-kappaB\/NLRP3 signaling pathway","volume":"119","author":"Zhao","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10735-023-10125-w","article-title":"Lack of Rab27a attenuates foam cell formation and macrophage inflammation in uremic apolipoprotein E knockout mice","volume":"54","author":"Shen","year":"2023","journal-title":"J. Mol. Histol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lankin, V.Z., Tikhaze, A.K., and Melkumyants, A.M. (2022). Dicarbonyl-Dependent Modification of LDL as a Key Factor of Endothelial Dysfunction and Atherosclerotic Vascular Wall Damage. Antioxidants, 11.","DOI":"10.3390\/antiox11081565"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, C., Tan, Y., Wu, J., Ma, Q., Bai, S., Xia, Z., Wan, X., and Liang, J. (2020). Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00796"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9972413","DOI":"10.1155\/2021\/9972413","article-title":"BTK Promotes Atherosclerosis by Regulating Oxidative Stress, Mitochondrial Injury, and ER Stress of Macrophages","volume":"2021","author":"Qiu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Li, Z., Li, Q., Wang, L., Li, C., Xu, M., Duan, Y., Ma, L., Li, T., Chen, Q., and Wang, Y. (2021). Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis. Redox Biol., 47.","DOI":"10.1016\/j.redox.2021.102156"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Jiang, Y.H., Jiang, L.Y., Wang, Y.C., Ma, D.F., and Li, X. (2020). Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00512"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8875729","DOI":"10.1155\/2021\/8875729","article-title":"Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1166\/jnn.2021.18633","article-title":"Effects of Atorvastatin Combined with Nano-Selenium on Blood Lipids and Oxidative Stress in Atherosclerotic Rats","volume":"21","author":"Han","year":"2021","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbrc.2022.09.041","article-title":"The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice","volume":"631","author":"Tan","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.120.049922","article-title":"Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis","volume":"143","author":"Miano","year":"2021","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/ATVBAHA.114.305144","article-title":"Lymphocytes in atherosclerosis","volume":"35","author":"Hedrick","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.115.306256","article-title":"Macrophage Phenotype and Function in Different Stages of Atherosclerosis","volume":"118","author":"Tabas","year":"2016","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2077602","DOI":"10.1080\/19490976.2022.2077602","article-title":"Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3","volume":"14","author":"Luo","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvx253","article-title":"Endothelial-mesenchymal transition in atherosclerosis","volume":"114","author":"Souilhol","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"117240","DOI":"10.1016\/j.jep.2023.117240","article-title":"Xinmaikang (XMK) tablets alleviate atherosclerosis by regulating the SREBP2-mediated NLRP3\/ASC\/Caspase-1 signaling pathway","volume":"319","author":"Hou","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jare.2023.04.007","article-title":"The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT\/MAPK\/NF-kappaB pathways","volume":"57","author":"Shen","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Cen, Y., Xiong, Y., Qin, R., Tao, H., Yang, Q., and Pan, X. (2023). Anti-malarial artesunate ameliorates atherosclerosis by modulating arterial inflammatory responses via inhibiting the NF-\u03baB-NLRP3 inflammasome pathway. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1123700"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ushio-Fukai, M., Xu, Y., Zhu, J., Hu, X., Wang, C., Lu, D., Gong, C., Yang, J., and Zong, L. (2016). CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166790"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/tox.23958","article-title":"Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis","volume":"39","author":"Hu","year":"2023","journal-title":"Environ. Toxicol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"994","DOI":"10.21873\/invivo.13173","article-title":"Rosuvastatin Attenuates Progression of Atherosclerosis and Reduces Serum IL6 and CCL2 Levels in Apolipoprotein-E-deficient Mice","volume":"37","author":"Tsilimigras","year":"2023","journal-title":"In Vivo"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/ATVBAHA.115.306697","article-title":"Inhibition of Thrombin with PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis","volume":"36","author":"Palekar","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Solanki, A., Savla, S.R., Borkar, M.R., and Bhatt, L.K. (2023). Sulfamethizole attenuates poloxamer 407-induced atherosclerotic neointima formation via inhibition of mTOR in C57BL\/6 mice. J. Biochem. Mol. Toxicol., 37.","DOI":"10.1002\/jbt.23322"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Huwait, E., Almassabi, R., Almowallad, S., Saddeek, S., Karim, S., Kalamegam, G., and Mirza, Z. (2022). Microarray Expression Profile of Myricetin-Treated THP-1 Macrophages Exhibits Alterations in Atherosclerosis-Related Regulator Molecules and LXR\/RXR Pathway. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010278"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/CIRCRESAHA.120.318353","article-title":"SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis","volume":"128","author":"Grootaert","year":"2021","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1038\/s41467-020-20141-z","article-title":"Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques","volume":"11","author":"Baardman","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/CS20220477","article-title":"Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice","volume":"137","author":"Wang","year":"2023","journal-title":"Clin. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10557-022-07348-6","article-title":"Silencing METTL3 Stabilizes Atherosclerotic Plaques by Regulating the Phenotypic Transformation of Vascular Smooth Muscle Cells via the miR-375-3p\/PDK1 Axis","volume":"37","author":"Chen","year":"2023","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Zhou, J., Liu, L., Wu, P., Zhao, L., and Wu, Y. (2022). Fusobacterium nucleatum Accelerates Atherosclerosis via Macrophage-Driven Aberrant Proinflammatory Response and Lipid Metabolism. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.798685"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s10020-023-00685-8","article-title":"HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-kappaB p65 and KLF4: A potential mechanism of atherosclerosis pathogenesis","volume":"29","author":"Han","year":"2023","journal-title":"Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e154922","DOI":"10.1172\/jci.insight.154922","article-title":"CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque","volume":"8","author":"Sakamoto","year":"2023","journal-title":"JCI Insight"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.amjmed.2019.04.043","article-title":"Peripheral Artery Disease: Past, Present, and Future","volume":"132","author":"Campia","year":"2019","journal-title":"Am. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and Inflammation in Atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","article-title":"Immune and inflammatory mechanisms of atherosclerosis (*)","volume":"27","author":"Galkina","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/tox.23309","article-title":"PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome","volume":"36","author":"Hu","year":"2021","journal-title":"Environ. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and cardiovascular disease: Mechanisms of endothelial dysfunction and early atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7541411","DOI":"10.1155\/2022\/7541411","article-title":"Reducing the Damage of Ox-LDL\/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis","volume":"2022","author":"Guo","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.vph.2018.08.002","article-title":"Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease","volume":"112","author":"Maguire","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/01.RES.0000018941.10726.FA","article-title":"Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypes","volume":"90","author":"Pinderski","year":"2002","journal-title":"Circ. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2022.08.012","article-title":"Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function","volume":"358","author":"Sawma","year":"2022","journal-title":"Atherosclerosis"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/cvr\/cvy021","article-title":"Role of smooth muscle cells in coronary artery bypass grafting failure","volume":"114","author":"Wadey","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","article-title":"Matrix metalloproteinases in vascular remodeling and atherogenesis: The good, the bad, and the ugly","volume":"90","author":"Galis","year":"2002","journal-title":"Circ. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2147\/VHRM.S68415","article-title":"Matrix metalloproteinases in atherosclerosis: Role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms","volume":"11","author":"Vacek","year":"2015","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1515\/CCLM.2004.024","article-title":"Matrix metalloproteinases, inflammation and atherosclerosis: Therapeutic perspectives","volume":"42","author":"Beaudeux","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/joim.12296","article-title":"Thrombosis formation on atherosclerotic lesions and plaque rupture","volume":"276","author":"Badimon","year":"2014","journal-title":"J. Intern. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","article-title":"Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression","volume":"127","author":"Sharma","year":"2020","journal-title":"Circ. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/cei.12477","article-title":"The role of T and B cells in human atherosclerosis and atherothrombosis","volume":"179","author":"Ammirati","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jacc.2016.10.043","article-title":"Dual Antiplatelet Therapy Versus Aspirin Monotherapy in Diabetics with Multivessel Disease Undergoing CABG: FREEDOM Insights","volume":"69","author":"Fuster","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2183815","DOI":"10.1080\/10717544.2023.2183815","article-title":"A detailed insight of the tumor targeting using nanocarrier drug delivery system","volume":"30","author":"Batool","year":"2023","journal-title":"Drug Deliv."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jcis.2023.09.019","article-title":"Functional nano drug delivery system with dual lubrication and immune escape for treating osteoarthritis","volume":"652","author":"Yang","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1111\/cns.14355","article-title":"Nano-delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives","volume":"29","author":"Movahedpour","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e2300967","DOI":"10.1002\/adhm.202300967","article-title":"A Biomimetic Nanogel System Restores Macrophage Phagocytosis for Magnetic Resonance Imaging-Guided Synergistic Chemoimmunotherapy of Breast Cancer","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.2147\/IJN.S377149","article-title":"Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin","volume":"17","author":"Chen","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e2000368","DOI":"10.1002\/marc.202000368","article-title":"Protein-Based Nano-Vessels Facilitates the Victoria Blue B Mediated Inhibition of Amyloid Fibrillation","volume":"41","author":"Nie","year":"2020","journal-title":"Macromol. Rapid Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1039\/D3TB00694H","article-title":"MicroRNA therapeutics and nucleic acid nano-delivery systems in bacterial infection: A review","volume":"11","author":"Ze","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Wu, C., Mao, J., Wang, X., Yang, R., Wang, C., Li, C., and Zhou, X. (2023). Advances in treatment strategies based on scavenging reactive oxygen species of nanoparticles for atherosclerosis. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-02058-z"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1002\/ps.7015","article-title":"Nano-EMB-SP improves the solubility, foliar affinity, photostability and bioactivity of emamectin benzoate","volume":"78","author":"Gao","year":"2022","journal-title":"Pest Manag. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/1389200218666170105165444","article-title":"Reduction of Doxorubicin-Induced Cardiotoxicity Using Nanocarriers: A Review","volume":"18","author":"Fojtu","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Nenna, A., Nappi, F., Larobina, D., Verghi, E., Chello, M., and Ambrosio, L. (2021). Polymers and Nanoparticles for Statin Delivery: Current Use and Future Perspectives in Cardiovascular Disease. Polymers, 13.","DOI":"10.3390\/polym13050711"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijbiomac.2015.12.044","article-title":"Chitosan\/poly-\u03b3-glutamic acid nanoparticles improve the solubility of lutein","volume":"85","author":"Hong","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1165\/rcmb.2020-0306TR","article-title":"Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases","volume":"64","author":"Deng","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/j.sodo.2016.05.002","article-title":"The fragmentation of childrens\u2019 oral health: Access to care in pediatric dentistry and orthodontics","volume":"22","author":"Laniado","year":"2016","journal-title":"Semin. Orthod."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.2147\/IJN.S434917","article-title":"Nano-Photosensitizer Directed Targeted Phototherapy Effective Against Oral Cancer in Animal Model","volume":"18","author":"Lina","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Maxius, G., and Veerakiet, B. (2023). Current applications of solid lipid nanoparticles and nanostructured lipid carriers as vehicles in oral delivery systems for antioxidant nutraceuticals: A review. Colloids Surf. B Biointerfaces, 233.","DOI":"10.1016\/j.colsurfb.2023.113608"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"114449","DOI":"10.1016\/j.addr.2022.114449","article-title":"Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms","volume":"188","author":"Zi","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.addr.2020.06.005","article-title":"Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers","volume":"157","author":"Fang","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_110","first-page":"161","article-title":"Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue","volume":"26","author":"Ballesteros","year":"2014","journal-title":"Cl\u00edn. Investig. Arterioscler."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.2016.160288","article-title":"Rosuvastatin Inhibits Interleukin (IL)-8 and IL-6 Production in Human Coronary Artery Endothelial Cells Stimulated with Aggregatibacter actinomycetemcomitans Serotype b","volume":"88","author":"Gualtero","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_112","first-page":"495","article-title":"Cholesterol (Blood lipid) lowering potential of Rosuvastatin chitosan nanoparticles for atherosclerosis: Preclinical study in rabbit model","volume":"67","author":"Chen","year":"2020","journal-title":"Acta Biochim. Pol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"123009","DOI":"10.1016\/j.ijpharm.2023.123009","article-title":"Modeling of chitosan modified PLGA atorvastatin-curcumin conjugate (AT-CU) nanoparticles, overcoming the barriers associated with PLGA: An approach for better management of atherosclerosis","volume":"640","author":"Dash","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/1440-1681.12362","article-title":"Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis","volume":"42","author":"Kilic","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2022.12683","article-title":"Atorvastatin regulates vascular smooth muscle cell phenotypic transformation by epigenetically modulating contractile proteins and mediating Akt\/FOXO4 axis","volume":"25","author":"Du","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Liu, M., Gao, T., Jiang, L., Li, S., Shi, B., and Li, F. (2023). Enhancing the biopharmaceutical attributes of atorvastatin calcium using polymeric and lipid-polymer hybrid nanoparticles: An approach for atherosclerosis treatment. Biomed. Pharmacother., 159.","DOI":"10.1016\/j.biopha.2023.114261"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"9544","DOI":"10.7150\/thno.45788","article-title":"Prevention of Obesity Related Diseases through Laminarin-induced targeted delivery of Bindarit","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"174120","DOI":"10.1016\/j.ejphar.2021.174120","article-title":"Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress","volume":"902","author":"Xiao","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Cao, H., Xiao, J., and Liu, H. (2019). Enhanced oxidase-like activity of selenium nanoparticles stabilized by chitosan and application in a facile colorimetric assay for mercury (II). Biochem. Eng. J., 152.","DOI":"10.1016\/j.bej.2019.107384"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Xiao, J., Li, N., Xiao, S., Wu, Y., and Liu, H. (2021). Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111612"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"123212","DOI":"10.1016\/j.ijpharm.2023.123212","article-title":"Enhanced therapeutic efficacy of Piperlongumine for cancer treatment using nano-liposomes mediated delivery","volume":"643","author":"Parveen","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcis.2016.07.013","article-title":"Synthesis and characterization of PEGylated bolaamphiphiles with enhanced retention in liposomes","volume":"482","author":"Zhang","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"ref_123","first-page":"2347","article-title":"RGD-decorated nanoliposomes for combined delivery of arsenic trioxide and curcumin to prostate cancer cells","volume":"397","author":"Fatemeh","year":"2023","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1021\/jf060405o","article-title":"Optimization in the preparation of coenzyme Q10 nanoliposomes","volume":"54","author":"Xia","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biomaterials.2012.09.058","article-title":"Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"123102","DOI":"10.1016\/j.ijpharm.2023.123102","article-title":"Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine","volume":"642","author":"Liu","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e2000465","DOI":"10.1002\/adhm.202000465","article-title":"Liposomal Nanotherapy for Treatment of Atherosclerosis","volume":"9","author":"Darwitan","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/17425247.2020.1777982","article-title":"Targeting efficiency of nanoliposomes on atherosclerotic foam cells: Polyethylene glycol-to-ligand ratio effects","volume":"17","author":"Darwitan","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1002\/jcp.26610","article-title":"Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet","volume":"233","author":"Krishna","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Rakshit, M., Darwitan, A., Muktabar, A., Das, P., Nguyen, L.T.H., Cao, Y., Vizetto-Duarte, C., Tang, J., Wong, Y.S., and Venkatraman, S. (2021). Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models. Nanomed. Nanotechnol. Biol. Med., 37.","DOI":"10.1016\/j.nano.2021.102434"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.18632\/aging.202566","article-title":"Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages","volume":"13","author":"Zheng","year":"2021","journal-title":"Aging"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbrc.2022.07.072","article-title":"Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPAR\u03b1 in ApoE\u2212\/\u2212 mice","volume":"624","author":"Man","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"121525","DOI":"10.1016\/j.ijpharm.2022.121525","article-title":"Berberine-loaded liposomes for oral delivery: Preparation, physicochemical characterization and in-vivo evaluation in an endogenous hyperlipidemic animal model","volume":"616","author":"Duong","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2174\/1389450120666190214141626","article-title":"Structure and Function of Proprotein Convertase Subtilisin\/kexin Type 9 (PCSK9) in Hyperlipidemia and Atherosclerosis","volume":"20","author":"Lu","year":"2019","journal-title":"Curr. Drug Targets"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"531","DOI":"10.7150\/thno.80289","article-title":"SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells","volume":"13","author":"Prattichizzo","year":"2023","journal-title":"Theranostics"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Li, Z., Zhu, H., Liu, H., Liu, D., Liu, J., Jiang, J., Zhang, Y., Qin, Z., Xu, Y., and Peng, Y. (2023). Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-01904-4"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.2174\/1381612825666190903155321","article-title":"Solid Lipid Nanoparticles: A Promising Nanomaterial in Drug Delivery","volume":"25","author":"Rajpoot","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10557-016-6675-0","article-title":"Reduction of Atherosclerotic Lesions by the Chemotherapeutic Agent Carmustine Associated to Lipid Nanoparticles","volume":"30","author":"Daminelli","year":"2016","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1021\/acs.bioconjchem.5b00590","article-title":"Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis","volume":"27","author":"Oumzil","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijpharm.2010.04.039","article-title":"The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats","volume":"394","author":"Zhang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"100066","DOI":"10.1016\/j.jlr.2021.100066","article-title":"Simvastatin inhibits POVPC-mediated induction of endothelial to mesenchymal cell transition","volume":"62","author":"Li","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3892\/ijmm.2014.1740","article-title":"Simvastatin attenuates TNF-\u03b1-induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1","volume":"34","author":"Du","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijpharm.2019.02.002","article-title":"Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model","volume":"560","author":"Rizvi","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_144","first-page":"8103","article-title":"Ezetimibe-Loaded Nanostructured Lipid Carrier for Oral Delivery: Response Surface Methodology; In Vitro Characterization and Assessing the Antihyperlipidemic Effect in Rats","volume":"9","author":"Elkhayat","year":"2024","journal-title":"ACS Omega"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Devel, L., Almer, G., Cabella, C., Beau, F., Bernes, M., Oliva, P., Navarro, F., Prassl, R., Mangge, H., and Texier, I. (2019). Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model. Molecules, 24.","DOI":"10.3390\/molecules24193499"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"102157","DOI":"10.1016\/j.nano.2020.102157","article-title":"Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE\u2212\/\u2212 mice","volume":"25","author":"Vigne","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jconrel.2017.03.008","article-title":"Nanoemulsion: Concepts, development and applications in drug delivery","volume":"252","author":"Singh","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/2589977511666191024173508","article-title":"Nanoemulsion as Oral Drug Delivery\u2014A Review","volume":"12","author":"Sabjan","year":"2020","journal-title":"Curr. Drug Res. Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/10837450.2021.1888980","article-title":"Brain targeting of agomelatine egg lecithin based chitosan coated nanoemulsion","volume":"26","author":"Shukr","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1248\/bpb.34.300","article-title":"Utility of nano-sized, water-in-oil emulsion as a sustained release formulation of glycyrrhizin","volume":"34","author":"Koga","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1007\/s11095-014-1374-7","article-title":"Nano Composite Emulsion for Sustained Drug Release and Improved Bioavailability","volume":"31","author":"Sun","year":"2014","journal-title":"Pharm. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1039\/D0FO02686G","article-title":"Nanoemulsion-based delivery approaches for nutraceuticals: Fabrication, application, characterization, biological fate, potential toxicity and future trends","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jps.21423","article-title":"Colloidal soft matter as drug delivery system","volume":"98","author":"Bonacucina","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref_154","first-page":"327","article-title":"Development of microemulsion for solubility enhancement of clopidogrel","volume":"9","author":"Patel","year":"2010","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"126","DOI":"10.32725\/jab.2020.016","article-title":"The effects of Rosmarinus officinalis L. essential oil and its nanoemulsion on dyslipidemic Wistar rats","volume":"18","author":"Souza","year":"2020","journal-title":"J. Appl. Biomed."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ijpharm.2017.09.010","article-title":"Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging","volume":"532","author":"Kauss","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4155\/tde-2016-0071","article-title":"Solidified self nano-emulsifying drug delivery system of rosuvastatin calcium to treat diet-induced hyperlipidemia in rat: In vitro and in vivo evaluations","volume":"8","author":"Ahsan","year":"2017","journal-title":"Ther. Deliv."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Jiang, F., Wu, G., Yang, H., Zhang, Y., Shen, X., and Tao, L. (2023). Diethylaminoethyl-dextran and monocyte cell membrane coated 1,8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.127365"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1021\/acsnano.2c12230","article-title":"Fabrication of a Polysaccharide-Protein\/Protein Complex Stabilized Oral Nanoemulsion to Facilitate the Therapeutic Effects of 1,8-Cineole on Atherosclerosis","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Chimento, A., De Amicis, F., Sirianni, R., Sinicropi, M., Puoci, F., Casaburi, I., Saturnino, C., and Pezzi, V. (2019). Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061381"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1208\/s12249-020-01670-8","article-title":"Development of Morin-Loaded Nanoemulsions Containing Various Polymers; Role of Polymers in Formulation Properties and Bioavailability","volume":"21","author":"Murata","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"123566","DOI":"10.1016\/j.ijpharm.2023.123566","article-title":"A Nanoemulgel for Nose-to-Brain Delivery of Quetiapine\u2014QbD-Enabled Formulation Development & In-vitro Characterization","volume":"648","author":"Dnyandev","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Riddhi, V., Caitlin, C., Lu, L., Amit Chandra, D., Rebecca, M., Fatih, Z., Yalcin, K., Vijay, S.G., and Jelena, M.J. (2023). A Reversibly Thermoresponsive, Theranostic Nanoemulgel for Tacrolimus Delivery to Activated Macrophages: Formulation and In Vitro Validation. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102372"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/1872210516666220210113256","article-title":"Nanocapsules: An Emerging Drug Delivery System","volume":"17","author":"Purohit","year":"2022","journal-title":"Recent Pat. Nanotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Hou, H., Chi, C., Wang, T., He, Y., Chen, L., and Li, X. (2023). Multi-responsive starch-based nanocapsules for colon-targeting delivery of peptides: In vitro and in vivo evaluation. Int. J. Biol. Macromol., 242.","DOI":"10.1016\/j.ijbiomac.2023.124953"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2147\/IJN.S149458","article-title":"Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy","volume":"13","author":"Yi","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/03639045.2020.1753763","article-title":"Formulation of lyophilized oily-core poly-\u0190-caprolactone nanocapsules to improve oral bioavailability of Olmesartan Medoxomil","volume":"46","author":"Khattab","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"123216","DOI":"10.1016\/j.ijpharm.2023.123216","article-title":"Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin","volume":"643","author":"Collantes","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.scitotenv.2019.01.380","article-title":"Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach","volume":"663","author":"Andrade","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neuint.2012.06.015","article-title":"Haloperidol-loaded polysorbate-coated polymeric nanocapsules decrease its adverse motor side effects and oxidative stress markers in rats","volume":"61","author":"Barcelos","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jconrel.2005.12.015","article-title":"Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree","volume":"111","author":"Prego","year":"2006","journal-title":"J. Control. Release"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejpb.2020.12.016","article-title":"Docosahexaenoic acid nanoencapsulated with anti-PECAM-1 as co-therapy for atherosclerosis regression","volume":"159","author":"Araki","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejpb.2016.07.002","article-title":"A nanoformulation containing a scFv reactive to electronegative LDL inhibits atherosclerosis in LDL receptor knockout mice","volume":"107","author":"Cavalcante","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Garcia, G.M., Roy, J., Pitta, I.R., Abdalla, D.S.P., Grabe-Guimar\u00e3es, A., Mosqueira, V.C.F., and Richard, S. (2021). Polylactide Nanocapsules Attenuate Adverse Cardiac Cellular Effects of Lyso-7, a Pan-PPAR Agonist\/Anti-Inflammatory New Thiazolidinedione. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13091521"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., de Carvalho, G.M., de Oliveira Zanuso, B., Figueira, M.E., Direito, R., de Alvares Goulart, R., Buglio, D.S., and Barbalho, S.M. (2023). Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010229"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"de Castro Le\u00e3o, M., Di Piazza, I., Caria, S.J., Broering, M.F., Farsky, S.H.P., Uchiyama, M.K., Araki, K., Bonjour, K., Cogliati, B., and Pohlmann, A.R. (2023). Effect of nanocapsules containing docosahexaenoic acid in mice with chronic inflammation. Biomed. Pharmacother., 167.","DOI":"10.1016\/j.biopha.2023.115474"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.3892\/mmr.2017.7314","article-title":"Ultrasound and magnetic resonance molecular imaging of atherosclerotic neovasculature with perfluorocarbon magnetic nanocapsules targeted against vascular endothelial growth factor receptor 2 in rats","volume":"16","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/13543784.2023.2267972","article-title":"MK-0616: An oral PCSK9 inhibitor for hypercholesterolemia treatment","volume":"32","author":"John","year":"2023","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2147\/IJN.S291945","article-title":"Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats","volume":"16","author":"Jasinski","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Salaheldin, T.A., Godugu, K., Bharali, D.J., Fujioka, K., Elshourbagy, N., and Mousa, S.A. (2021). Novel oral nano-hepatic targeted anti-PCSK9 in hypercholesterolemia. Nanomed. Nanotechnol. Biol. Med., 40.","DOI":"10.1016\/j.nano.2021.102480"},{"key":"ref_181","first-page":"1196","article-title":"Development of anti-atherosclerosis therapy based on the inflammatory and proliferative aspects of the disease","volume":"21","author":"Leite","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.21037\/atm-20-8106","article-title":"Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE\u2212\/\u2212 mice by down-regulating PCSK9 via ERK1\/2 pathway","volume":"9","author":"Ma","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1871529X18666180201130340","article-title":"Berberine Encapsulated PLGA-PEG Nanoparticles Modulate PCSK-9 in HepG2 Cells","volume":"18","author":"Ochin","year":"2018","journal-title":"Cardiovasc. Hematol. Disord.-Drug Targets"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-022-01027-6","article-title":"Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota","volume":"7","author":"Ma","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1177\/17085381211040974","article-title":"Curcumin improves atherosclerosis by inhibiting the epigenetic repression of lncRNA MIAT to miR-124","volume":"30","author":"Ouyang","year":"2022","journal-title":"Vascular"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0885328218815328","article-title":"A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice","volume":"33","author":"Meng","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"12603","DOI":"10.1021\/jf504603n","article-title":"Improving the Effectiveness of (\u2212)-Epigallocatechin Gallate (EGCG) against Rabbit Atherosclerosis by EGCG-Loaded Nanoparticles Prepared from Chitosan and Polyaspartic Acid","volume":"62","author":"Hong","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/FJC.0000000000000792","article-title":"Protective Effect of Epigallocatechin Gallate on Endothelial Disorders in Atherosclerosis","volume":"75","author":"Yamagata","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1001\/jama.2022.5218","article-title":"Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial","volume":"327","author":"Ueki","year":"2022","journal-title":"JAMA"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.122.061620","article-title":"Long-Term Evolocumab in Patients with Established Atherosclerotic Cardiovascular Disease","volume":"146","author":"Giugliano","year":"2022","journal-title":"Circulation"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2131\/jts.46.209","article-title":"Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p\/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis","volume":"46","author":"Tan","year":"2021","journal-title":"J. Toxicol. Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1142\/S0192415X21500063","article-title":"Epigallocatechin Gallate Reduces Homocysteine-Caused Oxidative Damages through Modulation SIRT1\/AMPK Pathway in Endothelial Cells","volume":"49","author":"Pai","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s10637-020-00905-6","article-title":"Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes","volume":"38","author":"Om","year":"2020","journal-title":"Investig. New Drugs"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"e22630","DOI":"10.1096\/fj.202200053RR","article-title":"Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels","volume":"36","author":"Mitra","year":"2022","journal-title":"FASEB J."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1111\/dom.15058","article-title":"Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and\/or chronic kidney disease: Design and baseline characteristics of SOUL, a randomized trial","volume":"25","author":"McGuire","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Liang, Y., Wang, M., Wang, C., Liu, Y., Naruse, K., and Takahashi, K. (2021). The Mechanisms of the Development of Atherosclerosis in Prediabetes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084108"},{"key":"ref_197","unstructured":"Ian, O.C., and Jayer, C. (2023). Contemporary Medical Management of Peripheral Arterial Disease. Cardiovasc. Drugs Ther."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1142\/S0192415X23500088","article-title":"Andrographolide Inhibits Lipotoxicity-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages","volume":"51","author":"Yen","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.17219\/acem\/137914","article-title":"Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1\/PPARgamma\/CD36 signaling","volume":"30","author":"Wang","year":"2021","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Jin, P., Gao, D., Cong, G., Yan, R., and Jia, S. (2021). Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoE\u2212\/\u2212 Mice. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.746989"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"11729","DOI":"10.1111\/jcmm.15783","article-title":"WISP1 alleviates lipid deposition in macrophages via the PPARgamma\/CD36 pathway in the plaque formation of atherosclerosis","volume":"24","author":"Liu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.3174\/ajnr.A4414","article-title":"Intraplaque Hemorrhage and the Plaque Surface in Carotid Atherosclerosis: The Plaque At RISK Study (PARISK)","volume":"36","author":"Truijman","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4103\/jmss.JMSS_48_19","article-title":"The Relation between Atherosclerosis Plaque Composition and Plaque Rupture","volume":"10","author":"Babaniamansour","year":"2020","journal-title":"J. Med. Signals Sens."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis","volume":"120","author":"Doring","year":"2017","journal-title":"Circ. Res."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Man, A.W.C., Li, H., and Xia, N. (2021). Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020676"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1182\/blood.2019000518","article-title":"Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps","volume":"134","author":"Marx","year":"2019","journal-title":"Blood"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41419-022-04923-5","article-title":"Programmed cell death in atherosclerosis and vascular calcification","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.121.057868","article-title":"Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification","volume":"145","author":"Ouyang","year":"2022","journal-title":"Circulation"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"25080","DOI":"10.1021\/acsami.2c02354","article-title":"A ROS-Responsive Simvastatin Nano-Prodrug and its Fibronectin-Targeted Co-Delivery System for Atherosclerosis Treatment","volume":"14","author":"Zhao","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41569-021-00663-9","article-title":"Update on the pathophysiology and medical treatment of peripheral artery disease","volume":"19","author":"Golledge","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/a-1724-4922","article-title":"When and How to Combine Antiplatelet and Anticoagulant Drugs?","volume":"42","year":"2022","journal-title":"H\u00e4mostaseologie"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/cvr\/cvz313","article-title":"PCSK9 and inflammation: Role of shear stress, pro-inflammatory cytokines and LOX-1 4","volume":"116","author":"Ding","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/eurjpc\/zwac034","article-title":"Time has come to develop routine exercise training interventions in patients with chronic coronary syndrome","volume":"29","author":"Urbinati","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"e000697","DOI":"10.1161\/JAHA.113.000697","article-title":"Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease","volume":"3","author":"Armstrong","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Li, J., Centurion, F., Chen, R., and Gu, Z. (2023). Intravascular Imaging of Atherosclerosis by Using Engineered Nanoparticles. Biosensors, 13.","DOI":"10.3390\/bios13030319"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2110660","DOI":"10.1002\/adma.202110660","article-title":"Targeting the Microenvironment of Vulnerable Atherosclerotic Plaques: An Emerging Diagnosis and Therapy Strategy for Atherosclerosis","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Luo, T., Zhang, Z., Xu, J., Liu, H., Cai, L., Huang, G., Wang, C., Chen, Y., Xia, L., and Ding, X. (2023). Atherosclerosis treatment with nanoagent: Potential targets, stimulus signals and drug delivery mechanisms. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1205751"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Tang, D., Wang, Y., Wijaya, A., Liu, B., Maruf, A., Wang, J., Xu, J., Liao, X., Wu, W., and Wang, G. (2021). ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis. Regen. Biomater., 8.","DOI":"10.1093\/rb\/rbab033"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.2174\/1389557522666220330152145","article-title":"Advances and Applications of Metal-Organic Framework Nanomaterials as Oral Delivery Carriers: A Review","volume":"22","author":"Li","year":"2022","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_220","first-page":"121445","article-title":"A review of carbon nanomaterials\/bacterial cellulose composites for nanomedicine applications","volume":"323","author":"Yingyu","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Zong, C., Bronckaers, A., Willems, G., He, H., and Cadenas de Llano-P\u00e9rula, M. (2023). Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14060290"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/919\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:12:34Z","timestamp":1760109154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/7\/919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":221,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ph17070919"],"URL":"https:\/\/doi.org\/10.3390\/ph17070919","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]}}}