{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:59:05Z","timestamp":1768442345487,"version":"3.49.0"},"reference-count":74,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"publisher","award":["RS-2023-0028575"],"award-info":[{"award-number":["RS-2023-0028575"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The incidence of cardiovascular diseases, such as high blood pressure, is increasing worldwide, owing to population aging and irregular lifestyle habits. Previous studies have reported the vasorelaxant effects of Prunus yedoensis bark methanol extract. However, various solvent extracts of P. yedoensis bark and their vascular relaxation mechanisms have not been sufficiently studied. We prepared extracts of P. yedoensis bark using various solvents (water, 30% ethanol, and 70% ethanol). P. yedoensis bark 30% ethanol extract (PYB-30E) decreased the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin in human umbilical vein endothelial cells (HUVECs) activated with 200 ng\/mL TNF-\u03b1. Additionally, PYB-30E showed vasodilatory effects on isolated rat aortic rings. This was confirmed to be the result of the activation of the NO\/cGMP pathway, regulation of non-selective calcium-activated K+ channels, and calcium channel blockade. Additionally, PYB-30E significantly reduced systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR). Taken together, our results indicated that PYB-30E is a candidate functional material with preventive and therapeutic effects against hypertension.<\/jats:p>","DOI":"10.3390\/ph17070926","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T16:23:41Z","timestamp":1720801421000},"page":"926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prunus yedoensis Bark Downregulates the Expression of Cell Adhesion Molecules in Human Endothelial Cell Lines and Relaxes Blood Vessels in Rat Aortic Rings"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-248X","authenticated-orcid":false,"given":"Ye Eun","family":"Choi","sequence":"first","affiliation":[{"name":"Haram Central Research Institute, Cheongju 28160, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Haram Central Research Institute, Cheongju 28160, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Haram Central Research Institute, Cheongju 28160, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5583-473X","authenticated-orcid":false,"given":"Sujin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5958-4944","authenticated-orcid":false,"given":"Junkyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-9480","authenticated-orcid":false,"given":"Kyungjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Haram Central Research Institute, Cheongju 28160, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.HYP.36.3.312","article-title":"Structure and Mechanical Properties of Resistance Arteries in Hypertension: Role of Adhesion Molecules and Extracellular Matrix Determinants","volume":"36","author":"Intengan","year":"2000","journal-title":"Hypertension"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/01.ASN.0000132474.50966.DA","article-title":"Endothelial Dysfunction","volume":"15","author":"Endemann","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global Burden of Hypertension: Analysis of Worldwide Data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","article-title":"Status of Hypertension in China: Results from the China Hypertension Survey, 2012\u20132015","volume":"137","author":"Wang","year":"2018","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.jacc.2020.04.038","article-title":"Association of Age of Onset of Hypertension with Cardiovascular Diseases and Mortality","volume":"75","author":"Wang","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/bs.apha.2016.08.001","article-title":"Vascular Cells in Blood Vessel Wall Development and Disease","volume":"78","author":"Mazurek","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_7","first-page":"3527","article-title":"Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders. Blood","volume":"91","author":"Cines","year":"1998","journal-title":"J. Am. Soc. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1097\/HJH.0000000000000237","article-title":"Arterial Stiffness and Hypertension in a Large Population of Untreated Individuals: The Rotterdam Study","volume":"32","author":"Verwoert","year":"2014","journal-title":"J. Hypertens"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40885-018-0104-6","article-title":"Adverse Effects and Non-Adherence to Antihypertensive Medications in University of Gondar Comprehensive Specialized Hospital","volume":"25","author":"Gebreyohannes","year":"2019","journal-title":"Clin. Hypertens."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"n189","DOI":"10.1136\/bmj.n189","article-title":"Association between Antihypertensive Treatment and Adverse Events: Systematic Review and Meta-Analysis","volume":"372","author":"Albasri","year":"2021","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/03071375.1999.9747253","article-title":"The Urban Forest of Tokyo","volume":"23","author":"Cheng","year":"1999","journal-title":"Arboric. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.scienta.2007.06.005","article-title":"Characterization of Wild Prunus Yedoensis Analyzed by Inter-Simple Sequence Repeat and Chloroplast DNA","volume":"114","author":"Roh","year":"2007","journal-title":"Sci. Hortic."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1266\/jjg.70.185","article-title":"DNA Fingerprinting Study on the Intraspecific Variation and the Origin of Prunus Yedoensis (Someiyoshino)","volume":"70","author":"Innan","year":"1995","journal-title":"Jpn. J. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.7783\/KJMCS.2012.20.3.159","article-title":"Comparison of the Physiological Activities of Extracts from Different Parts of Prunus Sargentii","volume":"20","author":"Yang","year":"2012","journal-title":"Korean J. Med. Crop Sci."},{"key":"ref_15","unstructured":"Ahn, D.K. (1998). Illustrated Book of Korean Medicinal Herbs, Kyo-hak Publishing Co."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.fct.2013.03.039","article-title":"Anti-Inflammatory Effect of Prunetin Via the Suppression of NF-\u03baB Pathway","volume":"58","author":"Yang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1021\/np100874f","article-title":"Secondary Metabolites from the Roots of Neolitsea Daibuensis and their Anti-Inflammatory Activity","volume":"74","author":"Wong","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.bcp.2013.02.020","article-title":"Molecular Mechanisms Underlying the Anti-Obesity Potential of Prunetin, an O-Methylated Isoflavone","volume":"85","author":"Ahn","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jnutbio.2015.07.021","article-title":"Prunetin Signals Via G-Protein-Coupled Receptor, GPR30 (GPER1): Stimulation of Adenylyl Cyclase and cAMP-Mediated Activation of MAPK Signaling Induces Runx2 Expression in Osteoblasts to Promote Bone Regeneration","volume":"26","author":"Khan","year":"2015","journal-title":"Jounal Nutr. Biochem."},{"key":"ref_20","first-page":"164","article-title":"Vasorelaxant Constituents of the Leaves of Prunus Serotina \u201ccapul\u00edn\u201d","volume":"37","author":"Rojas","year":"2009","journal-title":"Rev. Latinoam. Quim"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Luna-V\u00e1zquez, F.J., Ibarra-Alvarado, C., Rojas-Molina, A., Romo-Mancillas, A., L\u00f3pez-Vallejo, F.H., Sol\u00eds-Guti\u00e9rrez, M., Rojas-Molina, J.I., and Rivero-Cruz, F. (2016). Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus Serotina Fruits. Molecules, 21.","DOI":"10.3390\/molecules21010078"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jo, C., Kim, B., Lee, S., Ham, I., Lee, K., and Choi, H. (2019). Vasorelaxant Effect of Prunus Mume (Siebold) Siebold & Zucc. Branch through the Endothelium-Dependent Pathway. Molecules, 24.","DOI":"10.3390\/molecules24183340"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jo, C., Kim, B., Lee, K., and Choi, H. (2023). Vascular Relaxation and Blood Pressure Lowering Effects of Prunus Mume in Rats. Bioengineering, 10.","DOI":"10.3390\/bioengineering10010074"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kim, B., Jo, C., Choi, H., and Lee, K. (2018). Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels. Molecules, 23.","DOI":"10.3390\/molecules23092372"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lee, K., Ham, I., Yang, G., Lee, M., Bu, Y., Kim, H., and Choi, H. (2013). Vasorelaxant Effect of Prunus yedoensis Bark. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-31"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.3390\/ijms150711324","article-title":"Endothelial Dysfunction in Chronic Inflammatory Diseases","volume":"15","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"II","DOI":"10.1161\/01.CIR.0000129501.88485.1f","article-title":"Endothelial Function: A Critical Determinant in Atherosclerosis?","volume":"109","author":"Landmesser","year":"2004","journal-title":"Circulation"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1040-8428(03)00117-3","article-title":"Inherited Bleeding Disorders: Disorders of Platelet Adhesion and Aggregation","volume":"49","author":"Ramasamy","year":"2004","journal-title":"Crit. Revies Oncol.\/Hematol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1172\/JCI60229","article-title":"New Insights into the Mechanisms of Venous Thrombosis","volume":"122","author":"Mackman","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_30","first-page":"II","article-title":"Biology of the Endothelium","volume":"20","author":"Barton","year":"1997","journal-title":"Clin. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1096\/fasebj.7.2.7680013","article-title":"Intracellular Cyclic GMP Receptor Proteins","volume":"7","author":"Lincoln","year":"1993","journal-title":"FASEB J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.96.26.14753","article-title":"A Molecular Basis for Nitric Oxide Sensing by Soluble Guanylate Cyclase","volume":"96","author":"Zhao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","first-page":"625","article-title":"Multiple Signalling Options for Prostacyclin","volume":"24","author":"Wise","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10739680590896072","article-title":"Potassium Channels in the Peripheral Microcirculation","volume":"12","author":"Jackson","year":"2005","journal-title":"Microcirculation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/01.HYP.35.1.173","article-title":"Ion Channels and Vascular Tone","volume":"35","author":"Jackson","year":"2000","journal-title":"Hypertension"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"C799","DOI":"10.1152\/ajpcell.1995.268.4.C799","article-title":"Physiological Roles and Properties of Potassium Channels in Arterial Smooth Muscle","volume":"268","author":"Nelson","year":"1995","journal-title":"American J. Physiol.-Cell Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/01.RES.0000180663.42594.aa","article-title":"Sarco\/Endoplasmic Reticulum Ca2-ATPase Gene Transfer Reduces Vascular Smooth Muscle Cell Proliferation and Neointima Formation in the Rat","volume":"97","author":"Lipskaia","year":"2005","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/351233a0","article-title":"Isolation of a cDNA Encoding the Vascular Type-1 Angiotensin II Receptor","volume":"351","author":"Murphy","year":"1991","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0026-2862(85)90032-9","article-title":"Rarefication of the Arterioles and Capillary Network in the Brain of Rats with Different Forms of Hypertension","volume":"30","author":"Sokolova","year":"1985","journal-title":"Microvasc. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"H1534","DOI":"10.1152\/ajpheart.00742.2005","article-title":"Respective Contribution of Age, Mean Arterial Pressure, and Body Weight on Central Arterial Distensibility in SHR","volume":"290","author":"Labat","year":"2006","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/jmf.2013.2825","article-title":"Prunus Yedoensis Bark Inhibits Lipopolysaccharide-Induced Inflammatory Cytokine Synthesis by I\u03baB\u03b1 Degradation and MAPK Activation in Macrophages","volume":"17","author":"Yun","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"937904","DOI":"10.1155\/2015\/937904","article-title":"The Anti-Inflammatory Effect of Prunus Yedoensis Bark Extract on Adipose Tissue in Diet-Induced Obese Mice","volume":"2015","author":"Kang","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/1054-8807(92)90005-9","article-title":"The Role of Endothelial Cell Adhesion Molecules in the Development of Atherosclerosis","volume":"1","author":"Berman","year":"1992","journal-title":"Cardiovasc. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Sun, H., Wu, Z., Nie, X., and Bian, J. (2020). Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link between Inflammation and Hydrogen Sulfide. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01568"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0016-5085(99)70070-3","article-title":"VCAM-1 and ICAM-1 Mediate Leukocyte-Endothelial Cell Adhesion in Rat Experimental Colitis","volume":"116","author":"Sans","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrcardio.2009.228","article-title":"Monocytes in Atherosclerosis: Subsets and Functions","volume":"7","author":"Woollard","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lino, D., Freitas, I.A., Meneses, G.C., Martins, A., Daher, E.F., Rocha, J., and Silva Junior, G.B. (2019). Interleukin-6 and Adhesion Molecules VCAM-1 and ICAM-1 as Biomarkers of Post-Acute Myocardial Infarction Heart Failure. Braz. J. Med. Biol. Res., 52.","DOI":"10.1590\/1414-431x20198658"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cyto.2019.01.006","article-title":"Intercellular Adhesion Molecule-1 (ICAM-1) Associates with 24-Hour Ambulatory Blood Pressure Variability in Type 2 Diabetes and Controls","volume":"116","author":"Ciobanu","year":"2019","journal-title":"Cytokine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/molecules14062167","article-title":"Effect of Extraction Solvent\/Technique on the Antioxidant Activity of Selected Medicinal Plant Extracts","volume":"14","author":"Sultana","year":"2009","journal-title":"Molecules"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Venkatesan, T., Choi, Y., and Kim, Y. (2019). Impact of Different Extraction Solvents on Phenolic Content and Antioxidant Potential of Pinus Densiflora Bark Extract. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/3520675"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"H942","DOI":"10.1152\/ajpheart.00724.2001","article-title":"Wine Polyphenols Improve Cardiovascular Remodeling and Vascular Function in NO-Deficient Hypertension","volume":"282","author":"Stvrtina","year":"2002","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00424-010-0806-4","article-title":"Nutritional Improvement of the Endothelial Control of Vascular Tone by Polyphenols: Role of NO and EDHF","volume":"459","author":"Auger","year":"2010","journal-title":"Pfl\u00fcgers Arch.-Eur. J. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1111\/j.1582-4934.2009.00891.x","article-title":"The Aortic Ring Model of Angiogenesis: A Quarter Century of Search and Discovery","volume":"13","author":"Nicosia","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kapoor, A., Chen, C.G., and Iozzo, R.V. (2020). A Simplified Aortic Ring Assay: A Useful Ex Vivo Method to Assess Biochemical and Functional Parameters of Angiogenesis. Matrix Biol. Plus, 6.","DOI":"10.1016\/j.mbplus.2020.100025"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ajh.2007.5","article-title":"Effects of an ARB on Endothelial Progenitor Cell Function and Cardiovascular Oxidation in Hypertension","volume":"21","author":"Yu","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1161\/01.CIR.0000091407.86925.7A","article-title":"Physiological Genomics of Human Arteries: Quantitative Relationship between Gene Expression and Arterial Stiffness","volume":"108","author":"Durier","year":"2003","journal-title":"Circulation"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.2741\/3000","article-title":"Nitric Oxide the Gatekeeper of Endothelial Vasomotor Control","volume":"13","author":"Feletou","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5487\/TR.2014.30.3.141","article-title":"Endothelium-Derived Relaxing Factors of Small Resistance Arteries in Hypertension","volume":"30","author":"Kang","year":"2014","journal-title":"Toxicol. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pharmthera.2009.02.006","article-title":"Prostanoids and Reactive Oxygen Species: Team Players in Endothelium-Dependent Contractions","volume":"122","author":"Tang","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Tran, N., Garcia, T., Aniqa, M., Ali, S., Ally, A., and Nauli, S.M. (2022). Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: In Physiology and in Disease States. Am. J. Biomed. Sci. Res., 15.","DOI":"10.34297\/AJBSR.2022.15.002087"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/01.HYP.0000255954.80025.34","article-title":"Mechanism of Endothelial Nitric Oxide Synthase Phosphorylation and Activation by Thrombin","volume":"49","author":"Motley","year":"2007","journal-title":"Hypertensin"},{"key":"ref_62","first-page":"469","article-title":"Prostacyclin Increases cAMP in Coronary Arteries","volume":"5","author":"Kukovetz","year":"1979","journal-title":"J. Cycl. Nucleotide Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"361s","DOI":"10.1016\/S0223-5234(23)00136-8","article-title":"Endothelium-Derived Relaxing Factors","volume":"30","author":"Vanhoutte","year":"1995","journal-title":"Eur. J. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"926968","DOI":"10.1155\/2012\/926968","article-title":"PGI2 as a Regulator of Inflammatory Diseases","volume":"2012","author":"Dorris","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000158852","article-title":"Towards an Understanding of the Mechanism of Action of Cyclic AMP and Cyclic GMP in Smooth Muscle Relaxation","volume":"28","author":"Lincoln","year":"1991","journal-title":"J. Vasc. Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Glorian, M., and Limon, I. (2013). The Role of Cyclic 3\u2032-5\u2032adenosine Monophosphate (Camp) in Differentiated and Trans-Differentiated Vascular Smooth Muscle Cells. Current Trends in Atherogenesis, BoD\u2014Books on Demand GmbH.","DOI":"10.5772\/54726"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"F505","DOI":"10.1152\/ajprenal.00052.2011","article-title":"Role of Vascular Potassium Channels in the Regulation of Renal Hemodynamics","volume":"302","author":"Sorensen","year":"2012","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.apha.2016.07.001","article-title":"Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth","volume":"78","author":"Jackson","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e12421","DOI":"10.1111\/micc.12421","article-title":"KV Channels and the Regulation of Vascular Smooth Muscle Tone","volume":"25","author":"Jackson","year":"2018","journal-title":"Microcirculation"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjp.0704468","article-title":"The Developing Relationship between Receptor-operated and Store-operated Calcium Channels in Smooth Muscle","volume":"135","author":"McFadzean","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jash.2008.09.002","article-title":"Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1","volume":"3","author":"Wynne","year":"2009","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"258S","DOI":"10.1016\/S0895-7061(01)02154-9","article-title":"Arterial Compliance to Stratify Cardiovascular Risk: More Precision in Therapeutic Decision Making","volume":"14","author":"Cohn","year":"2001","journal-title":"Am. J. Hypertens."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/13697130500330325","article-title":"Importance of controlling blood pressure","volume":"8","author":"MacGregor","year":"2005","journal-title":"Climacteric"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1524-6175.2007.08027.x","article-title":"The importance of prompt blood pressure control","volume":"10","author":"Basile","year":"2008","journal-title":"J. Clin. 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