{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:25:40Z","timestamp":1793618740514,"version":"4.5.0"},"reference-count":81,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP13268729"],"award-info":[{"award-number":["AP13268729"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from Chamaenerion latifolium L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 \u00b1 3.44 mg GAE\/g DE) and flavonoid content (24.18 \u00b1 1.06 mg QE\/g DE) compared to ChL-EtOAc. HPLC-UV-ESI\/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC50 = 21.31 \u00b1 0.65 \u03bcg\/mL and 18.13 \u00b1 0.15 \u03bcg\/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain Candida albicans. These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.<\/jats:p>","DOI":"10.3390\/ph17080996","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T15:26:53Z","timestamp":1722526013000},"page":"996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L."],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-3037","authenticated-orcid":false,"given":"Akmaral","family":"Kozhantayeva","sequence":"first","affiliation":[{"name":"Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"},{"name":"Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurgul","family":"Tursynova","sequence":"additional","affiliation":[{"name":"Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainagul","family":"Kolpek","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-4581","authenticated-orcid":false,"given":"Yelaman","family":"Aibuldinov","sequence":"additional","affiliation":[{"name":"Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arailym","family":"Tursynova","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Togzhan","family":"Mashan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhazira","family":"Mukazhanova","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of IT and Natural Sciences, East Kazakhstan University Named after S. Amanzholov, Ust-Kamenogorsk 010008, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manshuk","family":"Ibrayeva","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, The Caspian University of Technology and Engineering Named after Sh.Yessenov, Aktau 130000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3586-8248","authenticated-orcid":false,"given":"Aizhan","family":"Zeinuldina","sequence":"additional","affiliation":[{"name":"Department of General and Biological Chemistry, NJSC \u201cAstana Medical University\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Nurlybayeva","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Technology, Faculty of Technology, M.Kh. Dulaty Taraz Regional University, Taraz 080000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4434-0707","authenticated-orcid":false,"given":"Zhanar","family":"Iskakova","sequence":"additional","affiliation":[{"name":"Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"},{"name":"Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerbolat","family":"Tashenov","sequence":"additional","affiliation":[{"name":"Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"},{"name":"Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-derived natural products: A source for drug discovery and development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"AlSheikh, H.M.A., Sultan, I., Kumar, V., Rather, I.A., Al-Sheikh, H., Tasleem Jan, A., and Haq, Q.M.R. (2020). Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance. Antibiotics, 9.","DOI":"10.3390\/antibiotics9080480"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Abdallah, E.M., Alhatlani, B.Y., de Paula Menezes, R., and Martins, C.H. (2023). 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