{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:36:47Z","timestamp":1792899407689,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Icariin (ICA), one of the main active components of Herba Epimedii, is a natural prenylated flavonol glycoside that possesses a wide range of pharmacological effects, including antioxidant, antiosteoporotic, anti-aging, neuroprotective, immunomodulatory, antitumor, and aphrodisiac effects, and prevents numerous health disorders, such as cardiovascular diseases, osteoporosis, cancer, sexual dysfunction, menstrual disorders, neurodegenerative diseases, asthma, chronic inflammation, and diabetes. In the reproductive system, it has been observed that ICA may play a role in preserving fertility by regulating different signalling pathways, such as PI3K\/AKT, which improves ovarian function, and ER\u03b1\/Nrf2, which enhances testicular function and prevents ROS generation. In contrast, regulating the NF\/kB signalling pathway causes anti-inflammatory effects, reducing spontaneous abortions. In this study, we review and examine the relevant literature on the therapeutic potential of ICA in reproduction, highlight the various mechanisms of action and limitations for the therapeutic applications of ICA, and summarise and highlight the existing preclinical research on its effects on male and female reproduction.<\/jats:p>","DOI":"10.3390\/ph17091104","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:38:43Z","timestamp":1724416723000},"page":"1104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Icariin as a Treatment Proposal in Mammalian Reproduction"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-8080","authenticated-orcid":false,"given":"Manuel","family":"S\u00e1nchez-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Academic Area of Medicine, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepci\u00f3n, Tilcuautla 42160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-9524","authenticated-orcid":false,"given":"Aleli Julieta","family":"Izquierdo-Vega","sequence":"additional","affiliation":[{"name":"Academic Area of Medicine, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepci\u00f3n, Tilcuautla 42160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-6350","authenticated-orcid":false,"given":"Eduardo Osiris","family":"Madrigal-Santill\u00e1n","sequence":"additional","affiliation":[{"name":"Academic Area of Medicine, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepci\u00f3n, Tilcuautla 42160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-5969","authenticated-orcid":false,"given":"Claudia","family":"Vel\u00e1zquez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Academic Area of Pharmacy, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepci\u00f3n, Tilcuautla 42160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-3693","authenticated-orcid":false,"given":"Jeannett Alejandra","family":"Izquierdo-Vega","sequence":"additional","affiliation":[{"name":"Academic Area of Medicine, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepci\u00f3n, Tilcuautla 42160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref_1","first-page":"20","article-title":"Taxonomy of Epimedium (Berberidaceae) with Special Reference to Chinese Species","volume":"14","author":"Zhang","year":"2021","journal-title":"Chin. 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