{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:08:06Z","timestamp":1764194886787,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","award":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"],"award-info":[{"award-number":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"]}]},{"DOI":"10.13039\/501100003593","name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior Brazil)","doi-asserted-by":"publisher","award":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"],"award-info":[{"award-number":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Federal University of Mato Grosso do Sul\u2014UFMS","award":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"],"award-info":[{"award-number":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"]}]},{"name":"FUNDECT (Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul)","award":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"],"award-info":[{"award-number":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"]}]},{"name":"Federal University of Grande Dourados","award":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"],"award-info":[{"award-number":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"],"award-info":[{"award-number":["427859\/2018-2","310053\/2023-4","59\/300.112\/2015","TO 136\/2023","SIAFEM 33098","001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The decoction of Salvia lachnostachys Benth. leaves is used in Brazilian folk medicine for anti-spasmodic, antipyretic, and anxiolytic purposes. Some of the biological effects of an S. lachnostachys extract have been shown to be anti-inflammatory, anti-cancer, and antidepressant effects. In addition, this medicinal plant produces several compounds including icetexane diterpenoids, such as fruticuline A and fruticuline B. The aim of the present work was to evaluate the anti-hyperalgesic and anti-inflammatory properties of fruticuline B (FRUT B) and the ethanolic extract obtained from the leaves of S. lachnostachys (EESL) in experimental mouse models. EESL (30, 100, and 300 mg\/kg) and FRUT B (1 mg\/kg) were evaluated in articular inflammation-induced models in Swiss mice. In articular inflammation induced by Zymosan, EESL (300 mg\/kg) and FRUT B (1 mg\/kg) significantly reduced mechanical hyperalgesia (83.17% inhibition for EESL and 81.19% for FRUT B); edema (68.75% reduction for EESL and 33.66% for FRUT B); leukocyte migration (81.3% for EESSL and 92.2% for FRUT B), and nitric oxide production (88.3% for EESL and 74.4% for FRUT B). The exposure to fruticuline B significantly inhibited the edema (51.5%), mechanical (88.12%) and cold hyperalgesia (80.8%), and myeloperoxidase (MPO) (63.4%) activity 24 h after CFA injection. In the pleurisy model, FRUT B reduced 89.1% of leukocyte migration and 50.3% in nitric oxide production. Four hours after carrageenan injection, FRUT B (1 mg\/kg) diminished 89.11% of mechanical hyperalgesia, 65.8% of paw edema, and 82.12% of the response to cold hyperalgesia. In the MTT test, EESL and fruticuline B caused no cytotoxicity. The present study revealed, for the first time, the anti-arthritic and anti-nociceptive effects of FRUT B, pointing out the therapeutic potential of the species to control inflammation and nociception. Future studies are needed to evaluate other biological properties of fruticuline B and to better understand its mechanism of action.<\/jats:p>","DOI":"10.3390\/ph17091226","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:43:13Z","timestamp":1726652593000},"page":"1226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Anti-Arthritic Potential of the Ethanolic Extract of Salvia Lachnostachys Benth. Leaves and Icetexane Dinor-Diterpenoid Fruticuline B"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-9138","authenticated-orcid":false,"given":"Nat\u00e1lia de M.","family":"Balsalobre","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisangela","family":"dos Santos-Procopio","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-393X","authenticated-orcid":false,"given":"Cristhian S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Chemistry Department, Federal University of Paran\u00e1, Curitiba 81530-900, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia C.","family":"Neves","sequence":"additional","affiliation":[{"name":"Faculty of Health, Federal University of Mato Grosso do Sul, CeTroGen, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2460-0372","authenticated-orcid":false,"given":"Maria H.","family":"Verdan","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Chemistry, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-7622","authenticated-orcid":false,"given":"Saulo E.","family":"Silva-Filho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo J.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Health, Federal University of Mato Grosso do Sul, CeTroGen, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c9. A.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Chemistry Department, Federal University of Paran\u00e1, Curitiba 81530-900, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-9219","authenticated-orcid":false,"given":"C\u00e2ndida A. L.","family":"Kassuya","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41573-020-0082-8","article-title":"Kinase inhibition in autoimmunity and inflammation","volume":"20","author":"Zarrin","year":"2021","journal-title":"Nat. Rev. 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