{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:57:37Z","timestamp":1765961857060,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"],"award-info":[{"award-number":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"]}]},{"name":"Asociaci\u00f3n Espa\u00f1ola de Gastroenterolog\u00eda-Asociaci\u00f3n Espa\u00f1ola de Neurogastroenterolog\u00eda y Motilidad","award":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"],"award-info":[{"award-number":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"]}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"],"award-info":[{"award-number":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programme H2020 Proposal Preparation Support","award":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"],"award-info":[{"award-number":["PID2019-111510RB-I00","Beca AEG-ASENEM","IRCL\/2017\/78","CS20192034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Cisplatin, a common chemotherapy agent, is well known to cause severe side effects in the gastrointestinal and nervous systems due to its toxic and pro-inflammatory effects. Although pharmacological manipulation of the endocannabinoid system (ECS) can alleviate these side effects, how chemotherapy affects the ECS components in these systems remains poorly understood. Our aim was to evaluate these changes. Methods: Male Wistar rats received cisplatin (5 mg\/kg, i.p.) or saline on day 0 (D0). Immediately after, serial X-rays were taken for 24 h (D0). Body weight was recorded (D0, D1, D2 and D7) and behavioural tests were performed on D4. On D7, animals were euthanized, and gastrointestinal tissue, dorsal root ganglia (DRGs) and brain areas were collected. Expression of genes related to the ECS was assessed via Rt-PCR, while LC-MS\/MS was used to analyse endocannabinoid and related N-acylethanolamine levels in tissue and plasma. Results: Animals treated with cisplatin showed a reduction in body weight. Cisplatin reduced gastric emptying during D0 and decreased MAGL gene expression in the antrum at D7. Despite cisplatin not causing mechanical or heat sensitivity, we observed ECS alterations in the prefrontal cortex (PFC) and DRGs similar to those seen in other chronic pain conditions, including an increased CB1 gene expression in L4\/L5 DRGs and a decreased MAGL expression in PFC. Conclusions: A single dose of cisplatin (5 mg\/kg, i.p.), subnoxious, but capable of inducing acute gastrointestinal effects, caused ECS changes in both gastrointestinal and nervous systems. Modulating the ECS could alleviate or potentially prevent chemotherapy-induced toxicity.<\/jats:p>","DOI":"10.3390\/ph17101256","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T08:56:06Z","timestamp":1727168166000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Endocannabinoid System of the Nervous and Gastrointestinal Systems Changes after a Subnoxious Cisplatin Dose in Male Rats"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-2451","authenticated-orcid":false,"given":"Yolanda","family":"L\u00f3pez-Tofi\u00f1o","sequence":"first","affiliation":[{"name":"Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-3850","authenticated-orcid":false,"given":"Mary A.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, School of Medicine, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Galway Neuroscience Centre, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Centre for Pain Research, University of Galway, H91W5P7 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Bagues","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"High Performance Research Group in Experimental Pharmacology (PHARMAKOM-URJC), University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"Associated R+D+i Unit to the Institute of Medicinal Chemistry (IQM), Spanish National Research Council (CSIC), 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Boullon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, School of Medicine, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Galway Neuroscience Centre, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Centre for Pain Research, University of Galway, H91W5P7 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-8795","authenticated-orcid":false,"given":"Raquel","family":"Abalo","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"High Performance Research Group in Experimental Pharmacology (PHARMAKOM-URJC), University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"Associated R+D+i Unit to the Institute of Medicinal Chemistry (IQM), Spanish National Research Council (CSIC), 28006 Madrid, Spain"},{"name":"Working Group of Basic Sciences on Pain and Analgesia, Spanish Pain Society, 28046 Madrid, Spain"},{"name":"Working Group of Basic Sciences on Cannabinoids, Spanish Pain Society, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-2619","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Llorente-Berzal","sequence":"additional","affiliation":[{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos (URJC), 28922 Alcorc\u00f3n, Spain"},{"name":"Department of Pharmacology and Therapeutics, School of Medicine, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Galway Neuroscience Centre, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Centre for Pain Research, University of Galway, H91W5P7 Galway, Ireland"},{"name":"Department of Physiology, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-3-031-27156-4_3","article-title":"Chemotherapy","volume":"185","author":"Hossain","year":"2023","journal-title":"Cancer Treat. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/FBP.0000000000000667","article-title":"Cannabinoid Drugs against Chemotherapy-Induced Adverse Effects: Focus on Nausea\/Vomiting, Peripheral Neuropathy and Chemofog in Animal Models","volume":"33","author":"Bagues","year":"2022","journal-title":"Behav. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s40265-019-01132-x","article-title":"Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain","volume":"79","author":"Blanton","year":"2019","journal-title":"Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.critrevonc.2016.05.001","article-title":"Chemotherapy-Induced Neurotoxicity in Pediatric Solid Non-CNS Tumor Patients: An Update on Current State of Research and Recommended Future Directions","volume":"103","author":"Sleurs","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ghosh, S. (2019). Cisplatin: The First Metal Based Anticancer Drug. Bioorg. Chem., 88.","DOI":"10.1016\/j.bioorg.2019.102925"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2018.03.009","article-title":"Cisplatin-Induced Gastrointestinal Toxicity: An Update on Possible Mechanisms and on Available Gastroprotective Strategies","volume":"827","author":"Shahid","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in Cancer Therapy: Molecular Mechanisms of Action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ctrv.2006.09.006","article-title":"Molecular Mechanisms of Resistance and Toxicity Associated with Platinating Agents","volume":"33","author":"Rabik","year":"2007","journal-title":"Cancer Treat. Rev."},{"key":"ref_9","unstructured":"(2024, May 03). FDA; CDER CISplatin Injection, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/018057s092lbl.pdf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/s41467-017-01837-1","article-title":"Cisplatin Is Retained in the Cochlea Indefinitely Following Chemotherapy","volume":"8","author":"Breglio","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000521683","article-title":"Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals","volume":"107","author":"Legare","year":"2022","journal-title":"Pharmacology"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pagano, C., Navarra, G., Coppola, L., Avilia, G., Bifulco, M., and Laezza, C. (2022). Cannabinoids: Therapeutic Use in Clinical Practice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063344"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s00109-005-0698-5","article-title":"The Endocannabinoid System in the Physiology and Pathophysiology of the Gastrointestinal Tract","volume":"83","author":"Massa","year":"2005","journal-title":"J. Mol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jcmgh.2022.05.015","article-title":"Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis","volume":"14","author":"Cuddihey","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1007\/s11033-021-06366-1","article-title":"Endocannabinoid System and Its Modulation of Brain, Gut, Joint and Skin Inflammation","volume":"48","author":"Osafo","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/j.gastro.2016.04.015","article-title":"The Role of the Endocannabinoid System in the Brain-Gut Axis","volume":"151","author":"Sharkey","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lowe, H., Toyang, N., Steele, B., Bryant, J., and Ngwa, W. (2021). The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179472"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/bph.12540","article-title":"A Role for PPAR\u03b1 in the Medial Prefrontal Cortex in Formalin-Evoked Nociceptive Responding in Rats","volume":"171","author":"Okine","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/bph.14175","article-title":"Non-Endocannabinoid N-Acylethanolamines and 2-Monoacylglycerols in the Intestine","volume":"176","author":"Hansen","year":"2019","journal-title":"Pharmacol. Br. J. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.17795\/jjnpp-3559","article-title":"Effect of Acute and Chronic Administration of Carbamazepine on Cisplatin-Induced Hyperalgesia in Rats","volume":"7","author":"Nayebi","year":"2012","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1177\/1078155219901305","article-title":"Toxicity, risk factors and management of cisplatin-induced toxicity: A prospective study","volume":"26","author":"Hamdi","year":"2020","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"797-e225","DOI":"10.1111\/j.1365-2982.2010.01483.x","article-title":"Cisplatin-Induced Gastrointestinal Dysmotility Is Aggravated after Chronic Administration in the Rat. Comparison with Pica","volume":"22","author":"Cabezos","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.autneu.2008.05.004","article-title":"Radiological Study of Gastrointestinal Motor Activity after Acute Cisplatin in the Rat. Temporal Relationship with Pica","volume":"141","author":"Cabezos","year":"2008","journal-title":"Auton. Neurosci."},{"key":"ref_24","first-page":"136","article-title":"Digestive Toxicity in Cancer Treatments. Bibliographic Review. Influence on Nutritional Status","volume":"70","year":"2023","journal-title":"Endocrinol. Diabetes Nutr. (Engl. Ed.)"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40620-017-0392-z","article-title":"Cisplatin Nephrotoxicity: A Review of the Literature","volume":"31","author":"Manohar","year":"2018","journal-title":"J. Nephrol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"151341","DOI":"10.1016\/j.semnephrol.2023.151341","article-title":"Cisplatin Nephrotoxicity: Novel Insights Into Mechanisms and Preventative Strategies","volume":"42","author":"Motwani","year":"2022","journal-title":"Semin. Nephrol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e13499","DOI":"10.1111\/nmo.13499","article-title":"Alterations of Colonic Sensitivity and Gastric Dysmotility after Acute Cisplatin and Granisetron","volume":"31","author":"Uranga","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e13047","DOI":"10.1111\/nmo.13047","article-title":"Alterations in the Small Intestinal Wall and Motor Function after Repeated Cisplatin in Rat","volume":"29","author":"Uranga","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116875","DOI":"10.1016\/j.taap.2024.116875","article-title":"Ondansetron Attenuates Cisplatin-Induced Behavioral and Cognitive Impairment through Downregulation of NOD-like Receptor Inflammasome Pathway","volume":"485","author":"Hassan","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10637-019-00836-x","article-title":"Prospective, Randomized, Cross-over Pilot Study of the Effects of Rikkunshito, a Japanese Traditional Herbal Medicine, on Anorexia and Plasma-Acylated Ghrelin Levels in Lung Cancer Patients Undergoing Cisplatin-Based Chemotherapy","volume":"38","author":"Yoshiya","year":"2020","journal-title":"Investig. New Drugs"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Rapoport, B.L. (2017). Delayed Chemotherapy-Induced Nausea and Vomiting: Pathogenesis, Incidence, and Current Management. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00019"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.autneu.2006.01.008","article-title":"Signals for Nausea and Emesis: Implications for Models of Upper Gastrointestinal Diseases","volume":"125","author":"Andrews","year":"2006","journal-title":"Auton. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"R756","DOI":"10.1152\/ajpregu.00820.2007","article-title":"Chemotherapy-Induced Pica and Anorexia Are Reduced by Common Hepatic Branch Vagotomy in the Rat","volume":"294","author":"Horn","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00280-005-0179-0","article-title":"Ghrelin Alleviates Cancer Chemotherapy-Associated Dyspepsia in Rodents","volume":"58","author":"Liu","year":"2006","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sanger, G.J., and Andrews, P.L.R. (2018). A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00913"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3940(00)01691-8","article-title":"Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation","volume":"297","author":"Sugiura","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11745-016-4144-y","article-title":"Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation","volume":"51","author":"Brose","year":"2016","journal-title":"Lipids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/nmo.12668","article-title":"In Vitro and Non-Invasive in Vivo Effects of the Cannabinoid-1 Receptor Agonist AM841 on Gastrointestinal Motor Function in the Rat","volume":"27","author":"Abalo","year":"2015","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1111\/bph.13069","article-title":"AM841, a Covalent Cannabinoid Ligand, Powerfully Slows Gastrointestinal Motility in Normal and Stressed Mice in a Peripherally Restricted Manner","volume":"172","author":"Keenan","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2982.2011.01674.x","article-title":"Enteric neuropathy evoked by repeated cisplatin in the rat","volume":"23","author":"Vera","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1053\/j.gastro.2005.06.018","article-title":"Fatty Acid Amide Hydrolase Controls Mouse Intestinal Motility in Vivo","volume":"129","author":"Capasso","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.pain.2014.05.005","article-title":"Vagal Anandamide Signaling via Cannabinoid Receptor 1 Contributes to Luminal 5-HT Modulation of Visceral Nociception in Rats","volume":"155","author":"Feng","year":"2014","journal-title":"Pain"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Tofi\u00f1o, Y., Barrag\u00e1n del Caz, L.F., Ben\u00edtez-\u00c1lvarez, D., Molero-Mateo, P., Nurgali, K., Vera, G., Bag\u00fces, A., and Abalo, R. (2023). Contractility of Isolated Colonic Smooth Muscle Strips from Rats Treated with Cancer Chemotherapy: Differential Effects of Cisplatin and Vincristine. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1304609"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pbb.2013.02.008","article-title":"Characterization of Cannabinoid-Induced Relief of Neuropathic Pain in a Rat Model of Cisplatin-Induced Neuropathy","volume":"105","author":"Vera","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.phrs.2014.09.008","article-title":"JZL184 Is Anti-Hyperalgesic in a Murine Model of Cisplatin-Induced Peripheral Neuropathy","volume":"90","author":"Khasabova","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phrs.2012.10.013","article-title":"Alterations in Endocannabinoid Tone Following Chemotherapy-Induced Peripheral Neuropathy: Effects of Endocannabinoid Deactivation Inhibitors Targeting Fatty-Acid Amide Hydrolase and Monoacylglycerol Lipase in Comparison to Reference Analgesics Following Cisplatin Treatment","volume":"67","author":"Guindon","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pain.2006.06.016","article-title":"Site-Specific Increases in Peripheral Cannabinoid Receptors and Their Endogenous Ligands in a Model of Neuropathic Pain","volume":"126","author":"Mitrirattanakul","year":"2006","journal-title":"Pain"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2011.07.052","article-title":"Cannabinoids and Emotionality: A Neuroanatomical Perspective","volume":"204","author":"McLaughlin","year":"2012","journal-title":"Neuroscience"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-662-46450-2_13","article-title":"Amygdala Pain Mechanisms","volume":"227","author":"Neugebauer","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuropharm.2017.06.015","article-title":"The Cannabinoid System and Pain","volume":"124","author":"Woodhams","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1523\/JNEUROSCI.4047-15.2016","article-title":"Rescue of Impaired MGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats","volume":"36","author":"Kiritoshi","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Vuic, B., Milos, T., Tudor, L., Konjevod, M., Nikolac Perkovic, M., Jazvinscak Jembrek, M., Nedic Erjavec, G., and Svob Strac, D. (2022). Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123000"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kasatkina, L.A., Rittchen, S., and Sturm, E.M. (2021). Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115431"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"118071","DOI":"10.1016\/j.lfs.2020.118071","article-title":"Chemotherapy-Induced Cognitive Impairment (CICI): An Overview of Etiology and Pathogenesis","volume":"258","author":"Mounier","year":"2020","journal-title":"Life Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"113118","DOI":"10.1016\/j.expneurol.2019.113118","article-title":"Doxorubicin and Cisplatin Induced Cognitive Impairment: The Possible Mechanisms and Interventions","volume":"324","author":"Ongnok","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12031-015-0547-0","article-title":"Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and INOS Signaling Pathways in Hippocampus of Aged Rats","volume":"56","author":"Chtourou","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/ejn.12468","article-title":"Involvement of the Endocannabinoid System in Osteoarthritis Pain","volume":"39","author":"Bura","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000235870","article-title":"Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome Following Traumatic Injury: A Preliminary Report","volume":"43","author":"Kaufmann","year":"2009","journal-title":"Eur. Surg. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.psyneuen.2008.02.009","article-title":"Anandamide and Neutrophil Function in Patients with Fibromyalgia","volume":"33","author":"Kaufmann","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e1045","DOI":"10.1097\/PR9.0000000000001045","article-title":"Plasma and interstitial levels of endocannabinoids and N-acylethanolamines in patients with chronic widespread pain and fibromyalgia: A systematic review and meta-analysis","volume":"7","author":"Kurlyandchik","year":"2022","journal-title":"Pain Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1468-2982.2005.01031.x","article-title":"Biochemical Changes in Endocannabinoid System Are Expressed in Platelets of Female but Not Male Migraineurs","volume":"26","author":"Cupini","year":"2006","journal-title":"Cephalalgia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/luts.12501","article-title":"Serum Anandamide and Lipids Associated with Linoleic Acid Can Distinguish Interstitial Cystitis\/Bladder Pain Syndrome from Overactive Bladder: An Exploratory Study","volume":"15","author":"Torimoto","year":"2023","journal-title":"LUTS Low. Urin. Tract Symptoms"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e13961","DOI":"10.1111\/nmo.13961","article-title":"Plasma Endocannabinoids and Cannabimimetic Fatty Acid Derivatives Are Altered in Gastroparesis: A Sex- and Subtype-Dependent Observation","volume":"33","author":"Bashashati","year":"2021","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroscience.2021.11.005","article-title":"Sexually Dimorphic Expression of Fear-Conditioned Analgesia in Rats and Associated Alterations in the Endocannabinoid System in the Periaqueductal Grey","volume":"480","author":"McGowan","year":"2022","journal-title":"Neuroscience"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbr.2013.04.043","article-title":"Alterations in the Endocannabinoid System in the Rat Valproic Acid Model of Autism","volume":"249","author":"Kerr","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.expneurol.2016.06.014","article-title":"Upregulation of the cannabinoid CB2 receptor in environmental and viral inflammation-driven rat models of Parkinson\u2019s disease","volume":"283","author":"Concannon","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_67","unstructured":"Greenberg, B. (2009). Introduction to the Practice of Statistics, WH Freeman and Company. [6th ed.]."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1256\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:01:43Z","timestamp":1760112103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":67,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ph17101256"],"URL":"https:\/\/doi.org\/10.3390\/ph17101256","relation":{},"ISSN":["1424-8247"],"issn-type":[{"type":"electronic","value":"1424-8247"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}