{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:02:24Z","timestamp":1787029344088,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia in Katowice (Poland)","award":["PCN-2-010\/N\/2\/F"],"award-info":[{"award-number":["PCN-2-010\/N\/2\/F"]}]},{"name":"Medical University of Silesia in Katowice (Poland)","award":["BNW-2-104\/K\/3\/F"],"award-info":[{"award-number":["BNW-2-104\/K\/3\/F"]}]},{"name":"Medical University of Silesia in Katowice (Poland)","award":["PCN-1-021\/K\/2\/F"],"award-info":[{"award-number":["PCN-1-021\/K\/2\/F"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Increasing drugs\u2019 stability and adequately protecting them against degradation will ensure a decrease in their price and broader availability of pharmaceutical substances. This is of great importance, especially for drugs used to treat the most common diseases in the population, such as hypertension. The study examined two newly synthesized substances from the angiotensin I-converting enzyme inhibitor (ACEI) group as potential drugs. ACEIs are among the leading drugs used in the treatment of hypertension in the world. The chemical modifications of the tested substances applied concerned the places most susceptible to degradation. The presented work analyzed the compatibility of new derivatives with selected excipients used in pharmacy. Methods: Thermogravimetric (TGA) and differential thermal analyses (c-DTA) were used as the main methods. In addition, non-thermal methods such as colorimetry analysis, Fourier-transform infrared (FTIR) and UV spectroscopy were used. Results: Based on the conducted studies, it can be concluded that the incompatibility of IND-1 with glucose anhydrous and lactose monohydrate occurs only when the mixture is stored at higher temperatures. For the remaining IND-1 and IND-2 mixtures with excipients, compatibility was demonstrated. Conclusions: The obtained results confirmed the usefulness of the applied thermal analyses (TGA and c-DTA) for assessing the compatibility of the tested potential drugs with excipients. However, in the case of incompatibility reactions of substances occurring under the influence of elevated temperatures, such as the Maillard reaction, it is necessary to use non-thermal methods to obtain the right result.<\/jats:p>","DOI":"10.3390\/ph17101323","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T03:26:36Z","timestamp":1728012396000},"page":"1323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thermal Compatibility of New ACEI Derivatives with Popular Excipients Used to Produce Solid Pharmaceutical Formulations"],"prefix":"10.3390","volume":"17","author":[{"given":"Mateusz","family":"Broncel","sequence":"first","affiliation":[{"name":"Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"},{"name":"Doctoral School, Medical University of Silesia, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Juszczak","sequence":"additional","affiliation":[{"name":"Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-4626","authenticated-orcid":false,"given":"Wojciech","family":"Szczolko","sequence":"additional","affiliation":[{"name":"Chair and Department of Chemical Technology of Drug, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Stdentsk\u00e1 2, 460 01 Liberec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-6424","authenticated-orcid":false,"given":"Agnieszka","family":"Bia\u0142ek-Dratwa","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia, Jordana 19, 41-808 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-8269","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"Wac\u0142awek","sequence":"additional","affiliation":[{"name":"Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Stdentsk\u00e1 2, 460 01 Liberec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia, Jordana 19, 41-808 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-6002","authenticated-orcid":false,"given":"Pawe\u0142","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref_1","unstructured":"Sznitowska, M. (2017). Farmacja Stosowana, PZWL."},{"key":"ref_2","unstructured":"Kostowski, W., and Herman, Z.S. (2016). Farmakologia, PZWL."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archinte.163.9.1069","article-title":"Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease","volume":"163","author":"Tzourio","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: Results from the Cardiovascular Health Study","volume":"169","author":"Sink","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_5","first-page":"233","article-title":"Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method","volume":"76","author":"Juszczak","year":"2019","journal-title":"Acta Pol. Pharm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15406\/ppij.2020.08.00276","article-title":"Evaluation of antioxidant properties of angiotensin-converting enzyme inhibitors-interactions with free radicals model examined by EPR spectroscopy","volume":"8","author":"Juszczak","year":"2020","journal-title":"Pharm. Pharmacol. Int. J."},{"key":"ref_7","unstructured":"Janiec, W. (2022). Farmakodynamika, PZWL."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11095-018-2465-7","article-title":"Valvejet Technology for the Production of a Personalised Fixed Dose Combination of Ramipril and Glimepiride: An Investigative Study on the Stability of Ramipril","volume":"35","author":"Kollamaram","year":"2018","journal-title":"Pharm. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11144-013-0558-1","article-title":"Cilazapril decomposition kinetics and mechanism in the solid state versus stability of the other ester pro-drug angiotensin converting enzyme inhibitors","volume":"109","author":"Paszun","year":"2013","journal-title":"React. Kinet. Mech. Catal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0731-7085(02)00325-4","article-title":"Evaluation of stability of enalapril maleate in solid phase","volume":"31","author":"Stanisz","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_11","first-page":"91","article-title":"The influence of relative humidity and temperature on stability of moexipril hydrochloride in solid phase","volume":"61","author":"Stanisz","year":"2004","journal-title":"Acta Polon. Pharm."},{"key":"ref_12","first-page":"10","article-title":"The excipients used in the non-coated tablests\u2014A review","volume":"102","author":"Polski","year":"2014","journal-title":"Med. Int. Revuo."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejps.2015.12.018","article-title":"Pharmaceutical excipients\u2014Quality, regulatory and biopharmaceutical considerations","volume":"87","author":"Elder","year":"2016","journal-title":"Eur. J. Pharm. Scien."},{"key":"ref_14","first-page":"3","article-title":"Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: A comprehensive review","volume":"1","author":"Bharate","year":"2010","journal-title":"J. Excip. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11027","DOI":"10.1021\/ja105148g","article-title":"Asymmetric Suzuki cross-couplings of activated secondary alkyl electrophiles: Arylations of racemic alpha-chloroamides","volume":"132","author":"Lundin","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1021\/acs.orglett.2c00121","article-title":"Photoassisted cross-coupling reaction of \u03b1-chlorocarbonyl compounds with arylboronic acids","volume":"24","author":"Oku","year":"2022","journal-title":"Org. Lett."},{"key":"ref_17","unstructured":"Rowe, R.C., Sheskey, P.J., and Quinn, M.E. (2009). Habdbook of Pharmaceutical Excipients, Pharmaceutical Press. [6th ed.]."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.31925\/farmacia.2021.3.22","article-title":"Compatibility studies of selected mucolytic drugs with excipients used in solid dosage forms: Thermogravimetry analysis","volume":"69","author":"Ramos","year":"2021","journal-title":"Farmacia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.31925\/farmacia.2022.3.6","article-title":"Thermal compatibility assessment of selected excipients used in the oral anti-cancer formulation containing busulfan","volume":"70","author":"Ramos","year":"2022","journal-title":"Farmacia"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kurek-G\u00f3recka, A., Ramos, P., K\u0142\u00f3sek, M., Bobela, E., Czuba, Z.P., Balwierz, R., and Olczyk, P. (2023). Propolis as a cariostatic agent in lozenges and impact of storage conditions on the stability of propolis. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061768"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1007\/s10973-023-12029-z","article-title":"Thermal analysis, antimicrobial and antioxidant studies of thiosemicarbazone derivatives","volume":"2023","author":"Pitucha","year":"2023","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s10973-018-7146-6","article-title":"Thermal and spectroscopic studies of 2,3,5-trisubstituted and 1,2,3,5-tetrassubstituted indoles as non-competitive antagonists of GluK1\/GluK2 receptors","volume":"133","author":"Bartyzel","year":"2018","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/19476337.2011.639960","article-title":"Towards an improved calorimetric methodology for glass transition temperature determination in amorphous sugars","volume":"10","author":"EsneiderAlcala","year":"2012","journal-title":"CyTA\u2014J. Food"},{"key":"ref_24","first-page":"1","article-title":"Non-isothermal dehydration kinetics of glucose monohydrate, maltose monohydrate and trehalose dihydrate by thermal analysis and DSC-FTIR study","volume":"1","author":"HongLiang","year":"2018","journal-title":"J. Biomed. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Hayashi, S., Xu, W., Wu, Z., Tanaka, S., Sun, S., Zhang, M., Kanayama, K., and Umemura, K. (2018). A Novel EcoFriendly Wood Adhesive Composed by Sucrose and Ammonium Dihydrogen Phosphate. Polymers, 10.","DOI":"10.3390\/polym10111251"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1021\/ef500940q","article-title":"Kinetic study on non-isothermal pyrolysis of sucrose biomass","volume":"28","author":"Wang","year":"2014","journal-title":"Energy Fuels"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.31925\/farmacia.2021.3.11","article-title":"Applying the principles of quality by design (QbD) coupled with multivariate data analysis (MVDA) in establishing the impact of raw material variability for extended release tablets","volume":"69","author":"Ilyes","year":"2021","journal-title":"Farmacia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s10973-013-3050-2","article-title":"Application of thermal analysis to the study of antituberculosis drugs\u2013excipient compatibility","volume":"115","author":"Lavor","year":"2014","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1051\/dst:2008027","article-title":"Thermal analysis of amorphous lactose and \u03b1-lactose monohydrate","volume":"89","author":"Listiohadi","year":"2009","journal-title":"Dairy. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"582913","DOI":"10.1155\/2014\/582913","article-title":"The effect of chemical and high-pressure homogenization treatment conditions on the morphology of cellulose nanoparticles","volume":"2014","author":"Suxia","year":"2014","journal-title":"J. Nanomat."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.17576\/mjas-2016-2005-17","article-title":"Thermal characteristics of microcrystalline cellulose from oil palm biomass","volume":"20","author":"Kuthi","year":"2016","journal-title":"Malaysian J. Analyt. Sci."},{"key":"ref_32","first-page":"42","article-title":"Thermal stability of carboxymethyl chitosan varying the degree of substitution","volume":"3","author":"Katugampola","year":"2014","journal-title":"Int. J. Pharm. Sci. Invent."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/BF03218428","article-title":"A kinetic study of thermal degradations of chitosan\/polycaprolactam blends","volume":"12","author":"Liao","year":"2004","journal-title":"Macromolec. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijbiomac.2017.01.033","article-title":"Structural features and thermal property of propionylated starches with different amylose\/amylopectin ratio","volume":"97","author":"Zhu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.24425\/afe.2019.129624","article-title":"Study of thermal degradation of starch-based binder by TG-DTG-DSC Py-GC\/MS and DRIFTS","volume":"19","author":"Kaczmarska","year":"2019","journal-title":"Arch. Found. Engine."},{"key":"ref_36","first-page":"443","article-title":"Application of thermal analysis to study the compatibility of sodium diclofenac with different pharmaceutical excipients","volume":"62","author":"Bandur","year":"2011","journal-title":"Rev. Chim."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1752-153X-7-140","article-title":"Thermal behaviour of procaine and benzocaine Part II: Compatibility study with some pharmaceutical excipients used in solid dosage forms","volume":"7","author":"Vlase","year":"2013","journal-title":"Chem. Cent. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10973-013-3070-y","article-title":"Thermogravimetric detection of incompatibilities between atenolol and excipients using multivariate techniques","volume":"113","author":"Rojek","year":"2013","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10973-016-5441-7","article-title":"Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis","volume":"127","author":"Rojek","year":"2017","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sip, S., Paczkowska-Walendowska, M., Rosiak, N., Miklaszewski, A., Graba\u0144ska-Marty\u0144ska, K., Samarzewska, K., and Cielecka-Piontek, J. (2021). Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems. Pharmaceuticals, 14.","DOI":"10.3390\/ph14080712"},{"key":"ref_41","first-page":"227","article-title":"Evaluation of chitosan used as an excipient in tablet formulations","volume":"56","author":"Kepsutlu","year":"1999","journal-title":"Acta Pol. Pharm."},{"key":"ref_42","first-page":"619","article-title":"Potential aspects of chitosan as pharmaceutical excipient","volume":"68","author":"Ray","year":"2011","journal-title":"Acta Pol. Pharm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.yrtph.2009.09.015","article-title":"The safety of chitosan as a pharmaceutical excipient","volume":"56","author":"Baldrick","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.17268\/sci.agropecu.2016.01.02","article-title":"Kinetics of color development in glucose\/amino acid model systems at different temperatures","volume":"7","author":"Ibarz","year":"2016","journal-title":"Sci. Agropecu."},{"key":"ref_45","first-page":"331","article-title":"Application of instrumental colour measurement in development and quality control of drugs and pharmaceutical excipients","volume":"63","author":"Subert","year":"2008","journal-title":"Die Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"MacDougall, D.B., and Mirjana Granov, M. (2005). Relationship between Ultraviolet and Visible Spectra in Maillard Reactions and CIELAB Colour Space and Visual Appearance. Woodhead Publishing Series in Food Science, Technology and Nutrition, Woodhead Publishing.","DOI":"10.1533\/9781845698447.4.160"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1021\/acs.iecr.1c00026","article-title":"Color Development Kinetics of Maillard Reactions","volume":"60","author":"Sun","year":"2021","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_48","first-page":"119","article-title":"Kinetics of color development of melanoidins formed from fructose\/amino acid model systems","volume":"20","author":"Ibarz","year":"2013","journal-title":"Food Sci. Tech. Intern."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3746\/pnf.2017.22.1.37","article-title":"Optimization of Maillard Reaction in Model System of Glucosamine and Cysteine Using Response Surface Methodology","volume":"22","author":"Arachchi","year":"2017","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sakiroff, L.M., Chennell, P., Yessaad, M., Pereira, B., Bouattour, Y., and Sautou, V. (2022). Evaluation of color changes during stability studies using spectrophotometric chromaticity measurements versus visual examination. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-13025-3"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Golonka, I., Wilk, S., and Musia\u0142, W. (2020). The influence of UV radiation on the degradation of pharmaceutical formulations containing quercetin. Molecules, 25.","DOI":"10.3390\/molecules25225454"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s41664-020-00146-9","article-title":"UV spectroscopic method for optimization and determination of glibenclamide in bulk, pharmaceutical dosage form and its application for in vitro interaction studies","volume":"4","author":"Akhtar","year":"2020","journal-title":"J. Anal. Test."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kukulski, T., Wac\u0142awek, S., Silvestri, D., Krawczyk, K., Padil, V.V.T., Fryczkowski, R., Janicki, J., and \u010cern\u00edk, M. (2020). A Polymeric Composite Material (rGO\/PANI) for Acid Blue 129 Adsorption. Polymers, 12.","DOI":"10.3390\/polym12051051"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1021\/acs.analchem.7b00242","article-title":"Facile Preparation of Titanium(IV)-Immobilized Hierarchically Porous Hybrid Monoliths","volume":"89","author":"Zhang","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"115806","DOI":"10.1016\/j.carbpol.2019.115806","article-title":"Synthesis of Ag Nanoparticles by a Chitosan-Poly(3-Hydroxybutyrate) Polymer Conjugate and Their Superb Catalytic Activity","volume":"232","author":"Silvestri","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Silvestri, D., Wac\u0142awek, S.K., Ramakrishnan, R., Venkateshaiah, A., Krawczyk, K., Padil, V.V.T., Sobel, B., and \u010cern\u00edk, M. (2019). The Use of a Biopolymer Conjugate for an Eco-Friendly One-Pot Synthesis of Palladium-Platinum Alloys. Polymers, 11.","DOI":"10.3390\/polym11121948"},{"key":"ref_57","unstructured":"ICH (2003). ICH Harmonised Tripartite Guideline: Stability Testing of New Drug Substances and Products, Q1A (R2), ICH."},{"key":"ref_58","first-page":"1667","article-title":"Brownikg assessment methods and polyphenol oxidase in UV-C irradiated Berangan banana fruit","volume":"21","author":"Ding","year":"2014","journal-title":"Intern. Food Res. J."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1323\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:10:14Z","timestamp":1760112614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ph17101323"],"URL":"https:\/\/doi.org\/10.3390\/ph17101323","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}