{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:59:11Z","timestamp":1792202351221,"version":"4.4.0"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2020R1A2C1004131"],"award-info":[{"award-number":["NRF-2020R1A2C1004131"]}]},{"name":"Chungnam National University","award":["NRF-2020R1A2C1004131"],"award-info":[{"award-number":["NRF-2020R1A2C1004131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: This study aims to explore the protective role of JB-V-60\u2014a novel synthetic derivative of decur-sin\u2014against lipopolysaccharide (LPS)-induced inflammation. Methods: We examined the effects of JB-V-60 on heme oxygenase (HO)-1, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) in LPS-activated human pulmonary artery endothelial cells (HPAECs). Additionally, we assessed its effects on iNOS, tumor necrosis factor (TNF)-\u03b1, and interleukin (IL)-1\u03b2 in LPS-exposed mice. Results: JB-V-60 enhanced HO-1 levels, inhibited NF-\u03baB activation, reduced COX-2\/PGE2 and iNOS\/NO concentra-tions, and lowered phosphorylation of signal transducer and activator of transcription 1. It also promoted the translocation of Nrf2 into the nucleus, allowing its binding to antioxidant response elements and resulting in reduced IL-1\u03b2 in LPS-stimulated HPAECs. The reduction in iNOS\/NO levels by JB-V-60 was reversed when HO-1 was inhibited via RNAi. In the animal model, JB-V-60 sig-nificantly decreased iNOS expression in lung tissues and TNF-\u03b1 levels in bronchoalveolar lavage fluid. Conclusions: These findings highlight the anti-inflammatory effects of JB-V-60 and its potential as a treat-ment for inflammatory disorders.<\/jats:p>","DOI":"10.3390\/ph17101337","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T06:23:18Z","timestamp":1728282198000},"page":"1337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory Effects of Decursin Derivative against Lipopolysaccharide-Induced Inflammation"],"prefix":"10.3390","volume":"17","author":[{"given":"Jinhee","family":"Lee","sequence":"first","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-6960","authenticated-orcid":false,"given":"Jong-Beom","family":"Heo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejon 34134, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghee","family":"Cho","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Woo","family":"Ryu","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Joon","family":"Heo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejon 34134, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Young","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Beauty Science, Kwangju Women\u2019s University, Gwangju 62396, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-588X","authenticated-orcid":false,"given":"Gaewon","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Bio-Cosmetic Science, Seowon University 377-3, Musimseoro, Seowon-gu, Cheongju, Chungbuk 28674, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu-Yong","family":"Song","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejon 34134, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-9367","authenticated-orcid":false,"given":"Jong-Sup","family":"Bae","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chau, L.Y. 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