{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:30:19Z","timestamp":1780493419547,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-24-00471"],"award-info":[{"award-number":["23-24-00471"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Objectives: This study aimed to investigate the in vitro and in vivo antibacterial and cytoprotective activities of marine fungal tripeptide derivatives with cinnamic acid moiety asterripeptides A\u2013C (1\u20133). Methods: The antimicrobial and antibiofilm activities of asterripeptides A\u2013C were tested using the Staphylococcus aureus ATCC 21027 strain. Human HaCaT keratinocytes infected with S. aureus were used for the in vitro investigation of the various aspects of the influence of asterripeptides A\u2013C by lumino- and fluorospectrometry, ELISA, flow cytometry, Western blotting, and microscopy techniques. In the in vivo experiments, mice with burns and scalped S. aureus-infected wounds were used according to ethical committee resolution. Results: Asterripeptides A\u2013C (10 \u00b5M) inhibited S. aureus growth and biofilm formation. Asterripeptides A\u2013C increased the viability, proliferation, and migration of S. aureus-infected HaCaT cells and reduced the release of reactive oxygen species (ROS), NO, TNF-\u03b1, and IL-18. Asterripeptides A\u2013C protected HaCaT cells against TNF-\u03b1-induced inflammation, decreased the transcriptional level of NF-\u03baB in JB6 Cl41 cells, and increased the protein levels of Nrf2 and glutathione synthetase in HaCaT cells. More active asterripeptide C was tested in in vivo burn wounds and S. aureus-infected incised wounds. Asterripeptide C significantly enhanced wound healing, normalized cytokine levels and profiles of peripheral blood samples, and decreased S. aureus contamination of wounds and blood in mice with infected incised wounds. Conclusions: Taken together, these results confirm the dual antibacterial and Nrf2-dependent anti-inflammatory activities of asterripeptides A-C in in vitro and in vivo assays.<\/jats:p>","DOI":"10.3390\/ph17101345","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:01:54Z","timestamp":1728388914000},"page":"1345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effects of Marine Fungal Asterripeptides A\u2013C on In Vitro and In Vivo Staphylococcus aureus Skin Infection"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-5757","authenticated-orcid":false,"given":"Ekaterina A.","family":"Chingizova","sequence":"first","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-0980","authenticated-orcid":false,"given":"Ekaterina A.","family":"Yurchenko","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur R.","family":"Chingizov","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Klimovich","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-0821","authenticated-orcid":false,"given":"Evgeny A.","family":"Pislyagin","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina S.","family":"Menchinskaya","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra S.","family":"Kuzmich","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-9360","authenticated-orcid":false,"given":"Phan Thi Hoai","family":"Trinh","sequence":"additional","affiliation":[{"name":"Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Thi Duy","family":"Ngoc","sequence":"additional","affiliation":[{"name":"Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi Thanh","family":"Van","sequence":"additional","affiliation":[{"name":"Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-7713","authenticated-orcid":false,"given":"Irina V.","family":"Guzhova","sequence":"additional","affiliation":[{"name":"Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave., 4, 194064 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-4994","authenticated-orcid":false,"given":"Dmitry L.","family":"Aminin","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"},{"name":"Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-3605","authenticated-orcid":false,"given":"Anton N.","family":"Yurchenko","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"ref_1","unstructured":"WHO (2024, June 21). Global Action Plan on Antimicrobial Resistance. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241509763."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41579-019-0288-0","article-title":"The global preclinical antibacterial pipeline","volume":"18","author":"Theuretzbacher","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1524-475X.2009.00523.x","article-title":"Loss of viability and induction of apoptosis in human keratinocytes exposed to Staphylococcus aureus biofilms in vitro","volume":"17","author":"Kirker","year":"2009","journal-title":"Wound Repair. Regen."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41429-022-00504-y","article-title":"Preventative treatment with Fluorothiazinon suppressed Acinetobacter baumannii-associated septicemia in mice","volume":"75","author":"Bondareva","year":"2022","journal-title":"J. Antibiot."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Savitskii, M.V., Moskaleva, N.E., Brito, A., Zigangirova, N.A., Soloveva, A.V., Sheremet, A.B., Bondareva, N.E., Lubenec, N.L., Kuznetsov, R.M., and Samoylov, V.M. (2023). Pharmacokinetics, quorum-sensing signal molecules and tryptophan-related metabolomics of the novel anti-virulence drug Fluorothiazinon in a Pseudomonas aeruginosa-induced pneumonia murine model. J. Pharm. Biomed. Anal., 236.","DOI":"10.1016\/j.jpba.2023.115739"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11101-020-09705-5","article-title":"Antimicrobial compounds from marine fungi","volume":"20","author":"Wang","year":"2021","journal-title":"Phytochem. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"114513","DOI":"10.1016\/j.ejmech.2022.114513","article-title":"Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development","volume":"239","author":"Deng","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Youssef, F.S., Ashour, M.L., Singab, A.N.B., and Wink, M. (2019). A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance. Mar. Drugs, 17.","DOI":"10.3390\/md17100559"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.bmcl.2012.12.020","article-title":"Dipeptide cis-cyclo (Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis","volume":"23","author":"Scopel","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hafez Ghoran, S., Taktaz, F., Sousa, E., Fernandes, C., and Kijjoa, A. (2023). Peptides from marine-derived fungi: Chemistry and biological activities. Mar. Drugs, 21.","DOI":"10.3390\/md21100510"},{"key":"ref_11","first-page":"563","article-title":"Biosynthesis and biological activity of enniatins","volume":"62","author":"Firakova","year":"2007","journal-title":"Pharm. Int. J. Pharm. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mib.2019.10.008","article-title":"Antibiotics: Past, present and future","volume":"51","author":"Hutchings","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11418-023-01684-z","article-title":"Enniatins from a marine-derived fungus Fusarium sp. inhibit biofilm formation by the pathogenic fungus Candida albicans","volume":"77","author":"Sasaki","year":"2023","journal-title":"J. Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1039\/C3NP70070D","article-title":"Discovery and development of first in class antifungal caspofungin (CANCIDAS\u00ae)\u2014A case study","volume":"31","author":"Balkovec","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Girich, E.V., Rasin, A.B., Popov, R.S., Yurchenko, E.A., Chingizova, E.A., Trinh, P.T.H., Ngoc, N.T.D., Pivkin, M.V., Zhuravleva, O.I., and Yurchenko, A.N. (2022). New tripeptide derivatives asperripeptides A-C from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Mar. Drugs, 20.","DOI":"10.3390\/md20010077"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhuravleva, O.I., Chingizova, E.A., Oleinikova, G.K., Starnovskaya, S.S., Antonov, A.S., Kirichuk, N.N., Menshov, A.S., Popov, R.S., Kim, N.Y., and Berdyshev, D.V. (2023). Anthraquinone derivatives and other aromatic compounds from marine fungus Asteromyces cruciatus KMM 4696 and their effects against Staphylococcus aureus. Mar. Drugs, 21.","DOI":"10.3390\/md21080431"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dyshlovoy, S.A., Fedorov, S.N., Shubina, L.K., Kuzmich, A.S., Bokemeyer, C., Keller-von Amsberg, G., and Honecker, F. (2014). Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-kappaB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/469309"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/oxygen3040024","article-title":"The Kelch\/Nrf2 antioxidant system as a target for some marine fungal metabolites","volume":"3","author":"Yurchenko","year":"2023","journal-title":"Oxygen"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/tx0502138","article-title":"Identification of Sensor Cysteines in Human Keap1 Modified by the Cancer Chemopreventive Agent Sulforaphane","volume":"18","author":"Hong","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.ijbiomac.2020.07.160","article-title":"Carboxymethyl cellulose-based materials for infection control and wound healing: A review","volume":"164","author":"Kanikireddy","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhang, W., Liu, Y., Xuan, Y., and Zhang, S. (2022). Synthesis and applications of carboxymethyl cellulose hydrogels. Gels, 8.","DOI":"10.3390\/gels8090529"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ruwizhi, N., and Aderibigbe, B.A. (2020). Cinnamic Acid Derivatives and Their Biological Efficacy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165712"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5941\/MYCO.2011.39.4.257","article-title":"Fungal and Plant Phenylalanine Ammonia-lyase","volume":"39","author":"Hyun","year":"2011","journal-title":"Mycobiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1080\/14786419.2017.1311890","article-title":"A new cinnamic acid derivative from plant-derived endophytic fungus Pyronema sp.","volume":"31","author":"Deng","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0031-9422(00)81824-5","article-title":"Role of cinnamate in benzoate production in Penicillium brevicompactum","volume":"26","author":"Campbell","year":"1987","journal-title":"Phytochemistry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1039\/C7SC02396K","article-title":"Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi","volume":"9","author":"Li","year":"2018","journal-title":"Chem. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19292","DOI":"10.3390\/molecules191219292","article-title":"Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity","volume":"19","author":"Guzman","year":"2014","journal-title":"Molecules"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Koczurkiewicz-Adamczyk, P., Kla\u015b, K., Gunia-Krzy\u017cak, A., Piska, K., Andrysiak, K., St\u0119pniewski, J., Lasota, S., W\u00f3jcik-Pszczo\u0142a, K., Dulak, J., and Madeja, Z. (2021). Cinnamic acid derivatives as cardioprotective agents against oxidative and structural damage induced by doxorubicin. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126217"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Simaan, H., Lev, S., and Horwitz, B.A. (2019). Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00567"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wang, L., Bi, C., Cai, H., Liu, B., Zhong, X., Deng, X., Wang, T., Xiang, H., Niu, X., and Wang, D. (2015). The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01031"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/22221751.2020.1711817","article-title":"The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus","volume":"9","author":"Mu","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Taofiq, O., Gonz\u00e1lez-Param\u00e1s, A.M., Barreiro, M.F., and Ferreira, I.C.F.R. (2017). Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review. Molecules, 22.","DOI":"10.3390\/molecules22020281"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1179\/1743132812Y.0000000022","article-title":"Ozagrel for acute ischemic stroke: A meta-analysis of data from randomized controlled trials","volume":"34","author":"Zhang","year":"2012","journal-title":"Neurol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zuo, C., Yan, F., Wang, J., Zhu, Y., Luo, W., Liu, Y., Liang, W., Yu, W., Zhang, J., and Peng, D. (2024). Design, synthesis, and evaluation of the novel ozagrel\u2013paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1362857"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1073\/pnas.051632198","article-title":"Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups","volume":"98","author":"Massiah","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.14336\/AD.2018.0513","article-title":"The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1\/Nrf2\/ARE Signaling Pathway in Chronic Diseases","volume":"10","author":"Tu","year":"2019","journal-title":"Aging Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s00018-005-5163-7","article-title":"Glutathione synthetase deficiency","volume":"62","year":"2005","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"He, J., Wu, X., Huang, S., Wang, J., Niu, S., Chen, M., Zhang, G., Cai, S., Wu, J., and Hong, B. (2022). Phenolic Metabolites from a Deep-Sea-Derived Fungus Aspergillus puniceus A2 and Their Nrf2-Dependent Anti-Inflammatory Effects. Mar. Drugs, 20.","DOI":"10.3390\/md20090575"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mib.2020.02.005","article-title":"Staphylococcus aureus bloodstream infections: Pathogenesis and regulatory mechanisms","volume":"53","author":"Kwiecinski","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.chom.2013.04.006","article-title":"The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors","volume":"13","author":"Spaan","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s11094-022-02732-w","article-title":"Wound-Healing Activity and Acute and Chronic Toxicity of a Gel Based on Guanidine-Containing Pectin Derivatives","volume":"56","author":"Akhmedov","year":"2022","journal-title":"Pharm. Chem. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/9780470559277.ch100115","article-title":"High-throughput assessment of bacterial growth inhibition by optical density measurements","volume":"2","author":"Campbell","year":"2010","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ja.2016.10","article-title":"Antimicrobial potency of single and combined mupirocin and monoterpenes, thymol, menthol and 1, 8-cineole against Staphylococcus aureus planktonic and biofilm growth","volume":"69","author":"Kifer","year":"2016","journal-title":"J. Antibiot."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kozlovskiy, S.A., Pislyagin, E.A., Menchinskaya, E.S., Chingizova, E.A., Sabutski, Y.E., Polonik, S.G., Likhatskaya, G.N., and Aminin, D.L. (2023). Anti-inflammatory activity of 1,4-naphthoquinones blocking P2X7 purinergic receptors in RAW 264.7 macrophage cells. Toxins, 15.","DOI":"10.3390\/toxins15010047"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Girich, E.V., Trinh, P.T., Nesterenko, L.E., Popov, R.S., Kim, N.Y., Rasin, A.B., Menchinskaya, E.S., Kuzmich, A.S., Chingizova, E.A., and Minin, A.S. (2023). Absolute stereochemistry and cytotoxic effects of vismione E from marine sponge-derived fungus Aspergillus sp. 1901NT-1.2.2. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098150"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"W270","DOI":"10.1093\/nar\/gkr366","article-title":"SwissDock, a protein-small molecule docking web service based on EADock DSS","volume":"39","author":"Grosdidier","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: The biomolecular simulation program","volume":"30","author":"Brooks","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jcc.20832","article-title":"FACTS: Fast analytical continuum treatment of solvation","volume":"29","author":"Caflisch","year":"2008","journal-title":"J. Comput. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/jcc.21797","article-title":"Fast docking using the CHARMM force field with EADock DSS","volume":"32","author":"Grosdidier","year":"2011","journal-title":"J. Comput. Chem."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1345\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:09:25Z","timestamp":1760112565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ph17101345"],"URL":"https:\/\/doi.org\/10.3390\/ph17101345","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]}}}