{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:35:10Z","timestamp":1791779710817,"version":"4.3.4"},"reference-count":413,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical\u2013pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which is considered a significant cause of liver conditions and contributes to an increased risk of death worldwide. Even though the possible causes of MAFLD can involve the interaction of genetics, hormones, and nutrition, lifestyle (diet and sedentary lifestyle) is the most influential factor in developing this condition. Polyphenols comprise many natural chemical compounds that can be helpful in managing metabolic diseases. Therefore, the aim of this review was to investigate the impact of oxidative stress, inflammation, mitochondrial dysfunction, and the role of polyphenols in managing MAFLD. Some polyphenols can reverse part of the liver damage related to inflammation, oxidative stress, or mitochondrial dysfunction, and among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, and silymarin. These compounds have actions in reducing plasma liver enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, and the HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1\u03b2, IL-6, tumor necrosis factor-\u03b1 (TNF-\u03b1), blood pressure, liver fat content, steatosis index, and fibrosis. On the other hand, they can improve HDL-c, adiponectin levels, and fibrogenesis markers. These results show that polyphenols are promising in the prevention and treatment of MAFLD.<\/jats:p>","DOI":"10.3390\/ph17101354","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:34:36Z","timestamp":1728560076000},"page":"1354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols"],"prefix":"10.3390","volume":"17","author":[{"given":"Raissa Bulaty","family":"Tauil","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Takano","family":"Golono","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo Pereira","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"de Alvares Goulart","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elen Landgraf","family":"Guiguer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"},{"name":"Department of Biochemistry and Nutrition, School of Food and Technology of Mar\u00edlia (FATEC), Mar\u00edlia 17500-000, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Dib","family":"Bechara","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C. T.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Nutrition, School of Food and Technology of Mar\u00edlia (FATEC), Mar\u00edlia 17500-000, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luiz","family":"Yanaguizawa Junior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M. R.","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Nutrition, School of Food and Technology of Mar\u00edlia (FATEC), Mar\u00edlia 17500-000, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5257-8048","authenticated-orcid":false,"given":"Nahum","family":"M\u00e9ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico"},{"name":"Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-1524","authenticated-orcid":false,"given":"Ludovico","family":"Abenavoli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University \u201cMagna Graecia\u201d, Viale Europa, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-4302","authenticated-orcid":false,"given":"Rosa","family":"Direito","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Integration Pharmacology, Clinical and Regulatory Science, Research Institute for Medicines, Universidade de Lisboa (iMed.ULisboa), Av. 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(2022). Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease. Genes, 13.","DOI":"10.3390\/genes13112142"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s13679-024-00574-z","article-title":"Non-invasive Scores and Serum Biomarkers for Fatty Liver in the Era of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): A Comprehensive Review from NAFLD to MAFLD and MASLD","volume":"13","author":"Abdelhameed","year":"2024","journal-title":"Curr. Obes. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.3390\/cimb46070376","article-title":"MAFLD Pandemic: Updates in Pharmacotherapeutic Approach Development","volume":"46","author":"Khaznadar","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Carpi, R.Z., Barbalho, S.M., Sloan, K.P., Laurindo, L.F., Gonzaga, H.F., Grippa, P.C., Zutin, T.L.M., Girio, R.J.S., Repetti, C.S.F., and Detregiachi, C.R.P. (2022). The Effects of Probiotics, Prebiotics and Synbiotics in Non-Alcoholic Fat Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158805"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e33418","DOI":"10.1016\/j.heliyon.2024.e33418","article-title":"Metabolomics analyses reveal the liver-protective mechanism of Wang\u2019s metabolic formula on metabolic-associated fatty liver disease","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): A systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s12072-024-10692-4","article-title":"Epidemiology, pathophysiology and clinical aspects of Hepatocellular Carcinoma in MAFLD patients","volume":"18","author":"Argenziano","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12072-023-10620-y","article-title":"Breaking new ground: MASLD vs. MAFLD-which holds the key for risk stratification?","volume":"18","author":"Eslam","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_10","first-page":"1567","article-title":"MAFLD predicts cardiovascular disease risk better than MASLD","volume":"44","author":"Pan","year":"2024","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1007\/s12072-024-10702-5","article-title":"A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease","volume":"18","author":"Zhang","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101133","DOI":"10.1016\/j.aohep.2023.101133","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"29","author":"Rinella","year":"2024","journal-title":"Ann. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1007\/s12072-024-10662-w","article-title":"Metabolic dysfunction associated fatty liver disease in healthy weight individuals","volume":"18","author":"Brouwer","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"De C\u00f3l, J.P., de Lima, E.P., Pompeu, F.M., Cressoni Ara\u00fajo, A., de Alvares Goulart, R., Bechara, M.D., Laurindo, L.F., M\u00e9ndez-S\u00e1nchez, N., and Barbalho, S.M. (2024). Underlying Mechanisms behind the Brain-Gut-Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073694"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Barbalho, S.M., M\u00e9ndez-S\u00e1nchez, N., and Fornari Laurindo, L. (2023). AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review. Biochem. Pharmacol., 218.","DOI":"10.1016\/j.bcp.2023.115871"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S2468-1253(22)00062-0","article-title":"Global multi-stakeholder endorsement of the MAFLD definition","volume":"7","author":"Bugianesi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ecl.2023.01.001","article-title":"Pathobiology of Metabolic-Associated Fatty Liver Disease","volume":"52","author":"Fouda","year":"2023","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1002\/oby.23868","article-title":"Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD","volume":"31","author":"Soysouvanh","year":"2023","journal-title":"Obesity (Silver Spring Md.)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/MPG.0000000000003919","article-title":"Updates in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Children","volume":"77","author":"Rupasinghe","year":"2023","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Gambardella, M.L., Scarlata, G.G.M., Lenci, I., Baiocchi, L., and Luzza, F. (2024). The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation. Medicina, 60.","DOI":"10.20944\/preprints202403.0587.v1"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"de Lima, E.P., Moretti, R.C., Torres Pomini, K., Laurindo, L.F., Sloan, K.P., Sloan, L.A., Castro, M.V.M., Baldi, E., Ferraz, B.F.R., and de Souza Bastos Mazuqueli Pereira, E. (2024). Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways. Biology, 13.","DOI":"10.3390\/biology13070519"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Girotto, O.S., Furlan, O.O., Moretti Junior, R.C., Goulart, R.A., Baldi Junior, E., Barbalho-Lamas, C., Fornari Laurindo, L., and Barbalho, S.M. (2024). Effects of apples (Malus domestica) and their derivatives on metabolic conditions related to inflammation and oxidative stress and an overview of by-products use in food processing. Crit. Rev. Food Sci. Nutr., 1\u201332.","DOI":"10.1080\/10408398.2024.2372690"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Direito, R., Barbalho, S.M., Sepodes, B., and Figueira, M.E. (2024). Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention. Pharmaceutics, 16.","DOI":"10.20944\/preprints202402.0641.v1"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Silva, I.F.D., Bragante, W.R., Junior, R.C.M., Laurindo, L.F., Guiguer, E.L., Ara\u00fajo, A.C., Fiorini, A.M.R., Nicolau, C.C.T., Oshiiwa, M., and Lima, E.P. (2024). Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review. Pharmaceuticals, 17.","DOI":"10.3390\/ph17050658"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., Rodrigues, V.D., Minniti, G., de Carvalho, A.C.A., Zutin, T.L.M., DeLiberto, L.K., Bishayee, A., and Barbalho, S.M. (2024). Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome. J. Nutr. Biochem., 131.","DOI":"10.1016\/j.jnutbio.2024.109670"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Santos, J., Maio, M.C., Lemes, M.A., Laurindo, L.F., Haber, J., Bechara, M.D., Prado, P.S.D., Rauen, E.C., Costa, F., and Pereira, B.C.A. (2022). Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010498"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Xu, L., Nagata, N., and Ota, T. (2019). Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235920"},{"key":"ref_28","first-page":"155170","article-title":"Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies","volume":"123","author":"Nunes","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ruiz-Tovar, J., Llavero, C., Rodriguez-Ortega, M., De Castro, N.M., Mart\u00edn-Crespo, M.C., Escobar-Aguilar, G., Martin-Nieto, A., and Gonzalez, G. (2024). Improvement of Metabolic-Associated Fatty Liver Disease by Magnetic Resonance Spectroscopy in Morbidly Obese Women Undergoing Roux-en-Y Gastric Bypass, following a Postoperative Mediterranean-like Diet. Nutrients, 16.","DOI":"10.3390\/nu16142280"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Beygi, M., Ahi, S., Zolghadri, S., and Stanek, A. (2024). Management of Metabolic-Associated Fatty Liver Disease\/Metabolic Dysfunction-Associated Steatotic Liver Disease: From Medication Therapy to Nutritional Interventions. Nutrients, 16.","DOI":"10.3390\/nu16142220"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s12072-024-10663-9","article-title":"Lifestyle intervention for metabolic dysfunction-associated fatty liver disease: A 24-h integrated behavior perspective","volume":"18","author":"Keating","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Valotto Neto, L.J., Reverete de Araujo, M., Moretti Junior, R.C., Mendes Machado, N., Joshi, R.K., Dos Santos Buglio, D., Barbalho Lamas, C., Direito, R., Fornari Laurindo, L., and Tanaka, M. (2024). Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis. Antioxidants, 13.","DOI":"10.3390\/antiox13040393"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Minniti, G., Laurindo, L.F., Machado, N.M., Duarte, L.G., Guiguer, E.L., Araujo, A.C., Dias, J.A., Lamas, C.B., Nunes, Y.C., and Bechara, M.D. (2023). Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review. Life, 13.","DOI":"10.3390\/life13122270"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Collignon, T.E., Webber, K., Piasecki, J., Rahman, A.S.W., Mondal, A., Barbalho, S.M., and Bishayee, A. (2023). Avocado (Persea americana Mill) and its phytoconstituents: Potential for cancer prevention and intervention. Crit. Rev. Food Sci. Nutr., 1\u201321.","DOI":"10.1080\/10408398.2023.2260474"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Direito, R., Barbalho, S.M., Figueira, M.E., Minniti, G., de Carvalho, G.M., de Oliveira Zanuso, B., de Oliveira Dos Santos, A.R., de G\u00f3es Corr\u00eaa, N., Rodrigues, V.D., and de Alvares Goulart, R. (2023). Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review. Metabolites, 13.","DOI":"10.3390\/metabo13060728"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., Barbalho, S.M., Ara\u00fajo, A.C., Guiguer, E.L., Mondal, A., Bachtel, G., and Bishayee, A. (2023). A\u00e7a\u00ed (Euterpe oleracea Mart.) in Health and Disease: A Critical Review. Nutrients, 15.","DOI":"10.3390\/nu15040989"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1080\/10408398.2019.1710692","article-title":"Grape juice or wine: Which is the best option?","volume":"60","author":"Barbalho","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/87559129.2023.2168281","article-title":"Grape processing waste: Effects on inflammatory bowel disease and colorectal cancer","volume":"40","author":"Laurindo","year":"2024","journal-title":"Food Rev. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/10408398.2021.1948817","article-title":"Green coffee: Economic relevance and a systematic review of the effects on human health","volume":"63","author":"Bosso","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1089\/jmf.2018.0162","article-title":"Effects of Green and Ripe Coffee in the Metabolic Profile and Muscle Enzymes in Animals Practicing Physical Exercise","volume":"22","author":"Bosso","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Paravati, M.R., Procopio, A.C., Milanovi\u0107, M., Scarlata, G.G.M., Milo\u0161evi\u0107, N., Ru\u017ei\u0107, M., Mili\u0107, N., and Abenavoli, L. (2024). Onion Polyphenols as Multi-Target-Directed Ligands in MASLD: A Preliminary Molecular Docking Study. Nutrients, 16.","DOI":"10.20944\/preprints202402.1735.v1"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Larussa, T., Corea, A., Procopio, A.C., Boccuto, L., Dallio, M., Federico, A., and Luzza, F. (2021). Dietary Polyphenols and Non-Alcoholic Fatty Liver Disease. Nutrients, 13.","DOI":"10.3390\/nu13020494"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"100313","DOI":"10.1016\/j.fufo.2024.100313","article-title":"A Conceptual Review on Classification, Extraction, Bioactive Potential and Role of Phytochemicals in Human Health","volume":"9","author":"Goswami","year":"2024","journal-title":"Future Foods"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kung, H.C., Lin, K.J., Kung, C.T., and Lin, T.K. (2021). Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson\u2019s Disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080918"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102156","DOI":"10.1016\/j.pupt.2022.102156","article-title":"Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions","volume":"76","author":"Shafiq","year":"2022","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1089\/ars.2013.5538","article-title":"Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: The protective effects of pomegranate with its active component punicalagin","volume":"21","author":"Zou","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"ref_47","first-page":"8409329","article-title":"Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer\u2019s Disease?","volume":"2019","author":"Romeiro","year":"2019","journal-title":"Oxid Med. Cell Longev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4084566","DOI":"10.1155\/2021\/4084566","article-title":"Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways","volume":"2021","author":"Yong","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Jinato, T., Chayanupatkul, M., Dissayabutra, T., Chutaputti, A., Tangkijvanich, P., and Chuaypen, N. (2022). Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study. Nutrients, 14.","DOI":"10.3390\/nu14142921"},{"key":"ref_50","first-page":"2187564","article-title":"Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3\/iNOS pathway","volume":"28","author":"Fang","year":"2023","journal-title":"Redox Rep. Commun. Free. Radic. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Wang, X., Jin, Y., Di, C., Zeng, Y., Zhou, Y., Chen, Y., Pan, Z., Li, Z., and Ling, W. (2024). Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients, 16.","DOI":"10.3390\/nu16081169"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3350\/cmh.2024.0047","article-title":"Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against non-alcoholic fatty liver disease","volume":"30","author":"Zheng","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"118054","DOI":"10.1016\/j.jep.2024.118054","article-title":"Extract of Silphium perfoliatum L. improve lipid accumulation in NAFLD mice by regulating AMPK\/FXR signaling pathway","volume":"327","author":"Xu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhang, D., Zhou, Q., Yang, X., Zhang, Z., Wang, D., Hu, D., Huang, Y., Sheng, J., and Wang, X. (2024). Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation. Molecules, 29.","DOI":"10.3390\/molecules29091999"},{"key":"ref_55","first-page":"9067","article-title":"Tea Polyphenol Epigallocatechin Gallate Protects Against Nonalcoholic Fatty Liver Disease and Associated Endotoxemia in Rats via Modulating Gut Microbiota Dysbiosis and Alleviating Intestinal Barrier Dysfunction and Related Inflammation","volume":"72","author":"Zuo","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e3502","DOI":"10.1002\/dmrr.3502","article-title":"Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors","volume":"38","author":"Barbalho","year":"2022","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101343","DOI":"10.1016\/j.fochx.2024.101343","article-title":"Effects of rosmarinic acid esters on the oxidation kinetic of organogel and emulsion gel","volume":"22","author":"Keramat","year":"2024","journal-title":"Food Chem. X"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1111\/liv.14675","article-title":"MAFLD identifies patients with significant hepatic fibrosis better than NAFLD","volume":"40","author":"Yamamura","year":"2020","journal-title":"Liver Int."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Quetglas-Llabr\u00e9s, M.M., Monserrat-Mesquida, M., Bouzas, C., Garc\u00eda, S., Mateos, D., Casares, M., G\u00f3mez, C., Ugarriza, L., Tur, J.A., and Sureda, A. (2024). Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial. Antioxidants, 13.","DOI":"10.3390\/antiox13070754"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12933-022-01697-0","article-title":"Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention","volume":"21","author":"Zhou","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_61","first-page":"291","article-title":"Does berberine impact anthropometric, hepatic, and metabolic parameters in patients with metabolic dysfunction-associated fatty liver disease? Randomized, double-blind placebo-controlled trial","volume":"75","author":"Koperska","year":"2024","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s12072-024-10706-1","article-title":"NAFLD and MAFLD independently increase the risk of major adverse cardiovascular events (MACE): A 20-year longitudinal follow-up study from regional Australia","volume":"18","author":"Vaz","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wang, Y., Chen, Y., Xiao, X., Deng, S., Kuang, J., and Li, Y. (2024). HRD1-mediated ubiquitination of HDAC2 regulates PPAR\u03b1-mediated autophagy and alleviates metabolic-associated fatty liver disease. Biochim. Biophys. Acta Mol. Cell Res., 1871.","DOI":"10.1016\/j.bbamcr.2024.119765"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ecl.2022.02.008","article-title":"Lipid and Lipoprotein Metabolism","volume":"51","author":"Feingold","year":"2022","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Charbe, N.B., Lagos, C.F., Ortiz, C.A.V., Tambuwala, M., Palakurthi, S.S., and Zacconi, F.C. (2022). PCSK9 conjugated liposomes for targeted delivery of paclitaxel to the cancer cell: A proof-of-concept study. Biomed. Pharmacother. = Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113428"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12944-020-01273-z","article-title":"A comprehensive metabolic profiling of the metabolically healthy obesity phenotype","volume":"19","author":"Christensen","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Wang, C.H., and Wei, Y.H. (2020). Roles of Mitochondrial Sirtuins in Mitochondrial Function, Redox Homeostasis, Insulin Resistance and Type 2 Diabetes. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155266"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1021\/acs.jafc.4c00590","article-title":"Molecular Mechanisms of Fucoxanthin in Alleviating Lipid Deposition in Metabolic Associated Fatty Liver Disease","volume":"72","author":"Yang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Jin, C., Felli, E., Lange, N.F., Berzigotti, A., Gracia-Sancho, J., and Dufour, J.F. (2022). Endoplasmic Reticulum and Mitochondria Contacts Correlate with the Presence and Severity of NASH in Humans. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158348"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"111303","DOI":"10.1016\/j.cellsig.2024.111303","article-title":"Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease","volume":"121","author":"Wang","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ecl.2023.01.003","article-title":"Lipid Disorders and Metabolic-Associated Fatty Liver Disease","volume":"52","author":"Anwar","year":"2023","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"939","DOI":"10.14218\/JCTH.2022.00067","article-title":"Reactive Oxygen Species and Oxidative Stress in the Pathogenesis of MAFLD","volume":"10","author":"Clare","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lin\u021ba, A.V., Lolescu, B.M., Ilie, C.A., Vlad, M., Blidi\u0219el, A., Sturza, A., Borza, C., Muntean, D.M., and Cre\u021bu, O.M. (2024). Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137420"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chi, W.Y., Lee, G.H., Tang, M.J., Chen, B.H., Lin, W.L., and Fu, T.F. (2024). Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation. BMC Biol., 22.","DOI":"10.1186\/s12915-024-01946-6"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Mollet, I.G., and Macedo, M.P. (2023). Pre-Diabetes-Linked miRNA miR-193b-3p Targets PPARGC1A, Disrupts Metabolic Gene Expression Profile and Increases Lipid Accumulation in Hepatocytes: Relevance for MAFLD. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043875"},{"key":"ref_76","first-page":"1689","article-title":"METTL3 inhibitor STM2457 improves metabolic dysfunction-associated fatty liver disease by regulating mitochondrial function in mice","volume":"43","author":"Gao","year":"2023","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao = J. South. Med. Univ."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcdb.2020.02.012","article-title":"Tracing insights into de novo lipogenesis in liver and adipose tissues","volume":"108","author":"Wallace","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Song, Z., Xiaoli, A.M., and Yang, F. (2018). Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues. Nutrients, 10.","DOI":"10.3390\/nu10101383"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.metabol.2014.04.003","article-title":"De novo lipogenesis in health and disease","volume":"63","author":"Ameer","year":"2014","journal-title":"Metab. Clin. Exp."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109709","DOI":"10.1016\/j.isci.2024.109709","article-title":"Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis","volume":"27","author":"Talari","year":"2024","journal-title":"iScience"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Yao, W., Fan, M., Qian, H., Li, Y., and Wang, L. (2024). Quinoa Polyphenol Extract Alleviates Non-Alcoholic Fatty Liver Disease via Inhibiting Lipid Accumulation, Inflammation and Oxidative Stress. Nutrients, 16.","DOI":"10.3390\/nu16142276"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Tian, T., Zhang, J., Xie, W., Ni, Y., Fang, X., Liu, M., Peng, X., Wang, J., Dai, Y., and Zhou, Y. (2022). Dietary Quality and Relationships with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) among United States Adults, Results from NHANES 2017\u20132018. Nutrients, 14.","DOI":"10.3390\/nu14214505"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Reis-Costa, A., Belew, G.D., Viegas, I., Tavares, L.C., Meneses, M.J., Patr\u00edcio, B., Gastaldelli, A., Macedo, M.P., and Jones, J.G. (2024). The Effects of Long-Term High Fat and\/or High Sugar Feeding on Sources of Postprandial Hepatic Glycogen and Triglyceride Synthesis in Mice. Nutrients, 16.","DOI":"10.3390\/nu16142186"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Parafati, M., La Russa, D., Lascala, A., Crupi, F., Riillo, C., Fotschki, B., Mollace, V., and Janda, E. (2024). Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease. Antioxidants, 13.","DOI":"10.20944\/preprints202404.0784.v1"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"309","DOI":"10.23736\/S2724-6507.21.03460-X","article-title":"Proinflammatory profile of visceral adipose tissue and oxidative stress in severe obese patients carrying the variant rs4612666 C of NLRP3 gene","volume":"46","author":"Perri","year":"2021","journal-title":"Minerva Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s12010-022-04100-6","article-title":"Nigericin Abrogates Maternal and Embryonic Oxidative Stress in the Streptozotocin-Induced Diabetic Pregnant Rats","volume":"195","author":"Guo","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Li, Y., He, Q., Chen, S., Dli, H., Zhao, J., Sun, X., Yang, P., Mao, Q., and Xia, H. (2024). BI-7273, a BRD9 inhibitor, reduces lipid accumulation by downregulating the AKT\/mTOR\/SREBP1 signaling pathway. Biochem. Pharmacol., 226.","DOI":"10.1016\/j.bcp.2024.116412"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/s42255-021-00487-4","article-title":"Serine catabolism generates liver NADPH and supports hepatic lipogenesis","volume":"3","author":"Zhang","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/joim.13531","article-title":"Current treatment of non-alcoholic fatty liver disease","volume":"292","author":"Paternostro","year":"2022","journal-title":"J. Intern. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s42255-021-00489-2","article-title":"Peroxisomal \u03b2-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis","volume":"3","author":"Ding","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): Functional analysis of lipid metabolism pathways","volume":"136","author":"Badmus","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s12325-024-02781-5","article-title":"Artificial Intelligence in Liver Diseases: Recent Advances","volume":"41","author":"Lu","year":"2024","journal-title":"Adv. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41387-024-00261-x","article-title":"The prognostic role of diet quality in patients with MAFLD and physical activity: Data from NHANES","volume":"14","author":"Huang","year":"2024","journal-title":"Nutr. Diabetes"},{"key":"ref_94","first-page":"205","article-title":"Dietary composition and its association with metabolic dysfunction-associated fatty liver disease among Chinese adults: A cross-sectional study","volume":"25","author":"Niu","year":"2024","journal-title":"Arab. J. Gastroenterol. Off. Publ. Pan-Arab. Assoc. Gastroenterol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Ohene-Marfo, P., Nguyen, H.V.M., Mohammed, S., Thadathil, N., Tran, A., Nicklas, E.H., Wang, D., Selvarani, R., Farriester, J., and Varshney, R. (2024). Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model. Int. J. Mol. Sci., 25.","DOI":"10.1101\/2024.01.10.575102"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Xia, Q., Lu, F., Chen, Y., Li, J., Huang, Z., Fang, K., Hu, M., Guo, Y., Dong, H., and Xu, L. (2024). 6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway. Biomed. Pharmacother. = Biomed. Pharmacother., 170.","DOI":"10.1016\/j.biopha.2023.116060"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s41043-023-00485-0","article-title":"Dietary patterns and metabolic dysfunction-associated fatty liver disease in China\u2019s multi-ethnic regions","volume":"42","author":"Zhu","year":"2023","journal-title":"J. Health Popul. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"12356","DOI":"10.1021\/acs.est.3c11009","article-title":"Disinfection Byproducts of Haloacetaldehydes Disrupt Hepatic Lipid Metabolism and Induce Lipotoxicity in High-Fat Culture Conditions","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.3390\/cimb46060351","article-title":"The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation","volume":"46","author":"Kim","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/1673-5374.343891","article-title":"Adipose tissue, systematic inflammation, and neurodegenerative diseases","volume":"18","author":"Boleti","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Rahman, M.S., Hossain, K.S., Das, S., Kundu, S., Adegoke, E.O., Rahman, M.A., Hannan, M.A., Uddin, M.J., and Pang, M.G. (2021). Role of Insulin in Health and Disease: An Update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126403"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"100472","DOI":"10.1016\/j.jlr.2023.100472","article-title":"The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP\/SREBP pathway","volume":"65","author":"Huang","year":"2024","journal-title":"J. Lipid Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11739-023-03226-7","article-title":"Diet and metabolic syndrome: A narrative review","volume":"18","author":"Angelico","year":"2023","journal-title":"Intern. Emerg. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.medj.2024.03.017","article-title":"An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease","volume":"5","author":"Zhang","year":"2024","journal-title":"Med"},{"key":"ref_105","first-page":"e943417","article-title":"From Liver to Brain: How MAFLD\/MASLD Impacts Cognitive Function","volume":"30","year":"2024","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Guo, W., Ge, X., Lu, J., Xu, X., Gao, J., Wang, Q., Song, C., Zhang, Q., and Yu, C. (2022). Diet and Risk of Non-Alcoholic Fatty Liver Disease, Cirrhosis, and Liver Cancer: A Large Prospective Cohort Study in UK Biobank. Nutrients, 14.","DOI":"10.3390\/nu14245335"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12072-022-10420-w","article-title":"N-terminal propeptide of type 3 collagen-based sequential algorithm can identify high-risk steatohepatitis and fibrosis in MAFLD","volume":"17","author":"Tang","year":"2023","journal-title":"Hepatol. Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S2468-1253(23)00141-3","article-title":"Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: An individual participant data meta-analysis","volume":"8","author":"Lee","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_109","unstructured":"Kumar, A., Arora, A., Choudhury, A., Arora, V., Rela, M., Jothimani, D.K., Mahtab, M.A., Devarbhavi, H., Eapen, C.E., and Goel, A. (2024). Impact of Diabetes, Drug-Induced Liver Injury, and Sepsis on Outcomes in MAFLD-Related Acute-on-Chronic Liver Failure. Am. J. Gastroenterol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5005\/jp-journals-10018-1434","article-title":"Ursodeoxycholic Acid\u2019s Effectiveness in the Management of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis","volume":"14","author":"Patel","year":"2024","journal-title":"Euroasian J. Hepato-Gastroenterol."},{"key":"ref_111","first-page":"e62405","article-title":"Assessing Liver Fibrosis in Type 2 Diabetes Mellitus Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: The Role of Non-invasive Scoring Systems and Associated Factors","volume":"16","author":"Naskar","year":"2024","journal-title":"Cureus"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.12998\/wjcc.v12.i15.2506","article-title":"Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without non-alcoholic fatty liver","volume":"12","author":"Chen","year":"2024","journal-title":"World J. Clin. Cases"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41577-021-00639-3","article-title":"Immune cell-mediated features of non-alcoholic steatohepatitis","volume":"22","author":"Huby","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Bikbov, M.M., Gilmanshin, T.R., Zainullin, R.M., Kazakbaeva, G.M., Iakupova, E.M., Fakhretdinova, A.A., Tuliakova, A.M., Panda-Jonas, S., Gilemzianova, L.I., and Khakimov, D.A. (2022). Prevalence of non-alcoholic fatty liver disease in the Russian Ural Eye and Medical Study and the Ural Very Old Study. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-12004-y"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1210\/clinem\/dgad429","article-title":"Liver Fat, Bone Marrow Adipose Tissue, and Bone Mineral Density in Children with Overweight","volume":"109","author":"Labayen","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.amjms.2023.11.007","article-title":"Metabolic dysfunction associated steatotic liver disease: Current practice, screening guidelines and management in the primary care setting","volume":"367","author":"Gupta","year":"2024","journal-title":"Am. J. Med. Sci."},{"key":"ref_117","first-page":"528","article-title":"American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)","volume":"28","author":"Cusi","year":"2022","journal-title":"Endocr. Pract. Off. J. Am. Coll. Endocrinol. Am. Assoc. Clin. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression from NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"140142","DOI":"10.1016\/j.foodchem.2024.140142","article-title":"Litchi (Litchi chinensis Sonn.): A comprehensive and critical review on cancer prevention and intervention","volume":"457","author":"Bishayee","year":"2024","journal-title":"Food Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12933-022-01518-4","article-title":"Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex","volume":"21","author":"Matsubayashi","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1055\/a-2277-4805","article-title":"Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms","volume":"90","author":"Banerjee","year":"2024","journal-title":"Planta Medica"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"111938","DOI":"10.1016\/j.mad.2024.111938","article-title":"Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites","volume":"219","author":"Heidari","year":"2024","journal-title":"Mech. Ageing Dev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1089\/jmf.2019.0089","article-title":"Effects of Green Wheat (Triticum turgidum) and Common Wheat (Triticum aestivum) on the Metabolic Profile of Wistar Rats","volume":"22","author":"Bueno","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1089\/jmf.2019.0062","article-title":"Effects of Rhodiola rosea and Panax ginseng on the Metabolic Parameters of Rats Submitted to Swimming","volume":"22","author":"Bang","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., de Carvalho, G.M., de Oliveira Zanuso, B., Figueira, M.E., Direito, R., de Alvares Goulart, R., Buglio, D.S., and Barbalho, S.M. (2023). Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010229"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.molcel.2020.12.012","article-title":"Increased demand for NAD(+) relative to ATP drives aerobic glycolysis","volume":"81","author":"Luengo","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3892\/etm.2024.12648","article-title":"Linalool exerts antioxidant activity in a rat model of diabetes by increasing catalase activity without antihyperglycemic effect","volume":"28","author":"Bar","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Thongrong, S., Promsrisuk, T., Sriraksa, N., Surapinit, S., Jittiwat, J., and Kongsui, R. (2024). Alleviative effect of scopolamine-induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from Boesenbergia rotunda (L.). Biomed. Rep., 21.","DOI":"10.3892\/br.2024.1818"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Saka, W.A., Adeogun, A.E., Adisa, V.I., Olayioye, A., Igbayilola, Y.D., and Akhigbe, R.E. (2024). L-arginine attenuates dichlorvos-induced testicular toxicity in male Wistar rats by suppressing oxidative stress-dependent activation of caspase 3-mediated apoptosis. Biomed. Pharmacother. = Biomed. Pharmacother., 178.","DOI":"10.1016\/j.biopha.2024.117136"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3164\/jcbn.22-62","article-title":"Monascus pigment prevent the oxidative cytotoxicity in myotube derived hydrogen peroxide","volume":"75","author":"Kobayashi","year":"2024","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Fan, Y., Ma, L., Fang, X., Du, S., Mauck, J., Loor, J.J., Sun, X., Jia, H., Xu, C., and Xu, Q. (2024). Role of hypoxia-inducible-factor-1\u03b1 (HIF-1\u03b1) in ferroptosis of adipose tissue during ketosis. J. Dairy Sci., in press.","DOI":"10.3168\/jds.2024-24822"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3892\/etm.2024.12645","article-title":"Vascular endothelial cells of Mongolian gerbils are resistant to cholesterol-induced mitochondrial dysfunction and oxidative damage","volume":"28","author":"Wang","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Fujii, J., and Imai, H. (2024). Oxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147544"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Lin, H., Wang, L., Jiang, X., and Wang, J. (2024). Glutathione dynamics in subcellular compartments and implications for drug development. Curr. Opin. Chem. Biol., 81.","DOI":"10.1016\/j.cbpa.2024.102505"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.advms.2022.05.001","article-title":"Diverse impact of N-acetylcysteine or alpha-lipoic acid supplementation during high-fat diet regime on fatty acid transporters in visceral and subcutaneous adipose tissue","volume":"67","author":"Maciejczyk","year":"2022","journal-title":"Adv. Med. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Zhang, S., Cui, Z., Zhang, H., Wang, P., Wang, F., and Zhang, J. (2024). Pea Albumin Extracted from Pea (Pisum sativum L.) Seeds Ameliorates High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease by Regulating Lipogenesis and Lipolysis Pathways. Nutrients, 16.","DOI":"10.3390\/nu16142232"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Tsou, S.H., Lin, S.C., Chen, W.J., Hung, H.C., Liao, C.C., Kornelius, E., Huang, C.N., Lin, C.L., and Yang, Y.S. (2024). Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071444"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"110389","DOI":"10.1016\/j.isci.2024.110389","article-title":"The crosstalk between fibroblast growth factor 21 (FGF21) system and substance use","volume":"27","author":"Wang","year":"2024","journal-title":"iScience"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Chaudhary, P., Janmeda, P., Docea, A.O., Yeskaliyeva, B., Abdull Razis, A.F., Modu, B., Calina, D., and Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1158198"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Bahadoran, Z., Mirmiran, P., and Ghasemi, A. (2024). Adipose organ dysfunction and type 2 diabetes: Role of nitric oxide. Biochem. Pharmacol., 221.","DOI":"10.1016\/j.bcp.2024.116043"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1007\/s11033-023-08508-z","article-title":"Caloric restriction prevents inflammation and insulin dysfunction in middle-aged ovariectomized mice","volume":"50","author":"Sapatini","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Sha, X., Zou, X., Liu, S., Guan, C., Shi, W., Gao, J., Zhong, X., and Jiang, X. (2024). Forkhead box O1 in metabolic dysfunction-associated fatty liver disease: Molecular mechanisms and drug research. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1426780"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s13340-022-00616-8","article-title":"Insulin resistance in adipose tissue and metabolic diseases","volume":"14","author":"Imi","year":"2023","journal-title":"Diabetol. Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.3748\/wjg.v30.i24.3016","article-title":"Alanine aminotransferase predicts incident steatotic liver disease of metabolic etiology: Long life to the old biomarker!","volume":"30","author":"Lonardo","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_145","first-page":"e943375","article-title":"Biochemical and Anthropometric Indices of Insulin Resistance in Obese and Overweight Children with Metabolic Dysfunction-Associated Fatty Liver Disease","volume":"30","author":"Trochimczyk","year":"2024","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.3390\/cimb45110570","article-title":"The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease-The Transition from an Adipocentric to Liver-Centric Approach","volume":"45","author":"Macut","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wang, W., Guo, X.L., Qiu, X.P., Yu, Y.J., and Tu, M. (2024). Systemic immune-inflammation index mediates the association between metabolic dysfunction-associated fatty liver disease and sub-clinical carotid atherosclerosis: A mediation analysis. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1406793"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12964-024-01720-9","article-title":"Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease","volume":"22","author":"He","year":"2024","journal-title":"Cell Commun. Signal. CCS"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.3748\/wjg.v29.i25.3999","article-title":"Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis","volume":"29","author":"Pal","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"155578","DOI":"10.1016\/j.metabol.2023.155578","article-title":"Mitochondria-SR interaction and mitochondrial fusion\/fission in the regulation of skeletal muscle metabolism","volume":"144","author":"Rieusset","year":"2023","journal-title":"Metab. Clin. Exp."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Yang, C., Yu, Y., and An, J. (2024). Effect of High-Sucrose Diet on the Occurrence and Progression of Diabetic Retinopathy and Dietary Modification Strategies. Nutrients, 16.","DOI":"10.20944\/preprints202404.0085.v1"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2478\/enr-2022-0002","article-title":"Predictive value of the glycated albumin versus glycosylated hemoglobin in follow-up of glucose homeostasis in hemodialysis-maintained type-2 diabetic patients","volume":"56","author":"Ahmed","year":"2022","journal-title":"Endocr. Regul."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Walke, P.B., Bansode, S.B., More, N.P., Chaurasiya, A.H., Joshi, R.S., and Kulkarni, M.J. (2021). Molecular investigation of glycated insulin-induced insulin resistance via insulin signaling and AGE-RAGE axis. Biochim. Biophys. Acta Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2020.166029"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s13679-022-00473-1","article-title":"Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver Disease","volume":"11","author":"Legaki","year":"2022","journal-title":"Curr. Obes. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"9154295","DOI":"10.1155\/2022\/9154295","article-title":"Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases","volume":"2022","author":"Panda","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Ahmed, B., Sultana, R., and Greene, M.W. (2021). Adipose tissue and insulin resistance in obese. Biomed. Pharmacother. = Biomed. Pharmacother., 137.","DOI":"10.1016\/j.biopha.2021.111315"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Wu, D., Eeda, V., Maria, Z., Rawal, K., Herlea-Pana, O., Undi, R.B., Lim, H.Y., and Wang, W. (2024). Targeting IRE1\u03b1 improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity. bioRxiv.","DOI":"10.1101\/2024.07.17.603931"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Alam, N., Jia, L., Cheng, A., Ren, H., Fu, Y., Ding, X., Haq, I.U., and Liu, E. (2024). Global research trends on gut microbiota and metabolic dysfunction-associated steatohepatitis: Insights from bibliometric and scientometric analysis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1390483"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/cvr\/cvz313","article-title":"PCSK9 and inflammation: Role of shear stress, pro-inflammatory cytokines, and LOX-1","volume":"116","author":"Ding","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e179752","DOI":"10.1172\/JCI179752","article-title":"Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD","volume":"134","author":"Wang","year":"2024","journal-title":"J. Clin. Investig."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Rajendran, R., Suman, S., Divakaran, S.J., Swatikrishna, S., Tripathi, P., Jain, R., Sagar, K., and Rajakumari, S. (2024). Sesaminol alters phospholipid metabolism and alleviates obesity-induced NAFLD. FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol., 38.","DOI":"10.1096\/fj.202400412RR"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"9132","DOI":"10.3390\/cimb45110573","article-title":"Molecular Aspects of MAFLD-New Insights on Pathogenesis and Treatment","volume":"45","author":"Filipovic","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41467-022-34606-w","article-title":"Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"9777866","DOI":"10.1155\/2024\/9777866","article-title":"Wulingsan Alleviates MAFLD by Activating Autophagy via Regulating the AMPK\/mTOR\/ULK1 Signaling Pathway","volume":"2024","author":"Biao","year":"2024","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s12072-024-10674-6","article-title":"Role of gut microbiota and immune cells in metabolic-associated fatty liver disease: Clinical impact","volume":"18","author":"Alisi","year":"2024","journal-title":"Hepatol. Int."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Cheng, Z., Chu, H., Seki, E., Lin, R., and Yang, L. (2024). Hepatocyte programmed cell death: The trigger for inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1431921"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"111299","DOI":"10.1016\/j.cellsig.2024.111299","article-title":"Paricalcitol attenuates oxidative stress and inflammatory response in the liver of NAFLD rats by regulating FOXO3a and NF\u03baB acetylation","volume":"121","author":"Malladi","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Orhan, S., Turkmen, R., Demirel, H.H., Akosman, M.S., Turkmen, T., and F\u0131rat, F. (2024). Chlorogenic acid mitigates potassium dichromate-induced acute hepato-nephrotoxicity by attenuating the NF-\u03baB signalling pathway. Mol. Biol. Rep., 51.","DOI":"10.1007\/s11033-024-09717-w"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Hao, J., Jin, X., Li, Z., Zhu, Y., Wang, L., Jiang, X., Wang, D., Qi, L., Jia, D., and Gao, B. (2024). Anti-Obesity Activity of Sanghuangporus vaninii by Inhibiting Inflammation in Mice Fed a High-Fat Diet. Nutrients, 16.","DOI":"10.3390\/nu16132159"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"112445","DOI":"10.1016\/j.intimp.2024.112445","article-title":"Multimodal modulation of hepatic ischemia\/reperfusion-induced injury by phytochemical agents: A mechanistic evaluation of hepatoprotective potential and safety profiles","volume":"138","author":"Ezelarab","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"108365","DOI":"10.1016\/j.mrrev.2021.108365","article-title":"Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer","volume":"787","author":"Caliri","year":"2021","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"14936","DOI":"10.1080\/21655979.2023.2184455","article-title":"Alkannin reverses lipopolysaccharides-induced inflammatory responses by suppressing mitogen-activated protein kinase and nuclear factor kappa-B signalling","volume":"13","author":"Yang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Shepard, C.R. (2020). TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.613639"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Gu, X., Chu, Q., Ma, X., Wang, J., Chen, C., Guan, J., Ren, Y., Wu, S., and Zhu, H. (2022). New insights into iNKT cells and their roles in liver diseases. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1035950"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Akk\u0131z, H., Gieseler, R.K., and Canbay, A. (2024). Liver Fibrosis: From Basic Science towards Clinical Progress, Focusing on the Central Role of Hepatic Stellate Cells. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202405.1666.v1"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Buakaew, W., Krobthong, S., Yingchutrakul, Y., Potup, P., Thongsri, Y., Daowtak, K., Ferrante, A., and Usuwanthim, K. (2024). Investigating the Antifibrotic Effects of \u03b2-Citronellol on a TGF-\u03b21-Stimulated LX-2 Hepatic Stellate Cell Model. Biomolecules, 14.","DOI":"10.20944\/preprints202406.0645.v1"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"100878","DOI":"10.1016\/j.xcrm.2022.100878","article-title":"CD8(+) T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy","volume":"4","author":"Huseni","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Sarmadi, N., Poustchi, H., Ali Yari, F., Radmard, A.R., Karami, S., Pakdel, A., Shabani, P., and Khaleghian, A. (2022). Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0266227"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12967-023-04431-w","article-title":"ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis","volume":"21","author":"Convertini","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"20772","DOI":"10.1021\/acsnano.4c07297","article-title":"Self-Sulfhydrated, Nitro-Fixed Albumin Nanoparticles as a Potent Therapeutic Agent for the Treatment of Acute Liver Injury","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Liu, X., Hussain, R., Mehmood, K., Tang, Z., Zhang, H., and Li, Y. (2022). Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/6459585"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"117041","DOI":"10.1016\/j.taap.2024.117041","article-title":"Alpha-Asarone attenuates alcohol-induced hepatotoxicity in a murine model by ameliorating oxidative stress, inflammation, and modulating apoptotic-Autophagic cell death","volume":"490","author":"Ali","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Nasr, H.E., Hegazy, A.M., El-Shaer, N.O., El-Shafey, R.S., Elgendy, S.A., Elnoury, H.A., Gazzar, W.B.E., and Mohammed, L.A. (2024). Ameliorative effects of sildenafil against carbon tetrachloride induced hepatic fibrosis in rat model through downregulation of osteopontin gene expression. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-67305-1"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Laib, I., Ali, B.D., Alsalme, A., Croun, D., Bechelany, M., and Barhoum, A. (2024). Therapeutic potential of silver nanoparticles from Helianthemum lippii extract for mitigating cadmium-induced hepatotoxicity: Liver function parameters, oxidative stress, and histopathology in wistar rats. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1400542"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zhou, Y., Wang, D., Huang, Z., Xiao, X., Zheng, Q., Li, S., Long, D., and Feng, L. (2023). Mitochondrial Dysfunction in Metabolic Dysfunction Fatty Liver Disease (MAFLD). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417514"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Gong, H., He, Q., Zhu, L., Feng, Z., Sun, M., Jiang, J., Yuan, X., Shen, Y., and Di, J. (2024). Associations between systemic inflammation indicators and nonalcoholic fatty liver disease: Evidence from a prospective study. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1389967"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Ding, Z., Wei, Y., Peng, J., Wang, S., Chen, G., and Sun, J. (2023). The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102711"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"goad059","DOI":"10.1093\/gastro\/goad059","article-title":"Predicted pro-inflammatory hs-CRP score and non-alcoholic fatty liver disease","volume":"11","author":"Okekunle","year":"2023","journal-title":"Gastroenterol. Rep."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e34638","DOI":"10.1097\/MD.0000000000034638","article-title":"Mendelian randomization explores the causal relationships between obesity, diabetes, inflammation and nonalcoholic fatty liver disease","volume":"102","author":"Wang","year":"2023","journal-title":"Medicine"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1515\/cclm-2023-0086","article-title":"Why C-reactive protein is one of the most requested tests in clinical laboratories?","volume":"61","author":"Plebani","year":"2023","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s11596-024-2868-0","article-title":"Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: A Cross-sectional Study Based on the NHANES","volume":"44","author":"Li","year":"2024","journal-title":"Curr. Med. Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1210\/clinem\/dgad749","article-title":"A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia","volume":"109","author":"Liu","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Semmler, G., Balcar, L., Wernly, S., V\u00f6lkerer, A., Semmler, L., Hauptmann, L., Wernly, B., Aigner, E., Niederseer, D., and Datz, C. (2023). Insulin resistance and central obesity determine hepatic steatosis and explain cardiovascular risk in steatotic liver disease. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1244405"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12011-023-03666-4","article-title":"Associations of Serum Iron Status with MAFLD and Liver Fibrosis in the USA: A Nationwide Cross-Section Study","volume":"202","author":"Yu","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Xie, C.H., Chen, L.W., Lin, C.L., Hu, C.C., and Chien, C.H. (2022). Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study. J. Pers. Med., 12.","DOI":"10.3390\/jpm12122009"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e18321","DOI":"10.1016\/j.heliyon.2023.e18321","article-title":"Atractylodin alleviates nonalcoholic fatty liver disease by regulating Nrf2-mediated ferroptosis","volume":"9","author":"Ye","year":"2023","journal-title":"Heliyon"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"102336","DOI":"10.1016\/j.clinre.2024.102336","article-title":"White adipose tissue in metabolic associated fatty liver disease","volume":"48","author":"Zhu","year":"2024","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Xin, M., Wang, H., Wang, M., Yang, B., Liang, S., Xu, X., Dong, L., Cai, T., Huang, Y., and Wang, Q. (2023). Attenuating effect of Polygala tenuifolia Willd. seed oil on progression of MAFLD. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1253715"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Lodge, M., Dykes, R., and Kennedy, A. (2024). Regulation of Fructose Metabolism in Nonalcoholic Fatty Liver Disease. Biomolecules, 14.","DOI":"10.3390\/biom14070845"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"175788","DOI":"10.1016\/j.ejphar.2023.175788","article-title":"Oroxin B improves metabolic-associated fatty liver disease by alleviating gut microbiota dysbiosis in a high-fat diet-induced rat model","volume":"951","author":"Huang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"100756","DOI":"10.1016\/j.aohep.2022.100756","article-title":"Hepatic mir-122-3p, mir-140-5p and mir-148b-5p expressions are correlated with cytokeratin-18 serum levels in MAFLD","volume":"27","author":"Uribe","year":"2022","journal-title":"Ann. Hepatol."},{"key":"ref_202","first-page":"56","article-title":"Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-\u03baB pathways","volume":"10","author":"Zhang","year":"2023","journal-title":"Mil. Med. Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e2301645","DOI":"10.1002\/advs.202301645","article-title":"Adipose METTL14-Elicited N(6)-Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing \u03b2 Adrenergic Signaling and Lipolysis","volume":"10","author":"Kang","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Zakaria, Z., Othman, Z.A., Suleiman, J.B., Che Jalil, N.A., Ghazali, W.S.W., Nna, V.U., and Mohamed, M. (2021). Hepatoprotective Effect of Bee Bread in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Rats: Impact on Oxidative Stress and Inflammation. Antioxidants, 10.","DOI":"10.3390\/antiox10122031"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1039\/D4FO00292J","article-title":"Hexane insoluble fraction from purple rice extract improves steatohepatitis and fibrosis via inhibition of NF-\u03baB and JNK signaling","volume":"15","author":"Yeewa","year":"2024","journal-title":"Food Funct."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"S\u0142u\u017ca\u0142y, P., Pa\u015bko, P., and Galanty, A. (2024). Natural Products as Hepatoprotective Agents-A Comprehensive Review of Clinical Trials. Plants, 13.","DOI":"10.3390\/plants13141985"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Lee, J.A., Gu, M.J., Lee, Y.R., Kim, Y., Choi, I., Kim, D., and Ha, S.K. (2024). Lindera obtusiloba Blume Alleviates Non-Alcoholic Fatty Liver Disease Promoted by N(\u03b5)-(carboxymethyl)lysine. Nutrients, 16.","DOI":"10.3390\/nu16142330"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, K., Feng, Y., Wu, L., Jia, Y., and Zhao, R. (2024). Alisma Orientalis Extract Ameliorates Hepatic Iron Deregulation in MAFLD Mice via FXR-Mediated Gene Repression. Nutrients, 16.","DOI":"10.3390\/nu16142272"},{"key":"ref_209","first-page":"1096","article-title":"Suppression of TGF-\u03b2\/Smad3 signaling pathway by Capparis spinosa and quercetin in a rat model of nonalcoholic steatohepatitis","volume":"27","author":"Afarin","year":"2024","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Zhang, H., You, Y., Xu, J., Jiang, H., Jiang, J., Su, Z., Chao, Z., Du, Q., and He, F. (2024). New sesquiterpenes and viridin derivatives from Penicillium sp. Ameliorates NAFLD by regulating the PINK1\/Parkin mitophagy pathway. Bioorgan. Chem., 151.","DOI":"10.1016\/j.bioorg.2024.107656"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Chen, C., Liu, X.C., and Deng, B. (2024). Protective Effects of Berberine on Nonalcoholic Fatty Liver Disease in db\/db Mice via AMPK\/SIRT1 Pathway Activation. Curr. Med. Sci.","DOI":"10.1007\/s11596-024-2914-y"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Castelnuovo, G., Perez-Diaz-Del-Campo, N., Rosso, C., Armandi, A., Caviglia, G.P., and Bugianesi, E. (2024). A Healthful Plant-Based Diet as an Alternative Dietary Approach in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease. Nutrients, 16.","DOI":"10.3390\/nu16132027"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"6815993","DOI":"10.1155\/2024\/6815993","article-title":"Effects of Moringa oleifera Leaf Extract on Liver Histopathology: A Systematic Review","volume":"2024","author":"Nurhayati","year":"2024","journal-title":"J. Nutr. Metab."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1111\/nph.19989","article-title":"Mitochondrial respiration is essential for photosynthesis-dependent ATP supply of the plant cytosol","volume":"243","author":"Novel","year":"2024","journal-title":"New Phytol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"25152564241261228","DOI":"10.1177\/25152564241261228","article-title":"The Discovery of Mitochondria-Endoplasmic Reticulum Contact Sites (MERCs) as Mitochondria-Associated Membranes (MAMs)","volume":"7","author":"Makio","year":"2024","journal-title":"Contact"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Jab\u016frek, M., Kl\u00f6ppel, E., Pr\u016fchov\u00e1, P., Mozheitova, O., Tauber, J., Engstov\u00e1, H., and Je\u017eek, P. (2024). Mitochondria to plasma membrane redox signaling is essential for fatty acid \u03b2-oxidation-driven insulin secretion. Redox Biol., 75.","DOI":"10.1016\/j.redox.2024.103283"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Yamada, A., Watanabe, A., Nara, A., Ishimaru, N., Maeda, K., Ido, Y., Kotake, K., Asano, M., Shinohara, Y., and Yamamoto, T. (2024). Longitudinal Analysis of Mitochondrial Function in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis Mouse Model. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25116193"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Fan, H., and Tan, Y. (2024). Lipid Droplet-Mitochondria Contacts in Health and Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25136878"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Cheng, D., Zhang, M., Zheng, Y., Wang, M., Gao, Y., Wang, X., Liu, X., Lv, W., Zeng, X., and Belosludtsev, K.N. (2024). \u03b1-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1\u03b1\/Nrf2 pathway. Redox Biol., 74.","DOI":"10.1016\/j.redox.2024.103230"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cmet.2024.03.003","article-title":"Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity","volume":"36","author":"Tong","year":"2024","journal-title":"Cell Metab."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.freeradbiomed.2021.03.011","article-title":"CoenzymeQ in cellular redox regulation and clinical heart failure","volume":"167","author":"Yuan","year":"2021","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"116350","DOI":"10.1016\/j.ecoenv.2024.116350","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs\/Th1\/Th2\/Th17\/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver","volume":"277","author":"Li","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/humrep\/dead250","article-title":"ROS-induced oxidative stress is a major contributor to sperm cryoinjury","volume":"39","author":"Shi","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"e0055821","DOI":"10.1128\/jb.00558-21","article-title":"Dissection and Reconstitution Provide Insights into Electron Transport in the Membrane-Bound Aldehyde Dehydrogenase Complex of Gluconacetobacter diazotrophicus","volume":"204","author":"Miah","year":"2022","journal-title":"J. Bacteriol."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Fedotcheva, N., Olenin, A., and Beloborodova, N. (2021). Influence of Microbial Metabolites on the Nonspecific Permeability of Mitochondrial Membranes under Conditions of Acidosis and Loading with Calcium and Iron Ions. Biomedicines, 9.","DOI":"10.3390\/biomedicines9050558"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.freeradbiomed.2020.11.009","article-title":"Physiological evidence of mitochondrial permeability transition pore opening caused by lipid deposition leading to hepatic steatosis in db\/db mice","volume":"162","author":"Li","year":"2021","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1262-3636(07)70098-8","article-title":"The ins and outs of mitochondrial dysfunction in NASH","volume":"30","author":"Fromenty","year":"2004","journal-title":"Diabetes Metab."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.2174\/1871520621666211126090906","article-title":"Role of Mitochondrial Membrane Potential and Lactate Dehydrogenase A in Apoptosis","volume":"22","author":"Zaib","year":"2022","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"16506","DOI":"10.1021\/acs.jafc.4c03978","article-title":"Drp1 Aggravates Copper Nanoparticle-Induced ER-Phagy by Disturbing Mitochondria-Associated Membranes in Chicken Hepatocytes","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Sami Alkafaas, S., Obeid, O.K., Ali Radwan, M., Elsalahaty, M.I., Samy ElKafas, S., Hafez, W., Jankovi\u0107, N., and Hessien, M. (2024). Novel insight into mitochondrial dynamin-related protein-1 as a new chemo-sensitizing target in resistant cancer cells. Bioorgan. Chem., 150.","DOI":"10.1016\/j.bioorg.2024.107574"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Krantz, S., Qin, X., Li, S., Gunasekara, H., Kim, Y.M., Zimnicka, A., Bae, M., Ma, K., and Toth, P.T. (2022). Caveolin-1 controls mitochondrial damage and ROS production by regulating fission\u2014Fusion dynamics and mitophagy. Redox Biol., 52.","DOI":"10.1016\/j.redox.2022.102304"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"P680","DOI":"10.1016\/j.tem.2024.06.002","article-title":"Food perception induces fast fragmentation of hepatic mitochondria","volume":"35","author":"Chevrollier","year":"2024","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial Dynamics and Its Involvement in Disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Ariyoshi, K., Nishiyama, K., Kato, Y., Mi, X., Ito, T., Azuma, Y.T., Nishimura, A., and Nishida, M. (2024). Inhibition of Drp1-Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria-Lipid Droplet Contact. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202404.0918.v1"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.adk1005","article-title":"Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver","volume":"384","author":"Henschke","year":"2024","journal-title":"Science"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/s12967-023-04367-1","article-title":"Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: New insights from pathogenic mechanisms to clinically targeted therapy","volume":"21","author":"Zheng","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5847\/wjem.j.1920-8642.2023.057","article-title":"Mutual promotion of mitochondrial fission and oxidative stress contributes to mitochondrial-DNA-mediated inflammation and epithelial-mesenchymal transition in paraquat-induced pulmonary fibrosis","volume":"14","author":"Zhang","year":"2023","journal-title":"World J. Emerg. Med."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"He, J., Qian, Y.C., Yin, Y.C., Kang, J.R., and Pan, T.R. (2024). Polydatin: A potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms\u2014A network pharmacology and experimental investigation. Chemico-Biol. Interact., 398.","DOI":"10.1016\/j.cbi.2024.111110"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12944-024-02122-z","article-title":"Machine learning-based algorithm identifies key mitochondria-related genes in non-alcoholic steatohepatitis","volume":"23","author":"Dai","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxlet.2024.04.002","article-title":"Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells","volume":"396","author":"Nakamura","year":"2024","journal-title":"Toxicol. Lett."},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Gnoni, A., Di Chiara Stanca, B., Giannotti, L., Gnoni, G.V., Siculella, L., and Damiano, F. (2022). Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1\/AMPK\/PP2A Axis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031044"},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Sahoo, D.K., Heilmann, R.M., Paital, B., Patel, A., Yadav, V.K., Wong, D., and Jergens, A.E. (2023). Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1217165"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tibs.2020.03.009","article-title":"Reciprocal Regulation of Mitochondrial Fission and Fusion","volume":"45","author":"Sabouny","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yjmcc.2021.10.007","article-title":"NAFLD as a continuous driver in the whole spectrum of vascular disease","volume":"163","author":"Li","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_245","first-page":"155585","article-title":"Oxysophoridine inhibits oxidative stress and inflammation in hepatic fibrosis via regulating Nrf2 and NF-\u03baB pathways","volume":"132","author":"Chen","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Arconzo, M., Piccinin, E., Pasculli, E., Cariello, M., Loiseau, N., Bertrand-Michel, J., Guillou, H., Matrella, M.L., Villani, G., and Moschetta, A. (2024). Hepatic-specific Pgc-1\u03b1 ablation drives fibrosis in a MASH model. Liver Int. Off. J. Int. Assoc. Study Liver, early view.","DOI":"10.1111\/liv.16052"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Ramanathan, R., Ali, A.H., and Ibdah, J.A. (2022). Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137280"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"13039","DOI":"10.1021\/acs.jafc.3c09132","article-title":"Elevated PINK1\/Parkin-Dependent Mitophagy and Boosted Mitochondrial Function Mediate Protection of HepG2 Cells from Excess Palmitic Acid by Hesperetin","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Tsuji, A., Yoshikawa, S., Ikeda, Y., Taniguchi, K., Sawamura, H., Morikawa, S., Nakashima, M., Asai, T., and Matsuda, S. (2023). Tactics with Prebiotics for the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease via the Improvement of Mitophagy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065465"},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Yu, L.P., Li, Y.Q., Li, Y.J., Zi, L., Tao, Y.X., Hao, J.J., Zhang, M., Gu, W., Zhang, F., and Yu, J. (2022). In vivo identification of the pharmacodynamic ingredients of Polygonum cuspidatum for remedying the mitochondria to alleviate metabolic dysfunction-associated fatty liver disease. Biomed. Pharmacother. = Biomed. Pharmacother., 156.","DOI":"10.1016\/j.biopha.2022.113849"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41419-024-06910-4","article-title":"Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis","volume":"15","author":"Gu","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Somasundaram, I., Jain, S.M., Blot-Chabaud, M., Pathak, S., Banerjee, A., Rawat, S., Sharma, N.R., and Duttaroy, A.K. (2024). Mitochondrial dysfunction and its association with age-related disorders. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1384966"},{"key":"ref_253","first-page":"533","article-title":"Isolation, characterization and modulatory potentials of \u03b2-stigmasterol, ergosterol and xylopic acid from Anchomanes difformis on mitochondrial permeability transition pore in vitro","volume":"15","author":"Sodeinde","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.clinbiochem.2012.03.024","article-title":"Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation","volume":"45","author":"Grattagliano","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"eadj5942","DOI":"10.1126\/sciadv.adj5942","article-title":"Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease","volume":"10","author":"Xu","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11130-024-01188-5","article-title":"Crithmum maritimum Extract Restores Lipid Homeostasis and Metabolic Profile of Liver Cancer Cells to a Normal Phenotype","volume":"79","author":"Gnocchi","year":"2024","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1111\/bph.16436","article-title":"Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver","volume":"181","author":"Andres","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12964-024-01666-y","article-title":"SIRT1 regulates hepatic vldlr levels","volume":"22","author":"Peyman","year":"2024","journal-title":"Cell Commun. Signal. CCS"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"34524","DOI":"10.1021\/acsami.4c04416","article-title":"Polystyrene Nanoplastics Induce Lipid Metabolism Disorder by Activating the PERK-ATF4 Signaling Pathway in Mice","volume":"16","author":"Yu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Wang, L., Xie, Z., Wu, M., Chen, Y., Wang, X., Li, X., and Liu, F. (2024). The role of taurine through endoplasmic reticulum in physiology and pathology. Biochem. Pharmacol., 226.","DOI":"10.1016\/j.bcp.2024.116386"},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Kanoni, S., Kumar, S., Amerikanou, C., Kurth, M.J., Stathopoulou, M.G., Bourgeois, S., Masson, C., Kannt, A., Cesarini, L., and Kontoe, M.S. (2021). Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients with NAFLD. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.683028"},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Seidita, A., Cusimano, A., Giuliano, A., Meli, M., Carroccio, A., Soresi, M., and Giannitrapani, L. (2024). Oxidative Stress as a Target for Non-Pharmacological Intervention in MAFLD: Could There Be a Role for EVOO?. Antioxidants, 13.","DOI":"10.3390\/antiox13060731"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Pinilla-Gonz\u00e1lez, V., Rojas-Sol\u00e9, C., G\u00f3mez-Hevia, F., Gonz\u00e1lez-Fern\u00e1ndez, T., Cereceda-Cornejo, A., Chichiarelli, S., Saso, L., and Rodrigo, R. (2024). Tapping into Nature\u2019s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention. Foods, 13.","DOI":"10.3390\/foods13131999"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1002\/ptr.8274","article-title":"Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta-analysis, and meta-regression","volume":"38","author":"Huertas","year":"2024","journal-title":"Phytother. Res. PTR"},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Ghani, I., An, Y., Qiao, Q., He, S., and Li, Z. (2024). Polyphenols from Foxtail Millet Improve Non-Alcoholic Fatty Liver Disease by Regulating Intestinal Microbiome in Mice. Foods, 13.","DOI":"10.3390\/foods13111683"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Toma, L., Deleanu, M., Sanda, G.M., Barb\u0103lat\u0103, T., Niculescu, L., Sima, A.V., and Stancu, C.S. (2024). Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084162"},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Rahimlou, M., Baghdadi, G., Khodi, A., Rahimi, Z., Saki, N., Banaei Jahromi, N., Cheraghian, B., Tavasolian, R., and Hosseini, S.A. (2024). Polyphenol consumption and Nonalcoholic fatty liver disease risk in adults. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-57416-0"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"138715","DOI":"10.1016\/j.foodchem.2024.138715","article-title":"Penthorum chinense Pursh leaf tea debittering mechanisms via green tea manufacturing process and its influence on NAFLD-alleviation activities","volume":"445","author":"Tian","year":"2024","journal-title":"Food Chem."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Thilakarathna, W., and Rupasinghe, H.P.V. (2024). Proanthocyanidins-Based Synbiotics as a Novel Strategy for Nonalcoholic Fatty Liver Disease (NAFLD) Risk Reduction. Molecules, 29.","DOI":"10.3390\/molecules29030709"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Ren, J., Zhang, X., Heiyan-Perhat, S.U., Yang, P., Han, H., Li, Y., Gao, J., He, E., and Li, Y. (2024). Therapeutic Role of Polyphenol Extract from Prunus cerasifera Ehrhart on Non-Alcoholic Fatty Liver. Plants, 13.","DOI":"10.3390\/plants13020288"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13668-023-00514-8","article-title":"Functional Food Chemical Ingredient Strategies for Non-alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis: Chemical Properties, Health Benefits, Action, and Application","volume":"13","author":"Yu","year":"2024","journal-title":"Curr. Nutr. Rep."},{"key":"ref_272","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Hua, J., and Huang, Z. (2022). Effects of beer, wine, and baijiu consumption on non-alcoholic fatty liver disease: Potential implications of the flavor compounds in the alcoholic beverages. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1022977"},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Guo, J., Wang, P., Cui, Y., Hu, X., Chen, F., and Ma, C. (2022). Alleviation Effects of Microbial Metabolites from Resveratrol on Non-Alcoholic Fatty Liver Disease. Foods, 12.","DOI":"10.3390\/foods12010094"},{"key":"ref_274","first-page":"97","article-title":"Mediterranean diet in liver steatosis: The role of polyphenols","volume":"64","author":"Colica","year":"2018","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1515\/jtim-2017-0027","article-title":"Polyphenols Treatment in Patients with Nonalcoholic Fatty Liver Disease","volume":"5","author":"Abenavoli","year":"2017","journal-title":"J. Transl. Intern. Med."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/YCO.0000000000000950","article-title":"Research and publication gaps on kratom and kratom products: A scoping review of current literature","volume":"37","author":"Vicknasingam","year":"2024","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Yabalak, E., Bahad\u0131rl\u0131, N.P., Yetkin, D., Yald\u0131z, F.D., and Han T\u00fcrkseven, \u00c7. (2024). Unlocking nature\u2019s potential: Anticancer potential of Helichrysum sanguineum (L.) Kostel on breast cancer cells and its chemical composition. Int. J. Environ. Health Res., 1\u201313.","DOI":"10.1080\/09603123.2024.2360548"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"100155","DOI":"10.1016\/j.fochms.2022.100155","article-title":"Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review","volume":"6","author":"Borsoi","year":"2023","journal-title":"Food Chem. Mol. Sci."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Ferro, Y., Maurotti, S., Mazza, E., Pujia, R., Sciacqua, A., Musolino, V., Mollace, V., Pujia, A., and Montalcini, T. (2022). Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease. Medicina, 58.","DOI":"10.3390\/medicina58121728"},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Dibwe, D.F., Kitayama, E., Oba, S., Takeishi, N., Chiba, H., and Hui, S.P. (2024). Inhibition of Lipid Accumulation and Oxidation in Hepatocytes by Bioactive Bean Extracts. Antioxidants, 13.","DOI":"10.3390\/antiox13050513"},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Xiao, Y., Zhang, X., Yi, D., Qiu, F., Wu, L., Tang, Y., and Wang, N. (2023). Mediterranean diet affects the metabolic outcome of metabolic dysfunction-associated fatty liver disease. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1225946"},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Ferreira, J., Tkacz, K., Turkiewicz, I.P., Santos, I., Camoesas, E.S.M., Lima, A., and Sousa, I. (2024). Exploring the Bioactive Properties and Therapeutic Benefits of Pear Pomace. Antioxidants, 13.","DOI":"10.3390\/antiox13070784"},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Russo, C., Valle, M.S., D\u2019Angeli, F., Surdo, S., and Malaguarnera, L. (2024). Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147503"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"107324","DOI":"10.1016\/j.phrs.2024.107324","article-title":"The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions","volume":"207","author":"Lin","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"102416","DOI":"10.1016\/j.arr.2024.102416","article-title":"The roles of dietary polyphenols at crosstalk between type 2 diabetes and Alzheimer\u2019s disease in ameliorating oxidative stress and mitochondrial dysfunction via PI3K\/Akt signaling pathways","volume":"99","author":"Wang","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/10409238.2024.2377094","article-title":"Mitochondrial sirtuin 3 and role of natural compounds: The effect of post-translational modifications on cellular metabolism","volume":"59","author":"Oppedisano","year":"2024","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Jamali, Z., Salimi, A., Khezri, S., Norozi, P., Garmabi, B., and Khaksari, M. (2024). Protective Role of Ellagic Acid Against Ethanol-Induced Neurodevelopmental Disorders in Newborn Male Rats: Insights into Maintenance of Mitochondrial Function and Inhibition of Oxidative Stress. J. Stud. Alcohol Drugs.","DOI":"10.15288\/jsad.24-00118"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.freeradbiomed.2024.04.242","article-title":"Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma","volume":"220","author":"Dong","year":"2024","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Direito, R., Rocha, J., Sepodes, B., and Eduardo-Figueira, M. (2021). Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020145"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"141423","DOI":"10.1016\/j.foodchem.2024.141423","article-title":"Study on the mechanism of polyphenols regulating the stability of pea isolate protein formed Pickering emulsion based on interfacial effects","volume":"463","author":"Ma","year":"2024","journal-title":"Food Chem."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2018.10.016","article-title":"Neuro-protective role of nanocapsulated curcumin against cerebral ischemia-reperfusion induced oxidative injury","volume":"1704","author":"Mukherjee","year":"2019","journal-title":"Brain Res."},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"de Brito Alves, J.L., de Sousa, V.P., Cavalcanti Neto, M.P., Magnani, M., Braga, V.A., da Costa-Silva, J.H., Leandro, C.G., Vidal, H., and Pirola, L. (2016). New Insights on the Use of Dietary Polyphenols or Probiotics for the Management of Arterial Hypertension. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00448"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"145421","DOI":"10.1155\/2013\/145421","article-title":"Dietary anthocyanins as nutritional therapy for nonalcoholic fatty liver disease","volume":"2013","author":"Valenti","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"106786","DOI":"10.1016\/j.phrs.2023.106786","article-title":"Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)","volume":"192","author":"Qiu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"117684","DOI":"10.1016\/j.jep.2023.117684","article-title":"PPAR\u03b1 is one of the key targets for dendrobine to improve hepatic steatosis in NAFLD","volume":"323","author":"Xu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3748\/wjg.v28.i26.3047","article-title":"Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review","volume":"28","author":"Ganguly","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Lai, Y.S., Nguyen, H.T., Salmanida, F.P., and Chang, K.T. (2021). MERTK(+\/hi) M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910604"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"E5896","DOI":"10.1073\/pnas.1801745115","article-title":"Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis","volume":"115","author":"Dai","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_299","doi-asserted-by":"crossref","unstructured":"Marinovic, M.P., Sousa-Filho, C.P.B., Batista, F.A.H., Avelino, T.M., Cogliati, B., Figueira, A.C.M., Otton, R., and Rodrigues, A.C. (2022). Green tea extract increases adiponectin and PPAR \u03b1 levels to improve hepatic steatosis. J. Nutr. Biochem., 103.","DOI":"10.1016\/j.jnutbio.2022.108957"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s13105-022-00926-0","article-title":"Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: A review of the current knowledge","volume":"79","author":"Trepiana","year":"2023","journal-title":"J. Physiol. Biochem."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Ma, K., Sheng, W., Song, X., Song, J., Li, Y., Huang, W., and Liu, Y. (2023). Chlorogenic Acid from Burdock Roots Ameliorates Oleic Acid-Induced Steatosis in HepG2 Cells through AMPK\/ACC\/CPT-1 Pathway. Molecules, 28.","DOI":"10.3390\/molecules28217257"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"15073","DOI":"10.1021\/acs.jafc.3c03710","article-title":"Chlorogenic Acid Modulates Autophagy by Inhibiting the Activity of ALKBH5 Demethylase, Thereby Ameliorating Hepatic Steatosis","volume":"71","author":"Meng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"113513","DOI":"10.1016\/j.foodres.2023.113513","article-title":"Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model","volume":"174","author":"Bacil","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"103776","DOI":"10.1016\/j.psj.2024.103776","article-title":"Pharmacokinetics and antioxidant activity of dihydrocaffeic acid grafted chitosan nanomicelles loaded with chicoric acid in broilers","volume":"103","author":"Ren","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_305","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ska-Trypu\u0107, A., Wydro, U., Wo\u0142ejko, E., Kalinowska, M., \u015awiderski, G., Kr\u0119towski, R., Naumowicz, M., Kondzior, P., Cechowska-Pasko, M., and Lewandowski, W. (2024). The Influence of Mesotrione on Human Colorectal Adenocarcinoma Cells and Possibility of Its Toxicity Mitigation by Cichoric Acid. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115655"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/fsn3.3758","article-title":"Cichoric acid improves isoproterenol-induced myocardial fibrosis via inhibition of HK1\/NLRP3 inflammasome-mediated signaling pathways by reducing oxidative stress, inflammation, and apoptosis","volume":"12","author":"Cheng","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1080\/14786419.2022.2106481","article-title":"Betalains: Colours for human health","volume":"37","author":"Calvi","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"e17495","DOI":"10.7717\/peerj.17495","article-title":"Curcumin improves atrial fibrillation susceptibility by regulating tsRNA expression in aging mouse atrium","volume":"12","author":"Luo","year":"2024","journal-title":"PeerJ"},{"key":"ref_309","doi-asserted-by":"crossref","unstructured":"Martins, A., Ara\u00fajo, O.R.P., Gomes, A.D.S., Araujo, F.L.C., Oliveira Junior, J., Vasconcelos, J.K.G., Rodrigues Junior, J.I., Cerqueira, I.T., Lins Neto M\u00c1, F., and Bueno, N.B. (2024). Effect of Curcumin Plus Piperine on Redox Imbalance, Fecal Calprotectin and Cytokine Levels in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Pharmaceuticals, 17.","DOI":"10.3390\/ph17070849"},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., Santos, A., Carvalho, A.C.A., Bechara, M.D., Guiguer, E.L., Goulart, R.A., Vargas Sinatora, R., Ara\u00fajo, A.C., and Barbalho, S.M. (2023). Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects. Metabolites, 13.","DOI":"10.3390\/metabo13010096"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1080\/10408398.2020.1850417","article-title":"Curcumin, autoimmune and inflammatory diseases: Going beyond conventional therapy\u2014A systematic review","volume":"62","author":"Marton","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/jmf.2020.0129","article-title":"Effects of the Use of Curcumin on Ulcerative Colitis and Crohn\u2019s Disease: A Systematic Review","volume":"24","author":"Goulart","year":"2021","journal-title":"J. Med. Food"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1080\/10408398.2018.1456403","article-title":"Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn\u2019s disease and ulcerative colitis?","volume":"59","author":"Marton","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/phrev.phrev_54_16","article-title":"Reflections about Osteoarthritis and Curcuma longa","volume":"11","author":"Akuri","year":"2017","journal-title":"Pharmacogn. Rev."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/jmf.2017.0146","article-title":"Is Curcumin a Possibility to Treat Inflammatory Bowel Diseases?","volume":"21","author":"Mazieiro","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1080\/17474124.2020.1808460","article-title":"Curcumin therapy for ulcerative colitis remission: Systematic review and meta-analysis","volume":"14","author":"Goulart","year":"2020","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/0004867421998795","article-title":"A systematic review of the antidepressant effects of curcumin: Beyond monoamines theory","volume":"55","author":"Matias","year":"2021","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"107003","DOI":"10.1016\/j.intimp.2020.107003","article-title":"Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4\/NF-\u03baB and PI3K\/Akt pathways in C57BL\/6J mice","volume":"88","author":"Feng","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13813455.2020.1789881","article-title":"Fish oil and chicoric acid combination protects better against palmitate-induced lipid accumulation via regulating AMPK-mediated SREBP-1\/FAS and PPAR\u03b1\/UCP2 pathways","volume":"129","author":"Mohammadi","year":"2023","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1080\/13880209.2022.2148170","article-title":"Didymin, a natural flavonoid, relieves the progression of myocardial infarction via inhibiting the NLR family pyrin domain containing 3 inflammasome","volume":"60","author":"Zhang","year":"2022","journal-title":"Pharm. Biol."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.10.012","article-title":"Green tea derivative (-)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo","volume":"161","author":"Xie","year":"2020","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_322","doi-asserted-by":"crossref","unstructured":"Tanabe, H., Suzuki, T., Ohishi, T., Isemura, M., Nakamura, Y., and Unno, K. (2023). Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity. Molecules, 28.","DOI":"10.3390\/molecules28020525"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"35127","DOI":"10.1039\/D3RA06537E","article-title":"Co-encapsulated astaxanthin and kaempferol nanoparticles: Fabrication, characterization, and their potential synergistic effects on treating non-alcoholic fatty liver disease","volume":"13","author":"Oanh","year":"2023","journal-title":"RSC Adv."},{"key":"ref_324","first-page":"1387665","article-title":"Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety","volume":"2023","author":"Alkandahri","year":"2023","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1080\/15548627.2023.2186112","article-title":"The role of autophagy in bone metabolism and clinical significance","volume":"19","author":"Wang","year":"2023","journal-title":"Autophagy"},{"key":"ref_326","first-page":"154740","article-title":"Ameliorative effects of mangiferin derivative TPX on insulin resistance via PI3K\/AKT and AMPK signaling pathways in human HepG2 and HL-7702 hepatocytes","volume":"114","author":"Fan","year":"2023","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_327","doi-asserted-by":"crossref","unstructured":"Lin, H., Teng, H., Wu, W., Li, Y., Lv, G., Huang, X., Yan, W., and Lin, Z. (2020). Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease. BMC Pharmacol. Toxicol., 21.","DOI":"10.1186\/s40360-020-00438-x"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"e2200663","DOI":"10.1002\/mnfr.202200663","article-title":"Puerarin Alleviates Oxidized Oil-Induced Oxidative Injury and Inflammation via Inhibition of the Nrf2\/Keap1 and HMGB1\/TLR4\/MAPK Signaling Pathways: An Investigation in a Chicken Model","volume":"67","author":"Zhou","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12944-023-01969-y","article-title":"Puerarin ameliorates metabolic dysfunction-associated fatty liver disease by inhibiting ferroptosis and inflammation","volume":"22","author":"Yang","year":"2023","journal-title":"Lipids Health Dis."},{"key":"ref_330","doi-asserted-by":"crossref","unstructured":"Subash-Babu, P., Al-Numair, N., Almuzaini, T., Athinarayanan, J., and Alshatwi, A.A. (2022). Punicalagin and Ketogenic Amino Acids Loaded Organic Lipid Carriers Enhance the Bioavailability, Mitochondrial \u03b2-Oxidation, and Ketogenesis in Maturing Adipocytes. Nanomaterials, 12.","DOI":"10.3390\/nano12030368"},{"key":"ref_331","first-page":"496","article-title":"An in vitro antiviral evaluation of punicalagin toward influenza A virus","volume":"14","author":"Karimi","year":"2024","journal-title":"Avicenna J. Phytomed."},{"key":"ref_332","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez, M., Casta\u00f1eta, G., Simirgiotis, M.J., Sepulveda, B., and Areche, C. (2024). Comprehensive phytochemical profile of leaves, stems and fruits from Orthopterygium huaucui (A. Gray) Hemsl. and their antioxidant activities. Chem. Biodivers., early view.","DOI":"10.1002\/cbdv.202400746"},{"key":"ref_333","doi-asserted-by":"crossref","unstructured":"Kundrapu, D.B., Chaitanya, A.K., Manaswi, K., Kumari, S., and Malla, R. (2024). Quercetin and taxifolin inhibits TMPRSS2 activity and its interaction with EGFR in paclitaxel-resistant breast cancer cells: An in silico and in vitro study. Chem. Biol. Drug Des., 104.","DOI":"10.1111\/cbdd.14600"},{"key":"ref_334","doi-asserted-by":"crossref","unstructured":"Xiang, L., Wang, Y., Liu, S., Ying, L., Zhang, K., Liang, N., Li, H., Luo, G., and Xiao, L. (2024). Quercetin Attenuates KLF4-Mediated Phenotypic Switch of VSMCs to Macrophage-like Cells in Atherosclerosis: A Critical Role for the JAK2\/STAT3 Pathway. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147755"},{"key":"ref_335","doi-asserted-by":"crossref","unstructured":"Huang, C.C., Liu, C.C., Tsao, J.P., Hsu, C.L., and Cheng, I.S. (2020). Effects of Oral Resveratrol Supplementation on Glycogen Replenishment and Mitochondria Biogenesis in Exercised Human Skeletal Muscle. Nutrients, 12.","DOI":"10.3390\/nu12123721"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3164\/jcbn.23-124","article-title":"Trans-resveratrol reduced hepatic oxidative stress in an animal model without inducing an upregulation of nuclear factor erythroid 2-related factor 2","volume":"75","author":"Santana","year":"2024","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00784-024-05771-7","article-title":"Anti-proliferative impact of resveratrol on gingival fibroblasts from juvenile hyaline fibromatosis","volume":"28","author":"Saygun","year":"2024","journal-title":"Clin. Oral Investig."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"114899","DOI":"10.1016\/j.expneurol.2024.114899","article-title":"Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1\/PGC-1\u03b1","volume":"380","author":"Su","year":"2024","journal-title":"Exp. Neurol."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/ptr.6865","article-title":"Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1\/TAZ-PPAR\u03b3\/PGC-1\u03b1 signaling pathway","volume":"35","author":"Luo","year":"2021","journal-title":"Phytother. Res. PTR"},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Musolino, V., Macr\u00ec, R., Cardamone, A., Tucci, L., Serra, M., Lupia, C., Maurotti, S., Mare, R., Nucera, S., and Guarnieri, L. (2023). Salvia rosmarinus Spenn. (Lamiaceae) Hydroalcoholic Extract: Phytochemical Analysis, Antioxidant Activity and In Vitro Evaluation of Fatty Acid Accumulation. Plants, 12.","DOI":"10.3390\/plants12183306"},{"key":"ref_341","doi-asserted-by":"crossref","unstructured":"Chen, W., Zhao, X., Huang, Z., Luo, S., Zhang, X., Sun, W., Lan, T., and He, R. (2024). Determination of Flavonolignan Compositional Ratios in Silybum marianum (Milk Thistle) Extracts Using High-Performance Liquid Chromatography. Molecules, 29.","DOI":"10.3390\/molecules29132949"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"2374062","DOI":"10.1080\/21623945.2024.2374062","article-title":"Silybin restores glucose uptake after tumour necrosis factor-alpha and lipopolysaccharide stimulation in 3T3-L1 adipocytes","volume":"13","author":"Escobedo","year":"2024","journal-title":"Adipocyte"},{"key":"ref_343","first-page":"137","article-title":"Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients","volume":"13","author":"Elahi","year":"2024","journal-title":"Mol. Biol. Res. Commun."},{"key":"ref_344","doi-asserted-by":"crossref","unstructured":"Satyam, S.M., Bairy, L.K., Rehman, A., Attia, M., Ahmed, L., Emad, K., Jaafer, Y., and Bahaaeldin, A. (2024). Unlocking Synergistic Hepatoprotection: Dapagliflozin and Silymarin Combination Therapy Modulates Nuclear Erythroid 2-Related Factor 2\/Heme Oxygenase-1 Pathway in Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats. Biology, 13.","DOI":"10.3390\/biology13070473"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.ijtb.2023.08.007","article-title":"From nature\u2019s bounty to drug discovery: Leveraging phytochemicals and molecular approaches to combat multi-drug-resistant (MDR) tuberculosis","volume":"71","author":"Nalam","year":"2024","journal-title":"Indian J. Tuberc."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/a-1948-4290","article-title":"Green Tea Catechol (-)-Epigallocatechin Gallate (EGCG) Conjugated with Phenylalanine Shows Enhanced Autophagy Stimulating Activity in Human Aortic Endothelial Cells","volume":"89","author":"Lee","year":"2023","journal-title":"Planta Medica"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"139155","DOI":"10.1016\/j.chemosphere.2023.139155","article-title":"The ferryl generation by fenton reaction driven by catechol","volume":"335","author":"Zarate","year":"2023","journal-title":"Chemosphere"},{"key":"ref_348","doi-asserted-by":"crossref","unstructured":"Aborziza, M., Amalia, R., Zuhrotun, A., Ikram, N.K.K., Novitasari, D., and Muchtaridi, M. (2024). Coffee Bean and Its Chemical Constituent Caffeine and Chlorogenic Acid as Promising Chemoprevention Agents: Updated Biological Studies against Cancer Cells. Molecules, 29.","DOI":"10.3390\/molecules29143302"},{"key":"ref_349","doi-asserted-by":"crossref","unstructured":"Singh, S., and Varshney, M. (2024). Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research. Comb. Chem. High Throughput Screen.","DOI":"10.2174\/0113862073321017240610060637"},{"key":"ref_350","doi-asserted-by":"crossref","unstructured":"Janda, K., Gutowska, I., Geszke-Moritz, M., and Jakubczyk, K. (2021). The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties\u2014A Review. Molecules, 26.","DOI":"10.3390\/molecules26061814"},{"key":"ref_351","doi-asserted-by":"crossref","unstructured":"Salvoza, N., Giraudi, P.J., Tiribelli, C., and Rosso, N. (2022). Natural Compounds for Counteracting Nonalcoholic Fatty Liver Disease (NAFLD): Advantages and Limitations of the Suggested Candidates. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052764"},{"key":"ref_352","doi-asserted-by":"crossref","unstructured":"Marton, L.T., Pescinini, E.S.L.M., Camargo, M.E.C., Barbalho, S.M., Haber, J., Sinatora, R.V., Detregiachi, C.R.P., Girio, R.J.S., Buchaim, D.V., and Cincotto Dos Santos Bueno, P. (2021). The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.669448"},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Rudrapal, M., Eltayeb, W.A., Rakshit, G., El-Arabey, A.A., Khan, J., Aldosari, S.M., Alshehri, B., and Abdalla, M. (2023). Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-35161-0"},{"key":"ref_354","doi-asserted-by":"crossref","unstructured":"Singh, A., Soni, U., Varadwaj, P.K., Misra, K., and Rizvi, S.I. (2023). Anti-inflammatory effect of curcumin in an accelerated senescence model of Wistar rat: An in vivo and in-silico study. J. Biomol. Struct. Dyn., 1\u201312.","DOI":"10.1080\/07391102.2023.2291832"},{"key":"ref_355","doi-asserted-by":"crossref","unstructured":"R\u00f3\u017ca\u0144ski, G., Kujawski, S., Newton, J.L., Zalewski, P., and S\u0142omko, J. (2021). Curcumin and Biochemical Parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)\u2014A Review. Nutrients, 13.","DOI":"10.3390\/nu13082654"},{"key":"ref_356","doi-asserted-by":"crossref","unstructured":"Lukkunaprasit, T., Tansawet, A., Boonmanunt, S., Sobhonslidsuk, A., McKay, G.J., Attia, J., and Thakkinstian, A. (2023). An updated meta-analysis of effects of curcumin on metabolic dysfunction-associated fatty liver disease based on available evidence from Iran and Thailand. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33023-3"},{"key":"ref_357","doi-asserted-by":"crossref","unstructured":"He, Y., Wang, H., Lin, S., Chen, T., Chang, D., Sun, Y., Wang, C., Liu, Y., Lu, Y., and Song, J. (2023). Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K\/AKT\/mTOR and HIF-1\/VEGF cascade. Biomed. Pharmacother. = Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115279"},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1186\/s12967-023-04790-4","article-title":"Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis","volume":"21","author":"Yang","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/1535370220962708","article-title":"Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects","volume":"246","author":"Chatree","year":"2021","journal-title":"Exp. Biol. Med."},{"key":"ref_360","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_361","first-page":"8644","article-title":"Pentoxifylline and its association with kaempferol improve NASH-associated manifestation in mice through anti-apoptotic, anti-necroptotic, antioxidant, and anti-inflammatory mechanisms","volume":"26","author":"Hamouda","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_362","doi-asserted-by":"crossref","unstructured":"Li, N., Yin, L., Shang, J., Liang, M., Liu, Z., Yang, H., Qiang, G., Du, G., and Yang, X. (2023). Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1\/AMPK signaling pathway. Biomed. Pharmacother. = Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115113"},{"key":"ref_363","doi-asserted-by":"crossref","unstructured":"Chi\u0219, A., Noubissi, P.A., Pop, O.L., Mure\u0219an, C.I., Fokam Tagne, M.A., Kamgang, R., Fodor, A., Sitar-T\u0103ut, A.V., Cozma, A., and Or\u0103\u0219an, O.H. (2023). Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties. Plants, 13.","DOI":"10.3390\/plants13010020"},{"key":"ref_364","doi-asserted-by":"crossref","unstructured":"Sun, W.L., Yang, J.W., Dou, H.Y., Li, G.Q., Li, X.Y., Shen, L., and Ji, H.F. (2021). Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis. Bioorgan. Chem., 112.","DOI":"10.1016\/j.bioorg.2021.104966"},{"key":"ref_365","doi-asserted-by":"crossref","unstructured":"Yao, C., Dai, S., Wang, C., Fu, K., Wu, R., Zhao, X., Yao, Y., and Li, Y. (2023). Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies. Biomed. Pharmacother. = Biomed. Pharmacother., 167.","DOI":"10.1016\/j.biopha.2023.115464"},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"3946320221137435","DOI":"10.1177\/03946320221137435","article-title":"Luteolin loaded on zinc oxide nanoparticles ameliorates non-alcoholic fatty liver disease associated with insulin resistance in diabetic rats via regulation of PI3K\/AKT\/FoxO1 pathway","volume":"36","author":"Ahmed","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3177\/jnsv.69.259","article-title":"Luteolin Ameliorates Hepatic Steatosis and Enhances Mitochondrial Biogenesis via AMPK\/PGC-1\u03b1 Pathway in Western Diet-Fed Mice","volume":"69","author":"Wang","year":"2023","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_368","doi-asserted-by":"crossref","unstructured":"Li, L., Dong, Y., Liu, X., and Wang, M. (2023). Mangiferin for the Management of Liver Diseases: A Review. Foods, 12.","DOI":"10.3390\/foods12132469"},{"key":"ref_369","doi-asserted-by":"crossref","unstructured":"Zhou, J., Zhang, N., Aldhahrani, A., Soliman, M.M., Zhang, L., and Zhou, F. (2022). Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.956688"},{"key":"ref_370","first-page":"670","article-title":"Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8","volume":"21","author":"Hu","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"103281","DOI":"10.1016\/j.psj.2023.103281","article-title":"Protective effects of puerarin on liver tissue in Salmonella-infected chicks: A proteomic analysis","volume":"103","author":"Lu","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_372","first-page":"133","article-title":"Puerarin alleviates liver fibrosis via inhibition of the ERK1\/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats","volume":"18","author":"Li","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1080\/10408398.2017.1422111","article-title":"Superfruits: Phytochemicals, antioxidant efficacies, and health effects\u2014A comprehensive review","volume":"59","author":"Chang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/cbdd.14295","article-title":"Coptidis rhizoma and evodiae fructus against lipid droplet deposition in nonalcoholic fatty liver disease-related liver cancer by AKT","volume":"102","author":"Li","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_375","doi-asserted-by":"crossref","unstructured":"Jin, T., Zhang, Y., Botchway, B.O.A., Huang, M., Lu, Q., and Liu, X. (2023). Quercetin activates the Sestrin2\/AMPK\/SIRT1 axis to improve amyotrophic lateral sclerosis. Biomed. Pharmacother. = Biomed. Pharmacother., 161.","DOI":"10.1016\/j.biopha.2023.114515"},{"key":"ref_376","doi-asserted-by":"crossref","unstructured":"Olla, S., Siguri, C., Fais, A., Era, B., Fantini, M.C., and Di Petrillo, A. (2023). Inhibitory Effect of Quercetin on Oxidative Endogen Enzymes: A Focus on Putative Binding Modes. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202305.1496.v1"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"106175","DOI":"10.1016\/j.jff.2024.106175","article-title":"The effect of quercetin supplementation on the components of metabolic syndrome in adults: A systematic review and dose\u2013response meta-analysis of randomized controlled trials","volume":"116","author":"Noshadi","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_378","doi-asserted-by":"crossref","unstructured":"Ashrafizadeh, M., Javanmardi, S., Moradi-Ozarlou, M., Mohammadinejad, R., Farkhondeh, T., Samarghandian, S., and Garg, M. (2020). Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: An updated review on resveratrol. Biosci. Rep., 40.","DOI":"10.1042\/BSR20200257"},{"key":"ref_379","doi-asserted-by":"crossref","unstructured":"Feng, S., Gui, J., Qin, B., Ye, J., Zhao, Q., Guo, A., Sang, M., and Sun, X. (2024). Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson\u2019s Disease Model. Mol. Neurobiol.","DOI":"10.1007\/s12035-024-04234-0"},{"key":"ref_380","doi-asserted-by":"crossref","unstructured":"Yang, S., Zhang, J., Xu, Z., Shao, W., Pang, X., Li, D., Huang, X., Luo, W., Du, Z., and Li, Y. (2024). Dietary resveratrol improves the flesh quality of Siberian sturgeon (Acipenser baerii) by enhancing myofiber growth, nutrient accumulation and antioxidant capacity. BMC Genom., 25.","DOI":"10.1186\/s12864-024-10436-6"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2174\/1570159X20666221012122855","article-title":"Resveratrol-Mediated Regulation of Mitochondria Biogenesis-associated Pathways in Neurodegenerative Diseases: Molecular Insights and Potential Therapeutic Applications","volume":"21","author":"Shaito","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s40203-024-00238-9","article-title":"Exploring the therapeutic potential of rosemary compounds against Alzheimer\u2019s disease through GC-MS and molecular docking analysis","volume":"12","author":"Singh","year":"2024","journal-title":"Silico Pharmacol."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/rej.2018.2107","article-title":"Rosmarinic Acid Ameliorates H2O2-Induced Oxidative Stress in L02 Cells Through MAPK and Nrf2 Pathways","volume":"22","author":"Ding","year":"2019","journal-title":"Rejuvenation Res."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1080\/07853890.2022.2069854","article-title":"Role of silymarin as antioxidant in clinical management of chronic liver diseases: A narrative review","volume":"54","author":"Aghemo","year":"2022","journal-title":"Ann. Med."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/13813455.2022.2138445","article-title":"Silymarin inhibits the lipogenic pathway and reduces worsening of non-alcoholic fatty liver disease (NAFLD) in mice","volume":"130","author":"Carvalho","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1097\/MD.0000000000000758","article-title":"A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease","volume":"94","author":"Zhang","year":"2015","journal-title":"Medicine"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"101843","DOI":"10.1016\/j.clinre.2021.101843","article-title":"Upregulated NLRP3 inflammasome activation is attenuated by anthocyanins in patients with nonalcoholic fatty liver disease: A case-control and an intervention study","volume":"46","author":"Zhu","year":"2022","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3892\/ijmm.2013.1503","article-title":"Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study","volume":"32","author":"Sakata","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_389","doi-asserted-by":"crossref","unstructured":"Castellino, G., Nikolic, D., Mag\u00e1n-Fern\u00e1ndez, A., Malfa, G.A., Chianetta, R., Patti, A.M., Amato, A., Montalto, G., Toth, P.P., and Banach, M. (2019). Altilix(\u00ae) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study. Nutrients, 11.","DOI":"10.3390\/nu11112580"},{"key":"ref_390","doi-asserted-by":"crossref","unstructured":"Saadati, S., Sadeghi, A., Mansour, A., Yari, Z., Poustchi, H., Hedayati, M., Hatami, B., and Hekmatdoost, A. (2019). Curcumin and inflammation in non-alcoholic fatty liver disease: A randomized, placebo controlled clinical trial. BMC Gastroenterol., 19.","DOI":"10.1186\/s12876-019-1055-4"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"183","DOI":"10.15403\/jgld-179","article-title":"Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"28","author":"Mirhafez","year":"2019","journal-title":"J. Gastrointest. Liver Dis. JGLD"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"102447","DOI":"10.1016\/j.ctim.2020.102447","article-title":"A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled, clinical trial","volume":"51","author":"Hariri","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jbmt.2020.02.021","article-title":"Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease","volume":"24","author":"Farzanegi","year":"2020","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: A double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1111\/dom.14804","article-title":"The effect of curcumin on hepatic fat content in individuals with obesity","volume":"24","author":"Hellmann","year":"2022","journal-title":"Diabetes Obes. Metab."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ajcnut.2024.05.017","article-title":"Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with nonalcoholic simple fatty liver disease: A randomized controlled trial","volume":"120","author":"He","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_397","doi-asserted-by":"crossref","unstructured":"Kwok, M.K., Leung, G.M., Xu, L., Tse, H.F., Lam, T.H., and Schooling, C.M. (2022). Effect of puerarin supplementation on cardiovascular disease risk factors: A randomized, double-blind, placebo-controlled, 2-way crossover trial. Biomed. Pharmacother. = Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113472"},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S0007114509359127","article-title":"Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study","volume":"102","author":"Egert","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.nutres.2014.09.005","article-title":"Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease","volume":"34","author":"Faghihzadeh","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_400","first-page":"226","article-title":"Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial","volume":"47","author":"Chen","year":"2015","journal-title":"Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/dom.13268","article-title":"Effects of resveratrol supplementation on liver fat content in overweight and insulin-resistant subjects: A randomized, double-blind, placebo-controlled clinical trial","volume":"20","author":"Kantartzis","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/07315724.2017.1392264","article-title":"Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial","volume":"37","author":"Asghari","year":"2018","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1024\/0300-9831\/a000528","article-title":"No beneficial effects of resveratrol supplementation on atherogenic risk factors in patients with nonalcoholic fatty liver disease","volume":"90","author":"Farzin","year":"2020","journal-title":"Int. J. Vitam. Nutr. Research. Int. Z. Fur Vitam.-Und Ernahrungsforschung. J. Int. Vitaminol. Nutr."},{"key":"ref_404","doi-asserted-by":"crossref","unstructured":"Ali Sangouni, A., Abdollahi, S., and Mozaffari-Khosravi, H. (2022). Effect of resveratrol supplementation on hepatic steatosis and cardiovascular indices in overweight subjects with type 2 diabetes: A double-blind, randomized controlled trial. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02637-2"},{"key":"ref_405","first-page":"193","article-title":"Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study","volume":"51","author":"Trappoliere","year":"2005","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/gut.2006.091967","article-title":"A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: Preliminary observations","volume":"55","author":"Federico","year":"2006","journal-title":"Gut"},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.freeradbiomed.2012.02.008","article-title":"Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial","volume":"52","author":"Loguercio","year":"2012","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_408","first-page":"3118","article-title":"Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study","volume":"19","author":"Aller","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40268-015-0084-x","article-title":"Efficacy of lifestyle changes in subjects with non-alcoholic liver steatosis and metabolic syndrome may be improved with an antioxidant nutraceutical: A controlled clinical study","volume":"15","author":"Sorrentino","year":"2015","journal-title":"Drugs RD"},{"key":"ref_410","first-page":"1940","article-title":"A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis","volume":"15","author":"Mahadeva","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_411","doi-asserted-by":"crossref","unstructured":"Nehmi-Filho, V., Santamarina, A.B., de Freitas, J.A., Trarbach, E.B., de Oliveira, D.R., Palace-Berl, F., de Souza, E., de Miranda, D.A., Escamilla-Garcia, A., and Otoch, J.P. (2022). Novel nutraceutical supplements with yeast \u03b2-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate obesity-related metabolic and clinical parameters: A double-blind randomized trial. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1089938"},{"key":"ref_412","doi-asserted-by":"crossref","unstructured":"Eilam, Y., Pintel, N., Khattib, H., Shagug, N., Taha, R., and Avni, D. (2022). Regulation of Cholesterol Metabolism by Phytochemicals Derived from Algae and Edible Mushrooms in Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213667"},{"key":"ref_413","first-page":"2611","article-title":"Dietary Patterns and Cardiovascular Risk: Are the Mediterranean Diet, the Heart-Healthy Diet, and Phytochemicals Associated with Lower Cardiovascular Risks?","volume":"52","author":"Irgat","year":"2023","journal-title":"Iran. J. Public Health"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1354\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:10:48Z","timestamp":1760112648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/10\/1354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":413,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ph17101354"],"URL":"https:\/\/doi.org\/10.3390\/ph17101354","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]}}}