{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:24:00Z","timestamp":1792157040397,"version":"4.4.0"},"reference-count":206,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Food and Health Bureau","award":["08192306"],"award-info":[{"award-number":["08192306"]}]},{"name":"Food and Health Bureau","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"Food and Health Bureau","award":["30205"],"award-info":[{"award-number":["30205"]}]},{"name":"Food and Health Bureau","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"Food and Health Bureau","award":["82374347"],"award-info":[{"award-number":["82374347"]}]},{"name":"Food and Health Bureau","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}]},{"name":"Food and Health Bureau","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}]},{"name":"Food and Health Bureau","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}]},{"name":"University Grants Committee, Hong Kong","award":["08192306"],"award-info":[{"award-number":["08192306"]}]},{"name":"University Grants Committee, Hong Kong","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"University Grants Committee, Hong Kong","award":["30205"],"award-info":[{"award-number":["30205"]}]},{"name":"University Grants Committee, Hong Kong","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"University Grants Committee, Hong Kong","award":["82374347"],"award-info":[{"award-number":["82374347"]}]},{"name":"University Grants Committee, Hong Kong","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}]},{"name":"University Grants Committee, Hong Kong","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}]},{"name":"University Grants Committee, Hong Kong","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}]},{"name":"University of Hong Kong","award":["08192306"],"award-info":[{"award-number":["08192306"]}]},{"name":"University of Hong Kong","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"University of Hong Kong","award":["30205"],"award-info":[{"award-number":["30205"]}]},{"name":"University of Hong Kong","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"University of Hong Kong","award":["82374347"],"award-info":[{"award-number":["82374347"]}]},{"name":"University of Hong Kong","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}]},{"name":"University of Hong Kong","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}]},{"name":"University of Hong Kong","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}]},{"name":"University Grants Committee, Hong Kong","award":["08192306"],"award-info":[{"award-number":["08192306"]}]},{"name":"University Grants Committee, Hong Kong","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"University Grants Committee, Hong Kong","award":["30205"],"award-info":[{"award-number":["30205"]}]},{"name":"University Grants Committee, Hong Kong","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"University Grants Committee, Hong Kong","award":["82374347"],"award-info":[{"award-number":["82374347"]}]},{"name":"University Grants Committee, Hong Kong","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}]},{"name":"University Grants Committee, Hong Kong","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}]},{"name":"University Grants Committee, Hong Kong","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["08192306"],"award-info":[{"award-number":["08192306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30205"],"award-info":[{"award-number":["30205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374347"],"award-info":[{"award-number":["82374347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["08192306"],"award-info":[{"award-number":["08192306"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["30205"],"award-info":[{"award-number":["30205"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["82374347"],"award-info":[{"award-number":["82374347"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Commission of Science and Technology","doi-asserted-by":"publisher","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["08192306"],"award-info":[{"award-number":["08192306"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["30205"],"award-info":[{"award-number":["30205"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["82374347"],"award-info":[{"award-number":["82374347"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}]},{"name":"Shanghai Human Resources and Social Security Bureau","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["08192306"],"award-info":[{"award-number":["08192306"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["30205"],"award-info":[{"award-number":["30205"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["AoE\/M-707\/18"],"award-info":[{"award-number":["AoE\/M-707\/18"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["82374347"],"award-info":[{"award-number":["82374347"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Health Commission of Shanghai","doi-asserted-by":"publisher","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Silent information regulator sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase with potent anti-arterial aging activities. Its protective function in aging-related diseases has been extensively studied. In the microcirculation, SIRT1 plays a crucial role in preventing microcirculatory endothelial senescence by suppressing inflammation and oxidative stress while promoting mitochondrial function and optimizing autophagy. It suppresses hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1)-mediated pathological angiogenesis while promoting healthy, physiological capillarization. As a result, SIRT1 protects against microvascular dysfunction, such as diabetic microangiopathy, while enhancing exercise-induced skeletal muscle capillarization and energy metabolism. In the brain, SIRT1 upregulates tight junction proteins and strengthens their interactions, thus maintaining the integrity of the blood\u2212brain barrier. The present review summarizes recent findings on the regulation of microvascular function by SIRT1, the underlying mechanisms, and various approaches to modulate SIRT1 activity in microcirculation. The importance of SIRT1 as a molecular target in aging-related diseases, such as diabetic retinopathy and stroke, is underscored, along with the need for more clinical evidence to support SIRT1 modulation in the microcirculation.<\/jats:p>","DOI":"10.3390\/ph17111495","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T06:41:22Z","timestamp":1730961682000},"page":"1495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1"],"prefix":"10.3390","volume":"17","author":[{"given":"Martin","family":"Law","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-1380","authenticated-orcid":false,"given":"Zhong-Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China"},{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-2940","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ccc.2019.12.011","article-title":"A Review on Microvascular Hemodynamics: The Control of Blood Flow Distribution and Tissue Oxygenation","volume":"36","author":"Munoz","year":"2020","journal-title":"Crit Care Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.14336\/AD.2019.0315","article-title":"A Microcirculatory Theory of Aging","volume":"10","author":"Jin","year":"2019","journal-title":"Aging Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.14336\/AD.2017.0430","article-title":"Age-related Impairment of Vascular Structure and Functions","volume":"8","author":"Xu","year":"2017","journal-title":"Aging Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.2337\/dc18-1236","article-title":"Atherosclerosis and Microvascular Complications: Results From the Canadian Study of Longevity in Type 1 Diabetes","volume":"41","author":"Lovshin","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Spione, F., Arevalos, V., Gabani, R., Sabat\u00e9, M., and Brugaletta, S. (2022). Coronary Microvascular Angina: A State-of-the-Art Review. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.800918"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/35065638","article-title":"Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans","volume":"410","author":"Tissenbaum","year":"2001","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1126\/science.289.5487.2126","article-title":"Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae","volume":"289","author":"Lin","year":"2000","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kim, J.Y., Mondaca-Ruff, D., Singh, S., and Wang, Y. (2022). SIRT1 and Autophagy: Implications in Endocrine Disorders. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.930919"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"H1371","DOI":"10.1152\/ajpheart.00024.2020","article-title":"Sirt1 during childhood is associated with microvascular function later in life","volume":"318","author":"Looney","year":"2020","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCRESAHA.122.320888","article-title":"Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels","volume":"131","author":"Mengozzi","year":"2022","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mariani, S., di Giorgio, M.R., Martini, P., Persichetti, A., Barbaro, G., Basciani, S., Contini, S., Poggiogalle, E., Sarnicola, A., and Genco, A. (2018). Inverse Association of Circulating SIRT1 and Adiposity: A Study on Underweight, Normal Weight, and Obese Patients. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00449"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mariani, S., Di Giorgio, M.R., Rossi, E., Tozzi, R., Contini, S., Bauleo, L., Cipriani, F., Toscano, R., Basciani, S., and Barbaro, G. (2020). Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa. Nutrients, 12.","DOI":"10.3390\/nu12113506"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Li, J., Zhang, Y., Zeng, X., Cheng, Y., Tang, L., Hong, D., and Yang, X. (2022). Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. J. Nutr. Biochem., 99.","DOI":"10.1016\/j.jnutbio.2021.108862"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alinho, G.H.F., Kuwabara, K.L., Faria, N.F.d.O., Goes, M.F.d.S., Roggerio, A., Avakian, S.D., Strunz, C.M.C., and Mansur, A.d.P. (2023). Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol. Nutrients, 15.","DOI":"10.3390\/nu15132949"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Elibol, B., and Kilic, U. (2018). High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00614"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10522-017-9685-9","article-title":"Sirtuins, a promising target in slowing down the ageing process","volume":"18","author":"Grabowska","year":"2017","journal-title":"Biogerontology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cell.2018.02.008","article-title":"Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging","volume":"173","author":"Das","year":"2018","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Scarf\u00f2, G., Daniele, S., Chelucci, E., Rizza, A., Fusi, J., Freggia, G., Costa, B., Taliani, S., Artini, P., and Martini, C. (2023). Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-44928-4"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E649","DOI":"10.1152\/ajpendo.00230.2011","article-title":"Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle","volume":"301","author":"Ringholm","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1210\/en.2011-1667","article-title":"Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1\u2212\/\u2212 mice","volume":"153","author":"Xu","year":"2012","journal-title":"Endocrinology"},{"key":"ref_21","first-page":"E313","article-title":"Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity","volume":"295","author":"Pang","year":"2008","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"105424","DOI":"10.1016\/j.isci.2022.105424","article-title":"Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue","volume":"25","author":"Furuuchi","year":"2022","journal-title":"iScience"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1139\/cjpp-2021-0454","article-title":"Fibroblast growth factor 21 improves lipopolysaccharide-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-\u03baB deacetylation","volume":"100","author":"Zhou","year":"2022","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yi, P., Pang, J., Alexander, J.S., and Rivera, C. (2013). The endotoxin\/toll-like receptor-4 axis mediates gut microvascular dysfunction associated with post-prandial lipidemia. BMC Physiol., 13.","DOI":"10.1186\/1472-6793-13-12"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.atherosclerosis.2014.10.090","article-title":"Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity","volume":"237","author":"Pang","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_26","first-page":"156","article-title":"Methylene Blue Reduces Retinal Cell Inflammation, Apoptosis, and Oxidative Stress in a Rat Model of Diabetic Retinopathy via Sirtuin 1 Activation","volume":"29","author":"Mai","year":"2023","journal-title":"Altern. Ther. Health Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13577-019-00240-w","article-title":"Down-regulation of miR-377 suppresses high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells by direct up-regulation of target gene SIRT1","volume":"32","author":"Cui","year":"2019","journal-title":"Hum. Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1089\/met.2017.0146","article-title":"Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial","volume":"16","author":"Sohrab","year":"2018","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1007\/s00125-021-05431-5","article-title":"Fasting and fasting-mimicking treatment activate SIRT1\/LXR\u03b1 and alleviate diabetes-induced systemic and microvascular dysfunction","volume":"64","author":"Hammer","year":"2021","journal-title":"Diabetologia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.abb.2018.11.016","article-title":"SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress","volume":"661","author":"Li","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1101\/gad.435107","article-title":"SIRT1 controls endothelial angiogenic functions during vascular growth","volume":"21","author":"Potente","year":"2007","journal-title":"Genes Dev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.bbrc.2016.08.066","article-title":"Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation","volume":"478","author":"Kida","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9425","DOI":"10.7150\/thno.43315","article-title":"Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1\/eNOS signaling pathway","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Takiyama, Y., and Haneda, M. (2014). Hypoxia in Diabetic Kidneys. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/837421"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00125-015-3622-8","article-title":"Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL\/6 mice","volume":"58","author":"Zheng","year":"2015","journal-title":"Diabetologia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-1536-5-13","article-title":"Diabetic angiopathy and angiogenic defects","volume":"5","author":"Xu","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xu, Y., Zou, H., Ding, Q., Zou, Y., Tang, C., Lu, Y., and Xu, X. (2022). tiRNA-Val promotes angiogenesis via Sirt1-Hif-1\u03b1 axis in mice with diabetic retinopathy. Biol. Res., 55.","DOI":"10.1186\/s40659-022-00381-7"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13098-022-00937-3","article-title":"Effect of plasma-derived extracellular vesicles on angiogenesis and the ensuing proliferative diabetic retinopathy through a miR-30b-dependent mechanism","volume":"14","author":"Wang","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wang, P., Konja, D., Singh, S., Zhang, B., and Wang, Y. (2024). Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25041978"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Li, J., Feng, Z., Lu, B., Fang, X., Huang, D., and Wang, B. (2023). Resveratrol alleviates high glucose-induced oxidative stress and apoptosis in rat cardiac microvascular endothelial cell through AMPK\/Sirt1 activation. Biochem. Biophys. Rep., 34.","DOI":"10.1016\/j.bbrep.2023.101444"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8882130","DOI":"10.1155\/2021\/8882130","article-title":"Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK\/SIRT1 Signaling Pathway","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, B., Wu, L., Cao, T., Zheng, H.M., and He, T. (2020). MiR-221\/SIRT1\/Nrf2 signal axis regulates high glucose induced apoptosis in human retinal microvascular endothelial cells. BMC Ophthalmol., 20.","DOI":"10.1186\/s12886-020-01559-x"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7584691","DOI":"10.1155\/2017\/7584691","article-title":"Resveratrol Prevents ROS-Induced Apoptosis in High Glucose-Treated Retinal Capillary Endothelial Cells via the Activation of AMPK\/Sirt1\/PGC-1\u03b1 Pathway","volume":"2017","author":"Li","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12931-021-01855-0","article-title":"Adiponectin ameliorates lung ischemia\u2013reperfusion injury through SIRT1-PINK1 signaling-mediated mitophagy in type 2 diabetic rats","volume":"22","author":"Jiang","year":"2021","journal-title":"Respir. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Lin, J., Zhang, L., Zhang, M., Hu, J., Wang, T., Duan, Y., Man, W., Wu, B., Feng, J., and Sun, L. (2016). Mst1 inhibits CMECs autophagy and participates in the development of diabetic coronary microvascular dysfunction. Sci. Rep., 6.","DOI":"10.1038\/srep34199"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.2147\/DMSO.S420253","article-title":"Stachydrine Relieved the Inflammation and Promoted the Autophagy in Diabetes Retinopathy Through Activating the AMPK\/SIRT1 Signaling Pathway","volume":"16","author":"Yu","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/eurheartj\/ehx818","article-title":"Coronary microvascular dysfunction and heart failure with preserved ejection fraction as female-pattern cardiovascular disease: The chicken or the egg?","volume":"39","author":"Nelson","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_48","first-page":"100389","article-title":"Coronary microvascular dysfunction, arrythmias, and sudden cardiac death: A literature review","volume":"41","author":"Dankar","year":"2024","journal-title":"Am. Heart J. Plus"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11239-023-02862-2","article-title":"Molecular mechanisms of endothelial dysfunction in coronary microcirculation dysfunction","volume":"56","author":"Zhang","year":"2023","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, A.J., Tang, Y., Zhang, J., Wang, B.J., Xiao, M., Lu, G., Li, J., Liu, Q., Guo, Y., and Gu, J. (2022). Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox Biol., 52.","DOI":"10.1016\/j.redox.2022.102310"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lu, G., Liu, Q., Gao, T., Li, J., Zhang, J., Chen, O., Cao, C., Mao, M., Xiao, M., and Zhang, X. (2022). Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway. Nutrients, 14.","DOI":"10.3390\/nu14194017"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhang, W., Wang, X., Tang, Y., and Huang, C. (2023). Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1\/Nrf2 pathway. Biomed. Pharmacother., 162.","DOI":"10.1016\/j.biopha.2023.114591"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/cvr\/cvab053","article-title":"Coronary microcirculation damage in anthracycline cardiotoxicity","volume":"118","author":"Lobo","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"175150","DOI":"10.1016\/j.ejphar.2022.175150","article-title":"Ligustrazine prevents coronary microcirculation dysfunction in rats via suppression of miR-34a-5p and promotion of Sirt1","volume":"929","author":"Gao","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"H1691","DOI":"10.1152\/ajpheart.00281.2014","article-title":"Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction","volume":"307","author":"Maizel","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"111014","DOI":"10.1016\/j.diabres.2023.111014","article-title":"ACMSD mediated de novo NAD+ biosynthetic impairment in cardiac endothelial cells as a potential therapeutic target for diabetic cardiomyopathy","volume":"206","author":"Zeng","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1161\/STROKEAHA.120.030063","article-title":"Microvascular Brain Disease Progression and Risk of Stroke The ARIC Study","volume":"51","author":"Koton","year":"2020","journal-title":"Stroke"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood-brain barrier: Ageing and microvascular disease--systematic review and meta-analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol Aging"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nbd.2018.09.006","article-title":"Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging","volume":"126","author":"Stamatovic","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.redox.2017.09.016","article-title":"Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia","volume":"14","author":"Chen","year":"2018","journal-title":"Redox Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ejn.14223","article-title":"Inhibition of calcium\/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood\u2013brain barrier after stroke","volume":"49","author":"Sun","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Tian, J., Liu, Y., Wang, Z., Zhang, S., Yang, Y., Zhu, Y., and Yang, C. (2021). LncRNA Snhg8 attenuates microglial inflammation response and blood-brain barrier damage in ischemic stroke through regulating miR-425-5p mediated SIRT1\/NF-\u03baB signaling. J. Biochem. Mol. Toxicol., 35.","DOI":"10.1002\/jbt.22724"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1007\/s12035-022-02903-6","article-title":"Nicotinamide Mononucleotide Adenylyltransferase 1 Regulates Cerebral Ischemia-Induced Blood-Brain Barrier Disruption Through NAD(+)\/SIRT1 Signaling Pathway","volume":"59","author":"Zhang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"114115","DOI":"10.1016\/j.expneurol.2022.114115","article-title":"circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1\/SIRT1","volume":"355","author":"Chen","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/jnen\/nlae005","article-title":"Long noncoding RNA KCNQ1OT1 aggravates cerebral infarction by regulating PTBT1\/SIRT1 via miR-16-5p","volume":"83","author":"Jiang","year":"2024","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Li, Y., Liu, X.-T., Zhang, P.-L., Li, Y.-C., Sun, M.-R., Wang, Y.-T., Wang, S.-P., Yang, H., Liu, B.-L., and Wang, M. (2022). Hydroxysafflor Yellow A Blocks HIF-1\u03b1 Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium. Antioxidants, 11.","DOI":"10.21203\/rs.3.rs-1180303\/v1"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Qu, Y., Cao, J., Wang, D., Wang, S., Li, Y., and Zhu, Y. (2022). 14,15-Epoxyeicosatrienoic Acid Protect Against Glucose Deprivation and Reperfusion-Induced Cerebral Microvascular Endothelial Cells Injury by Modulating Mitochondrial Autophagy via SIRT1\/FOXO3a Signaling Pathway and TSPO Protein. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.888836"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3892\/etm.2015.2365","article-title":"Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion","volume":"9","author":"Tan","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1080\/21655979.2022.2045833","article-title":"Donepezil ameliorates oxygen-glucose deprivation\/reoxygenation-induced brain microvascular endothelial cell dysfunction via the SIRT1\/FOXO3a\/NF-\u03baB pathways","volume":"13","author":"Sun","year":"2022","journal-title":"Bioengineered"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2018.11.024","article-title":"MALAT1 lncRNA Induces Autophagy and Protects Brain Microvascular Endothelial Cells Against Oxygen\u2013Glucose Deprivation by Binding to miR-200c-3p and Upregulating SIRT1 Expression","volume":"397","author":"Wang","year":"2019","journal-title":"Neuroscience"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2018.10.031","article-title":"LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL","volume":"1707","author":"Zhou","year":"2019","journal-title":"Brain Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/WCO.0000000000000913","article-title":"Cerebral small vessel disease and vascular cognitive impairment: From diagnosis to management","volume":"34","author":"Zotin","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/svn-2018-000213","article-title":"Cerebral microvascular dysfunction and neurodegeneration in dementia","volume":"4","author":"Han","year":"2019","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jocn.2018.10.029","article-title":"Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson\u2019s disease","volume":"58","author":"Schwartz","year":"2018","journal-title":"J. Clin. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","article-title":"The blood-brain barrier in aging and neurodegeneration","volume":"27","author":"Knox","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.5213\/inj.2142340.170","article-title":"Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion","volume":"25","author":"Lee","year":"2021","journal-title":"Int. Neurourol. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11357-019-00074-2","article-title":"Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: A potential mechanism for the prevention of vascular cognitive impairment","volume":"41","author":"Kiss","year":"2019","journal-title":"GeroScience"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41419-020-03293-0","article-title":"Sirtuin 1-dependent regulation of high mobility box 1 in hypoxia\u2013reoxygenated brain microvascular endothelial cells: Roles in neuronal amyloidogenesis","volume":"11","author":"Lee","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wang, X.-F., Liu, D.-X., Liang, Y., Xing, L.-L., Zhao, W.-H., Qin, X.-X., Shang, D.-S., Li, B., Fang, W.-G., and Cao, L. (2016). Cystatin C Shifts APP Processing from Amyloid-\u03b2 Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161093"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e006421","DOI":"10.1161\/JAHA.117.006421","article-title":"Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4\/Glucagon-Like Peptide-1-Adiponectin Axis","volume":"6","author":"Piao","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.18632\/aging.101518","article-title":"A promising connection between BDNF and Alzheimer\u2019s disease","volume":"10","author":"Giuffrida","year":"2018","journal-title":"Aging"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Fang, X., Chen, Y., Wang, Y., Ren, J., and Zhang, C. (2019). Depressive symptoms in schizophrenia patients: A possible relationship between SIRT1 and BDNF. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 95.","DOI":"10.1016\/j.pnpbp.2019.109673"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Lee, Y., and Im, E. (2021). Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS. Antioxidants, 10.","DOI":"10.3390\/antiox10030377"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1073\/pnas.0704329104","article-title":"SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase","volume":"104","author":"Mattagajasingh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wu, C.H., Chiu, Y.L., Hsieh, C.Y., Tsung, G.S., Wu, L.S., Cheng, C.C., and Tsai, T.N. (2021). Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1\/Kr\u00fcppel-like Factor 2 Pathway in Endothelial Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910287"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.niox.2013.04.001","article-title":"Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol","volume":"32","author":"Xia","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1161\/ATVBAHA.110.210500","article-title":"Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway","volume":"30","author":"Ota","year":"2010","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"105125","DOI":"10.1016\/j.phrs.2020.105125","article-title":"Role of hydrogen sulfide in cardiovascular ageing","volume":"160","author":"Testai","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2022.04.008","article-title":"Nicotinamide riboside relieves the severity of experimental necrotizing enterocolitis by regulating endothelial function via eNOS deacetylation","volume":"184","author":"Zhang","year":"2022","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Tseng, S.-Y., Chang, H.-Y., Li, Y.-H., and Chao, T.-H. (2022). Effects of Cilostazol on Angiogenesis in Diabetes through Adiponectin\/Adiponectin Receptors\/Sirtuin1 Signaling Pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314839"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s13577-022-00703-7","article-title":"The inhibitory effects of Dulaglutide on cellular senescence against high glucose in human retinal endothelial cells","volume":"35","author":"Nian","year":"2022","journal-title":"Hum. Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/cns.13042","article-title":"DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic\/high-glucose conditions, potentially through the SIRT1\/HIF-1\/VEGF pathway","volume":"25","author":"Mi","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e00150","DOI":"10.1002\/prp2.150","article-title":"Reduced activity of SKC a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats","volume":"3","author":"Kong","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/apha.12628","article-title":"Endothelium-dependent hyperpolarization: Age, gender and blood pressure, do they matter?","volume":"219","author":"Leung","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/sj.bjp.0706091","article-title":"Reciprocal changes in endothelium-derived hyperpolarizing factor- and nitric oxide-system in the mesenteric artery of adult female rats following ovariectomy","volume":"144","author":"Nawate","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/bph.12290","article-title":"17-\u03b2 Oestradiol prevents cardiovascular dysfunction in post-menopausal metabolic syndrome by affecting SIRT1\/AMPK\/H3 acetylation","volume":"170","author":"Bendale","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5551\/jat.ED119","article-title":"SIRT1 and Gender Differences in Atherosclerotic Cardiovascular Disease","volume":"27","author":"Shimabukuro","year":"2020","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: The dark side of tumor suppression","volume":"5","author":"Desprez","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5483\/BMBRep.2019.52.1.290","article-title":"Sirtuin signaling in cellular senescence and aging","volume":"52","author":"Lee","year":"2019","journal-title":"BMB Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbrc.2010.05.160","article-title":"Involvement of the p65\/RelA subunit of NF-kappaB in TNF-alpha-induced SIRT1 expression in vascular smooth muscle cells","volume":"397","author":"Zhang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1074\/jbc.RA119.011982","article-title":"Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-\u03baB and expression of the long-noncoding RNA HAS2-AS1","volume":"295","author":"Caon","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1128\/MCB.01343-09","article-title":"Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB","volume":"30","author":"Yang","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/TP.0000000000003435","article-title":"microRNA-145 Inhibition Upregulates SIRT1 and Attenuates Autophagy in a Mouse Model of Lung Ischemia\/Reperfusion Injury via NF-\u03baB-dependent Beclin 1","volume":"105","author":"Dai","year":"2021","journal-title":"Transplantation"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.bbadis.2017.04.024","article-title":"Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy","volume":"1863","author":"Mishra","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/SHK.0000000000002404","article-title":"Hydrogen-rich saline upregulates the Sirt1\/NF-\u03baB signaling pathway and reduces vascular endothelial glycocalyx shedding in sepsis-induced acute kidney injury","volume":"62","author":"Lin","year":"2024","journal-title":"Shock"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"C846","DOI":"10.1152\/ajpcell.00288.2015","article-title":"Mechanotransduction of the endothelial glycocalyx mediates nitric oxide production through activation of TRP channels","volume":"311","author":"Dragovich","year":"2016","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Lipphardt, M., Dihazi, H., M\u00fcller, G.A., and Goligorsky, M.S. (2018). Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01325"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1074\/jbc.M113.506899","article-title":"Angiopoietin-2 secretion by endothelial cell exosomes: Regulation by the phosphatidylinositol 3-kinase (PI3K)\/Akt\/endothelial nitric oxide synthase (eNOS) and syndecan-4\/syntenin pathways","volume":"289","author":"Ju","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"20230698","DOI":"10.1515\/med-2023-0698","article-title":"Dihydroartemisinin ameliorates cerebral I\/R injury in rats via regulating VWF and autophagy-mediated SIRT1\/FOXO1 pathway","volume":"18","author":"Duan","year":"2023","journal-title":"Open Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41556-020-00579-5","article-title":"SIRT1 is downregulated by autophagy in senescence and ageing","volume":"22","author":"Xu","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12603-022-1750-7","article-title":"Autophagy-Sirtuin1(SIRT1) Alleviated the Coronary Atherosclerosis (AS) in Mice through Regulating the Proliferation and Migration of Endothelial Progenitor Cells (EPCs) via wnt\/\u03b2-catenin\/GSK3\u03b2 Signaling Pathway","volume":"26","author":"Li","year":"2022","journal-title":"J. Nutr. Health Aging"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41420-021-00683-x","article-title":"The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson\u2019s disease is promoted by conserved oxidation sites","volume":"7","author":"Baeken","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1080\/15384101.2020.1804179","article-title":"NaSH increases SIRT1 activity and autophagy flux through sulfhydration to protect SH-SY5Y cells induced by MPP~+","volume":"19","author":"Li","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.18632\/aging.205430","article-title":"MicroRNA-141-3p reduces pulmonary hypoxia\/reoxygenation injury through suppression of Beclin-1-dependent autophagy","volume":"16","author":"Zhan","year":"2024","journal-title":"Aging"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1089\/rej.2017.1980","article-title":"The NAD+\/PARP1\/SIRT1 Axis in Aging","volume":"20","author":"Mendelsohn","year":"2017","journal-title":"Rejuvenation Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Fan, C., Ma, Q., Xu, M., Qiao, Y., Zhang, Y., Li, P., Bi, Y., and Tang, M. (2019). Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194936"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2337\/db11-0416","article-title":"Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1\/AMPK\/ROS pathway and therapeutic effects of metformin","volume":"61","author":"Zheng","year":"2012","journal-title":"Diabetes"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"16456","DOI":"10.1074\/jbc.M501485200","article-title":"SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}","volume":"280","author":"Nemoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Abu Shelbayeh, O., Arroum, T., Morris, S., and Busch, K.B. (2023). PGC-1\u03b1 Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response. Antioxidants, 12.","DOI":"10.3390\/antiox12051075"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/156720211796558069","article-title":"Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress","volume":"8","author":"Hou","year":"2011","journal-title":"Curr. Neurovascular Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4093\/dmj.2014.38.5.337","article-title":"Diabetic cardiomyopathy and its prevention by nrf2: Current status","volume":"38","author":"Chen","year":"2014","journal-title":"Diabetes Metab. J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","article-title":"The multifaceted role of Nrf2 in mitochondrial function","volume":"1","author":"Kostov","year":"2016","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Kratz, E.M., So\u0142kiewicz, K., Kubis-Kubiak, A., and Piwowar, A. (2021). Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020630"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10753-020-01242-9","article-title":"Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation","volume":"43","author":"Singh","year":"2020","journal-title":"Inflammation"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yexcr.2017.09.042","article-title":"The crosstalk between Sirt1 and Keap1\/Nrf2\/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-\u03b21 expressions in rat glomerular mesangial cells","volume":"361","author":"Huang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1089\/ars.2012.4615","article-title":"p53 orchestrates the PGC-1\u03b1-mediated antioxidant response upon mild redox and metabolic imbalance","volume":"18","author":"Aquilano","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1089\/ars.2012.4713","article-title":"SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a\/PGC-1\u03b1 complex","volume":"19","author":"Olmos","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Thounaojam, M.C., Jadeja, R.N., Warren, M., Powell, F.L., Raju, R., Gutsaeva, D., Khurana, S., Martin, P.M., and Bartoli, M. (2019). MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. Antioxidants, 8.","DOI":"10.3390\/antiox8090328"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5603\/FM.a2023.0002","article-title":"FOXO6 transcription inhibition of CTRP3 promotes OGD\/R-triggered cardiac microvascular endothelial barrier disruption via SIRT1\/Nrf2 signalling","volume":"83","author":"Zheng","year":"2024","journal-title":"Folia Morphol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1159\/000488736","article-title":"Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia\/Reperfusion Through NOX4-Mediated Gene Regulation","volume":"46","author":"Chai","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Akil, A., Guti\u00e9rrez-Garc\u00eda, A.K., Guenter, R., Rose, J.B., Beck, A.W., Chen, H., and Ren, B. (2021). Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.642352"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2040-2384-1-8","article-title":"Novel insights into the differential functions of Notch ligands in vascular formation","volume":"1","author":"Kume","year":"2009","journal-title":"J. Angiogenesis Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1093\/cvr\/cvaa248","article-title":"Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors","volume":"117","author":"Wang","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Xi, H., Wang, C., Li, Q., Ye, Q., Zhu, Y., and Mao, Y. (2023). S-Propargyl-Cysteine Ameliorates Peripheral Nerve Injury through Microvascular Reconstruction. Antioxidants, 12.","DOI":"10.3390\/antiox12020294"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-physiol-021113-170322","article-title":"Hypoxia-Inducible Factor 1 and Cardiovascular Disease","volume":"76","author":"Semenza","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Zhou, M., Hou, J., Li, Y., Mou, S., Wang, Z., Horch, R.E., Sun, J., and Yuan, Q. (2019). The pro-angiogenic role of hypoxia inducible factor stabilizer FG-4592 and its application in an in vivo tissue engineering chamber model. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-41924-5"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.molcel.2010.05.023","article-title":"Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha","volume":"38","author":"Lim","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Yu, M., Zhang, L., Sun, S., and Zhang, Z. (2021). Gliquidone improves retinal injury to relieve diabetic retinopathy via regulation of SIRT1\/Notch1 pathway. BMC Ophthalmol., 21.","DOI":"10.1186\/s12886-021-02215-8"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1124\/jpet.115.226894","article-title":"Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin","volume":"356","author":"Arunachalam","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"921","DOI":"10.5966\/sctm.2012-0026","article-title":"Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation","volume":"1","author":"Yuen","year":"2012","journal-title":"STEM CELLS Transl. Med."},{"key":"ref_142","first-page":"E932","article-title":"Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and YAP\/HIF1\u03b1\/VEGFA depletion","volume":"319","author":"Pan","year":"2020","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1167\/iovs.17-23558","article-title":"SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A\/VEGFR-2 and MMP14","volume":"59","author":"Lin","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Guillot, E., Lemay, A., Allouche, M., Silva, S.V., Coppola, H., Sabatier, F., Dignat-George, F., Sarre, A., Peyter, A.-C., and Simoncini, S. (2023). Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119747"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies","volume":"27","author":"Dejana","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Takata, F., Nakagawa, S., Matsumoto, J., and Dohgu, S. (2021). Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.661838"},{"key":"ref_147","first-page":"995","article-title":"SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders","volume":"44","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41401-018-0045-3","article-title":"Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability","volume":"40","author":"Fu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Feng, S., Zou, L., Wang, H., He, R., Liu, K., and Zhu, H. (2018). RhoA\/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability. Molecules, 23.","DOI":"10.3390\/molecules23092371"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12035-014-8637-5","article-title":"The potential role of rho GTPases in Alzheimer\u2019s disease pathogenesis","volume":"50","author":"Bolognin","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.trsl.2020.05.006","article-title":"Microvascular thrombosis: Experimental and clinical implications","volume":"225","author":"Bray","year":"2020","journal-title":"Transl. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1161\/01.CIR.101.13.1500","article-title":"Oxidized lipoproteins degrade the endothelial surface layer: Implications for platelet-endothelial cell adhesion","volume":"101","author":"Vink","year":"2000","journal-title":"Circulation"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.2353\/ajpath.2010.090316","article-title":"Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney","volume":"176","author":"Nakayama","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.31557\/APJCP.2021.22.10.3393","article-title":"Anti-Proliferative and Pro-Apoptotic Activities of Synthesized 3,4,5 Tri-Methoxy Ciprofloxacin Chalcone Hybrid, through p53 Up-Regulation in HepG2 and MCF7 Cell Lines","volume":"22","author":"Eisa","year":"2021","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1113\/expphysiol.2007.038588","article-title":"Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium","volume":"93","author":"Mitchell","year":"2008","journal-title":"Exp. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.1073\/pnas.1219073110","article-title":"COX-2, the dominant source of prostacyclin","volume":"110","author":"Ricciotti","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1056\/NEJMoa050405","article-title":"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention","volume":"352","author":"Solomon","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nrd1225","article-title":"COX-2 and beyond: Approaches to prostaglandin inhibition in human disease","volume":"2","author":"FitzGerald","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/CIRCULATIONAHA.112.097295","article-title":"Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner","volume":"126","author":"Barbieri","year":"2012","journal-title":"Circulation"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/sj.bjp.0707383","article-title":"1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2\/prostacyclin pathway","volume":"152","author":"Chlopicki","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"12290","DOI":"10.1074\/jbc.M114.615948","article-title":"Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia","volume":"290","author":"Kumari","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/09537104.2016.1190005","article-title":"SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets","volume":"27","author":"Kim","year":"2016","journal-title":"Platelets"},{"key":"ref_163","first-page":"A271","article-title":"BS38\u2005SIRT1: A novel regulator of integrin \u03b1iib\u03b23 and actin cytoskeleton dynamics in platelets","volume":"109","author":"Blanco","year":"2023","journal-title":"Heart"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.omtn.2021.01.023","article-title":"SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging","volume":"23","author":"Lan","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1097\/CCM.0000000000000949","article-title":"The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans","volume":"43","author":"Scicluna","year":"2015","journal-title":"Crit. Care Med."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Brown, K., Theofanous, D., Britton, R.G., Aburido, G., Pepper, C., Undru, S.S., and Howells, L. (2024). Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020747"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/gerona\/glx041","article-title":"Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults","volume":"72","author":"Pollack","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Neves, A.R., Queiroz, J.F., and Reis, S. (2016). Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E. J. Nanobiotechnol., 14.","DOI":"10.1186\/s12951-016-0177-x"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.2174\/1381612828666220705113514","article-title":"Role of Drug Delivery System in Improving the Bioavailability of Resveratrol","volume":"28","author":"Saleem","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"DTI-S9442","DOI":"10.4137\/DTI.S9442","article-title":"Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent","volume":"6","author":"Annabi","year":"2012","journal-title":"Drug Target Insights"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Grabowska, A.D., W\u0105troba, M., Witkowska, J., Mikulska, A., Sep\u00falveda, N., and Szukiewicz, D. (2023). Interplay between Systemic Glycemia and Neuroprotective Activity of Resveratrol in Modulating Astrocyte SIRT1 Response to Neuroinflammation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411640"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.18632\/aging.202467","article-title":"Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1","volume":"13","author":"Xu","year":"2021","journal-title":"Aging"},{"key":"ref_173","first-page":"463","article-title":"Wogonoside alleviates high glucose-induced dysfunction of retinal microvascular endothelial cells and diabetic retinopathy in rats by up-regulating SIRT1","volume":"42","author":"Shao","year":"2022","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3892\/etm.2023.12358","article-title":"Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1","volume":"27","author":"He","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1567202618666211109104419","article-title":"Hydroxysafflor Yellow a Promotes Angiogenesis in Rat Brain Microvascular Endothelial Cells Injured by Oxygen-glucose Deprivation\/reoxygenation(OGD\/R) through SIRT1-HIF-1\u03b1-VEGFA Signaling Pathway","volume":"18","author":"Ruan","year":"2021","journal-title":"Curr. Neurovascular Res."},{"key":"ref_176","first-page":"162","article-title":"Tetramethylpyrazine regulates angiogenesis of endothelial cells in cerebral ischemic stroke injury via SIRT1\/VEGFA signaling pathway","volume":"49","author":"Shu","year":"2024","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1112394","DOI":"10.1155\/2022\/1112394","article-title":"Salvianolic Acid B Alleviates Limb Ischemia in Mice via Promoting SIRT1\/PI3K\/AKT Pathway-Mediated M2 Macrophage Polarization","volume":"2022","author":"Niu","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2022.03.012","article-title":"Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1\u03b1-PPAR\u03b1 pathway","volume":"183","author":"Hu","year":"2022","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/ars.2017.7195","article-title":"Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide","volume":"30","author":"Du","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13048-021-00912-y","article-title":"Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1\/Akt in granulosa cells of PCOS","volume":"14","author":"Zheng","year":"2021","journal-title":"J. Ovarian Res."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Ram\u00edrez, R., Gonz\u00e1lez-Fern\u00e1ndez, R., Hern\u00e1ndez, J., Mart\u00edn-Vasallo, P., Palumbo, A., and \u00c1vila, J. (2021). Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress. Antioxidants, 10.","DOI":"10.3390\/antiox10121871"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Rajeswari, J.J., and Unniappan, S. (2020). Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-63226-x"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.18632\/aging.205468","article-title":"Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress","volume":"16","author":"Chai","year":"2024","journal-title":"Aging"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.metabol.2013.12.011","article-title":"Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway","volume":"63","author":"Shimada","year":"2014","journal-title":"Metabolism"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00125-014-3197-9","article-title":"miR-195 regulates SIRT1-mediated changes in diabetic retinopathy","volume":"57","author":"Mortuza","year":"2014","journal-title":"Diabetologia"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Zeng, Y., Cui, Z., Liu, J., Chen, J., and Tang, S. (2019). MicroRNA-29b-3p Promotes Human Retinal Microvascular Endothelial Cell Apoptosis via Blocking SIRT1 in Diabetic Retinopathy. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01621"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10456-021-09778-6","article-title":"Hydrogel-mediated delivery of microRNA-92a inhibitor polyplex nanoparticles induces localized angiogenesis","volume":"24","author":"Radmanesh","year":"2021","journal-title":"Angiogenesis"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s10528-023-10521-7","article-title":"miR-29a-SIRT1-Wnt\/\u03b2-Catenin Axis Regulates Tumor Progression and Survival in Hepatocellular Carcinoma","volume":"62","author":"Qian","year":"2023","journal-title":"Biochem. Genet."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3892\/mmr.2020.11804","article-title":"miR-126 overexpression attenuates oxygen-glucose deprivation\/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1\/Nrf2 signaling pathway in human umbilical vein endothelial cells","volume":"23","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.7150\/thno.42174","article-title":"Circular RNA-protein interactions: Functions, mechanisms, and identification","volume":"10","author":"Huang","year":"2020","journal-title":"Theranostics"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1073\/pnas.1814874116","article-title":"Targeting pericyte-endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41419-021-04059-y","article-title":"Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1093\/nar\/gkz141","article-title":"circ-Sirt1 controls NF-\u03baB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132\/212 in vascular smooth muscle cells","volume":"47","author":"Kong","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/cbin.11758","article-title":"Circ-Sirt1 inhibits vascular smooth muscle cells proliferation via the c-Myc\/cyclin B1 axis","volume":"46","author":"Huang","year":"2022","journal-title":"Cell Biol. Int."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Kong, P., Li, C.-L., Dou, Y.-Q., Cao, L., Zhang, X.-Y., Zhang, W.-D., Bi, Z.-Q., Peng, Z.-Y., Yan, A.-Q., and Han, M. (2021). circ-Sirt1 Decelerates Senescence by Inhibiting p53 Activation in Vascular Smooth Muscle Cells, Ameliorating Neointima Formation. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.724592"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jgg.2023.09.012","article-title":"Unraveling the complexity of polycystic ovary syndrome with animal models","volume":"51","author":"Liu","year":"2024","journal-title":"J. Genet. Genom."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2018.08.026","article-title":"LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia\/reperfusion injury through activating AMPK signaling pathway","volume":"690","author":"Yin","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"29761","DOI":"10.1074\/jbc.R115.694661","article-title":"The Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human Health","volume":"290","author":"Saikia","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_199","first-page":"5243","article-title":"A novel dressing seeded with embryonic artery CD133+ cells and loaded with the Sirt1 agonist SRT1720 accelerates the healing of diabetic ischemic ulcers","volume":"15","author":"Cheng","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1189\/jlb.3MA0114-034RR","article-title":"SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome","volume":"96","author":"Vachharajani","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Orecchia, A., Scarponi, C., Di Felice, F., Cesarini, E., Avitabile, S., Mai, A., Mauro, M.L., Sirri, V., Zambruno, G., and Albanesi, C. (2011). Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS ONE, 6.","DOI":"10.1371\/annotation\/0174b439-c62b-42e8-a420-3defbfe5c8e9"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.3892\/mmr.2015.4164","article-title":"Fenofibrate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway","volume":"12","author":"Zhao","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/bph.12496","article-title":"Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1","volume":"171","author":"Arunachalam","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s13577-024-01038-1","article-title":"Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: An implication in diabetes retinopathy","volume":"37","author":"Hou","year":"2024","journal-title":"Hum. Cell"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Wici\u0144ski, M., G\u00f3rski, K., Walczak, M., W\u00f3dkiewicz, E., S\u0142upski, M., Pawlak-Osi\u0144ska, K., and Malinowski, B. (2019). Neuroprotective Properties of Linagliptin: Focus on Biochemical Mechanisms in Cerebral Ischemia, Vascular Dysfunction and Certain Neurodegenerative Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20164052"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Abouhish, H., Thounaojam, M.C., Jadeja, R.N., Gutsaeva, D.R., Powell, F.L., Khriza, M., Martin, P.M., and Bartoli, M. (2020). Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. Antioxidants, 9.","DOI":"10.3390\/antiox9070599"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/11\/1495\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:27:58Z","timestamp":1760113678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/17\/11\/1495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":206,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ph17111495"],"URL":"https:\/\/doi.org\/10.3390\/ph17111495","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}