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Genetic predispositions, comorbid medical conditions, nutritional choices, and environmental factors increasingly recognize the multifactorial etiology of the disease. Methods: Recent research has highlighted the potential of phytochemicals, particularly flavonoids, saponins, and alkaloids, to manage hyperuricemia (HUA) and its associated complications. Results: Plant\u2019s natural compounds have garnered attention for their anti-inflammatory, antioxidant, and uric acid-lowering properties, suggesting their role in alternative and complementary medicine. Phytochemicals have demonstrated promise in mitigating gout symptoms and potentially modifying the disease course by addressing different aspects of hyperuricemia and inflammation. Herbal remedies, with their complex phytochemical profiles, offer a unique advantage by potentially complementing conventional pharmacological treatments. The integration of herbal therapies with standard medications could lead to enhanced therapeutic outcomes through synergistic effects, optimizing disease management, and improving patient quality of life. Conclusions: This review examines the current understanding of the multifaceted etiology of gout, explores the role of phytochemicals in managing hyperuricemia, and discusses the potential benefits of combining herbal remedies with conventional treatments to improve patient care and therapeutic efficacy.<\/jats:p>","DOI":"10.3390\/ph17111507","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:52:07Z","timestamp":1731297127000},"page":"1507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Therapeutic Management of Chemical and Herbal Medications on Uric Acid Levels and Gout: Modern and Traditional Wisdom"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-068X","authenticated-orcid":false,"given":"Zhijian","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-371X","authenticated-orcid":false,"given":"Jeetendra Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmaceutical Research, GLA University Mathura, Chaumuhan 281406, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-1941","authenticated-orcid":false,"given":"Mohsin","family":"Maqbool","sequence":"additional","affiliation":[{"name":"Department of Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-4590","authenticated-orcid":false,"given":"Krishan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-744X","authenticated-orcid":false,"given":"Ayushi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, Taipei City 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-710X","authenticated-orcid":false,"given":"Nitin","family":"Wahi","sequence":"additional","affiliation":[{"name":"Pathfinder Research and Training Foundation, Gr. 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