{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T17:30:56Z","timestamp":1781371856449,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405888\/2018"],"award-info":[{"award-number":["405888\/2018"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNPq","award":["405888\/2018"],"award-info":[{"award-number":["405888\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: The present work aimed to compare the effects of the standardized dry extract from the leaves of Monteverdia ilicifolia, popularly known as \u201cespinheira-santa\u201d, with omeprazole in the management of dyspepsia related to gastroesophageal reflux disease (GERD). Methods: A double-blind, randomized, non-inferiority and double-dummy clinical trial was conducted. In total, 86 patients with GERD symptoms were randomized into three groups: Omeprazol (20 mg), M. ilicifolia (400 mg), or M. ilicifolia (860 mg). Capsules were provided by SUSTENTEC\u00ae, Pato Bragato, Brazil. It was requested that the participants take three capsules before breakfast and dinner for 4\u2009weeks. Clinical outcomes were obtained at the beginning and end of the study, with GERD symptoms (QS-GERD), the impact of heartburn symptoms on quality of life (HBQOL), and medical records. Results: Overall, 75.6% of the participants showed adherence without any differences among the experimental groups. All groups had significant reductions in both QS-GERD and HBQOL scores. Omeprazole and 400 and 860 mg of M. ilicifolia decreased the QS-GERD total scores at the endpoint compared to the baseline (Chi-square = 129.808; p &lt; 0.0001), as well as individual item scores, such as heartburn intensity (Chi-square = 93.568, p &lt; 0.0001) and heartburn after meals (Chi-square = 126.426, p &lt; 0.0001). There were no differences among the experimental groups after the intervention. Conclusions: Our results suggest that capsules with a standardized dry extract from the leaves of M. ilicifolia at a dosage of 400 or 860 mg are non-inferior to omeprazole, a proton pump inhibitor.<\/jats:p>","DOI":"10.3390\/ph17111559","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:46:11Z","timestamp":1732164371000},"page":"1559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacological Evaluation of the Traditional Brazilian Medicinal Plant Monteverdia ilicifolia in Gastroesophageal Reflux Disease: Preliminary Results of a Randomized Double-Blind Controlled Clinical Trial"],"prefix":"10.3390","volume":"17","author":[{"given":"Mait\u00ea Scherer","family":"da Silva","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Farmacologia e Terap\u00eautica, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Vargas Antunes","family":"Schunck","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0162-5443","authenticated-orcid":false,"given":"Maicon Pereira","family":"Moraes","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giana Blume","family":"Corssac","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Farmacologia e Terap\u00eautica, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"},{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-0440","authenticated-orcid":false,"given":"Gabriela","family":"Meirelles","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"},{"name":"Laborat\u00f3rio de Desenvolvimento Gal\u00eanico, Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-6587","authenticated-orcid":false,"given":"Sara Elis","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"},{"name":"Laborat\u00f3rio de Desenvolvimento Gal\u00eanico, Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Vieira","family":"Targa","sequence":"additional","affiliation":[{"name":"Curso de Medicina, Universidade de Caxias do Sul, Caxias do Sul 95070-560, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-5855","authenticated-orcid":false,"given":"Valquiria","family":"Bassani","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento Gal\u00eanico, Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90160-093, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-8547","authenticated-orcid":false,"given":"Marcelo Rodrigues","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-7148","authenticated-orcid":false,"given":"Caroline","family":"Dani","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Farmacologia e Terap\u00eautica, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"},{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-0978","authenticated-orcid":false,"given":"Ionara Rodrigues","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Farmacologia e Terap\u00eautica, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"},{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","first-page":"241","article-title":"Brazilian Consensus on Gastroesophageal Reflux Disease: Proposals for 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