{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:31:38Z","timestamp":1787823098561,"version":"build-2784847793"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian agencies National Council for Scientific and Technological Development (CNPq)"},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)"},{"name":"Federal University of Para\u00edba (UFPB)"},{"name":"Research Institute for Drugs and Medicines (IPeFarM)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Acute lung injury (ALI) is an inflammatory disorder affecting patients in intensive care with high mortality. No specific pharmacological treatment is available. Musa paradisiaca L. (banana) is a cosmopolitan plant, and homemade syrup from its inflorescence is used in many countries to treat pulmonary inflammation. Therefore, this study analyzed the hydroalcoholic extract (HEM) of the inflorescence on the ALI experimental model. Methods: Swiss mice were challenged with lipopolysaccharide and treated with HEM after 1, 24, and 48 h (five animals\/group, three times). Results: The HEM-treated ALI mice presented a decrease in neutrophil migration in the bronchoalveolar lavage fluid (BALF), in the alveolar region, and in the blood, correlating to downregulation of CD18 expression. The HEM treatment also reduced the protein concentration in the BALF, caused lung edema formation, impaired NF-\u03baB activation via inhibition of TLR4 signaling pathway, and decreased IL-1\u03b2, TNF-\u03b1 production, free DNA release, and myeloperoxidase (MPO) activity. However, the extract induced an increased IL-10 in the BALF. Conclusions: Therefore, HEM\u2019s anti-inflammatory and immunomodulatory activities in ALI mice are by deactivating neutrophils by decreasing CD18 receptor, free DNA release, and MPO activity and inducing IL-10 production. Thus, this study supports the use of banana inflorescence in folk medicine and suggests its rational use to develop a phytomedicine to treat pulmonary inflammation.<\/jats:p>","DOI":"10.3390\/ph18010008","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T10:58:32Z","timestamp":1735037912000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Musa paradisiaca L. Inflorescence Abrogates Neutrophil Activation by Downregulating TLR4\/NF-KB Signaling Pathway in LPS-Induced Acute Lung Injury Model"],"prefix":"10.3390","volume":"18","author":[{"given":"Francisco Allysson Assis Ferreira","family":"Gadelha","sequence":"first","affiliation":[{"name":"Laboratory of Immunopharmacology, Research Institute for Drugs and Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"},{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Fragoso Pereira","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmo Isaias Duvirgens","family":"Vieira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Batista","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou\u00edse Mangueira","family":"De Lima","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Francisco","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Phisiology and Phatology, Health Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Marley Bezerra","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f4nia Maria","family":"Batista","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-1572","authenticated-orcid":false,"given":"Naiara Naiana","family":"Dejani","sequence":"additional","affiliation":[{"name":"Department of Phisiology and Phatology, Health Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Regina","family":"Piuvezam","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"},{"name":"Department of Phisiology and Phatology, Health Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.rcl.2022.06.005","article-title":"Pathogenesis, Imaging, and Evolution of Acute Lung Injury","volume":"60","author":"Kligerman","year":"2022","journal-title":"Radiol. 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