{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:44:32Z","timestamp":1792737872256,"version":"4.5.0"},"reference-count":142,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Inappropriate and excessive use of antibiotics is responsible for the rapid development of antimicrobial resistance, which is associated with increased patient morbidity and mortality. There is an urgent need to explore new antibiotics or alternative antimicrobial agents. S. aureus a commensal microorganism but is also responsible for numerous infections. In addition to innate resistance to \u03b2-lactam antibiotics, S. aureus strains resistant to methicillin (MRSA) often show resistance to other classes of antibiotics (multidrug resistance). The advancement of phage therapy against MRSA infections offers a promising alternative in the context of increasing antibiotic resistance. Therapeutic phages are easier to obtain and cheaper to produce than antibiotics. However, there is still a lack of standards to ensure the safe use of phages, including purification, dosage, means of administration, and the quantity of phages used. Some bacteria have developed defense mechanisms against phages. The use of phage cocktails or the combination of antibiotics and phages is preferred. For personalized therapy, it is essential to set up large collections to enable phage selection. In the future, the fight against MRSA strains using phages should be based on a multidisciplinary approach, including molecular biology and medicine. Other therapies in the fight against MRSA strains include the use of endolysin antimicrobial peptides (including defensins and cathelicidins). Researchers\u2019 activities also focus on the potential use of plant extracts, honey, propolis, alkaloids, and essential oils. To date, no vaccine has been approved against S. aureus strains.<\/jats:p>","DOI":"10.3390\/ph18010081","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:49:17Z","timestamp":1736761757000},"page":"81","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Antibiotic Resistance of Staphylococcus aureus Strains\u2014Searching for New Antimicrobial Agents\u2014Review"],"prefix":"10.3390","volume":"18","author":[{"given":"Micha\u0142","family":"Michalik","sequence":"first","affiliation":[{"name":"MML Medical Centre, Bagno 2, 00-112 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Podbielska-Kubera","sequence":"additional","affiliation":[{"name":"MML Medical Centre, Bagno 2, 00-112 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Dmowska-Koroblewska","sequence":"additional","affiliation":[{"name":"MML Medical Centre, Bagno 2, 00-112 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, S., Hon, K., Bouras, G., Psaltis, A.J., Shearwin, S., Wormald, P.J., and Vreugde, S. (2022). APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting Staphylococcus aureus and MRSA Biofilms. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116116"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liu, K., Wang, C., Zhou, X., Guo, X., Yang, Y., Liu, W., Zhao, R., and Song, H. (2024). Bacteriophage therapy for drug-resistant Staphylococcus aureus infections. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1336821"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e0207121","DOI":"10.1128\/aac.02071-21","article-title":"Considerations for the Use of Phage Therapy in Clinical Practice","volume":"66","author":"Suh","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/AAC.49.4.1465-1467.2005","article-title":"Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults","volume":"49","author":"Wertheim","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/1751-7915.14268","article-title":"Novel antimicrobial strategies to treat multi-drug resistant Staphylococcus aureus infections","volume":"16","author":"Douglas","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/IJGM.S153268","article-title":"In vitro biofilm formation by Staphylococcus aureus isolated from wounds of hospital-admitted patients and their association with antimicrobial resistance","volume":"11","author":"Neopane","year":"2018","journal-title":"Int. J. Gen. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1556\/1886.2023.00064","article-title":"Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review","volume":"14","author":"Fortaleza","year":"2024","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e01006-19","DOI":"10.1128\/JCM.01006-19","article-title":"Methicillin-Resistant Staphylococcus aureus in Hospitals: Latest Trends and Treatments Based on Bacteriophages","volume":"57","author":"Iglesias","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e01415","DOI":"10.1016\/j.heliyon.2019.e01415","article-title":"SCCmec typing of PVL-positive community-acquired Staphylococcus aureus (CA-MRSA) at a Japanese hospital","volume":"5","author":"Funaki","year":"2019","journal-title":"Heliyon"},{"key":"ref_10","unstructured":"Mroczkowska, A., and Empel, J. (2023). Staphylococcus aureus\u2014Chorobotw\u00f3rczo\u015b\u0107, Antybiotykooporno\u015b\u0107, Epidemiologia, Perspektywa Szczepionki, Narodowy Instytut Lek\u00f3w. Oporno\u015b\u0107 na antybiotyki, Information bulletin."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Singh, S., Numan, A., Somaily, H.H., Gorain, B., Ranjan, S., Rilla, K., Siddique, H.R., and Kesharwani, P. (2021). Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus. Mater. Sci. Eng. C Mater. Biol. Appl., 129.","DOI":"10.1016\/j.msec.2021.112384"},{"key":"ref_12","unstructured":"Picoli, S.U., R\u00f6hnelt, N.M., and Schenkel, T.S. (2021). Bacteriophages as Anti-Methicillin Re-sistant Staphylococcus aureus Agents. Insights into Drug Resistance in Staphylococcus aureus, IntechOpen."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajic.2008.05.007","article-title":"The role of colonization pressure in nosocomial transmission of methicillin-resistant Staphylococcus aureus","volume":"37","author":"Williams","year":"2009","journal-title":"Am. J. Infect. Control"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10068-013-0272-9","article-title":"Antibacterial activity of a novel flavonoid, 7-O-butyl naringenin, against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"22","author":"Lee","year":"2013","journal-title":"Food Sci. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000501788","article-title":"Antimicrobial resistance patterns in methicillin-resistant Staphylococcus aureus from patients hospitalized during 2015\u20132017 in hospitals in Poland","volume":"29","author":"Ko","year":"2020","journal-title":"Med. Princ. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Li, G.Q., Quan, F., Qu, T., Lu, J., Chen, S.I., Cui, L.Y., Guo, D., and Wang, Y. (2015). Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus. Biosci. Rep., 35.","DOI":"10.1042\/BSR20140167"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/AAC.05702-11","article-title":"Resistance to linezolid caused by modifications at its binding site on the ribosome","volume":"56","author":"Long","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_18","unstructured":"Siddiqui, A.H., and Koirala, J. (2023, April 02). Methicillin Resistant Staphylococcus aureus (MRSA), Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482221\/."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.ijantimicag.2013.04.006","article-title":"Treatment of bacteraemia: Methicillin-resistant Staphylococcus aureus (MRSA) to vancomycin-resistant S. aureus (VRSA)","volume":"42","author":"Gould","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1056\/NEJMoa1303359","article-title":"Transferable vancomycin resistance in a community-associated MRSA lineage","volume":"370","author":"Rossi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sanmukh, S.G., dos Santos, N.J., Barquilha, C.N., Cucielo, M., De Carvalho, M., Pintor Dos Reis, P., Delella, F.K., Carvalho, F.H., and Felisbino, S.L. (2021). Bacteriophages M13 and T4 Increase the Expression of Anchorage-Dependent Survival Pathway Genes and Down Regulate Androgen Receptor Expression in LNCaP Prostate Cell Line. Viruses, 13.","DOI":"10.3390\/v13091754"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cell.2016.12.003","article-title":"Acquisition of phage sensitivity by bacteria through exchange of phage receptors","volume":"168","author":"Tzipilevich","year":"2017","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.1001418107","article-title":"Biased gene transfer mimics patterns created through shared ancestry","volume":"107","author":"Andam","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chom.2017.06.018","article-title":"Synergy between the host immune system and bacteriophage is essential for successful phage therapy against an acute respiratory pathogen","volume":"22","author":"Roach","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"G\u00f3rski, A., Borysowski, J., and Mi\u0119dzybrodzki, R. (2020). Phage Therapy: Towards a Successful Clinical Trial. Antibiotics, 9.","DOI":"10.3390\/antibiotics9110827"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Furfaro, L.L., Payne, M.S., and Chang, B.J. (2018). Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles. Front. Cell. Infect. Microbiol., 8.","DOI":"10.3389\/fcimb.2018.00376"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zeynali Kelishomi, F., Khanjani, S., Fardsanei, F., Saghi Sarabi, H., Nikkhahi, F., and Dehghani, B. (2022). Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: A review. BMC Infect. Dis., 22.","DOI":"10.1186\/s12879-022-07944-9"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Alkhalil, S.S. (2023). The role of bacteriophages in shaping bacterial composition and diversity in the human gut. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1232413"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1128\/AEM.69.1.285-289.2003","article-title":"Elevated abundance of bacteriophage infecting bacteria in soil","volume":"69","author":"Ashelford","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_30","first-page":"251","article-title":"Bacteriophages: Update on applications as models for viruses in water","volume":"27","author":"Grabow","year":"2001","journal-title":"Water SA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2672.2009.04143.x","article-title":"The bacteriophages in human- and animal body-associated microbial communities","volume":"107","author":"Letarov","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ballest\u00e9, E., Blanch, A.R., Muniesa, M., Garc\u00eda-Aljaro, C., Rodr\u00edguez-Rubio, L., Mart\u00edn-D\u00edaz, J., Pascual-Benito, M., and Jofre, J. (2022). Bacteriophages in sewage: Abundance, roles, and applications. FEMS Microbes., 3.","DOI":"10.1093\/femsmc\/xtac009"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41564-019-0634-z","article-title":"Safety of bacteriophage therapy in severe Staphylococcus aureus infection","volume":"5","author":"Petrovic","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e02117-17","DOI":"10.1128\/JVI.02117-17","article-title":"Shigella phages isolated during a dysentery outbreak reveal uncommon structures and broad species diversity","volume":"92","author":"Doore","year":"2018","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.1073\/pnas.1320538111","article-title":"Staphylococcal pathogenicity island DNA packaging system involving cos-site packaging and phage-encoded HNH endonucleases","volume":"111","author":"Carpena","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rohde, C., Resch, G., Pirnay, J.-P., Blasde, B.G., Debarbieux, L., Gelman, D., G\u00f3rski, A., Hazan, R., Huys, I., and Kakabadze, E. (2018). Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains. Viruses, 10.","DOI":"10.3390\/v10040178"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhvania, P., Hoyle, N.S., Nadareishvili, L., Nizharadze, D., and Kutateladze, M. (2017). Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome. Front. Med., 4.","DOI":"10.3389\/fmed.2017.00094"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Moye, Z.D., Woolston, J., and Sulakvelidze, A. (2018). Bacteriophage Applications for Food Production and Processing. Viruses, 10.","DOI":"10.3390\/v10040205"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mutti, M., and Corsini, L. (2019). Robust Approaches for the Production of Active Ingredient and Drug Product for Human Phage Therapy. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02289"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kolenda, C., Medina, M., Bonhomme, M., Laumay, F., Roussel-Gaillard, T., Martins-Simoes, P., Tristan, A., and Pirot, F. (2022). Phage Therapy against Staphylococcus aureus: Selection and Optimization of Production Protocols of Novel Broad-Spectrum Silviavirus Phages. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14091885"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101208","DOI":"10.1016\/j.coviro.2022.101208","article-title":"Phage Banks as Potential Tools to Rapidly and Cost-Effectively Manage Antimicrobial Resistance in the Developing World","volume":"53","author":"Nagel","year":"2022","journal-title":"Curr. Opin. Virol."},{"key":"ref_42","unstructured":"(2023, February 16). Available online: http:\/\/phage.ge\/products\/staphylococcal-bacteriophage\/."},{"key":"ref_43","unstructured":"(2014, July 22). Available online: https:\/\/www.bacteriofag.ru\/products\/bakteriofag-stafilokokkovyy20-ml\/."},{"key":"ref_44","unstructured":"(2009, June 19). Available online: https:\/\/www.microgen.ru\/en\/products\/bakteriofagi\/sekstafag-piobakteriofag-polivalentnyy\/."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/mdr.2020.0083","article-title":"Environmental phage-based cocktail and antibiotic combination effects on acinetobacter baumannii biofilm in a human urine model","volume":"27","author":"Grygorcewicz","year":"2020","journal-title":"Microb. Drug Resist."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Comeau, A.M., T\u00e9tart, F., Trojet, S.N., Pr\u00e8re, M.F., and Krisch, H.M. (2007). Phage-antibiotic synergy (PAS): B-lactam and quinolone antibiotics stimulate virulent phage growth. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000799"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e01462-20","DOI":"10.1128\/mBio.01462-20","article-title":"Phage-antibiotic synergy is driven by a unique combination of antibacterial mechanism of action and stoichiometry","volume":"11","author":"Min","year":"2020","journal-title":"mBio"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41579-021-00602-y","article-title":"Interactions between bacterial and phage communities in natural environments","volume":"20","author":"Chevallereau","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1214449","article-title":"Repeatability and contingency in the evolution of a key innovation in phage lambda","volume":"335","author":"Meyer","year":"2012","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Patpatia, S., Schaedig, E., Dirks, A., Paasonen, L., Skurnik, M., and Kiljunen, S. (2022). Rapid hydrogel-based phage susceptibility test for pathogenic bacteria. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1032052"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"G\u00f3rski, A., Bollyky, P.L., Przybylski, M., Borysowski, J., Mi\u0119dzybrodzki, R., Jo\u0144czyk-Matysiak, E., and Weber-D\u0105browska, B. (2019). Perspectives of phage therapy in nonacterial infections. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.03306"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/14712598.2019.1651287","article-title":"The fall and rise of phage therapy in modern medicine","volume":"19","author":"Borysowski","year":"2019","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijantimicag.2007.04.006","article-title":"Bacteriophages: An appraisal of their role in the treatment of bacterial infections","volume":"30","author":"Hanlon","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Oechslin, F. (2018). Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy. Viruses, 10.","DOI":"10.3390\/v10070351"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1365-294X.2010.04903.x","article-title":"Genetic basis of infectivity evolution in a bacteriophage","volume":"20","author":"Scanlan","year":"2011","journal-title":"Mol. Ecol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.healthpol.2017.07.011","article-title":"Time for a change in how new antibiotics are reimbursed: Development of an insurance framework for funding new antibiotics based on a policy of risk mitigation","volume":"121","author":"Towse","year":"2017","journal-title":"Health Policy"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ochieng, J.M., Kadija, E., Nyachieo, A., Mureithi, M.W., and Skurnik, M. (2020). Bioprospecting Staphylococcus Phages with Therapeutic and Bio-Control Potential. Viruses, 12.","DOI":"10.3390\/v12020133"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e00461-20","DOI":"10.1128\/AAC.00461-20","article-title":"Bacteriophage-antibiotic combination strategy: An alternative against methicillin-resistant phenotypes of Staphylococcus aureus","volume":"64","author":"Kebriaei","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Valente, L.G., Federer, L., Iten, M., Grandgirard, D., Leib, S.L., Haenggi, M., Cameron, D.R., Que, Y.A., and Prazak, J. (2021). Searching for synergy: Combining systemic daptomycin treatment with localised phage therapy for the treatment of experimental pneumonia due to MRSA. BMC Res. Notes, 14.","DOI":"10.1186\/s13104-021-05796-1"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1099\/mic.0.000178","article-title":"Staphylococcus haemolyticus\u2014An emerging threat in the twilight of the antibiotics age","volume":"161","author":"Czekaj","year":"2015","journal-title":"Microbiology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1093\/jac\/dkr262","article-title":"Discovery research: The scientific challenge of finding new antibiotics","volume":"66","author":"Livermore","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1002\/ppul.24945","article-title":"Combining bacteriophages with cefiderocol and meropenem\/vaborbactam to treat a pandrug resistant Achromobacter species infection in a pediatric cystic fibrosis patient","volume":"55","author":"Gainey","year":"2020","journal-title":"Pediatr. Pulmonol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s41591-019-0437-z","article-title":"Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus","volume":"25","author":"Dedrick","year":"2019","journal-title":"Nat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ingmer, H., Gerlach, D., and Wolz, C. (2019). Temperate Phages of Staphylococcus aureus. Microbiol. Spectr., 7.","DOI":"10.1128\/microbiolspec.GPP3-0058-2018"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.tim.2021.04.008","article-title":"The phages of staphylococci: Critical catalysts in health and disease Asma Hatoum-Aslan","volume":"29","year":"2021","journal-title":"Trends Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1758-2229.2012.00378.x","article-title":"Bacteriophages of Staphylococcus aureus efficiently package various bacterial genes and mobile genetic elements including SCCmec with different frequencies","volume":"5","author":"Doskar","year":"2013","journal-title":"Environ. Microbiol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1574-695X.2005.00009.x","article-title":"SCCmec in staphylococci: Genes on the move","volume":"46","author":"Hanssen","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"570572","DOI":"10.3389\/fmed.2020.570572","article-title":"Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee","volume":"7","author":"Ferry","year":"2020","journal-title":"Infect. Front. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/ejcts\/ezz295","article-title":"Treatment of Chronic Left Ventricular Assist Device Infection with Local Application of Bacteriophages","volume":"57","author":"Mulzer","year":"2020","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/1534734619835115","article-title":"Bacteriophage Therapy of Chronic Nonhealing Wound: Clinical Study","volume":"18","author":"Gupta","year":"2019","journal-title":"Int. J. Low. Extrem. Wounds"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Fish, R., Kutter, E., Bryan, D., Wheat, G., and Kuhl, S. (2018). Resolving Digital Staphylococcal Osteomyelitis Using Bacteriophage\u2014A Case Report. Antibiotics, 7.","DOI":"10.3390\/antibiotics7040087"},{"key":"ref_72","first-page":"563","article-title":"Studies on bacteriophage penetration in patients subjected to phage therapy","volume":"35","author":"Dabrowski","year":"1987","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.3390\/v6072551","article-title":"Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool","volume":"6","year":"2014","journal-title":"Viruses"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Simon, K., Pier, W., Kr\u00fcttgen, A., and Horz, H.P. (2021). Synergy between phage Sb1 and oxacillin against methicillin-resistant Staphylococcus aureus. Antibiotics, 10.","DOI":"10.3390\/antibiotics10070849"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Joo, H., Wu, S.M., Soni, I., Wang-Crocker, C., Matern, T., Beck, J.P., and Loc-Carrillo, C. (2023). Phage and antibiotic combinations reduce Staphylococcus aureus in static and dynamic biofilms grown on an implant material. Viruses, 15.","DOI":"10.3390\/v15020460"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ramirez-Sanchez, C., Gonzales, F., Buckley, M., Biswas, B., Henry, M., Deschenes, M.V., Horne, B., Fackler, J., Brownstein, M.J., and Schooley, R.T. (2021). Successful treatment of Staphylococcus aureus prosthetic joint infection with bacteriophage therapy. Viruses, 13.","DOI":"10.3390\/v13061182"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijid.2022.04.049","article-title":"Case Report: Successful use of phage therapy in refractory MRSA chronic rhinosinusitis","volume":"121","author":"Rodriguez","year":"2022","journal-title":"Int. J. Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.2217\/fmb-2017-0073","article-title":"Can phage therapy solve the problem of recalcitrant chronic rhinosinusitis?","volume":"12","author":"Szaleniec","year":"2017","journal-title":"Future Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/alr.22741","article-title":"International consensus statement on allergy and rhinology: Rhinosinusitis 2021","volume":"11","author":"Orlandi","year":"2021","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Uyttebroek, S., Onsea, J., Metsemakers, W.J., Dupont, L., Devolder, D., Wagemans, J., Lavigne, R., Spriet, I., and Van Gerven, L. (2021). The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis. Antibiotics, 10.","DOI":"10.3390\/antibiotics10060675"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.trsl.2018.12.002","article-title":"Safety and efficacy of a bacteriofage cocktail in an in vivo model of Pseudomonas aeruginosa sinusitis","volume":"206","author":"Fong","year":"2019","journal-title":"Transl Res."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Szaleniec, J., Giba\u0142a, A., Pobiega, M., Parasion, S., Sk\u0142adzie\u0144, J., Str\u0119k, P., Gosiewski, T., and Szaleniec, M. (2019). Exacerbations of Chronic Rhinosinusitis\u2014Microbiology and Perspectives of Phage Therapy. Antibiotics, 8, (4).","DOI":"10.3390\/antibiotics8040175"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/alr.22046","article-title":"Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients","volume":"8","author":"Zhang","year":"2018","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Doss, J., Culbertson, K., Hahn, D., Camacho, J., and Barekzi, N. (2017). A review of phage therapy against bacterial pathogens of aquatic and terrestrial organisms. Viruses, 9.","DOI":"10.3390\/v9030050"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Kornienko, M., Bespiatykh, D., Gorodnichev, R., Abdraimova, N., and Shitikov, E. (2023). Transcriptional Landscapes of Herelleviridae Bacteriophages and Staphylococcus aureus during Phage Infection: An Overview. Viruses, 15.","DOI":"10.3390\/v15071427"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s10529-007-9346-1","article-title":"Biotechnological challenges of phage therapy","volume":"29","author":"Skurnik","year":"2007","journal-title":"Biotechnol. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/138920110790725311","article-title":"Phage choice, isolation, and preparation for phage therapy","volume":"11","author":"Gill","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrmicro2315","article-title":"Bacteriophage resistance mechanisms","volume":"8","author":"Labrie","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Torres-Barcel\u00f3, C. (2018). Phage therapy faces evolutionary challenges. Viruses, 10.","DOI":"10.3390\/v10060323"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3934\/microbiol.2017.2.186","article-title":"Phage \u201cdelay\u201d towards enhancing bacterial escape from biofilms: A more comprehensive way of viewing resistance to bacteriophages","volume":"3","author":"Abedon","year":"2017","journal-title":"AIMS Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Van Belleghem, J.D., Clement, F., Merabishvili, M., Lavigne, R., and Vaneechoutte, M. (2017). Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-08336-9"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Cooper, C.J., Mirzaei, M.K., and Nilsson, A.S. (2016). Adapting drug approval pathways for bacteriophage-based therapeutics. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01209"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cels.2015.08.013","article-title":"Engineering modular viral scaffolds for targeted bacterial population editing","volume":"1","author":"Ando","year":"2015","journal-title":"Cell Syst."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.surg.2005.02.012","article-title":"Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model","volume":"137","author":"Matsuda","year":"2005","journal-title":"Surgery"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s40259-021-00480-z","article-title":"Engineered bacteriophage therapeutics: Rationale, challenges and future","volume":"35","author":"Dabrowska","year":"2021","journal-title":"BioDrugs"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Arroyo-Moreno, S., Cummings, M., Corcoran, D.B., Coffey, A., and McCarthy, R.R. (2022). Identification and characterization of novel endolysins targeting Gardnella vaginalis biofilms to treat bacterial vaginosis. Npj Biofilms Microbiomes, 8.","DOI":"10.1038\/s41522-022-00285-0"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/mdr.2012.0024","article-title":"Phage endolysins with broad antimicrobial activity against Enterococcus faecalis clinical strains","volume":"18","author":"Fernandes","year":"2012","journal-title":"Microb. Drug Resist."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jgar.2020.01.005","article-title":"Antimicrobial activity of LysSS, a novel phage endolysin, against Acinetobacter baumannii and Pseudomonas aeruginosa","volume":"22","author":"Kim","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e00731-18","DOI":"10.1128\/AAC.00731-18","article-title":"Effects of phage endolysins SAL200 combined with antibiotics on Staphylococcus aureus infection","volume":"62","author":"Kim","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.mib.2007.08.002","article-title":"Taking aim on bacterial pathogens: From phage therapy to enzybiotics","volume":"10","author":"Hermoso","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1128\/AAC.01097-10","article-title":"H Comparison of the antibacterial properties of phage endolysins SAL-1 and LysK","volume":"55","author":"Jun","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1128\/AAC.02009-18","article-title":"Efficacy of intranasal administration of the recombinant endolysin SAL200 in a lethal murine Staphylococcus aureus Pneumonia model","volume":"63","author":"Bae","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Viksne, R., Sumeraga, G., and Pilmane, M. (2023). Antimicrobial and Defense Proteins in Chronic Rhinosinusitis with Nasal Polyps. Medicina, 59.","DOI":"10.3390\/medicina59071259"},{"key":"ref_104","first-page":"20172687","article-title":"Predicting drug resistance evolution: Insights from antimicrobial peptides and antibiotics","volume":"285","author":"Yu","year":"2018","journal-title":"Proc. Biol. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wang, S., Zeng, X., Yang, Q., and Qiao, S. (2016). Antimicrobial peptides as potential alternatives to antibiotics in food animal industry. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050603"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.it.2008.12.003","article-title":"AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense","volume":"30","author":"Lai","year":"2009","journal-title":"Trends Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fmicb.2020.582779","article-title":"Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields","volume":"11","author":"Huan","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.peptides.2003.08.023","article-title":"The relationship between peptide structure and antibacterial activity","volume":"24","author":"Powers","year":"2003","journal-title":"Peptides"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1007\/s00018-011-0710-x","article-title":"Multifunctional cationic host defence peptides and their clinical applications","volume":"68","author":"Yeung","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Aristiz\u00e1bal, I., and Ocampo-Ib\u00e1\u00f1ez, I.D. (2021). Antimicrobial Peptides with Antibacterial Activity against Vancomycin-Resistant Staphylococcus aureus Strains: Classification, Structures, and Mechanisms of Action. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157927"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kumar, P., Kizhakkedathu, J., and Straus, S. (2018). Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo. Biomolecules, 8.","DOI":"10.3390\/biom8010004"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.bbamem.2006.07.007","article-title":"The human beta-defensin-3, an antibacterial peptide with multiple biological functions","volume":"1758","author":"Dhople","year":"2006","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jss.2012.11.048","article-title":"Human \u03b2-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation","volume":"183","author":"Zhu","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/0036554021000028089","article-title":"Antimicrobial Peptide LL-37 is Upregulated in Chronic Nasal Inflammatory Disease","volume":"123","author":"Kim","year":"2003","journal-title":"Acta Oto-Laryngol,."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2500\/ajr.2007.21.3025","article-title":"Fungal Allergens Induce Cathelicidin LL-37 Expression in Chronic Rhinosinusitis Patients in a Nasal Explant Model","volume":"21","author":"Ooi","year":"2007","journal-title":"Am. J. Rhinol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00399424","article-title":"Applications of the bacteriocin, nisin","volume":"69","author":"Blackburn","year":"1996","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1099\/jmm.0.000202","article-title":"Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination","volume":"65","author":"Dridi","year":"2016","journal-title":"J. Med. Microbiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1750-3841.2011.02475.x","article-title":"Inhibitory effects of nisin against Clostridium perfringens food poisoning and nonfood-borne isolates","volume":"77","author":"Udompijitkul","year":"2012","journal-title":"J. Food Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/jam.13033","article-title":"Biomedical applications of nisin","volume":"120","author":"Shin","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/mdr.2019.0038","article-title":"Comparative Proteomics of Methicillin-Resistant Staphylococcus aureus Subjected to Synergistic Effects of the Lantibiotic Nisin and Oxacillin","volume":"26","author":"Alves","year":"2020","journal-title":"Microb. Drug Resis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00281-011-0299-z","article-title":"Exploring Staphylococcus aureus pathways to disease for vaccine development","volume":"34","author":"DeDent","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/femsre\/fuz030","article-title":"Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms","volume":"44","author":"Miller","year":"2020","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1126\/science.284.5419.1523","article-title":"Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen","volume":"284","author":"McKenney","year":"1999","journal-title":"Science"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"16942","DOI":"10.1073\/pnas.0606863103","article-title":"Vaccine assembly from Surface proteins of Staphylococcus aureus","volume":"103","author":"Bae","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1086\/324430","article-title":"Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant","volume":"184","author":"Josefsson","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1016\/j.vaccine.2006.03.020","article-title":"An immunogenicity study of a newly fusion protein Cna-FnBP vaccinated against Staphylococcus aureus infections in a mice model","volume":"24","author":"Zhou","year":"2006","journal-title":"Vaccine"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/cid\/cir828","article-title":"Progress toward a Staphylococcus aureus vaccine","volume":"54","author":"Daum","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1046\/j.1365-2958.2001.02411.x","article-title":"Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus","volume":"40","author":"Mazmanian","year":"2001","journal-title":"Mol. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mtchem.2018.05.001","article-title":"Role of plant alkaloids on human health: A review of biological activities","volume":"9","author":"Debnath","year":"2018","journal-title":"Mater. Today Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijantimicag.2014.06.001","article-title":"Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities","volume":"44","author":"Cushnie","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"xlviii","DOI":"10.1016\/j.phytol.2014.06.015","article-title":"Alkaloids as drug leads\u2014A predictive structural and biodiversity-based analysis","volume":"10","author":"Amirkia","year":"2014","journal-title":"Phytochem. Lett."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Casciaro, B., Calcaterra, A., Cappiello, F., Mori, M., Loffredo, M.R., Ghirga, F., Mangoni, M.L., Botta, B., and Quaglio, D. (2019). Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections. Toxins, 11.","DOI":"10.3390\/toxins11090511"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Benjamin, A.B., Moule, M.G., Didwania, M.K., Hardy, J., Saenkham-Huntsinger, P., Sule, P., Nielsen, J.E., Lin, J.S., Contag, C.H., and Barron, A.E. (2022). Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.00534-22"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/alr.22423","article-title":"Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: Phase 1 randomized, single-blinded, placebo-controlled trial","volume":"9","author":"Ooi","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Cutro, A.C., Coria, M.S., Bordon, A., Rodriguez, S.A., and Hollmann, A. (2023). Antimicrobial properties of the essential oil of Schinus areira (Aguaribay) against planktonic cells and biofilms of S. aureus. Arch. Biochem. Biophys., 744.","DOI":"10.1016\/j.abb.2023.109670"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"35918","DOI":"10.1021\/acsami.0c09364","article-title":"Antibody-Enabled Antimicrobial Nanocapsules for Selective Elimination of Staphylococcus aureus","volume":"12","author":"Ivanova","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"463","DOI":"10.12980\/APJTB.4.2014C1203","article-title":"Antimicrobial activity of some essential oils against oral multidrug-resistant Enterococcus faecalis in both planktonic and biofilm state","volume":"4","author":"Khadir","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11262-020-01735-7","article-title":"Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections","volume":"56","author":"Reuter","year":"2020","journal-title":"Virus Genes"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Rahman, M.U., Wang, W., Sun, Q., Shah, J.A., Li, C., Sun, Y., Li, Y., Zhang, B., Chen, W., and Wang, S. (2021). Endolysin, a promising solution against antimicrobial resistance. Antibiotics, 10.","DOI":"10.3390\/antibiotics10111277"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1586\/14787210.2015.990383","article-title":"Phage approved in food, why not as a therapeutic?","volume":"13","author":"Sarhan","year":"2015","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Ganeshan, S.D., and Hosseinidoust, Z. (2019). Phage therapy with a focus on the human microbiota. Antibiotics, 8.","DOI":"10.3390\/antibiotics8030131"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1089\/phage.2020.0042","article-title":"The application of bacteriophage diagnostics for bacterial pathogens in the agricultural supply chain: From farm-to-fork","volume":"1","author":"Jones","year":"2020","journal-title":"Phage"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/1\/81\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:26:55Z","timestamp":1759919215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/1\/81"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,11]]},"references-count":142,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ph18010081"],"URL":"https:\/\/doi.org\/10.3390\/ph18010081","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,11]]}}}