{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:08:47Z","timestamp":1781719727797,"version":"3.54.5"},"reference-count":89,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The rapid development of nuclear medicine offers vast opportunities for diagnosing neoplasms, particularly in endocrinology. The use of the [11C]C-methionine radiotracer is currently limited due to its physical properties and the complex production process. However, studies conducted so far have demonstrated its utility in PET imaging, helping to detect lesions that often remain elusive with other modalities. This systematic review focuses on [11C]C-methionine in diagnosing hyperparathyroidism and pituitary tumors, highlighting its high effectiveness, which can be crucial in diagnosis. Despite some disadvantages, it should be considered when available, especially when other modalities or radiotracers fail.<\/jats:p>","DOI":"10.3390\/ph18020229","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T11:03:51Z","timestamp":1738926231000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Use of [11C]C-Methionine in Diagnostics of Endocrine Disorders with Focus on Pituitary and Parathyroid Glands"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-2577","authenticated-orcid":false,"given":"Adam Daniel","family":"Durma","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5800-0500","authenticated-orcid":false,"given":"Marek","family":"Saracyn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-264X","authenticated-orcid":false,"given":"Maciej","family":"Ko\u0142odziej","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6756-5415","authenticated-orcid":false,"given":"Katarzyna","family":"J\u00f3\u017awik-Plebanek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-0634","authenticated-orcid":false,"given":"Grzegorz","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zanzonico, P. (2020). Physics Instrumentation, and Radiation Safety and Regulations. Clinical Nuclear Medicine, Springer.","DOI":"10.1007\/978-3-030-39457-8_1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1136\/bmj.326.7404.1449","article-title":"How does it work? Positron emission tomography","volume":"326","author":"Berger","year":"2003","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00259-014-2961-x","article-title":"FDG PET\/CT: EANM procedure guidelines for tumour imaging: Version 2.0","volume":"42","author":"Boellaard","year":"2015","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.zemedi.2022.08.003","article-title":"EANM guidelines for PET-CT and PET-MR routine quality control","volume":"33","author":"Koole","year":"2022","journal-title":"Z. Fur Med. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1148\/rg.242025724","article-title":"An Introduction to PET-CT Imaging","volume":"24","author":"Kapoor","year":"2004","journal-title":"RadioGraphics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2214\/AJR.18.20001","article-title":"Clinical PET\/MRI: 2018 Update","volume":"211","author":"Broski","year":"2018","journal-title":"Am. J. Roentgenol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/rpd\/ncz153","article-title":"Effective radiation dose of 18F-FDG PET\/CT: How much does diagnostic CT contribute?","volume":"187","author":"Li","year":"2019","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.5152\/dir.2015.15221","article-title":"Comparison of effective radiation doses from X-ray, CT, and PET\/CT in pediatric patients with neuroblastoma using a dose monitoring program","volume":"22","author":"Kim","year":"2016","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40658-016-0144-5","article-title":"Physics of pure and non-pure positron emitters for PET: A review and a discussion","volume":"3","author":"Conti","year":"2016","journal-title":"EJNMMI Phys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00726-017-2494-2","article-title":"The role of methionine on metabolism, oxidative stress, and diseases","volume":"49","author":"Li","year":"2017","journal-title":"Amino Acids"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101500","DOI":"10.1016\/j.arr.2021.101500","article-title":"Methionine as a double-edged sword in health and disease: Current perspective and future challenges","volume":"72","author":"Navik","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.2967\/jnumed.112.118125","article-title":"Evaluation of the Biodistribution of 11C-Methionine in Children and Young Adults","volume":"54","author":"Harris","year":"2013","journal-title":"J. Nucl. Med."},{"key":"ref_13","unstructured":"Leung, K. (2011, December 21). l-[methyl-11C]Methionine, Molecular Imaging and Contrast Agent Database (MICAD), Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK23696\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8998","DOI":"10.1002\/anie.200800222","article-title":"Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography","volume":"47","author":"Miller","year":"2008","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s002590050265","article-title":"Estimation of internal absorbed dose of l -[methyl- 11 C]methionine using whole-body positron emission tomography","volume":"25","author":"Deloar","year":"1998","journal-title":"Eur. J. Nucl. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.36740\/WLek202009234","article-title":"The role of PET\/CT with 11C-methionine in contemporary nuclear medicine","volume":"73","author":"Bober","year":"2020","journal-title":"Wiad Lek."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s12149-024-01932-6","article-title":"11C-Methionine uptake in meningiomas after stereotactic radiotherapy","volume":"38","author":"Jeltema","year":"2024","journal-title":"Ann. Nucl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00259-001-0690-4","article-title":"Usefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PET","volume":"29","author":"Chung","year":"2002","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/neuonc\/noac040","article-title":"Preoperative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas","volume":"24","author":"Ninatti","year":"2022","journal-title":"Neuro-Oncology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"van Dijken, B.R.J., Ankrah, A.O., Stormezand, G.N., Dierckx, R., van Laar, P.J., and van der Hoorn, A. (2022). Prognostic value of 11C-methionine volume-based PET parameters in IDH wild type glioblastoma. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0264387"},{"key":"ref_21","first-page":"333","article-title":"Hyperparathyroidism","volume":"69","author":"Taniegra","year":"2004","journal-title":"Am. Fam. Physician"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/jbmr.4665","article-title":"Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism","volume":"37","author":"Minisola","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5603\/EP.a2020.0028","article-title":"Primary hyperparathyroidism","volume":"71","author":"Kowalski","year":"2020","journal-title":"Endokrynol. Polska"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1097\/SLA.0000000000005522","article-title":"The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Secondary and Tertiary Renal Hyperparathyroidism","volume":"276","author":"Dream","year":"2022","journal-title":"Ann. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.otc.2023.07.010","article-title":"Secondary Hyperparathyroidism","volume":"57","author":"Stack","year":"2024","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"666","DOI":"10.20945\/2359-3997000000556","article-title":"Normocalcemic primary hyperparathyroidism","volume":"66","author":"Cusano","year":"2022","journal-title":"Arch. Bras. Endocrinol. Metabol."},{"key":"ref_27","unstructured":"Byrd, C., Kashyap, S., and Kwartowitz, G. (2023). Parathyroid Cancer. StatPearls, StatPearls Publishing."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.3748\/wjg.v17.i36.4063","article-title":"Digestive manifestations of parathyroid disorders","volume":"17","author":"Abboud","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/aam.aam_73_20","article-title":"Primary Hyperparathyroidism: Correlation between cervical ultrasound and MIBI scan","volume":"21","author":"Salhi","year":"2022","journal-title":"Ann. Afr. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3413\/nukmed-0057","article-title":"99mTc-MIBI SPECT in primary hyperparathyroidism. Influence of concomitant vitamin D deficiency for visualization of parathyroid adenomas","volume":"47","author":"Schmidt","year":"2008","journal-title":"Nuklearmedizin"},{"key":"ref_31","first-page":"1577","article-title":"Diagnostic value and influencing factors of 99mTc-MIBI SPECT\/CT imaging combined with semiquantitative analysis in hyperparathyroidism","volume":"41","author":"Zheng","year":"2021","journal-title":"J. South. Med. Univ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0046-8177(95)90068-3","article-title":"Ultrasound-guided fine-needle aspiration of parathyroid lesions: A morphological and immunocytochemical approach","volume":"26","author":"Abati","year":"1995","journal-title":"Hum. Pathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00259-021-05334-y","article-title":"The EANM practice guidelines for parathyroid imaging","volume":"48","author":"Giovanella","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.diii.2021.12.005","article-title":"18F-fluorocholine PET\/CT and conventional imaging in primary hyperparathyroidism","volume":"103","author":"Dudoignon","year":"2022","journal-title":"Diagn. Interv. Imaging"},{"key":"ref_35","first-page":"785","article-title":"18F-fluorocholine PET\/CT is more sensitive than 11C-methionine PET\/CT for the localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism","volume":"63","author":"Mathey","year":"2022","journal-title":"J. Nucl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MNM.0000000000000216","article-title":"A comparison between 11C-methionine PET\/CT and MIBI SPECT\/CT for localization of parathyroid adenomas\/hyperplasia","volume":"36","author":"Hayakawa","year":"2015","journal-title":"Nucl. Med. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3413\/Nukmed-0686-14-07","article-title":"11C-methionine PET\/CT after in conclusive 99mTc-MIBI-SPECT\/CT for localisation of parathyroid adenomas in primary hyperparathyroidism","volume":"54","author":"Braeuning","year":"2015","journal-title":"Nuklearmedizin"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2967\/jnumed.112.109561","article-title":"Planar Scintigraphy with 123I\/99mTc-Sestamibi, 99mTc-Sestamibi SPECT\/CT, 11C-Methionine PET\/CT, or Selective Venous Sampling Before Reoperation of Primary Hyperparathyroidism?","volume":"54","author":"Heiskanen","year":"2013","journal-title":"J. Nucl. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cen.14933","article-title":"Diagnostic utility of 11C-methionine PET\/CT in primary hyperparathyroidism in a UK cohort: A single-centre experience and literature review","volume":"99","author":"Huynh","year":"2023","journal-title":"Clin. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4103\/ijem.IJEM_445_16","article-title":"Five-year retrospective study on primary hyperparathyroidism in South India: Emerging roles of minimally invasive parathyroidectomy and preoperative localization with methionine positron emission tomography-computed tomography scan","volume":"22","author":"Mathew","year":"2018","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s00259-023-06488-7","article-title":"Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism","volume":"51","author":"Noltes","year":"2024","journal-title":"Eur. J. Nucl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1007\/s00423-022-02648-9","article-title":"Questionable value of [99mTc]-sestamibi scintigraphy in patients with pHPT and negative ultrasound","volume":"407","author":"Lenschow","year":"2022","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s11307-023-01808-7","article-title":"Head-to-Head Comparison of Tc-99m-sestamibi SPECT\/CT and C-11-L-Methionin PET\/CT in Parathyroid Scanning Before Operation for Primary Hyperparathyroidism","volume":"25","author":"Vestergaard","year":"2023","journal-title":"Mol. Imaging Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"36837","DOI":"10.1177\/14574969211036837","article-title":"C-11 methionine positron emission tomography scans improve the preoperative localization of pathologic parathyroid glands in primary hyperparathyroidism","volume":"111","author":"Iversen","year":"2022","journal-title":"Scand. J. Surg."},{"key":"ref_45","first-page":"93","article-title":"Comparison of 99mTc-sestamibi and 11C-methionine PET\/CT in the localization of parathyroid adenomas in primary hyperparathyroidism","volume":"33","author":"Quirce","year":"2014","journal-title":"Rev. Esp. De Med. Nucl. E Imagen Mol."},{"key":"ref_46","first-page":"974","article-title":"Positron emission tomography with 11C-methionine in hyperparathyroidism","volume":"116","author":"Hellman","year":"1994","journal-title":"Surgery"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.21037\/qims-22-584","article-title":"11C-methionine PET\/CT and conventional imaging techniques in the diagnosis of primary hyperparathyroidism","volume":"13","author":"Pogosian","year":"2023","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Yoo, J., and Cheon, M. (2021). Role of 11C-Methionine PET\/CT in 99mTc-Sestamibi-Negative Parathyroid Adenoma: A Case Report. Diagnostics, 11.","DOI":"10.3390\/diagnostics11050831"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"NP5","DOI":"10.1177\/0145561320977466","article-title":"An Unusual Case of Primary Hyperparathyroidism: Case Report of a Bifocal Intrathyroidal Parathyroid Carcinoma","volume":"102","author":"Damien","year":"2023","journal-title":"Ear Nose Throat. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00259-005-0008-z","article-title":"11C-methionine PET\/CT in 99mTc-sestamibi-negative hyperparathyroidism in patients with renal failure on chronic haemodialysis","volume":"33","author":"Rubello","year":"2006","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_51","first-page":"1766","article-title":"PET and parathyroid L-[carbon-11]methionine accumulation in hyperparathyroidism","volume":"37","author":"Sundin","year":"1996","journal-title":"J. Nucl. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/cmmi.243","article-title":"Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET\/CT","volume":"3","author":"Tang","year":"2008","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00259-004-1610-1","article-title":"Pre-operative localisation of hyperfunctional parathyroid tissue with 11C-methionine PET","volume":"31","author":"Otto","year":"2004","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1007\/s00268-015-2992-x","article-title":"Preoperative 11C-Methionine PET\/CT Enables Focussed Parathyroidectomy in MIBI-SPECT Negative Parathyroid Adenoma","volume":"39","author":"Lenschow","year":"2015","journal-title":"World J. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/eje.0.1390195","article-title":"[11C]Methionine positron emission tomography for patients with persistent or recurrent hyperparathyroidism after surgery","volume":"139","author":"Cook","year":"1998","journal-title":"Eur. J. Endocrinol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ko\u0142odziej, M., Saracyn, M., Lubas, A., Dziuk, M., Durma, A.D., Smoszna, J., Zelichowski, G., Niemczyk, S., and Kami\u0144ski, G. (2022). Usefulness of PET\/CT with Carbon-11-Labeled Methionine in the Diagnosis of Tertiary Hyperparathyroidism. Nutrients, 15.","DOI":"10.3390\/nu15010188"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","article-title":"Overview of the 2022 WHO Classification of Pituitary Tumors","volume":"33","author":"Asa","year":"2022","journal-title":"Endocr. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/ERC-23-0021","article-title":"The World Health Organization classifications of pituitary neuroendocrine tumours: A clinico-pathological appraisal","volume":"30","author":"Villa","year":"2023","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1001\/jama.2023.5444","article-title":"Diagnosis and Management of Pituitary Adenomas: A Review","volume":"329","author":"Tritos","year":"2023","journal-title":"JAMA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5603\/EP.a2018.0093","article-title":"Diagnostics and treatment of acromegaly\u2014Updated recommendations of the Polish Society of Endocrinology","volume":"70","author":"Bolanowski","year":"2019","journal-title":"Endokrynol. Pol."},{"key":"ref_61","first-page":"1018","article-title":"Tyreotropinoma--gruczolak przysadki wydzielajacy TSH [Thyrotropin--TSH secreting pituitary tumor]","volume":"59","author":"Koziarski","year":"2002","journal-title":"Przegl Lek."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e13111","DOI":"10.1111\/jne.13111","article-title":"Diagnostic workup of Cushing\u2019s syndrome","volume":"34","author":"Balomenaki","year":"2022","journal-title":"J. Neuroendocr."},{"key":"ref_63","unstructured":"Yatavelli, R.K.R., and Bhusal, K. (2023). Prolactinoma. StatPearls, StatPearls Publishing."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1210\/jcem-45-4-653","article-title":"FSH and LH Secreting Pituitary Adenoma","volume":"45","author":"Demura","year":"1977","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_65","first-page":"322","article-title":"Clinically functioning gonadotropin-secreting pituitary adenoma","volume":"2024","author":"Alnasrallah","year":"2024","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"ref_66","first-page":"1","article-title":"Zmiany stezenia podjednostki alfa hormon\u00f3w glikoproteidowych w surowicy chorych z guzami przysadki typu \"alfoma\" w przebiegu test\u00f3w stymulacji LH-RH + TRH [Changes in serum levels of glycoprotein hormone alpha subunits in patients with alphoma-type pituitary tumors during LHRH and TRH stimulation tests]","volume":"40","year":"1989","journal-title":"Endokrynol. Pol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11102-009-0205-z","article-title":"Acromegaly with negative pituitary MRI and no evidence of ectopic source: The role of transphenoidal pituitary exploration?","volume":"14","author":"Daud","year":"2011","journal-title":"Pituitary"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/cen.14560","article-title":"Paediatric patients with Cushing disease and negative pituitary MRI have a higher risk of nonremission after transsphenoidal surgery","volume":"95","author":"Tatsi","year":"2021","journal-title":"Clin. Endocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00004728-198705000-00003","article-title":"Amino Acid Distribution and Metabolism in Pituitary Adenomas Using Positron Emission Tomography with D-[11C]Methionine and L-[11C]Methionine","volume":"11","author":"Muhr","year":"1987","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/0284185116651005","article-title":"Accumulation of 11C-methionine in the normal pituitary gland on 11C-methionine PET","volume":"58","author":"Tomura","year":"2017","journal-title":"Acta Radiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00259-005-1882-0","article-title":"11C-methionine PET for the diagnosis and management of recurrent pituitary adenomas","volume":"33","author":"Tang","year":"2006","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11102-022-01229-9","article-title":"11C-methionine PET aids localization of microprolactinomas in patients with intolerance or resistance to dopamine agonist therapy","volume":"25","author":"Bashari","year":"2022","journal-title":"Pituitary"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ejendo\/lvae028","article-title":"Real-world experience with 11C-methionine positron emission tomography in the management of acromegaly","volume":"190","author":"Haberbosch","year":"2024","journal-title":"Eur. J. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1530\/EJE-16-0639","article-title":"Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI","volume":"175","author":"Koulouri","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.wneu.2013.11.011","article-title":"Clinical Usefulness of Coregistered 11C-Methionine Positron Emission Tomography\/3-T Magnetic Resonance Imaging at the Follow-Up of Acromegaly","volume":"82","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13550-022-00899-7","article-title":"Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction","volume":"12","author":"Gillett","year":"2022","journal-title":"EJNMMI Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3171\/2023.5.JNS23179","article-title":"Clinical decision-making based on 11C-methionine PET in recurrent Cushing\u2019s disease with equivocal MRI findings","volume":"139","author":"Ishida","year":"2023","journal-title":"J. Neurosurg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s11102-021-01160-5","article-title":"Selective resection of cushing microadenoma guided by preoperative hybrid 18-fluoroethyl-L-tyrosine and 11-C-methionine PET\/MRI","volume":"24","author":"Berkmann","year":"2021","journal-title":"Pituitary"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"M107","DOI":"10.1530\/EJE-15-0616","article-title":"A role for 11C-methionine PET imaging in ACTH-dependent Cushing\u2019s syndrome","volume":"173","author":"Koulouri","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1097\/RLU.0000000000001085","article-title":"Utility of 11C-Methionine and 18F-FDG PET\/CT in Patients with Functioning Pituitary Adenomas","volume":"41","author":"Feng","year":"2016","journal-title":"Clin. Nucl. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3171\/2009.7.JNS09285","article-title":"Usefulness of composite methionine\u2013positron emission tomography\/3.0-tesla magnetic resonance imaging to detect the localization and extent of early-stage Cushing adenoma","volume":"112","author":"Ikeda","year":"2010","journal-title":"J. Neurosurg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-023-01298-2","article-title":"Ectopic sphenoidal ACTH-secreting adenoma revealed by 11C Methionine PET scan: Case report","volume":"23","author":"Lurquin","year":"2023","journal-title":"BMC Endocr. Disord."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0039-6060(97)90274-9","article-title":"False-positive parathyroid scan leading to sternotomy: Incidental detection of a thymoma by C-11 methionine positron emission tomography","volume":"122","author":"Adler","year":"1997","journal-title":"Surgery"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4103\/0972-3919.106719","article-title":"False positive localisation of C-11 methionine in a colloid nodule","volume":"26","author":"Tripathi","year":"2011","journal-title":"Indian J. Nucl. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00423-017-1549-x","article-title":"Localization of parathyroid adenomas using 11C-methionine pet after prior inconclusive imaging","volume":"402","author":"Noltes","year":"2017","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s11154-022-09723-y","article-title":"Diagnostic accuracy of bilateral inferior petrosal sinus sampling using desmopressin or corticotropic- releasing hormone in ACTH-dependent Cushing\u2019s syndrome: A systematic review and meta-analysis","volume":"23","author":"Valizadeh","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_87","first-page":"127","article-title":"Comparison of SPET\/CT, SPET and planar imaging using Tc-99m-MIBI as independent techniques to support minimally invasive parathyroidectomy in primary hyperparathyroidism: A meta-analysis","volume":"18","author":"Wei","year":"2015","journal-title":"Hell J. Nucl. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s12149-012-0643-y","article-title":"Diagnostic performance of planar scintigraphy using 99mTc-MIBI in patients with secondary hyperparathyroidism: A meta-analysis","volume":"26","author":"Caldarella","year":"2012","journal-title":"Ann. Nucl. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.surg.2004.06.047","article-title":"Effect of calcium channel blockers on the sensitivity of preoperative 99mTc-MIBI SPECT for hyperparathyroidism","volume":"136","author":"Friedman","year":"2004","journal-title":"Surgery"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/2\/229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:29:00Z","timestamp":1760027340000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/2\/229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":89,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ph18020229"],"URL":"https:\/\/doi.org\/10.3390\/ph18020229","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]}}}