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This phenomenon is the result of the convergence of multiple processes, including mitochondrial dysfunction, fibrosis, inflammation, dysregulation of cell death processes, and immunosenescence. These processes have as their point of convergence an increase in the production of ROS. Avocado oil (Persea americana Mill.) contains a diverse array of bioactive compounds, including oleic acid, phytosterols, chlorophylls, xanthones, xanthines, and carotenoids. These bioactive compounds have the capacity to modulate the excessive production of ROS, thereby reducing the progression of age-related diseases and extending lifespan in experimental models of aging. In addition, several studies have demonstrated the efficacy of avocado oil in mitigating age-related diseases, including hypertension; insulin resistance; diabetes; non-alcoholic liver disease; and degenerative processes such as hearing loss, cognitive decline, neurodegeneration, and impaired wound healing. In light of these findings, it is hypothesized that avocado oil is a promising agent capable of promoting healthspan in later stages of life owing to its direct antioxidant actions and the activation of pathways that enhance endogenous antioxidant levels.<\/jats:p>","DOI":"10.3390\/ph18020246","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T04:37:04Z","timestamp":1739335024000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects"],"prefix":"10.3390","volume":"18","author":[{"given":"Olin","family":"Torres-Isidro","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-5622","authenticated-orcid":false,"given":"Marcela","family":"Gonz\u00e1lez-Montoya","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3239-123X","authenticated-orcid":false,"given":"Manuel Alejandro","family":"Vargas-Vargas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"Florian-Rodriguez","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmico Farmacobiolog\u00eda, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58240, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Isabel","family":"Garc\u00eda-Berumen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-1358","authenticated-orcid":false,"given":"Roc\u00edo","family":"Montoya-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-2950","authenticated-orcid":false,"given":"Alfredo","family":"Saavedra-Molina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-6980","authenticated-orcid":false,"given":"Elizabeth","family":"Calder\u00f3n-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Facultad de Enfermer\u00eda, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58260, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-6535","authenticated-orcid":false,"given":"Alain Raimundo","family":"Rodr\u00edguez-Orozco","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \u201cDr. Ignacio Ch\u00e1vez\u201d, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58020, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-772X","authenticated-orcid":false,"given":"Christian","family":"Cort\u00e9s-Rojo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58030, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1089\/ars.2010.3228","article-title":"Aging and Immune Function: Molecular Mechanisms to Interventions","volume":"14","author":"Ponnappan","year":"2011","journal-title":"Antioxid. 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