{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:01:46Z","timestamp":1785207706106,"version":"3.55.0"},"reference-count":77,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Knee osteoarthritis (OA) is a degenerative chronic disease characterized by a reduction in articular cartilage, as well as pain and functional limitations. We evaluated both the efficacy and safety of cross-linked high-molecular-weight hyaluronic acid in patients with knee OA. Methods: In this observational prospective single-arm study, a cross-linked high-molecular-weight hyaluronic acid (DIART ONE 90 mg in 3 mL) was administered in single injections to 50 patients aged 18\u201365 years, with a follow-up at 3, 6, and 12 months. Several scores were evaluated, including the Knee Injury and Osteoarthritis Outcome Score as the primary outcome measure and the Visual Analogue Scale, Timed Up and Go Test, Six-Minute Walking Test, General Health Assessment with 36-Item Short Form Health Survey, Zung\u2019s Self-Rating Anxiety Scale, and Zung\u2019s Self-Rating Depression Scale as secondary outcome measures. Both physicians and patients knew the kind of treatment they received. Results: During the follow-ups, we observed a statistically significant improvement in clinical scores at 3 and 6 months, with a decrease in clinical benefit at 12 months. Functional and psychological benefits were significant at 3, 6, and 12 months. No side effects were described except pain associated with the site of injection. Conclusions: In conclusion, we documented that cross-linked high-molecular-weight hyaluronic acid (DIART ONE 90 mg in 3 mL) represents an effective option in the management of mild\u2013moderate osteoarthritis.<\/jats:p>","DOI":"10.3390\/ph18030302","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:46:57Z","timestamp":1740383217000},"page":"302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Safety of Intra-Articular Therapy with Cross-Linked Hyaluronic Acid in Patients with Knee Osteoarthritis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-5259","authenticated-orcid":false,"given":"Vincenzo","family":"Rania","sequence":"first","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9551","authenticated-orcid":false,"given":"Gianmarco","family":"Marcian\u00f2","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8641-0974","authenticated-orcid":false,"given":"Cristina","family":"Vocca","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Palleria","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bianco","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Caroleo","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"},{"name":"Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-7902","authenticated-orcid":false,"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"},{"name":"Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990\u20132017: A systematic analysis of the Global Burden of Disease Study 2017","volume":"79","author":"Safiri","year":"2020","journal-title":"Ann. 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