{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:57:28Z","timestamp":1791730648869,"version":"4.3.4"},"reference-count":89,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["2020\/39\/D\/NZ7\/01824"],"award-info":[{"award-number":["2020\/39\/D\/NZ7\/01824"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Green tea (Camellia sinensis) exhibits significant potential in oral health due to its antioxidant, anti-inflammatory, and antimicrobial properties. This review explores its role in managing periodontal disease, a common condition characterized by inflammation, microbial imbalances, and tissue destruction. The primary bioactive components, particularly epigallocatechin-3-gallate (EGCG), contribute to green tea\u2019s therapeutic effects by inhibiting bacterial adhesion, modulating inflammatory pathways, and reducing oxidative stress. Clinical studies suggest green tea improves periodontal health by reducing pocket depth, inflammation, and bleeding. It can serve as an adjunct to conventional therapies, including scaling and root planing, and be incorporated into oral care products such as mouthwashes and dentifrices. Furthermore, green tea presents a natural alternative to chemical agents like chlorhexidine, potentially mitigating side effects and addressing concerns about antibiotic resistance. However, its efficacy remains moderate compared to established treatments, highlighting the need for further research to optimize its formulation and therapeutic applications. Green tea represents a sustainable and biocompatible approach to periodontal therapy, supporting its integration into preventive and therapeutic oral health strategies.<\/jats:p>","DOI":"10.3390\/ph18030409","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:02:16Z","timestamp":1741935736000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Green Tea: A Novel Perspective on the Traditional Plant\u2019s Potential in Managing Periodontal Diseases"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-9336","authenticated-orcid":false,"given":"Magdalena","family":"Paczkowska-Walendowska","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"},{"name":"Science-Bridge Sp. z o.o., Chociszewskiego 24\/8, 60-258 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0276-4870","authenticated-orcid":false,"given":"Jan","family":"Grzegorzewski","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Kwiatek","sequence":"additional","affiliation":[{"name":"Kwiatek Dental Clinic Sp. z o.o., Kordeckiego 22, 60-144 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Le\u015bna","sequence":"additional","affiliation":[{"name":"Kwiatek Dental Clinic Sp. z o.o., Kordeckiego 22, 60-144 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5419","authenticated-orcid":false,"given":"Judyta","family":"Cielecka-Piontek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"},{"name":"Science-Bridge Sp. z o.o., Chociszewskiego 24\/8, 60-258 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). Global Oral Health Status Report: Towards Universal Health Coverage for Oral Health by 2030, World Health Organization. [1st ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral Diseases: A Global Public Health Challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2146160","DOI":"10.1155\/2020\/2146160","article-title":"Global Prevalence of Periodontal Disease and Lack of Its Surveillance","volume":"2020","author":"Nazir","year":"2020","journal-title":"Sci. World J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jcpe.12517","article-title":"Are Periodontal Diseases Really Silent? A Systematic Review of Their Effect on Quality of Life","volume":"43","author":"Buset","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1016\/j.jmb.2019.05.016","article-title":"The Structure of Dental Plaque Microbial Communities in the Transition from Health to Dental Caries and Periodontal Disease","volume":"431","author":"Valm","year":"2019","journal-title":"J. Mol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Liu, D., Liu, S., Zhang, S., and Pan, Y. (2021). The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.585917"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","article-title":"The Oral Microbiome: Diversity, Biogeography and Human Health","volume":"22","author":"Baker","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sadek, K., El Moshy, S., Radwan, I., Rady, D., Abbass, M., El-Rashidy, A., D\u00f6rfer, C., and Fawzy El-Sayed, K. (2023). Molecular Basis beyond Interrelated Bone Resorption\/Regeneration in Periodontal Diseases: A Concise Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054599"},{"key":"ref_9","first-page":"e60779","article-title":"Role of Oxidative Stress in Periodontal Diseases","volume":"16","author":"Patil","year":"2024","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis Is an Inflammatory Disease of Oxidative Stress: We Should Treat It That Way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/prd.12337","article-title":"A Public Health Approach for Prevention of Periodontal Disease","volume":"84","author":"Janakiram","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/prd.12332","article-title":"Contemporary Practices for Mechanical Oral Hygiene to Prevent Periodontal Disease","volume":"84","author":"Graetz","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Rajendiran, M., Trivedi, H.M., Chen, D., Gajendrareddy, P., and Chen, L. (2021). Recent Development of Active Ingredients in Mouthwashes and Toothpastes for Periodontal Diseases. Molecules, 26.","DOI":"10.3390\/molecules26072001"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103497","DOI":"10.1016\/j.jdent.2020.103497","article-title":"Current Uses of Chlorhexidine for Management of Oral Disease: A Narrative Review","volume":"103","author":"Brookes","year":"2020","journal-title":"J. Dent."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4103\/ijdr.ijdr_293_22","article-title":"Comparative Evaluation of Efficacy of Herbal and Chlorhexidine Mouthwash on Gingival Health","volume":"34","author":"Senkalvarayan","year":"2023","journal-title":"Indian J. Dent. Res."},{"key":"ref_16","first-page":"ZC13","article-title":"Comparative Evaluation of the Efficacy of Probiotic, Herbal and Chlorhexidine Mouthwash on Gingival Health: A Randomized Clinical Trial","volume":"11","author":"Deshmukh","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_17","first-page":"306","article-title":"A Systematic Review of Medicinal Plants and Herbal Products\u2019 Effectiveness in Oral Health and Dental Cure with Health Promotion Approach","volume":"12","author":"Amanpour","year":"2023","journal-title":"J. Educ. Health Promot."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Go\u015bciniak, A., Paczkowska-Walendowska, M., Skotnicka, A., Rucha\u0142a, M.A., and Cielecka-Piontek, J. (2021). Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13122185"},{"key":"ref_19","first-page":"430","article-title":"Herbal and Nano-Based Herbal Medicine: New Insights into Their Therapeutic Aspects against Periodontitis","volume":"14","author":"RezaeiTazangi","year":"2023","journal-title":"Avicenna J. Phytomed."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/jispcd.JISPCD_210_22","article-title":"Role of Medicinal Herbs in Periodontal Therapy: A Systematic Review","volume":"13","author":"Pasupuleti","year":"2023","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mekhemar, M., Hassan, Y., and D\u00f6rfer, C. (2020). Nigella Sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy. Antioxidants, 9.","DOI":"10.3390\/antiox9121260"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.micpath.2017.10.054","article-title":"Antibacterial and Antibiofilm Activities of Eugenol from Essential Oil of Syzygium aromaticum (L.) Merr. & L. M. Perry (Clove) Leaf against Periodontal Pathogen Porphyromonas gingivalis","volume":"113","author":"Zhang","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lima, M.D.R., Lopes, A.P., Martins, C., Brito, G.A.C., Carneiro, V.C., and Goes, P. (2017). The Effect of Calendula officinalis on Oxidative Stress and Bone Loss in Experimental Periodontitis. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00440"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ctcp.2015.12.001","article-title":"Evaluation of the Efficacy of a Polyherbal Mouthwash Containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis Extracts in Patients with Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial","volume":"22","author":"Mahyari","year":"2016","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Valverde, N., L\u00f3pez-Valverde, A., Montero, J., Rodr\u00edguez, C., Macedo De Sousa, B., and Aragoneses, J.M. (2023). Antioxidant, Anti-Inflammatory and Antimicrobial Activity of Natural Products in Periodontal Disease: A Comprehensive Review. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1226907"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.36740\/WLek202107131","article-title":"Effectiveness of Composed Herbal Extract in the Treatment of Gingivitis and Oral and Pharyngeal Mucosa\u2014Review of Studies","volume":"74","author":"Surdacka","year":"2021","journal-title":"Wiad. Lek."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1021\/acs.jafc.8b05037","article-title":"Plant Resources, Chemical Constituents, and Bioactivities of Tea Plants from the Genus Camellia Section","volume":"67","author":"Meng","year":"2019","journal-title":"Thea. J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.fct.2007.10.006","article-title":"Modulation of Nrf2-Mediated Antioxidant and Detoxifying Enzyme Induction by the Green Tea Polyphenol EGCG","volume":"46","author":"Na","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_29","first-page":"74","article-title":"Anti-Inflammatory Action of Green Tea","volume":"15","author":"Ohishi","year":"2016","journal-title":"AIA AMC"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"132135","DOI":"10.1016\/j.foodchem.2022.132135","article-title":"Epigallocatechin 3-Gallate: From Green Tea to Cancer Therapeutics","volume":"379","author":"Alam","year":"2022","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Santos, R.A., Pessoa, H.R., Daleprane, J.B., De Faria Lopes, G.P., and Da Costa, D.C.F. (2023). Comparative Anticancer Potential of Green Tea Extract and Epigallocatechin-3-Gallate on Breast Cancer Spheroids. Foods, 13.","DOI":"10.3390\/foods13010064"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, X.-X., Liu, C., Dong, S.-L., Ou, C.-S., Lu, J.-L., Ye, J.-H., Liang, Y.-R., and Zheng, X.-Q. (2022). Anticarcinogenic Potentials of Tea Catechins. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1060783"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Farhan, M. (2022). Green Tea Catechins: Nature\u2019s Way of Preventing and Treating Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810713"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/jioh.jioh_217_22","article-title":"Antifungal Efficiency of Different Forms of Tea Extract (Camellia sinensis) against Candida Albicans: An in Vitro Experimental Study","volume":"15","author":"Shivakumar","year":"2023","journal-title":"J Int. Oral Heal."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Higuchi, M., Abiko, Y., Washio, J., and Takahashi, N. (2024). Antimicrobial Effects of Epigallocatechin-3-Gallate, a Catechin Abundant in Green Tea, on Periodontal Disease-Associated Bacteria. Arch. Oral Biol., 167.","DOI":"10.1016\/j.archoralbio.2024.106063"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Reygaert, W.C. (2018). Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases. BioMed Res. Int., 2018.","DOI":"10.1155\/2018\/9105261"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., and Tuomilehto, J. (2017). Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management. Nutrients, 9.","DOI":"10.3390\/nu9121310"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Afzal, O., Dalhat, M.H., Altamimi, A.S.A., Rasool, R., Alzarea, S.I., Almalki, W.H., Murtaza, B.N., Iftikhar, S., Nadeem, S., and Nadeem, M.S. (2022). Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits. Molecules, 27.","DOI":"10.3390\/molecules27217604"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11130-019-00771-5","article-title":"The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: A Systematic Review","volume":"75","author":"Williams","year":"2020","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.2174\/1381612823666170105151800","article-title":"Effect of Green Tea Phytochemicals on Mood and Cognition","volume":"23","author":"Dietz","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"111936","DOI":"10.1016\/j.nut.2022.111936","article-title":"Green Tea Consumption and the Risk of Stroke: A Systematic Review and Meta-Analysis of Cohort Studies","volume":"107","author":"Wang","year":"2023","journal-title":"Nutrition"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.tcm.2021.08.004","article-title":"Coffee and Tea on Cardiovascular Disease (CVD) Prevention","volume":"32","author":"Chieng","year":"2022","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_43","unstructured":"European Medicines Agency (2025, January 05). Assessment Report on Camellia sinensis (L.) Kuntze, Non Fermentatum Folium. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/camelliae-sinensis-non-fermentatum-folium."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.yrtph.2018.03.019","article-title":"The Safety of Green Tea and Green Tea Extract Consumption in Adults\u2014Results of a Systematic Review","volume":"95","author":"Hu","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2017.06.008","article-title":"Safety Assessment of Green Tea Based Beverages and Dried Green Tea Extracts as Nutritional Supplements","volume":"277","author":"Dekant","year":"2017","journal-title":"Toxicol. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipi\u010d, M., Frutos, M.J., Galtier, P., and Gott, D. (2018). Scientific opinion on the safety of green tea catechins. EFSA, 16, e05239.","DOI":"10.2903\/j.efsa.2018.5239"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Han, K., Hwang, E., and Park, J.-B. (2016). Excessive Consumption of Green Tea as a Risk Factor for Periodontal Disease among Korean Adults. Nutrients, 8.","DOI":"10.3390\/nu8070408"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jare.2023.12.004","article-title":"Biological Potential and Mechanisms of Tea\u2019s Bioactive Compounds: An Updated Review","volume":"65","author":"Luo","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/10408398.2012.678949","article-title":"Tea and Its Consumption: Benefits and Risks","volume":"55","author":"Hayat","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_50","first-page":"65","article-title":"Potential Bioactive Components and Health Promotional Benefits of Tea (Camellia sinensis)","volume":"41","author":"Samanta","year":"2022","journal-title":"J. Am. Nutr. Assoc."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tang, G.-Y., Meng, X., Gan, R.-Y., Zhao, C.-N., Liu, Q., Feng, Y.-B., Li, S., Wei, X.-L., Atanasov, A.G., and Corke, H. (2019). Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246196"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhao, T., Li, C., Wang, S., and Song, X. (2022). Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology. Molecules, 27.","DOI":"10.3390\/molecules27123909"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Khan, N., and Mukhtar, H. (2018). Tea Polyphenols in Promotion of Human Health. Nutrients, 11.","DOI":"10.3390\/nu11010039"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Aboulwafa, M.M., Youssef, F.S., Gad, H.A., Altyar, A.E., Al-Azizi, M.M., and Ashour, M.L. (2019). A Comprehensive Insight on the Health Benefits and Phytoconstituents of Camellia sinensis and Recent Approaches for Its Quality Control. Antioxidants, 8.","DOI":"10.3390\/antiox8100455"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Li, M.-Y., Liu, H.-Y., Wu, D.-T., Kenaan, A., Geng, F., Li, H.-B., Gunaratne, A., Li, H., and Gan, R.-Y. (2022). L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis, L.) with Multiple Health Benefits and Food Applications. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.853846"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9370","DOI":"10.1039\/D0FO02054K","article-title":"Antibacterial Green Tea Catechins from a Molecular Perspective: Mechanisms of Action and Structure\u2013Activity Relationships","volume":"11","author":"Renzetti","year":"2020","journal-title":"Food Funct."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Reygaert, W.C. (2014). The Antimicrobial Possibilities of Green Tea. Front. Microbiol., 5.","DOI":"10.3389\/fmicb.2014.00434"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1099\/mic.0.2007\/007807-0","article-title":"The \u03b2-Lactam-Resistance Modifier (\u2212)-Epicatechin Gallate Alters the Architecture of the Cell Wall of Staphylococcus aureus","volume":"153","author":"Stapleton","year":"2007","journal-title":"Microbiology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/jac\/42.2.211","article-title":"The Effect of a Component of Tea (Camellia sinensis) on Methicillin Resistance, PBP2\u2032 Synthesis, and Beta-Lactamase Production in Staphylococcus aureus","volume":"42","author":"Yam","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ijantimicag.2003.09.027","article-title":"Modulation of \u03b2-Lactam Resistance in Staphylococcus aureus by Catechins and Gallates","volume":"23","author":"Stapleton","year":"2004","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.phymed.2016.11.007","article-title":"Antibacterial Activity of Epigallocatechin-3-Gallate (EGCG) and Its Synergism with \u03b2-Lactam Antibiotics Sensitizing Carbapenem-Associated Multidrug Resistant Clinical Isolates of Acinetobacter baumannii","volume":"24","author":"Lee","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1099\/jmm.0.001060","article-title":"Restoring the Activity of the Antibiotic Aztreonam Using the Polyphenol Epigallocatechin Gallate (EGCG) against Multidrug-Resistant Clinical Isolates of Pseudomonas aeruginosa","volume":"68","author":"Betts","year":"2019","journal-title":"J. Med. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wu, M., and Brown, A.C. (2021). Applications of Catechins in the Treatment of Bacterial Infections. Pathogens, 10.","DOI":"10.3390\/pathogens10050546"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/AAC.48.6.1968-1973.2004","article-title":"Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells","volume":"48","author":"Blanco","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kong, C., Zhang, H., Li, L., and Liu, Z. (2022). Effects of Green Tea Extract Epigallocatechin-3-Gallate (EGCG) on Oral Disease-Associated Microbes: A Review. J. Oral Microbiol., 14.","DOI":"10.1080\/20002297.2022.2131117"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.archoralbio.2016.01.014","article-title":"Green Tea Catechins Potentiate the Effect of Antibiotics and Modulate Adherence and Gene Expression in Porphyromonas gingivalis","volume":"65","author":"Morin","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"ref_67","first-page":"631","article-title":"Antimicrobial Potential of Aqueous Extract of Camellia sinensis against Representative Microbes","volume":"32","author":"Khan","year":"2019","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/ijdr.IJDR_227_20","article-title":"Efficacy of Antioxidants Therapy on Progression of Periodontal Disease\u2014A Randomized Control Trial","volume":"32","author":"Wasti","year":"2021","journal-title":"Indian J. Dent. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, Y., Mei, Y., Zou, R., Niu, L., and Dong, S. (2022). Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases\u2014Art of Destruction and Reconstruction. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112905"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Koch, W., Zag\u00f3rska, J., Marzec, Z., and Kukula-Koch, W. (2019). Applications of Tea (Camellia sinensis) and Its Active Constituents in Cosmetics. Molecules, 24.","DOI":"10.3390\/molecules24234277"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Tkaczenko, H., and Kurhaluk, N. (2025). Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26031098"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Zawani, M., and Fauzi, M. (2021). Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies. Polymers, 13.","DOI":"10.3390\/polym13213656"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"German, I.J.S., Barbalho, S.M., Andreo, J.C., Zutin, T.L.M., Laurindo, L.F., Rodrigues, V.D., Ara\u00fajo, A.C., Guiguer, E.L., Direito, R., and Pomini, K.T. (2024). Exploring the Impact of Catechins on Bone Metabolism: A Comprehensive Review of Current Research and Future Directions. Metabolites, 14.","DOI":"10.3390\/metabo14100560"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/iep.12379","article-title":"Green Tea Extract Rich in Epigallocatechin Gallate Impairs Alveolar Bone Loss in Ovariectomized Rats with Experimental Periodontal Disease","volume":"101","author":"Pitol","year":"2020","journal-title":"Int. J. Exp. Path."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Chen, S.-T., Kang, L., Wang, C.-Z., Huang, P.-J., Huang, H.-T., Lin, S.-Y., Chou, S.-H., Lu, C.-C., Shen, P.-C., and Lin, Y.-S. (2019). (\u2212)-Epigallocatechin-3-Gallate Decreases Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin. Molecules, 24.","DOI":"10.3390\/molecules24010156"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.fob.2015.06.003","article-title":"Epigallocatechin Gallate (EGCG) Suppresses Lipopolysaccharide-induced Inflammatory Bone Resorption, and Protects against Alveolar Bone Loss in Mice","volume":"5","author":"Tominari","year":"2015","journal-title":"FEBS Open Bio"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107464","DOI":"10.1016\/j.intimp.2021.107464","article-title":"(-)-Epigallocatechin-3-Gallate Inhibits Osteoclastogenesis by Blocking RANKL\u2013RANK Interaction and Suppressing NF-\u03baB and MAPK Signaling Pathways","volume":"95","author":"Xu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.intimp.2015.08.033","article-title":"Green Tea Epigallocatechin-3-Gallate Alleviates Porphyromonas gingivalis-Induced Periodontitis in Mice","volume":"29","author":"Cai","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.job.2020.04.002","article-title":"Drinking Green Tea Alleviates Alveolar Bone Resorption in Ligature-Induced Periodontitis in Mice","volume":"62","author":"Kaboosaya","year":"2020","journal-title":"J. Oral Biosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.archoralbio.2019.03.028","article-title":"Influence of Adjuvant Therapy with Green Tea Extract in the Treatment of Experimental Periodontitis","volume":"102","author":"Marques","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdsr.2020.11.003","article-title":"Impact of Green Tea (Camellia sinensis) on Periodontitis and Caries. Systematic Review and Meta-Analysis","volume":"57","author":"Mazur","year":"2021","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1902\/jop.2009.080510","article-title":"Relationship Between Intake of Green Tea and Periodontal Disease","volume":"80","author":"Kushiyama","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_83","first-page":"293","article-title":"Green Tea Intake as an Adjunct to Mechanical Periodontal Therapy for the Management of Mild to Moderate Chronic Periodontitis: A Randomized Controlled Clinical Trial","volume":"14","author":"Chopra","year":"2016","journal-title":"Oral Health Prev. Dent."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8992313","DOI":"10.1155\/2022\/8992313","article-title":"Effect of Green Tea on the Level of Salivary Interleukin-1 Beta in Patients with Chronic Periodontitis: A Randomized Clinical Trial","volume":"2022","author":"Rezvani","year":"2022","journal-title":"Int. J. Dent."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/idh.12131","article-title":"Effect of Adjunctive Use of Green Tea Dentifrice in Periodontitis Patients\u2014A Randomized Controlled Pilot Study","volume":"14","author":"Hrishi","year":"2016","journal-title":"Int. J. Dent. Hyg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10266-014-0190-1","article-title":"Clinical Effect of Locally Delivered Gel Containing Green Tea Extract as an Adjunct to Non-Surgical Periodontal Treatment","volume":"104","author":"Rattanasuwan","year":"2016","journal-title":"Odontology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-018-2684-7","article-title":"The Effect of Green Tea as an Adjunct to Scaling and Root Planing in Non-Surgical Periodontitis Therapy: A Systematic Review","volume":"23","author":"Gartenmann","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_88","first-page":"249","article-title":"Camellia sinensis Mouthwashes in Oral Care: A Systematic Review","volume":"21","author":"Tafazoli","year":"2020","journal-title":"J. Dent."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"975148","DOI":"10.5402\/2013\/975148","article-title":"Effect of Green Tea Mouthwash on Oral Malodor","volume":"2013","author":"Rassameemasmaung","year":"2013","journal-title":"ISRN Prev. 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