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In this study, we conducted a comprehensive bibliometric analysis, with conventional metrics associated with a critical review based on the neuropharmacological activities, to identify potential medical applications and also gaps in knowledge that require further investigation. Fifty-two articles were included according to the eligibility criteria. In the country analysis, Brazil emerged as the main contributor to research with the highest number of publications and citations. Notably, nine of the ten main research institutions are Brazilian, with the Universidade Federal de Santa Maria standing out with 761 citations. The keywords \u201canesthesia\u201d, \u201cLippia alba\u201d, and \u201cessential oil\u201d were the most frequent, highlighting their importance in this field. Essential oils are the most common type of extraction, which linalool, citral, geraniol, carvone, and limonene were the main constituents identified. According to the type of study, preclinical studies presented the highest frequency, primarily through fish experimental models. The main neuropharmacological activities identified were sedative\u2013anesthetic, anxiolytic, anticonvulsant, and analgesic, with mechanisms of action via the GABAergic pathway. This bibliometric review provided new evidence reinforcing the potential of L. alba as a promising alternative for the treatment of neuropsychiatric disorders. It also highlighted existing knowledge gaps, mainly related to the comparison of the actions of the different chemotypes of the species and the investigation of the mechanisms underlying their neuropharmacological properties. Additionally, there is a lack of knowledge in other emerging areas related to the central nervous system, such as mood and cognitive disorders.<\/jats:p>","DOI":"10.3390\/ph18030420","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:49:57Z","timestamp":1742197797000},"page":"420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unraveling the Neuropharmacological Properties of Lippia alba: A Scientometric Approach"],"prefix":"10.3390","volume":"18","author":[{"given":"Pedro I. C.","family":"Silva","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia e Bioqu\u00edmica, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"},{"name":"Laborat\u00f3rio de Farmacologia da Inflama\u00e7\u00e3o e do Comportamento, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"},{"name":"Centro de Estudos Pr\u00e9-Cl\u00ednicos da Amaz\u00f4nia, Universidade do Estado do Par\u00e1, Bel\u00e9m 66087-662, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas V. P. S.","family":"Pantoja","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia e Bioqu\u00edmica, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda C.","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia e Bioqu\u00edmica, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta E. O.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia da Inflama\u00e7\u00e3o e do Comportamento, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza F. R.","family":"Soares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia da Inflama\u00e7\u00e3o e do Comportamento, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7547-6463","authenticated-orcid":false,"given":"Rui Daniel","family":"Prediger","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Experimental de Doen\u00e7as Neurodegenerativas, Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Florian\u00f3polis 88049-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6186-9581","authenticated-orcid":false,"given":"En\u00e9as A.","family":"Fontes-J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia da Inflama\u00e7\u00e3o e do Comportamento, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-7177","authenticated-orcid":false,"given":"Jofre J. S.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Centro de Estudos Pr\u00e9-Cl\u00ednicos da Amaz\u00f4nia, Universidade do Estado do Par\u00e1, Bel\u00e9m 66087-662, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-7375","authenticated-orcid":false,"given":"Cristiane S. 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