{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:07:49Z","timestamp":1760058469113,"version":"build-2065373602"},"reference-count":81,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: The species Mikania glomerata and Mikania laevigata are commonly referred to as guaco. Their preparations are used in traditional Brazilian medicine, mainly to address respiratory conditions affecting the upper airways. Considering the wide popular use of this species, the present study aims to survey the biological activities of guaco that have already been proven in the literature and to generate an evidence gap map for these biological activities. Methods: A scoping review was conducted using the electronic databases PubMed, Scopus, and Web of Science (7 October 2024), which included all studies that have evaluated the biological activities of the leaves of the M. glomerata or M. laevigata species. Results: A total of 57 studies (31 assessed only M. glomerata, 17 assessed only M. laevigata, and 9 assessed both species) evaluating 38 different biological activities demonstrated that preclinical studies reported 23 biological activities for M. glomerata and 24 for M. laevigata. The most extensively researched activity for both species is their anti-inflammatory properties, which have been associated with their efficacy in treating bronchoconstriction and their popular uses as an antiophidic agent. The gap map illustrates the lack of evidence to support the biological activity of these species, which may explain some of their popular uses, such as their use as expectorants, antipyretics, for arthritis, rheumatism, neuralgia, and as an antisyphilitic. Conclusions: Considering these findings, there is a clear need for further studies to evaluate the activity of these species for these purposes, mainly through clinical studies.<\/jats:p>","DOI":"10.3390\/ph18040552","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:05:56Z","timestamp":1744200356000},"page":"552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biological Activities of Mikania glomerata and Mikania laevigata: A Scoping Review and Evidence Gap Mapping"],"prefix":"10.3390","volume":"18","author":[{"given":"Tha\u00eds Pelegrin","family":"Garcia","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5569-6588","authenticated-orcid":false,"given":"Daniela","family":"Gorski","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-3928","authenticated-orcid":false,"given":"Alexandre de F\u00e1tima","family":"Cobre","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-1239","authenticated-orcid":false,"given":"Raul Edison Luna","family":"Lazo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Bertol","sequence":"additional","affiliation":[{"name":"Dall PhytoLab S.A., Curitiba 82540-040, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-587X","authenticated-orcid":false,"given":"Luana Mota","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"},{"name":"Department of Pharmacy, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7049-4363","authenticated-orcid":false,"given":"Roberto","family":"Pontarolo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"},{"name":"Department of Pharmacy, Universidade Federal do Paran\u00e1, Curitiba 80020-300, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1211\/jpp.62.07.0001","article-title":"Scientific evidence for Mikania laevigata and Mikania glomerata as a pharmacological tool","volume":"62","author":"Napimoga","year":"2010","journal-title":"J. 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