{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:00:34Z","timestamp":1791601234873,"version":"4.3.4"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background:\u00a0Stachys alpina is a medicinal plant from the Lamiaceae family whose biological potential remains poorly explored. Methods: The aim of this study was to comprehensively assess the pol-yphenol profile, macro- and microelement composition, and the antioxidant, an-ti-diabetic, and anti-obesity activities of various plant organs (leaves, flowers, stems, and roots). Results: The leaves and flowers exhibited the highest concentration of phenolic compounds, while anthocyanins were detected exclusively in the flowers (215.05 mg\/100 g dry matter (dm)) and constituted 3% of the total polyphenols. Verbas-coside and chlorogenic acid were the most abundant polyphenols, reaching 4618.88 and 3277.83 mg\/ 100 g dm in the leaves. The highest ABTS and FRAP scavenging activity was observed in leaves (19.30 and 7.62 mmol TE\/g dm, respectively). Principal component analysis demonstrated a strong correlation between polyphenol content and antioxidant activity (ABTS-r= 0.87 and FRAP-r = 0.90), which was further confirmed by Pearson\u2019s correlation coefficients. The study also highlighted the significant impact of mineral composition on biological activity\u2014calcium and magnesium dominated in stems (10,100 and 3900 mg\/kg) and in roots (9200 and 3100 mg\/kg), supporting the functioning of an-tioxidant enzymes, while zinc and manganese in leaves (89.43 and 155.33 mg\/kg) con-tributed to intense metabolic processes. Conclusions:\u00a0S. aplina could serve as a valuable source of natural antioxidants and enzyme inhibitors associated with glucose and lipid metabolism, suggesting its promising application in the prevention and management of metabolic disorders..<\/jats:p>","DOI":"10.3390\/ph18050674","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:35:13Z","timestamp":1746185713000},"page":"674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polyphenolic Composition, Mineral Profile, and Biological Activities in Different Organs of Alpine Woundwort\u2014Insights into Antioxidant and Enzyme Inhibitory Potential"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-0211","authenticated-orcid":false,"given":"Sabina","family":"Lachowicz-Wi\u015bniewska","sequence":"first","affiliation":[{"name":"Department of Medicine and Health Science, University of Kalisz (Calisia University), plac Wojciecha Bogus\u0142awskiego 2, 62-800 Kalisz, Poland"},{"name":"Department of Production Engineering, Wroclaw University of Economics and Business, Komandorska 118\/120, 53-345 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-1927","authenticated-orcid":false,"given":"Ireneusz","family":"Ochmian","sequence":"additional","affiliation":[{"name":"Department of Horticulture, West Pomeranian University of Technology in Szczecin, 71-434 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Oszmia\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Science, University of Kalisz (Calisia University), plac Wojciecha Bogus\u0142awskiego 2, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Wi\u015bniewski","sequence":"additional","affiliation":[{"name":"Department of Production Engineering, Wroclaw University of Economics and Business, Komandorska 118\/120, 53-345 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Bernatek","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Science, University of Kalisz (Calisia University), plac Wojciecha Bogus\u0142awskiego 2, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Rubi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Science, University of Kalisz (Calisia University), plac Wojciecha Bogus\u0142awskiego 2, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"De Vita","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Ambientale, Universit\u00e0 di Roma \u201cLa Sapienza\u201d, Piazzale Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4103\/0250-474X.43021","article-title":"Antimicrobial studies on extracts of four species of Stachys","volume":"70","author":"Saeedi","year":"2008","journal-title":"Indian J. 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