{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:22:04Z","timestamp":1772468524683,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation (DFG)","award":["LA2746\/1-2"],"award-info":[{"award-number":["LA2746\/1-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Taeniasis, a zoonotic infection, is a common foodborne disease. Niclosamide and praziquantel have proven to be effective in treating it, but the use of the same drugs can lead to resistance, so alternative drugs need to be explored. This study investigated the anthelmintic potential of derived fractions from hydroethanolic extracts (HEs) of Aframomum melegueta (AM) and Xylopia aethiopica (XA), two medicinal plants known for their diverse bioactive properties. Methods: AM-HE fractions (dichloromethane fraction (DCMF), ether fraction (EF), aqueous fraction (AF)) and XA-HE fractions (chloroform fraction (CF), ether fraction (EF), and aqueous fraction (AF)) were used, and in vitro anthelmintic activity was assessed against Taenia spp. by using an adult motility assay for the worm\u2019s paralysis time determination. The parasiticidal and parasitostatic activity was also tested on Taenia spp. adult worms. Cell viability was further evaluated using propidium iodide (PI) staining, with albendazole (20 mg\/mL) as the reference drug. Results: The three fractions of each plant exhibited significant, dose-dependent anthelmintic activity, with AM-HE and XA-CF showing the greatest effects at 20 mg\/mL. AM-EF demonstrated significant activity at 0.4% and 0.8%. Irreversibility tests revealed that most of the treated worms remained paralysis, except those exposed to the AF of both plants. PI staining confirmed the dose-dependent mortality of Taenia cells treated with HE, DCMF, and AF of AM. Conclusions: These results underscore the potential of AM and XA extracts and fractions as alternative treatments for helminth infections. Further, in vivo studies are warranted to confirm their safety and therapeutic efficacy.<\/jats:p>","DOI":"10.3390\/ph18050749","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:54:28Z","timestamp":1747724068000},"page":"749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential of Aframomum melegueta and Xylopia aethiopica Against Taenia spp.: Plant-Based Remedies as Novel Anthelmintics"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9073-2428","authenticated-orcid":false,"given":"Fekandine V.","family":"Douti","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche en Immunologie et Immuno-Modulation (UR2IM), Laboratoire de Microbiologie et de Contr\u00f4le de Qualit\u00e9 des Denr\u00e9es Alimentaires, \u00c9cole Sup\u00e9rieure des Techniques Biologiques et Alimentaires (ESTBA), Universit\u00e9 de Lom\u00e9, Lom\u00e9 01 BP 1515, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-5274","authenticated-orcid":false,"given":"Gnatoulma","family":"Katawa","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche en Immunologie et Immuno-Modulation (UR2IM), Laboratoire de Microbiologie et de Contr\u00f4le de Qualit\u00e9 des Denr\u00e9es Alimentaires, \u00c9cole Sup\u00e9rieure des Techniques Biologiques et Alimentaires (ESTBA), Universit\u00e9 de Lom\u00e9, Lom\u00e9 01 BP 1515, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-4861","authenticated-orcid":false,"given":"Kathrin","family":"Arndts","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), 53127 Bonn, Germany"},{"name":"German-West African Centre for Global Health and Pandemic Prevention (G-WAC), Partner Site Bonn, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fagd\u00e9ba D.","family":"Bara","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche en Immunologie et Immuno-Modulation (UR2IM), Laboratoire de Microbiologie et de Contr\u00f4le de Qualit\u00e9 des Denr\u00e9es Alimentaires, \u00c9cole Sup\u00e9rieure des Techniques Biologiques et Alimentaires (ESTBA), Universit\u00e9 de Lom\u00e9, Lom\u00e9 01 BP 1515, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essimanam R.","family":"Awesso","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche en Immunologie et Immuno-Modulation (UR2IM), Laboratoire de Microbiologie et de Contr\u00f4le de Qualit\u00e9 des Denr\u00e9es Alimentaires, \u00c9cole Sup\u00e9rieure des Techniques Biologiques et Alimentaires (ESTBA), Universit\u00e9 de Lom\u00e9, Lom\u00e9 01 BP 1515, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-7487","authenticated-orcid":false,"given":"Simplice D.","family":"Karou","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche en Immunologie et Immuno-Modulation (UR2IM), Laboratoire de Microbiologie et de Contr\u00f4le de Qualit\u00e9 des Denr\u00e9es Alimentaires, \u00c9cole Sup\u00e9rieure des Techniques Biologiques et Alimentaires (ESTBA), Universit\u00e9 de Lom\u00e9, Lom\u00e9 01 BP 1515, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-3831","authenticated-orcid":false,"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), 53127 Bonn, Germany"},{"name":"German-West African Centre for Global Health and Pandemic Prevention (G-WAC), Partner Site Bonn, 53127 Bonn, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8667-2067","authenticated-orcid":false,"given":"Manuel","family":"Ritter","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), 53127 Bonn, Germany"},{"name":"German-West African Centre for Global Health and Pandemic Prevention (G-WAC), Partner Site Bonn, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref_1","first-page":"182","article-title":"Review on taeniasis and its zoonotic importance","volume":"7","author":"Gebrie","year":"2015","journal-title":"Eur. 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