{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:42Z","timestamp":1790885562508,"version":"4.1.0"},"reference-count":207,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Zagreb","award":["BM 10106-22-3071"],"award-info":[{"award-number":["BM 10106-22-3071"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>In this study, pharmacotherapies of abdominal compartment syndrome (ACS) and intra-abdominal hypertension (IAH) in animal studies were reviewed from the perspective of ACS\/IAH as failed cytoprotection issues, as non-specific injuries, and from the point of view of the cytoprotection concept as resolution. Therefore, this review challenges the unresolved theoretical and practical issues of severe multiorgan failure, acknowledged significance in clinics, and resolving outcomes (i.e., open abdomen). Generally, the reported agents not aligned with cytoprotection align with current pharmacotherapy limitations and have (non-)confirmed effectiveness, mostly in only one organ, mild\/moderate IAH, prophylactic application, and provide only a tentative resolution. Contrarily, stable gastric pentadecapeptide BPC 157 therapy, as a novel and relevant cytoprotective mediator having pleiotropic beneficial effects, simultaneously resolves many targets, resolving established disturbances, specifically compression\/ischemia (grade III and grade IV), and decompression\/advanced reperfusion. BPC 157 therapy rapidly activates collateral bypassing pathways, and, in ACS and IAH, and later, in reperfusion, there is a \u201cbypassing key\u201d (i.e., azygos vein direct blood flow delivery). This serves to counteract multiorgan and vessel failure, including lesions and hemorrhages in the brain, heart, lung, liver, kidney and gastrointestinal tract, thrombosis, peripherally and centrally, intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, occlusion\/occlusion-like syndrome, advanced Virchow triad circumstances, and free radical formation acting as a membrane stabilizer and free radical scavenger. Likewise, not only in ACS\/IAH resolving, but also in other occlusion\/occlusion-like syndromes, this \u201cbypassing key\u201d could be an effect of the essential endothelial cytoprotective capacity of BPC 157 and a particular modulatory effect on the NO-system, and a rescuing impact on vasomotor tone.<\/jats:p>","DOI":"10.3390\/ph18060866","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:18:43Z","timestamp":1749543523000},"page":"866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute Compartment Syndrome and Intra-Abdominal Hypertension, Decompression, Current Pharmacotherapy, and Stable Gastric Pentadecapeptide BPC 157 Solution"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-2252","authenticated-orcid":false,"given":"Predrag","family":"Sikiric","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School 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Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Knezevic, M., Gojkovic, S., Krezic, I., Zizek, H., Vranes, H., Malekinusic, D., Vrdoljak, B., Knezevic, T., Horvat Pavlov, K., and Drmic, D. (2021). Complex syndrome of complete occlusion of the end of the superior mesenteric vein, opposed with the stable gastric pentadecapeptide BPC 157 in rats. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081029"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Knezevic, M., Gojkovic, S., Krezic, I., Zizek, H., Malekinusic, D., Vrdoljak, B., Knezevic, T., Vranes, H., Drmic, D., and Staroveski, M. (2021). Occluded superior mesenteric artery and vein. Therapy with the stable gastric pentadecapeptide BPC 157. Biomedicines, 9.","DOI":"10.3390\/biomedicines9070792"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Knezevic, M., Gojkovic, S., Krezic, I., Zizek, H., Malekinusic, D., Vrdoljak, B., Vranes, H., Knezevic, T., Barisic, I., and Horvat Pavlov, K. (2021). Occlusion of the superior mesenteric artery in rats reversed by collateral pathways activation: Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome, intracranial, portal and caval hypertension, and aortal hypotension. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060609"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kralj, T., Kokot, A., Zlatar, M., Masnec, S., Kasnik Kovac, K., Milkovic Perisa, M., Batelja Vuletic, L., Giljanovic, A., Strbe, S., and Sikiric, S. (2021). Stable gastric pentadecapeptide BPC 157 therapy of rat glaucoma. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010089"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gojkovic, S., Krezic, I., Vranes, H., Zizek, H., Drmic, D., Horvat Pavlov, K., Petrovic, A., Batelja Vuletic, L., Milavic, M., and Sikiric, S. (2021). BPC 157 therapy and permanent occlusion of the superior sagittal sinus in rats: Vascular recruitment. Biomedicines, 9.","DOI":"10.3390\/biomedicines9070744"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tepes, M., Gojkovic, S., Krezic, I., Zizek, H., Vranes, H., Madzar, Z., Santak, G., Batelja, L., Milavic, M., and Sikiric, S. (2021). Stable gastric pentadecapeptide BPC 157 therapy for primary abdominal compartment syndrome. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.718147"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tepes, M., Krezic, I., Vranes, H., Smoday, I.M., Kalogjera, L., Zizek, H., Vukovic, V., Oroz, K., Kovac, K.K., and Madzar, Z. (2023). Stable gastric pentadecapeptide BPC 157: Effect on reperfusion following maintained intra-abdominal hypertension (grade III and grade IV) in rats. Pharmaceuticals, 16.","DOI":"10.3390\/ph16111554"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Smoday, I.M., Petrovic, I., Kalogjera, L., Vranes, H., Zizek, H., Krezic, I., Gojkovic, S., Skorak, I., Hriberski, K., and Brizic, I. (2022). Therapy effect of the stable gastric pentadecapeptide BPC 157 on acute pancreatitis as vascular failure-induced severe peripheral and central syndrome in rats. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061299"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.3748\/wjg.v29.i27.4289","article-title":"Stomach perforation-induced general occlusion\/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect","volume":"29","author":"Kalogjera","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e01726","DOI":"10.1002\/brb3.1726","article-title":"The effect of pentadecapeptide BPC 157 on hippocampal ischemia\/reperfusion injuries in rats","volume":"10","author":"Vrdoljak","year":"2020","journal-title":"Brain Behav."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Barisic, I., Balenovic, D., Udovicic, M., Bardak, D., Strinic, D., Vlaini\u0107, J., Vranes, H., Smoday, I.M., Krezic, I., and Milavic, M. (2022). Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020265"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Strbe, S., Gojkovic, S., Krezic, I., Zizek, H., Vranes, H., Barisic, I., Strinic, D., Orct, T., Vukojevic, J., and Ilic, S. (2021). Over-dose lithium toxicity as an occlusive-like syndrome in rats and gastric pentadecapeptide BPC 157. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111506"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gojkovic, S., Krezic, I., Vranes, H., Zizek, H., Drmic, D., Batelja Vuletic, L., Milavic, M., Sikiric, S., Stilinovic, I., and Simeon, P. (2021). Robert\u2019s intragastric alcohol-induced gastric lesion model as an escalated general peripheral and central syndrome, counteracted by the stable gastric pentadecapeptide BPC 157. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101300"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Smoday, I.M., Krezic, I., Kalogjera, L., Vukovic, V., Zizek, H., Skoro, M., Kovac, K.K., Vranes, H., Barisic, I., and Sikiric, S. (2023). Pentadecapeptide BPC 157 as therapy for inferior caval vein embolization: Recovery of sodium laurate-post-embolization syndrome in rats. Pharmaceuticals, 16.","DOI":"10.3390\/ph16101507"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Premuzic Mestrovic, I., Smoday, I.M., Kalogjera, L., Krezic, I., Zizek, H., Vranes, H., Vukovic, V., Oroz, K., Skorak, I., and Brizic, I. (2023). Antiarrhythmic sotalol, occlusion\/occlusion-like syndrome in rats, and stable gastric pentadecapeptide BPC 157 therapy. Pharmaceuticals, 16.","DOI":"10.3390\/ph16070977"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Strbe, S., Smoday, I.M., Krezic, I., Kalogjera, L., Vukovic, V., Zizek, H., Gojkovic, S., Vranes, H., Barisic, I., and Sikiric, S. (2023). Innate vascular failure by application of neuroleptics, amphetamine, and domperidone rapidly induced severe occlusion\/occlusion-like syndromes in rats and stable gastric pentadecapeptide BPC 157 as therapy. Pharmaceuticals, 16.","DOI":"10.3390\/ph16060788"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5603\/AIT.2014.0064","article-title":"The polycompartment syndrome: A concise state-of-the-art review","volume":"46","author":"Malbrain","year":"2014","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00423-008-0347-x","article-title":"Current insights in intra-abdominal hypertension and abdominal compartment syndrome: Open the abdomen and keep it open!","volume":"393","author":"Ravyts","year":"2008","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Jacobs, R., Wise, R.D., Myatchin, I., Vanhonacker, D., Minini, A., Mekeirele, M., Kirkpatrick, A.W., Pereira, B.M., Sugrue, M., and De Keulenaer, B. (2022). Fluid managenent, intra-abdominal hypertension and the abdominal compartment syndrome: A narrrative review. Life, 12.","DOI":"10.3390\/life12091390"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13054-020-2782-1","article-title":"A clinician\u2019s guide to managemet of intra-abdominal hypertensio and abdominal compartment syndrome in critically ill patients","volume":"24","author":"Malbrain","year":"2020","journal-title":"Crit. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bpa.2013.06.009","article-title":"Intra-abdominal hypertension: Definitions, monitoring, interpretation and management","volume":"27","author":"Malbrain","year":"2013","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1007\/s00268-009-0039-x","article-title":"IAH\/ACS: The rationale for surveillance","volume":"33","author":"Malbrain","year":"2009","journal-title":"World J. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccm.2008.09.003","article-title":"Intra-abdominal hypertension: Evolving concepts","volume":"30","author":"Malbrain","year":"2009","journal-title":"Clin. Chest Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ccell.2012.03.004","article-title":"Intra-abdominal hypertension: Evolving concepts","volume":"24","author":"Malbrain","year":"2012","journal-title":"Crit. Care Nurs. Clin. N. Am."},{"key":"ref_26","first-page":"1425","article-title":"The management of the open abdomen in trauma and emergency general surgery: Part 1\u2014damage control","volume":"68","author":"Diaz","year":"2010","journal-title":"J. Trauma"},{"key":"ref_27","first-page":"502","article-title":"Eastern Association for the Surgery of Trauma: A review of the management of the open abdomen\u2014Part 2 \u201cManagement of the open abdomen\u201d","volume":"71","author":"Diaz","year":"2011","journal-title":"J. Trauma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1007\/s11605-022-05372-3","article-title":"Long-term outcomes after emergency laparatomy: A retrospective study","volume":"26","author":"Ylimartimo","year":"2022","journal-title":"J. Gastrointest. Surg."},{"key":"ref_29","first-page":"119","article-title":"Postoperative complications and outcome after emergency laparatomy: A retrospective study","volume":"47","author":"Ylimartimo","year":"2023","journal-title":"J. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e0120421","DOI":"10.1128\/msystems.01204-21","article-title":"Multi-omic profiling reveals that intra-abdominal-hypertension-induced intestinal damage can be prevented by microbiome and metabolic modulations with 5-hydroxyindoleacetic acid as a diagnostic marker","volume":"7","author":"Li","year":"2022","journal-title":"mSystems"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhao, H.B., Jia, L., Yan, Q.Q., Deng, Q., and Wei, B. (2020). Effect of Clostridium butyricum and butyrate on intestinal barrier functions: Study of a rat model of severe acute pancreatitis with intra-abdominal hypertension. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.561061"},{"key":"ref_32","first-page":"e922009","article-title":"Basic fibroblast growth factor (bFGF) protects the blood-brain barrier by binding of FGFR1 and activating the ERK signaling pathway after intra-abdominal hypertension and traumatic brain injury","volume":"26","author":"Chen","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.18632\/oncotarget.23498","article-title":"Hydrogen protects against liver injury during CO(2)pneumoperitoneum in rats","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000490309","article-title":"Glycine protects liver from reperfusion injury following pneumoperitoneum","volume":"59","author":"Nickkholgh","year":"2018","journal-title":"Eur. Surg. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jss.2017.09.028","article-title":"Carbon monoxide and hydrogen sulphide reduce reperfusion injury in abdominal compartment syndrome","volume":"222","author":"Murphy","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chang, M., Tang, H., Liu, D., Li, Y., and Zhang, L. (2016). Comparison of melatonin, hypertonic saline and hydroxethyl starch for resuscitation of secondary intra-abdominal hypertension in an animal model. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161688"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2016.06.001","article-title":"Melatonin","volume":"97","author":"Chang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Cho, J.S., Oh, Y.J., Kim, O.S., and Na, S. (2015). The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats. BMC Anesthesiol., 15.","DOI":"10.1186\/s12871-015-0112-y"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3109\/0886022X.2015.1040706","article-title":"Protective effect of theophylline on renal functions in experimental pneumoperiotoneum model","volume":"37","author":"Ozturk","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jss.2015.01.007","article-title":"Melanocortin-4 receptor agonists alleviate intestinal dysfunction in secondary intra-abdominal hypertension in rat model","volume":"195","author":"Liu","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.npep.2014.12.003","article-title":"Melanocortin MC4 receptor agonists alleviate brain damage in abdominal compartment syndrome in the rat","volume":"49","author":"Liu","year":"2015","journal-title":"Neuropeptides"},{"key":"ref_42","first-page":"1698","article-title":"Ameliorating effects of CAPE on oxidative damage caused by pneumoperitoneum in rat lung tissue","volume":"7","author":"Davarci","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2014.02.036","article-title":"Aprotinin reduces oxidative stress induced by pneumoperitoneum in rats","volume":"189","author":"Baltatzis","year":"2014","journal-title":"Surg. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E124","DOI":"10.25011\/cim.v37i3.21379","article-title":"Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats","volume":"37","author":"Xingwei","year":"2014","journal-title":"Clin. Investig. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/0886022X.2013.832317","article-title":"Caffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the rat","volume":"36","author":"Rifaioglu","year":"2014","journal-title":"Ren. Fail."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cekic, B., Geze, S., Ozkan, G., Besir, A., Sonmez, M., Karahan, S.C., and Mentese, A. (2014). The effect of dexmedetomidine on oxidative stress during pneumoperitoneum. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/760323"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/08941939.2013.808289","article-title":"The preventive effect of dopamine infusion in rats with abdominal compartment syndrome","volume":"26","author":"Saracoglu","year":"2013","journal-title":"J. Investig. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jss.2012.04.036","article-title":"Minocycline ameliorates lung and liver dysfunction in a rodent model of hemorrhagic shock\/resuscitation plus abdominal compartment syndrome","volume":"180","author":"Chen","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/SLE.0b013e31826183df","article-title":"Use of dexmedetomidine to prevent pulmonary injury after pneumoperitoneum in ventilated rats","volume":"22","author":"Geze","year":"2012","journal-title":"Surg. Laparosc. Endosc. Percutaneous Tech."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/eurjhf\/hfs102","article-title":"Phosphodiesterase 5 inhibition protects against increased intra-abdominal pressure-induced renal dysfunction in experimental congestive heart failure","volume":"14","author":"Bishara","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"ref_51","first-page":"707","article-title":"The influence of dachengqi tang on acute lung injury and intraabdominal hypertension in rats with acute pancreatitis","volume":"42","author":"Wan","year":"2011","journal-title":"J. Sichuan Univ. Med. Sci. Ed."},{"key":"ref_52","first-page":"613","article-title":"Dopamine\u2014A preventive agent for mesenteric ischemia and reperfusion injury in abdominal compartment syndrome","volume":"20","author":"Saracoglu","year":"2011","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jss.2009.09.048","article-title":"Effects of doxycycline on renal ischemia reperfusion injury induced by abdominal compartment syndrome","volume":"167","author":"Ihtiyar","year":"2011","journal-title":"J. Surg. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5505\/tjtes.2011.73555","article-title":"The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats","volume":"17","author":"Tihan","year":"2011","journal-title":"Ulus Travma Acil Cerrahi Derg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.curtheres.2010.06.004","article-title":"Effects of doxycycline on intestinal ischemia reperfusion injury induced by abdominal compartment syndrome in a rat model","volume":"71","author":"Ozdemir","year":"2010","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s00464-008-9856-5","article-title":"The effect of pentoxifylline on oxidative stress in CO2 pneumoperitoneum","volume":"23","author":"Dinckan","year":"2009","journal-title":"Surg. Endosc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00464-008-9881-4","article-title":"Impact of pneumoperitoneum on renal perfusion and excretory function: Beneficial effects of nitroglycerine","volume":"23","author":"Bishara","year":"2009","journal-title":"Surg. Endosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.gassur.2003.09.026","article-title":"Octreotide improves reperfusion-induced oxidative injury in acute abdominal hypertension in rats","volume":"8","author":"Polat","year":"2004","journal-title":"J. Gastrointest. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1034\/j.1600-079X.2003.00070.x","article-title":"Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats","volume":"35","author":"Sener","year":"2003","journal-title":"J. Pineal Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.peptides.2003.09.004","article-title":"Octreotide: A new approach to the management of acute abdominal hypertension","volume":"24","author":"Polat","year":"2003","journal-title":"Peptides"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s00464-001-9208-1","article-title":"Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery","volume":"16","author":"Kim","year":"2002","journal-title":"Surg. Endosc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/jsre.1998.5409","article-title":"Vasopressin","volume":"79","author":"Dolgor","year":"1998","journal-title":"J. Surg. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Bajramagic, S., Sever, M., Rasic, F., Staresinic, M., Skrtic, A., Beketic Oreskovic, L., Oreskovic, I., Strbe, S., Loga Zec, S., and Hrabar, J. (2024). Stable gastric pentadecapeptide BPC 157 and intestinal anastomoses therapy in rats. A review. Pharmaceuticals, 17.","DOI":"10.3390\/ph17081081"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1007\/s10787-024-01499-8","article-title":"New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. Significance of counteraction of vascular and multiorgan failure of occlusion\/occlusion-like syndrome in cytoprotection\/organoprotection","volume":"32","author":"Sikiric","year":"2024","journal-title":"Inflammopharmacology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.2174\/0929867329666221005111553","article-title":"Stable gastric pentadecapeptide BPC 157: Prompt particular activation of collateral pathways","volume":"30","author":"Sikiric","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.2174\/1381612824666180608101119","article-title":"Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157. Vascular recruitment and gastrointestinal tract healing","volume":"24","author":"Sikiric","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0016-5085(79)90235-X","article-title":"Cytoprotection by prostaglandins","volume":"77","author":"Robert","year":"1979","journal-title":"Gastroenterology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0090-6980(81)90123-4","article-title":"Current history of cytoprotection","volume":"21","author":"Robert","year":"1981","journal-title":"Prostaglandins"},{"key":"ref_69","first-page":"G113","article-title":"Mild irritants prevent gastric necrosis through \u201cadaptive cytoprotection\u201d mediated by prostaglandins","volume":"245","author":"Robert","year":"1983","journal-title":"Am. J. Physiol."},{"key":"ref_70","first-page":"203","article-title":"Role of sulfhydryls and early vascular lesions in gastric mucosal injury","volume":"64","year":"1984","journal-title":"Acta Physiol. Hung."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0016-5085(87)90834-1","article-title":"Ethanol-induced damage to mucosal capillaries of rat stomach. Ultrastructural features and effects of prostaglandin F2 beta and cysteamine","volume":"92","author":"Trier","year":"1987","journal-title":"Gastroenterology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/0016-5085(86)90195-2","article-title":"Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16;16-dimethyl prostaglandin E2 or sodium thiosulfate","volume":"91","author":"Pihan","year":"1986","journal-title":"Gastroenterology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0016-5085(85)80176-1","article-title":"Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat","volume":"88","author":"Szabo","year":"1985","journal-title":"Gastroenterology"},{"key":"ref_74","first-page":"16","article-title":"Experimental basis for a role for sulfhydryls and dopamine in ulcerogenesis: A primer for cytoprotection\u2014Organoprotection","volume":"64","author":"Szabo","year":"1986","journal-title":"Klin. Wochenschr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF01945097","article-title":"Cytoprotection-organoprotection by somatostatin: Gastric and hepatic lesions","volume":"38","author":"Szabo","year":"1982","journal-title":"Experientia"},{"key":"ref_76","first-page":"677","article-title":"Prevention by prostaglandins of caerulein-induced pancreatitis in rats","volume":"60","author":"Robert","year":"1989","journal-title":"Lab. Investig."},{"key":"ref_77","first-page":"396","article-title":"Intra-abdominal compartment syndrome as a complication of ruptured abdominal aortic aneurysm repair","volume":"55","author":"Fietsam","year":"1989","journal-title":"Am. Surg."},{"key":"ref_78","first-page":"7","article-title":"Ueber den einflussdes intraabdominalen Druckes auf die absonderungs gechwindigkeit des harnes","volume":"52","author":"Wendt","year":"1867","journal-title":"Arch. Physiol. Heilk."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s00134-006-0349-5","article-title":"Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions","volume":"32","author":"Malbrain","year":"2006","journal-title":"Intensive Care Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.12998\/wjcc.v10.i10.3005","article-title":"Elevated intra-abdominal pressure: A review of current knowledge","volume":"10","author":"Sokolski","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/00003246-200006000-00008","article-title":"Incidence and clinical pattern of the abdominal compartment syndrome after \u201cdamage-control\u201d laparotomy in 311 patients with severe abdominal and\/or pelvic trauma","volume":"28","author":"Ertel","year":"2000","journal-title":"Crit. Care Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/anae.13721","article-title":"Complications after emergency laparotomy beyond the immediate postoperative period\u2014A retrospective, observational cohort study of 1139 patients","volume":"72","author":"Tengberg","year":"2017","journal-title":"Anaesthesia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/TA.0000000000000517","article-title":"The excess morbidity and mortality of emergency general surgery","volume":"78","author":"Havens","year":"2015","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00423-016-1493-1","article-title":"Morbidity and mortality rates after emergency abdominal surgery: An analysis of 4346 patients scheduled for emergency laparotomy or laparoscopy","volume":"402","author":"Tolstrup","year":"2017","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.surg.2017.05.008","article-title":"Outcomes of hospitalized patients undergoing emergency general surgery remote from admission","volume":"162","author":"Sharoky","year":"2017","journal-title":"Surgery"},{"key":"ref_86","first-page":"A5523","article-title":"A nationwide cohort study of short- and long-term outcomes following emergency laparotomy","volume":"66","author":"Jeppesen","year":"2019","journal-title":"Dan. Med. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1007\/s00268-012-1614-0","article-title":"One- and two-year outcomes and predictors of mortality following emergency laparotomy: A consecutive series from a United Kingdom teaching hospital","volume":"36","author":"Awad","year":"2012","journal-title":"World J. Surg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.anclin.2014.11.012","article-title":"Anesthesia for emergency abdominal surgery","volume":"33","author":"Peden","year":"2015","journal-title":"Anesthesiol. Clin."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/TA.0000000000000787","article-title":"The financial burden of emergency general surgery: National estimates 2010 to 2060","volume":"79","author":"Ogola","year":"2015","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e160480","DOI":"10.1001\/jamasurg.2016.0480","article-title":"Use of national burden to define operative emergency general surgery","volume":"151","author":"Scott","year":"2016","journal-title":"JAMA Surg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jamcollsurg.2010.09.026","article-title":"Comparison of hospital performance in emergency versus elective general surgery operations at 198 hospitals","volume":"212","author":"Ingraham","year":"2011","journal-title":"J. Am. Coll. Surg."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/01.CCM.0000153408.09806.1B","article-title":"Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: A multiple-center epidemiological study","volume":"33","author":"Malbrain","year":"2005","journal-title":"Crit. Care Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s00134-004-2169-9","article-title":"Prevalence of intra-abdominal hypertension in critically ill patients: A multicentre epidemiological study","volume":"30","author":"Malbrain","year":"2004","journal-title":"Intensive Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00268-009-0040-4","article-title":"Intra-abdominal pressure and abdominal compartment syndrome in acute general surgery","volume":"33","author":"Sugrue","year":"2009","journal-title":"World J. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s004649901130","article-title":"Portal venous flow during CO2 pneumoperitoneum in the rat","volume":"13","author":"Gutt","year":"1999","journal-title":"Surg. Endosc."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13017-024-00564-5","article-title":"International cross-sectional survey on current and updated definitions of intra-abdominal hypertension and abdominal compartment syndrome","volume":"19","author":"Nasa","year":"2024","journal-title":"World J. Emerg. Surg."},{"key":"ref_97","first-page":"647","article-title":"Increased intra-abdominal, intrathoracic, and intracranial pressure after severe brain injury: Multiple compartment syndrome","volume":"62","author":"Scalea","year":"2007","journal-title":"J. Trauma"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00134-005-2729-7","article-title":"Normalizing physiological variables in acute illness: Five reasons for caution","volume":"31","author":"Kavanagh","year":"2005","journal-title":"Intensive Care Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5114\/ait.2019.87648","article-title":"The Abdominal Compartment Society FTW. Awareness and knowledge of intra-abdominal hypertension and abdominal compartment syndrome: Results of a repeat, international, cross-sectional survey","volume":"51","author":"Wise","year":"2019","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00134-007-0843-4","article-title":"The polycompartment syndrome: Towards an understanding of the interactions between different compartments!","volume":"33","author":"Malbrain","year":"2007","journal-title":"Intensive Care Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S445","DOI":"10.1097\/CCM.0b013e3181ec5d09","article-title":"Compartment syndromes from head to toe","volume":"38","author":"Balogh","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s00134-013-2906-z","article-title":"Intra-abdominal hypertension and the abdominal compartment syndrome: Updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome","volume":"39","author":"Kirkpatrick","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00134-008-1135-3","article-title":"AIDS is coming to your ICU: Be prepared for acute bowel injury and acute intestinal distress syndrome","volume":"34","author":"Malbrain","year":"2008","journal-title":"Intensive Care Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Vincent, J.L. (2008). Fluid resuscitation and intra-abdominal hypertension. Yearbook of Intensive Care and Emergency Medicine, Springer.","DOI":"10.1007\/978-3-540-77290-3"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/CCM.0b013e3181935001","article-title":"It\u2019s all in the gut: Introducing the concept of acute bowel injury and acute intestinal distress syndrome","volume":"37","author":"Malbrain","year":"2009","journal-title":"Crit Care Med."},{"key":"ref_106","first-page":"657","article-title":"Acute intestinal distress syndrome: The importance of intra-abdominal pressure","volume":"74","author":"Malbrain","year":"2008","journal-title":"Minerva Anestesiol."},{"key":"ref_107","first-page":"1730","article-title":"Intracranial pressure. Part one: Historical overview and basic concepts","volume":"30","author":"Andrews","year":"2004","journal-title":"Intensive Care Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1007\/s00134-004-2377-3","article-title":"Intracranial pressure. Part two: Clinical applications and technology","volume":"30","author":"Citerio","year":"2004","journal-title":"Intensive Care Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0002-9610(03)00046-1","article-title":"Delayed celiotomy for the treatment of bile leak, compartment syndrome, and other hazards of nonoperative management of blunt liver injury","volume":"185","author":"Goldman","year":"2003","journal-title":"Am. J. Surg."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/00005373-199910000-00035","article-title":"Compartment syndrome of the liver","volume":"47","author":"Pearl","year":"1999","journal-title":"J. Trauma"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.CCM.0000249824.48222.B7","article-title":"Renal arterial resistive index response to intraabdominal hypertension in a porcine model","volume":"35","author":"Kirkpatrick","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_112","first-page":"713","article-title":"Pathophysiology of renal hemodynamics and renal cortical microcirculation in a porcine model of elevated intra-abdominal pressure","volume":"66","author":"Wauters","year":"2009","journal-title":"J. Trauma"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/17843286.1955.11717352","article-title":"The effect of increased intra-abdominal pressure on the renal excretion of water and electrolytes in normal human subjects and in patients with diabetes insipidus","volume":"10","author":"Bradley","year":"1955","journal-title":"Acta Clin. Belg."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1179\/acb.2007.62.s1.015","article-title":"Renal implications of increased intra-abdominal pressure: Are the kidneys the canary for abdominal hypertension?","volume":"62","author":"Malbrain","year":"2007","journal-title":"Acta Clin. Belg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jacc.2013.04.070","article-title":"Abdominal contributions to cardiorenal dysfunction in congestive heart failure","volume":"62","author":"Verbrugge","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.3748\/wjg.v18.i24.3035","article-title":"Kidneys in chronic liver diseases","volume":"18","author":"Hartleb","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1053\/snep.2002.33670","article-title":"Hepatorenal syndrome","volume":"22","author":"Kramer","year":"2002","journal-title":"Semin. Nephrol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/17843286.1994.11718360","article-title":"Orthodeoxia and platypnea in liver cirrhosis: Effects of propranolol","volume":"49","author":"Lambrecht","year":"1994","journal-title":"Acta Clin. Belg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/hep.21431","article-title":"Portopulmonary hypertension: Results from a 10-year screening algorithm","volume":"44","author":"Krowka","year":"2006","journal-title":"Hepatology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jss.2012.06.024","article-title":"The search for a magic bullet to fight multiple organ failure secondary to ischemia\/reperfusion injury and abdominal compartment syndrome","volume":"184","author":"Guo","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12265-022-10299-w","article-title":"NO-donation increases visceral circulation in a porcine model of abdominal hypertension","volume":"16","author":"Skoog","year":"2023","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"9034376","DOI":"10.1155\/2021\/9034376","article-title":"Hydromorphone protects against CO(2) pneumoperitoneum induced lung injury via heme oxygenase-1-regulated mitochondrial dynamics","volume":"2021","author":"Shi","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_123","first-page":"15","article-title":"Influence of mydocalm on the degree of intra-abdominal hypertension and local blood circulation in the intestinal wall in experiment","volume":"77","author":"Sapegin","year":"2014","journal-title":"Eksp. Klin. Farmakol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1752-8062.2009.00154.x","article-title":"Inclusion of a nitric oxide congener in the insufflation gas repletes S-nitrosohemoglobin and stabilizes physiologic status during prolonged carbon dioxide pneumoperitoneum","volume":"2","author":"Shimazutsu","year":"2009","journal-title":"Clin. Transl. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1177\/000313481408000239","article-title":"Potential cerebroprotective role of pentoxifyllin in preventing the detrimental cerebral consequences of intra-abdominal hypertension","volume":"80","author":"Youssef","year":"2014","journal-title":"Am. Surg."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.transproceed.2012.01.127","article-title":"Oxygen inhalation improves survival time of mice with acute intra-abdominal hypertension and protects liver cells","volume":"44","author":"He","year":"2012","journal-title":"Transplant. Proc."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1467-2995.2012.00710.x","article-title":"Influence of fentanyl on intra-abdominal pressure during laparoscopy in dogs","volume":"39","author":"Ambrisko","year":"2012","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/01.sla.0000153034.54128.5e","article-title":"A method to attenuate pneumoperitoneum-induced reductions in splanchnic blood flow","volume":"241","author":"Ali","year":"2005","journal-title":"Ann. Surg."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1089\/end.2005.19.1026","article-title":"Effects of enalaprilat on the renin-angiotensin-aldosterone system and on renal function during CO2 pneumoperitoneum","volume":"19","author":"Borba","year":"2005","journal-title":"J. Endourol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/00000539-200111000-00011","article-title":"The effects of vasoactive drugs on hepatic blood flow changes induced by CO2 laparoscopy: An animal study","volume":"93","author":"Elizalde","year":"2001","journal-title":"Anesth. Analg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00003246-200002000-00030","article-title":"Dobutamine restores intestinal mucosal blood flow in a porcine model of intra-abdominal hyperpressure","volume":"28","author":"Elizalde","year":"2000","journal-title":"Crit. Care Med."},{"key":"ref_132","first-page":"525","article-title":"The effects of neuromuscular block on peak airway pressure and abdominal elastance during pneumoperitoneum","volume":"82","author":"Chassard","year":"1996","journal-title":"Anesth. Analg."},{"key":"ref_133","first-page":"A584","article-title":"A multicenter, randomized, double blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis","volume":"128","author":"Ruenzi","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_134","first-page":"A309","article-title":"Safety, tolerability and pharmacokinetics of PL14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers","volume":"51","author":"Veljaca","year":"2003","journal-title":"Gut"},{"key":"ref_135","first-page":"8","article-title":"Intra-articular injection of BPC 157 for multiple types of knee pain","volume":"27","author":"Lee","year":"2021","journal-title":"Altern. Ther. Health Med."},{"key":"ref_136","first-page":"12","article-title":"Effect of BPC-157 on symptoms in patients with interstitial cystitis: A pilot study","volume":"30","author":"Lee","year":"2024","journal-title":"Altern. Ther. Health Med."},{"key":"ref_137","first-page":"1094","article-title":"Experimental models on abdominal compartment syndrome","volume":"4","author":"Csiszko","year":"2019","journal-title":"Emerg. Med. Investig."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1179\/acb.2007.62.s1.031","article-title":"What is the best animal model for acs?","volume":"62","author":"Schachtrupp","year":"2007","journal-title":"Acta Clin. Belg."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1684\/mrh.2012.0310","article-title":"Increase in intra-abdominal pressure raises brain venous pressure; leads to brain ischaemia and decreases brain magnesium content","volume":"25","author":"Jarosz","year":"2012","journal-title":"Magnes. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jss.2017.09.014","article-title":"Neurodevelopment impact of CO(2)-pneumoperitoneum in neonates: Experimental study in a rat model","volume":"221","author":"Miranda","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.sle.0000202192.66946.25","article-title":"The effects of carbon dioxide pneumoperitoneum on tyrosine hydroxylase activity","volume":"16","author":"Sare","year":"2006","journal-title":"Surg. Laparosc. Endosc. Percutaneous Tech."},{"key":"ref_142","first-page":"1254","article-title":"Comparison of SPO2; hearth rate and body temperature values in abdominal compartment syndrome in a rat model with intraabdominal sepsis and intraabdominal hypertension","volume":"27","author":"Balci","year":"2006","journal-title":"Saudi Med. J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.juro.2011.03.040","article-title":"Pneumoperitoneum aggravates renal function in cases of decompensated but not compensated experimental congestive heart failure: Role of nitric oxide","volume":"186","author":"Bishara","year":"2011","journal-title":"J. Urol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00464-001-8248-x","article-title":"Impact of carbon dioxide and helium insufflation on cardiorespiratory function during prolonged pneumoperitoneum in an experimental rat model","volume":"16","author":"Hazebroek","year":"2002","journal-title":"Surg. Endosc."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Santos, C.L., Santos, R.S., Moraes, L., Samary, C.S., Felix, N.S., Silva, J.D., Morales, M.M., Huhle, R., Abreu, M.G., and Schanaider, A. (2017). Effects of pressure support and pressure-controlled ventilation on lung damage in a model of mild extrapulmonary acute lung injury with intra-abdominal hypertension. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178207"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5603\/AIT.a2017.0021","article-title":"Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model","volume":"49","author":"Lima","year":"2017","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Papakrivou, E., Makris, D., Manoulakas, E., Mitroudi, M., Tepetes, K., Papazoglou, K., and Zakynthinos, E. (2017). Intra-Abdominal hypertension causes bacterial growth in lungs: An animal study. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/4601348"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1186\/cc13920","article-title":"The biological effects of higher and lower positive end-expiratory pressure in pulmonary and extrapulmonary acute lung injury with intra-abdominal hypertension","volume":"18","author":"Santos","year":"2014","journal-title":"Crit. Care"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.resp.2011.11.007","article-title":"Effects of intra-abdominal pressure on respiratory system mechanics in mechanically ventilated rats","volume":"180","author":"Runck","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00068-010-0068-z","article-title":"Lung tissue apoptosis in abdominal hypertension: Apoptosis and necrosis of lung tissue in abdominal hypertension","volume":"37","author":"Akbulut","year":"2011","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jss.2015.04.049","article-title":"Hepatic microvascular changes in rat abdominal compartment syndrome","volume":"197","author":"Chadi","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_152","first-page":"511","article-title":"Experimental study of liver injury in rats of abdominal infection with abdominal compartment syndrome","volume":"14","author":"Chen","year":"2011","journal-title":"Chin. J. Gastrointest. Surg."},{"key":"ref_153","first-page":"335","article-title":"Open abdomen management treatment of liver injury in rats with abdominal compartment syndrome and sepsis","volume":"49","author":"Chen","year":"2011","journal-title":"Chin. J. Gastrointest. Surg."},{"key":"ref_154","first-page":"44","article-title":"Pathomorphological alterations in the liver and small intestine in experimental modelling of abdominal compartment syndrome","volume":"6","author":"Zabelin","year":"2010","journal-title":"Eksp. Klin. Gastroenterol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1055\/s-2008-1038920","article-title":"Effect of elevated intra-abdominal pressure and hyperoxia on portal vein blood flow; hepatocyte proliferation and apoptosis in a rat model","volume":"18","author":"Mogilner","year":"2008","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00595-006-3196-7","article-title":"Liver injury in sepsis and abdominal compartment syndrome in rats","volume":"36","author":"Muftuoglu","year":"2006","journal-title":"Surg. Today"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/01.TA.0000087648.01543.9F","article-title":"Increased susceptibility to oxidant injury in hepatocytes from rats with intra-abdominal hypertension","volume":"57","author":"Hsu","year":"2004","journal-title":"J. Trauma"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/pr.2017.263","article-title":"Hypoxic renal injury in newborns with abdominal compartment syndrome (clinical and experimental study)","volume":"83","author":"Morozov","year":"2018","journal-title":"Pediatr. Res."},{"key":"ref_159","first-page":"49","article-title":"Biochemical and histopathological changes of intra-abdominal hypertension on the kidneys: Experimental study in rats","volume":"29","author":"Borazan","year":"2013","journal-title":"Ulus Cerrahi Derg."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e000595","DOI":"10.1136\/tsaco-2020-000595","article-title":"Relation between intra-abdominal pressure and early intestinal ischemia in rats","volume":"5","author":"Strang","year":"2020","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/lap.2016.0212","article-title":"The effect of elevated intra-abdominal pressure on TLR4 signaling in intestinal mucosa and intestinal bacterial translocation in a rat","volume":"27","author":"Strier","year":"2017","journal-title":"J. Laparoendosc. Adv. Surg. Tech. A"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Leng, Y., Yi, M., Fan, J., Bai, Y., Ge, Q., and Yao, G. (2016). Effects of acute intra-abdominal hypertension on multiple intestinal barrier functions in rats. Sci. Rep., 6.","DOI":"10.1038\/srep22814"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Leng, Y., Zhang, K., Fan, J., Yi, M., Ge, Q., Chen, L., Zhang, L., and Yao, G. (2014). Effect of acute, slightly increased intra-abdominal pressure on intestinal permeability and oxidative stress in a rat model. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109350"},{"key":"ref_164","first-page":"239","article-title":"Influence of haemoxygenase 1 (HO-1) gene expression on intestinal mucosa injury induced by intra-abdominal hypertension in rats","volume":"29","author":"Cheng","year":"2013","journal-title":"Chin. J. Burns"},{"key":"ref_165","first-page":"19","article-title":"Intraabdominal hypertention\u2014Predisposing factor for visceral alterations and abdominal compartment syndrome","volume":"4","author":"Deenichin","year":"2013","journal-title":"Khirurgiia (Sofiia)"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/08941930903214719","article-title":"Microscopic and ultrastructural changes of the intestine in abdominal compartment syndrome","volume":"22","author":"Gong","year":"2009","journal-title":"J. Investig. Surg."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000218102","article-title":"Interstitial cells of Cajal in abdominal sepsis and hypertension-induced ileus in rats","volume":"43","author":"Lou","year":"2009","journal-title":"Eur. Surg. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00383-008-2262-1","article-title":"Effect of elevated intra-abdominal pressure and 100% oxygen on superior mesenteric artery blood flow and enterocyte turnover in a rat","volume":"24","author":"Sukhotnik","year":"2008","journal-title":"Pediatr. Surg. Int."},{"key":"ref_169","first-page":"97","article-title":"Influence of the intra-abdominal hypertension on the blood coagulation system (experimental study)","volume":"256\u2013257","author":"Turgunov","year":"2016","journal-title":"Georgian Med. News."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3233\/CH-168027","article-title":"Hemorheological factors can be informative in comparing treatment possibilities of abdominal compartment syndrome","volume":"64","author":"Nemeth","year":"2016","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.thromres.2011.07.035","article-title":"Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin; warfarin or aspirin","volume":"129","author":"Stupnisek","year":"2012","journal-title":"Thromb. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"9084643","DOI":"10.1155\/2019\/9084643","article-title":"Intragastric application of aspirin, clopidogrel, cilostazol, and BPC 157 in rats: Platelet aggregation and blood clot","volume":"2019","author":"Konosic","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4291\/wjgp.v11.i1.1","article-title":"Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats","volume":"11","author":"Gojkovic","year":"2020","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_174","unstructured":"Ray, A., and Gulati, K. (2023). Stable gastric pentadecapeptide BPC 157 and NO-system. Nitric Oxide: From Research to Therapeutics; Advances in Biochemistry in Health and Disease 22, Springer Nature."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2174\/13816128113190990411","article-title":"Stable gastric pentadecapeptide BPC 157-NO-system relation","volume":"20","author":"Sikiric","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(97)01033-9","article-title":"The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure","volume":"332","author":"Seiwerth","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"ref_177","first-page":"287","article-title":"Stable gastric pentadecapeptide BPC 157 studied for inflammatory bowel disease (PLD-116, PL14736, Pliva) induces nitric oxide synthesis","volume":"126","author":"Turkovic","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Stupnisek, M., Kokot, A., Drmic, D., Hrelec Patrlj, M., Zenko Sever, A., Kolenc, D., Radic, B., Suran, J., Bojic, D., and Vcev, A. (2015). Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123454"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.2147\/DDDT.S284163","article-title":"Clopidogrel-induced gastric injury in rats is attenuated by stable gastric pentadecapeptide BPC 157","volume":"14","author":"Wu","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Hsieh, M.J., Lee, C.H., Chueh, H.Y., Chang, G.J., Huang, H.Y., Lin, Y., and Pang, J.S. (2020). Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-74022-y"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00109-016-1488-y","article-title":"Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation","volume":"95","author":"Hsieh","year":"2017","journal-title":"J. Mol. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.2174\/1381612826666200523180301","article-title":"BPC 157 rescued NSAID-cytotoxicity via stabilizing intestinal permeability and enhancing cytoprotection","volume":"26","author":"Park","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2007.05.072","article-title":"Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression","volume":"570","author":"Brajsa","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.2174\/1381612824666180614082950","article-title":"BPC157 as potential agent rescuing from cancer cachexia","volume":"24","author":"Kang","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1097\/00008390-200408000-00050","article-title":"BPC 157 inhibits cell growth and VEGF signalling via the MAPK kinase pathway in the human melanoma cell line","volume":"14","author":"Radeljak","year":"2004","journal-title":"Melanoma Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/DDDT.S82030","article-title":"Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro","volume":"9","author":"Huang","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"121072","DOI":"10.1016\/j.lfs.2022.121072","article-title":"Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro","volume":"310","author":"Huang","year":"2022","journal-title":"Life Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12264-018-0269-8","article-title":"Cytoprotective mechanism of the novel gastric peptide in gastrointestinal tract and cultured enteric neurons and glial cells","volume":"35","author":"Wang","year":"2019","journal-title":"Neurosci. Bull."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"19066","DOI":"10.3390\/molecules191119066","article-title":"Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts","volume":"19","author":"Chang","year":"2014","journal-title":"Molecules"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1152\/japplphysiol.00945.2010","article-title":"The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration","volume":"110","author":"Chang","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00701-019-03868-7","article-title":"The significance of intra-abdominal pressure in neurosurgery and neurological diseases: A narrative review and a conceptual proposal","volume":"161","author":"Depauw","year":"2019","journal-title":"Acta Neurochir."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/TA.0b013e31822a3254","article-title":"Intra-abdominal hypertension causes reversible blood-brain barrier disruption","volume":"72","author":"Youssef","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4077\/CJP.2009.AMH036","article-title":"From neurogenic pulmonary edema to fat embolism syndrome: A brief review of experimental and clinical investigations of acute lung injury and acute respiratory distress syndrome","volume":"52","author":"Chen","year":"2009","journal-title":"Chin. J. Physiol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.2174\/1381612824666180712110447","article-title":"BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing","volume":"24","author":"Seiwerth","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Sikiric, P., Gojkovic, S., Krezic, I., Smoday, I.M., Kalogjera, L., Zizek, H., Oroz, K., Vranes, H., Vukovic, V., and Labidi, M. (2023). Stable gastric pentadecapeptide BPC 157 may recover brain-gut axis and gut-brain axis function. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050676"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Sikiric, P., Boban Blagaic, A., Strbe, S., Beketic Oreskovic, L., Oreskovic, I., Sikiric, S., Staresinic, M., Sever, M., Kokot, A., and Jurjevic, I. (2024). The stable gastric pentadecapeptide BPC 157 pleiotropic beneficial activity and its possible relations with neurotransmitter activity. Pharmaceuticals, 17.","DOI":"10.3390\/ph17040461"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Staresinic, M., Japjec, M., Vranes, H., Prtoric, A., Zizek, H., Krezic, I., Gojkovic, S., Smoday, I.M., Oroz, K., and Staresinic, E. (2022). Stable gastric pentadecapeptide BPC 157 and striated, smooth, and heart muscle. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123221"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Sikiric, P., Udovicic, M., Barisic, I., Balenovic, D., Zivanovic Posilovic, G., Strinic, D., Uzun, S., Sikiric, S., Krezic, I., and Zizek, H. (2022). Stable gastric pentadecapeptide BPC157 as useful cytoprotective peptide therapy in the heart disturbances, myocardial infarction, pulmonary hypertension, arrhythmias, and thrombosis presentation. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112696"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0928-4257(97)89478-8","article-title":"The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicken","volume":"91","author":"Grabarevic","year":"1997","journal-title":"J. Physiol. Paris"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Tlak Gajger, I., Smodi\u0161 \u0160kerl, M.I., \u0160o\u0161tari\u0107, P., \u0160uran, J., Sikiri\u0107, P., and Vlaini\u0107, J. (2021). Physiological and immunological status of adult honeybees (Apis mellifera) fed sugar syrup supplemented with pentadecapeptide BPC 157. Biology, 10.","DOI":"10.3390\/biology10090891"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/jvp.12509","article-title":"Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions","volume":"41","year":"2018","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"ref_202","first-page":"667.14","article-title":"Stable gastric pentadecapeptide BPC 157 antagonizes hydrogen peroxide induced oxidative stress in Drosophila melanogaster","volume":"31","author":"Filosevic","year":"2018","journal-title":"FASEB J."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/vec.13125","article-title":"Pathophysiology of intraabdominal hypertension and abdominal compartment syndrome and relevance to veterinary critical care","volume":"32","author":"Gardner","year":"2022","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"109931","DOI":"10.1016\/j.jneumeth.2023.109931","article-title":"Methodical advances in reproducibility research: A proof of concept qualitative comparative analysis of reproducing animal data in humans","volume":"397","author":"Leenaars","year":"2023","journal-title":"J. Neurosci. Methods"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Dirven, H., Vist, G.E., Bandhakavi, S., Mehta, J., Fitch, S.E., Pound, P., Ram, R., Kincaid, B., Leenaars, C.H.C., and Chen, M. (2021). Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-85708-2"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12967-019-1976-2","article-title":"Animal to human translation: A systematic scoping review of reported concordance rates","volume":"17","author":"Leenaars","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/cpt196235665","article-title":"Symposium on clinical drug evaluation and human pharmacology. XVI. Evaluation of the safety of new drugs by means of tests in animals","volume":"3","author":"Litchfield","year":"1962","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/6\/866\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:49:27Z","timestamp":1760032167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/6\/866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":207,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ph18060866"],"URL":"https:\/\/doi.org\/10.3390\/ph18060866","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}