{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:15:31Z","timestamp":1791976531745,"version":"4.4.0"},"reference-count":113,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Agency for Research and Development (ANID)","award":["21212100"],"award-info":[{"award-number":["21212100"]}]},{"name":"National Agency for Research and Development (ANID)","award":["21220031"],"award-info":[{"award-number":["21220031"]}]},{"name":"National Agency for Research and Development (ANID)","award":["INGE210025"],"award-info":[{"award-number":["INGE210025"]}]},{"name":"University of Talca","award":["21212100"],"award-info":[{"award-number":["21212100"]}]},{"name":"University of Talca","award":["21220031"],"award-info":[{"award-number":["21220031"]}]},{"name":"University of Talca","award":["INGE210025"],"award-info":[{"award-number":["INGE210025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background:\u00a0Taraxacum officinale (T. officinale), commonly known as dandelion, is a plant with recognized therapeutic properties in both traditional and modern medicine. Historically, it has been used to treat various conditions, particularly liver disorders, owing to its antioxidant and anti-inflammatory activities. This narrative review focuses on its biological activity, with an emphasis on hepatoprotective effects. Methods: We performed a compilation and analysis of published studies on the effects of T. officinale in animal models and its potential application in liver diseases. Results: Preclinical studies have reported that extracts of this plant protect against liver damage induced by toxic agents such as alcohol, carbon tetrachloride, and paracetamol. Among the most relevant and predominant bioactive compounds of T. officinale is taraxasterol, which modulates inflammatory and oxidative stress pathways, helping to prevent liver damage. Conclusions: While preclinical studies are promising, further clinical trials are essential to confirm the safety and efficacy of T. officinale in the treatment of liver diseases. Determining the optimal dosing, evaluating its potential as an adjuvant in pharmacological treatments, as well as evaluating possible interactions with conventional drugs, is necessary for the potential use of T. officinale as an adjuvant agent in the treatment of liver diseases.<\/jats:p>","DOI":"10.3390\/ph18070990","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:55:43Z","timestamp":1751442943000},"page":"990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Dandelion (Taraxacum officinale) in Liver Health and Hepatoprotective Properties"],"prefix":"10.3390","volume":"18","author":[{"given":"Francisca","family":"Herrera Vielma","sequence":"first","affiliation":[{"name":"Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile"},{"name":"Doctorate Program in Science, Mention in Research and Development of Bioactive Products, Institute of Chemistry of Natural Resources, University of Talca, Talca 3465548, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Qui\u00f1ones San Martin","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile"},{"name":"Doctorate Program in Science, Mention in Research and Development of Bioactive Products, Institute of Chemistry of Natural Resources, University of Talca, Talca 3465548, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Mu\u00f1oz-Carrasco","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile"},{"name":"School of Biotechnology Engineering, Faculty of Agricultural and Forestry Sciences, Catholic University of Maule, Talca 3466706, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Berrocal-Navarrete","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile"},{"name":"School of Biochemistry, Institute of Cell Biology and Biotechnology, University of Talca, Talca 3466706, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-8998","authenticated-orcid":false,"given":"Daniel R.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-991X","authenticated-orcid":false,"given":"Jessica","family":"Z\u00fa\u00f1iga-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-7847.95849","article-title":"Historical review of medicinal plants\u2019 usage","volume":"6","author":"Petrovska","year":"2012","journal-title":"Pharmacogn. 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