{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:31:56Z","timestamp":1792146716094,"version":"4.4.0"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Cannabidiol (CBD) has demonstrated potential as a therapeutic agent for muscle tension, pain, and sleep bruxism, yet its broader impact on comorbid conditions such as sleep disturbance and migraine disability remains underexplored. This study aimed to assess the effects of topical CBD on sleep quality and migraine-related disability in patients with bruxism-associated muscular pain. Methods: In a randomized, double-blind clinical trial, 60 participants with bruxism were allocated equally into three groups: control (placebo gel), 5% CBD gel, and 10% CBD gel. Participants applied the gel intraorally to the masseter muscles nightly for 30 days. Sleep quality and migraine-related disability were assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Migraine Disability Assessment Scale (MIDAS), respectively. Surface electromyography (sEMG) and the Bruxoff\u00ae device were used for objective evaluation of muscle tension and bruxism intensity. Results: Both CBD treatment groups demonstrated statistically significant improvements in PSQI and MIDAS scores compared to the control group (p &lt; 0.001). No significant differences were observed between the 5% and 10% CBD groups, suggesting comparable efficacy. The sEMG findings corroborated a reduction in muscle tension. Improvements in sleep and migraine outcomes were positively correlated with reductions in muscle activity and pain. Conclusions: Topical CBD gel significantly improved sleep quality and reduced migraine-related disability in patients with bruxism-associated muscular pain, supporting its role as a multifaceted therapeutic option in the management of TMD and related comorbidities. Further research is needed to confirm long-term benefits and determine optimal dosing strategies.<\/jats:p>","DOI":"10.3390\/ph18071064","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:56:14Z","timestamp":1753084574000},"page":"1064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expanding the Therapeutic Profile of Topical Cannabidiol in Temporomandibular Disorders: Effects on Sleep Quality and Migraine Disability in Patients with Bruxism-Associated Muscle Pain"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-7765","authenticated-orcid":false,"given":"Karolina","family":"Walczy\u0144ska-Dragon","sequence":"first","affiliation":[{"name":"Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3173-9389","authenticated-orcid":false,"given":"Jakub","family":"Fiegler-Rudol","sequence":"additional","affiliation":[{"name":"Scientific Society, Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-2130","authenticated-orcid":false,"given":"Aleksandra","family":"Nitecka-Buchta","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"C\u00e1sedas, G., Yarza-Sancho, M.d., and L\u00f3pez, V. (2024). Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical Evidence in the Treatment of Pain. Pharmaceuticals, 17.","DOI":"10.3390\/ph17111438"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.apha.2017.03.004","article-title":"Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads","volume":"80","author":"Russo","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"120582","DOI":"10.1016\/j.lfs.2022.120582","article-title":"Pharmacological Effects of Cannabidiol by Transient Receptor Potential Channels","volume":"300","author":"Etemad","year":"2022","journal-title":"Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/bcpt.13710","article-title":"A Narrative Review of Molecular Mechanism and Therapeutic Effect of Cannabidiol (CBD)","volume":"130","author":"Peng","year":"2022","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Walczy\u0144ska-Dragon, K., Kurek-G\u00f3recka, A., Fiegler-Rudol, J., Nitecka-Buchta, A., and Baron, S. (2025). The Therapeutic Potential of Cannabidiol in the Management of Temporomandibular Disorders and Orofacial Pain. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17030328"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e0022","DOI":"10.5041\/RMMJ.10129","article-title":"The endocannabinoid system, cannabinoids, and pain","volume":"4","author":"Fine","year":"2013","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Matei, D., Trofin, D., Iordan, D.A., Onu, I., Condurache, I., Ionite, C., and Buculei, I. (2023). The Endocannabinoid System and Physical Exercise. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031989"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.5935\/2595-0118.20230038-en","article-title":"The endocannabinoid system and orofacial pains: Updates and perspectives","volume":"6","author":"Tanganeli","year":"2023","journal-title":"BrJP"},{"key":"ref_9","unstructured":"Grinspoon, P. (2021, August 11). The Endocannabinoid System: Essential and Mysterious. Harvard Health Blog. 11 August 2021. Available online: https:\/\/www.health.harvard.edu\/blog\/the-endocannabinoid-system-essential-and-mysterious-202108112569."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13191-011-0041-5","article-title":"Bruxism: A literature review","volume":"10","author":"Shetty","year":"2010","journal-title":"J. Indian. Prosthodont. Soc."},{"key":"ref_11","first-page":"200","article-title":"Self-Report of the Perception of Stress and Signs of Bruxism Generated during the Pandemic in Students of the Health Area","volume":"24","year":"2022","journal-title":"Odovtos Int. J. Dent. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.12775\/JEHS.2020.10.09.021","article-title":"The influence of stress on the occurrence of bruxism","volume":"10","author":"Kozyra","year":"2020","journal-title":"J. Educ. Health Sport."},{"key":"ref_13","unstructured":"Lal, S.J., Sankari, A., Kurt, K., and Weber, D.D.S. (2024, May 01). Bruxism Management, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482466\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/ors.12473","article-title":"Temporomandibular disorders: A review of current concepts in aetiology, diagnosis and management","volume":"13","author":"Kapos","year":"2020","journal-title":"Oral Surg."},{"key":"ref_15","first-page":"52","article-title":"Associations between sleep bruxism and primary headaches: A descriptive study","volume":"38","author":"Duarte","year":"2024","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41392-024-01845-w","article-title":"Pathology of pain and its implications for therapeutic interventions","volume":"9","author":"Cao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/j.pain.0000000000003056","article-title":"Co-occurrence of chronic pain and anxiety\/depression symptoms in U.S. adults: Prevalence, functional impacts, and opportunities","volume":"165","author":"Brady","year":"2024","journal-title":"Pain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/157015906778019527","article-title":"Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes","volume":"4","author":"Manzanares","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Leinen, Z.J., Mohan, R., Premadasa, L.S., Acharya, A., Mohan, M., and Byrareddy, S.N. (2023). Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102630"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Matos, C., Pereira, A.T., Dias, M.J., Sousa, C., Vinha, A.F., Moutinho, C., and Carvalho, M. (2025). Cannabis for Chronic Pain: Mechanistic Insights and Therapeutic Challenges. Stresses, 5.","DOI":"10.3390\/stresses5010007"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"T10","DOI":"10.1016\/j.jpain.2015.08.010","article-title":"Assessment of Chronic Pain: Domains, Methods, and Mechanisms","volume":"17","author":"Fillingim","year":"2016","journal-title":"J. Pain."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Benzon, H.T., Rathmell, J.P., Wu, C.L., Turk, D.C., and Argoff, C.E. (2008). Outcomes, efficacy, and complications of headache management. Raj\u2019s Practical Management of Pain, Elsevier. [4th ed.].","DOI":"10.1016\/B978-032304184-3.50073-X"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1212\/WNL.56.suppl_1.S29","article-title":"Potential of the Migraine Disability Assessment (MIDAS) Questionnaire as a public health initiative and in clinical practice","volume":"56","author":"Edmeads","year":"2001","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-1781(00)00232-8","article-title":"Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects","volume":"97","author":"Doi","year":"2000","journal-title":"Psychiatry Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Esmaeli, M., Dehabadi, M.D., and Khaleghi, A.A. (2025). Cannabidiol as a novel therapeutic agent in breast cancer: Evidence from literature. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-14175-z"},{"key":"ref_27","first-page":"254","article-title":"Cannabinoids as Immune System Modulators: Cannabidiol Potential Therapeutic Approaches and Limitations","volume":"8","author":"Aziz","year":"2023","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"104940","DOI":"10.1016\/j.phrs.2020.104940","article-title":"Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1\/CB2 heteromer receptors","volume":"159","author":"Navarro","year":"2020","journal-title":"Pharmacol Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.2174\/1381612826666201202125807","article-title":"Medicinal Applications of Cannabinoids Extracted from Cannabis sativa (L.): A New Route in the Fight Against COVID-19?","volume":"27","author":"Khalid","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s00103-019-02964-4","article-title":"Fortschritte in der Cannabis-Forschung aus pharmazeutisch-chemischer Sicht [Progress in cannabis research from a pharmaceutical chemist\u2019s point of view]","volume":"62","year":"2019","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11916-023-01101-w","article-title":"Medical Cannabis for Chronic Nonmalignant Pain Management","volume":"27","author":"Hameed","year":"2023","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pharmthera.2017.02.041","article-title":"Cannabidiol: State of the Art and New Challenges for Therapeutic Applications","volume":"175","author":"Pisanti","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_33","unstructured":"de Souza, R.S., Takahashi, R.N., and Corr\u00eaa, F.M.A. (2022). Cannabinoids in Migraine: A Review of Clinical Evidence. Front. Neurol., 13."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Martynowicz, H., Smardz, J., Michalek-Zrabkowska, M., Mazur, G., and Wojakowska, A. (2019). Correlation Between Sleep Bruxism and Headache Impact Test (HIT-6) Scores Among Adults. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00487"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Walczy\u0144ska-Dragon, K., Fiegler-Rudol, J., Nitecka-Buchta, A., and Baron, S. (2025). Cannabidiol for Orofacial and Upper-Quarter Pain: A Systematic Evaluation of Therapeutic Potential. J. Clin Med., 14.","DOI":"10.3390\/jcm14124186"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"114793","DOI":"10.1016\/j.bbr.2023.114793","article-title":"Antinociceptive Action of Cannabidiol on Thermal Sensitivity and Post-Operative Pain in Male and Female Rats","volume":"459","author":"Arantes","year":"2024","journal-title":"Behav. Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1089\/can.2021.0108","article-title":"Evaluating the Antinociceptive Efficacy of Cannabidiol Alone or in Combination with Morphine Using the Formalin Test in Male and Female Mice","volume":"7","author":"Sepulveda","year":"2022","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"108700","DOI":"10.1016\/j.neuropharm.2021.108700","article-title":"do Cannabidiol Has Therapeutic Potential for Myofascial Pain in Female and Male Parkinsonian Rats","volume":"196","author":"Guimaraes","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_39","unstructured":"(2018). Primary Packaging Materials for Medicinal Products (Standard No. ISO 15378:2018)."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/7\/1064\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:12:28Z","timestamp":1760033548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/7\/1064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ph18071064"],"URL":"https:\/\/doi.org\/10.3390\/ph18071064","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,19]]}}}